Luke Gilbert, PhD

Title(s)Associate Professor, Urology
SchoolSchool of Medicine
Address1450 Third St, #382
San Francisco CA 94158
Phone415-476-9791
ORCID ORCID Icon0000-0001-5854-0825 Additional info
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    Collapse Research 
    Collapse Research Activities and Funding
    Editing CG and non-CG DNA methylation to identify genomic elements that regulate gene expression
    NIH R01HG012227Sep 10, 2021 - Jun 30, 2025
    Role: Principal Investigator
    Drug target identification using CRISPRi/a screening
    NIH R41GM137625May 1, 2020 - Apr 30, 2021
    Role: Co-Principal Investigator
    A GENETIC INTERACTION MAP OF THE HUMAN NUCLEUS
    NIH DP2CA239597Sep 30, 2018 - May 31, 2023
    Role: Principal Investigator
    A functional genomics approach to determine the mechanism of cellular response to new anti-cancer
    NIH R00CA204602Apr 1, 2017 - Mar 31, 2020
    Role: Principal Investigator
    A functional genomics approach to determine the mechanism of cellular response to new anti-cancer drugs
    NIH K99CA204602Apr 1, 2016 - Mar 31, 2017
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Improving prime editing with an endogenous small RNA-binding protein. Nature. 2024 Apr 03. Yan J, Oyler-Castrillo P, Ravisankar P, Ward CC, Levesque S, Jing Y, Simpson D, Zhao A, Li H, Yan W, Goudy L, Schmidt R, Solley SC, Gilbert LA, Chan MM, Bauer DE, Marson A, Parsons LR, Adamson B. PMID: 38570691.
      View in: PubMed   Mentions:    Fields:    
    2. Higher-order combinatorial chromatin perturbations by engineered CRISPR-Cas12a for functional genomics. bioRxiv. 2024 Feb 09. Hsiung CC, Wilson CM, Sambold NA, Dai R, Chen Q, Misiukiewicz S, Arab A, Teyssier N, O'Loughlin T, Cofsky JC, Shi J, Gilbert LA. PMID: 37781594; PMCID: PMC10541102.
      View in: PubMed   Mentions:
    3. Epigenetic reprogramming shapes the cellular landscape of schwannoma. Nat Commun. 2024 Jan 12; 15(1):476. Liu SJ, Casey-Clyde T, Cho NW, Swinderman J, Pekmezci M, Dougherty MC, Foster K, Chen WC, Villanueva-Meyer JE, Swaney DL, Vasudevan HN, Choudhury A, Pak J, Breshears JD, Lang UE, Eaton CD, Hiam-Galvez KJ, Stevenson E, Chen KH, Lien BV, Wu D, Braunstein SE, Sneed PK, Magill ST, Lim D, McDermott MW, Berger MS, Perry A, Krogan NJ, Hansen MR, Spitzer MH, Gilbert L, Theodosopoulos PV, Raleigh DR. PMID: 38216587; PMCID: PMC10786948.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    4. ENPP1 is an innate immune checkpoint of the anticancer cGAMP-STING pathway in breast cancer. Proc Natl Acad Sci U S A. 2023 Dec 26; 120(52):e2313693120. Wang S, Böhnert V, Joseph AJ, Sudaryo V, Skariah G, Swinderman JT, Yu FB, Subramanyam V, Wolf DM, Lyu X, Gilbert LA, Van't Veer LJ, Goodarzi H, Li L. PMID: 38117852; PMCID: PMC10756298.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    5. Base-editing mutagenesis maps alleles to tune human T cell functions. Nature. 2024 Jan; 625(7996):805-812. Schmidt R, Ward CC, Dajani R, Armour-Garb Z, Ota M, Allain V, Hernandez R, Layeghi M, Xing G, Goudy L, Dorovskyi D, Wang C, Chen YY, Ye CJ, Shy BR, Gilbert LA, Eyquem J, Pritchard JK, Dodgson SE, Marson A. PMID: 38093011.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    6. Mediator Kinase/CDK8 Inhibition As a Strategy to Improve FLT3 Inhibitor Activity in Acute Myeloid Leukemia. Blood. 2023 Nov 28; 142(Supplement 1):4173. Ferng FT, Pintar PS, Kennedy KV, Tarver TT, Kabir KS, Steri SV, Serrano SJ, Salangsang SF, Phojanakong PP, Hübner HJ, Morales MC, Rivera RJ, Logan LA, Braun BB, Stieglitz SE, Gilbert GL, Smith SC. .
      View in: Publisher Site   Mentions:
    7. EPCO-12. IN VIVO PERTURB-SEQ DEFINES BIOLOGICAL DRIVERS AND THERAPEUTIC VULNERABILITIES UNDERLYING RADIOTHERAPY RESISTANCE IN GLIOBLASTOMA. Neuro-Oncology. 2023 Nov 10; 25(Supplement_5):v125-v126. Liu LJ, Pak PJ, Zou ZC, Pan PS, Payne PE, Foster FK, Lin LK, Casey-Clyde CT, Seo SK, O'Loughlin OT, Wu WD, Lim LD, Vasudevan VH, Diaz DA, Ozawa OT, Berger BM, de Groot dJ, Weiss WW, Gilbert GL, Raleigh RD. .
      View in: Publisher Site   Mentions:
    8. EXTH-78. CRISPROFF EPIGENOME EDITING AND FUNCTIONAL GENOMICS DEFINE MEDIATORS OF CHEMOTHERAPY RESISTANCE IN GLIOBLASTOMA. Neuro-Oncology. 2023 Nov 10; 25(Supplement_5):v242-v242. Lin LK, Goudy GL, Pak PJ, Foster FK, Payne PE, Ozawa OT, de Groot dJ, Vasudevan VH, Raleigh RD, Gilbert GL, Berger BM, Liu LJ. .
      View in: Publisher Site   Mentions:
    9. CRISPR-Based Epigenome Editing and Genome Wide Screening Define Mediators of Chemotherapy Response in Glioblastoma. International Journal of Radiation Oncology • Biology • Physics. 2023 Oct 1; 117(2):s42-s43. Lin LK, Goudy GL, Pak PJ, Foster FK, Payne PE, Ozawa OT, de Groot dJ, Vasudevan VH, Raleigh RD, Gilbert GL, Berger BM, Liu LS. .
      View in: Publisher Site   Mentions:
    10. Identifying Gene-Treatment Interactions and Targetable Radiation Vulnerabilities in Glioblastoma through Coupling of In Vivo CRISPR Perturbation and Single Cell Transcriptomics. International Journal of Radiation Oncology • Biology • Physics. 2023 Oct 1; 117(2):s102. Liu LS, Pak PJ, Zou ZC, Payne PE, Foster FK, Vasudevan VH, Casey-Clyde CT, Seo SK, O'Loughlin OT, Wu WD, Lim LD, Ozawa OT, de Groot dJ, Berger BM, Weiss WW, Gilbert GL, Raleigh RD. .
      View in: Publisher Site   Mentions:
    11. Environmental challenge rewires functional connections among human genes. bioRxiv. 2023 Aug 09. Herken BW, Wong GT, Norman TM, Gilbert LA. PMID: 37609173; PMCID: PMC10441384.
      View in: PubMed   Mentions:
    12. ENPP1 is an innate immune checkpoint of the anticancer cGAMP-STING pathway. bioRxiv. 2023 Jun 05. Wang S, Böhnert V, Joseph AJ, Sudaryo V, Swinderman J, Yu FB, Lyu X, Skariah G, Subramanyam V, Gilbert LA, Goodarzi H, Lingyin L. PMID: 37333273; PMCID: PMC10274658.
      View in: PubMed   Mentions:
    13. Integrative identification of non-coding regulatory regions driving metastatic prostate cancer. bioRxiv. 2023 Jun 02. Woo BJ, Moussavi-Baygi R, Karner H, Karimzadeh M, Garcia K, Joshi T, Yin K, Navickas A, Gilbert LA, Wang B, Asgharian H, Feng FY, Goodarzi H. PMID: 37398273; PMCID: PMC10312451.
      View in: PubMed   Mentions:
    14. Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors. Elife. 2022 Dec 28; 11. Replogle JM, Bonnar JL, Pogson AN, Liem CR, Maier NK, Ding Y, Russell BJ, Wang X, Leng K, Guna A, Norman TM, Pak RA, Ramos DM, Ward ME, Gilbert LA, Kampmann M, Weissman JS, Jost M. PMID: 36576240.
      View in: PubMed   Mentions: 15     Fields:    
    15. IFITM proteins assist cellular uptake of diverse linked chemotypes. Science. 2022 12 09; 378(6624):1097-1104. Lou K, Wassarman DR, Yang T, Paung Y, Zhang Z, O'Loughlin TA, Moore MK, Egan RK, Greninger P, Benes CH, Seeliger MA, Taunton J, Gilbert LA, Shokat KM. PMID: 36480603; PMCID: PMC9924227.
      View in: PubMed   Mentions: 4     Fields:    
    16. The 5-Hydroxymethylcytosine Landscape of Prostate Cancer. Cancer Res. 2022 11 02; 82(21):3888-3902. Sjöström M, Zhao SG, Levy S, Zhang M, Ning Y, Shrestha R, Lundberg A, Herberts C, Foye A, Aggarwal R, Hua JT, Li H, Bergamaschi A, Maurice-Dror C, Maheshwari A, Chen S, Ng SWS, Ye W, Petricca J, Fraser M, Chesner L, Perry MD, Moreno-Rodriguez T, Chen WS, Alumkal JJ, Chou J, Morgans AK, Beer TM, Thomas GV, Gleave M, Lloyd P, Phillips T, McCarthy E, Haffner MC, Zoubeidi A, Annala M, Reiter RE, Rettig MB, Witte ON, Fong L, Bose R, Huang FW, Luo J, Bjartell A, Lang JM, Mahajan NP, Lara PN, Evans CP, Tran PT, Posadas EM, He C, Cui XL, Huang J, Zwart W, Gilbert LA, Maher CA, Boutros PC, Chi KN, Ashworth A, Small EJ, He HH, Wyatt AW, Quigley DA, Feng FY. PMID: 36251389; PMCID: PMC9627125.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    17. Abstract B021: Long non-coding RNAs that are required for robust cell growth in ewing Sarcoma. Clinical Cancer Research. 2022 Sep 15; 28(18_Supplement):b021-b021. Briones Martin del Campo BM, Lee LA, Horlbeck HM, Dinh DT, Roman-Moreno RM, Sayles SL, Seong SB, Stegmaier SK, Gilbert GL, Sweet-Cordero SE. .
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    18. Highly efficient generation of isogenic pluripotent stem cell models using prime editing. Elife. 2022 09 07; 11. Li H, Busquets O, Verma Y, Syed KM, Kutnowski N, Pangilinan GR, Gilbert LA, Bateup HS, Rio DC, Hockemeyer D, Soldner F. PMID: 36069759; PMCID: PMC9584603.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    19. A campaign targeting a conserved Hsp70 binding site uncovers how subcellular localization is linked to distinct biological activities. Cell Chem Biol. 2022 08 18; 29(8):1303-1316.e3. Shao H, Taguwa S, Gilbert L, Shkedi A, Sannino S, Guerriero CJ, Gale-Day ZJ, Young ZT, Brodsky JL, Weissman J, Gestwicki JE, Frydman J. PMID: 35830852; PMCID: PMC9513760.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    20. Applications of CRISPRi and CRISPRa in Drug Discovery. . 2022 Mar 17; 139-150. Gilbert GL. .
      View in: Publisher Site   Mentions:
    21. A pan-CRISPR analysis of mammalian cell specificity identifies ultra-compact sgRNA subsets for genome-scale experiments. Nat Commun. 2022 02 02; 13(1):625. Zhao B, Rao Y, Leighow S, O'Brien EP, Gilbert L, Pritchard JR. PMID: 35110534; PMCID: PMC8810922.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    22. RNA Polymerase II Is a Therapeutic Target to Overcome FLT3 Inhibitor Resistance Mediated By the Bone Marrow Microenvironment. Blood. 2021 Nov 5; 138(Supplement 1):2236-2236. Ferng FT, Tarver TT, Kabir KS, Braun BB, Logan LA, Gilbert GL, Smith SC. .
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    23. A global cancer data integrator reveals principles of synthetic lethality, sex disparity and immunotherapy. Genome Med. 2021 10 18; 13(1):167. Yogodzinski C, Arab A, Pritchard JR, Goodarzi H, Gilbert LA. PMID: 34663427; PMCID: PMC8524992.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    24. A new era in functional genomics screens. Nat Rev Genet. 2022 02; 23(2):89-103. Przybyla L, Gilbert LA. PMID: 34545248.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    25. An integrated functional and clinical genomics approach reveals genes driving aggressive metastatic prostate cancer. Nat Commun. 2021 07 29; 12(1):4601. Das R, Sjöström M, Shrestha R, Yogodzinski C, Egusa EA, Chesner LN, Chen WS, Chou J, Dang DK, Swinderman JT, Ge A, Hua JT, Kabir S, Quigley DA, Small EJ, Ashworth A, Feng FY, Gilbert LA. PMID: 34326322; PMCID: PMC8322386.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    26. Revealing molecular pathways for cancer cell fitness through a genetic screen of the cancer translatome. Cell Rep. 2021 06 29; 35(13):109321. Kuzuoglu-Ozturk D, Hu Z, Rama M, Devericks E, Weiss J, Chiang GG, Worland ST, Brenner SE, Goodarzi H, Gilbert LA, Ruggero D. PMID: 34192540; PMCID: PMC8323864.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    27. Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing. Cell. 2021 04 29; 184(9):2503-2519.e17. Nuñez JK, Chen J, Pommier GC, Cogan JZ, Replogle JM, Adriaens C, Ramadoss GN, Shi Q, Hung KL, Samelson AJ, Pogson AN, Kim JYS, Chung A, Leonetti MD, Chang HY, Kampmann M, Bernstein BE, Hovestadt V, Gilbert LA, Weissman JS. PMID: 33838111; PMCID: PMC8376083.
      View in: PubMed   Mentions: 165     Fields:    Translation:HumansCells
    28. Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell. 2021 Feb 04; 184(3):844. Qi LS, Larson MH, Gilbert LA, Doudna JA, Weissman JS, Arkin AP, Lim WA. PMID: 33545038.
      View in: PubMed   Mentions: 17     Fields:    
    29. Mapping cancer genetics at single-cell resolution. Sci Transl Med. 2020 08 26; 12(558). Gilbert LA. PMID: 32848092.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    30. The DNA methylation landscape of advanced prostate cancer. Nat Genet. 2020 08; 52(8):778-789. Zhao SG, Chen WS, Li H, Foye A, Zhang M, Sjöström M, Aggarwal R, Playdle D, Liao A, Alumkal JJ, Das R, Chou J, Hua JT, Barnard TJ, Bailey AM, Chow ED, Perry MD, Dang HX, Yang R, Moussavi-Baygi R, Zhang L, Alshalalfa M, Laura Chang S, Houlahan KE, Shiah YJ, Beer TM, Thomas G, Chi KN, Gleave M, Zoubeidi A, Reiter RE, Rettig MB, Witte O, Yvonne Kim M, Fong L, Spratt DE, Morgan TM, Bose R, Huang FW, Li H, Chesner L, Shenoy T, Goodarzi H, Asangani IA, Sandhu S, Lang JM, Mahajan NP, Lara PN, Evans CP, Febbo P, Batzoglou S, Knudsen KE, He HH, Huang J, Zwart W, Costello JF, Luo J, Tomlins SA, Wyatt AW, Dehm SM, Ashworth A, Gilbert LA, Boutros PC, Farh K, Chinnaiyan AM, Maher CA, Small EJ, Quigley DA, Feng FY. PMID: 32661416; PMCID: PMC7454228.
      View in: PubMed   Mentions: 122     Fields:    Translation:HumansCells
    31. Pharmaceutical-Grade Rigosertib Is a Microtubule-Destabilizing Agent. Mol Cell. 2020 07 02; 79(1):191-198.e3. Jost M, Chen Y, Gilbert LA, Horlbeck MA, Krenning L, Menchon G, Rai A, Cho MY, Stern JJ, Prota AE, Kampmann M, Akhmanova A, Steinmetz MO, Tanenbaum ME, Weissman JS. PMID: 32619469; PMCID: PMC7332992.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCellsPHPublic Health
    32. Keap1ing an eye on Slc33A1. Nat Cancer. 2020 06; 1(6):575-576. Gilbert LA. PMID: 35121976.
      View in: PubMed   Mentions:    Fields:    
    33. Clonal ZEB1-Driven Mesenchymal Transition Promotes Targetable Oncologic Antiangiogenic Therapy Resistance. Cancer Res. 2020 04 01; 80(7):1498-1511. Chandra A, Jahangiri A, Chen W, Nguyen AT, Yagnik G, Pereira MP, Jain S, Garcia JH, Shah SS, Wadhwa H, Joshi RS, Weiss J, Wolf KJ, Lin JG, Müller S, Rick JW, Diaz AA, Gilbert LA, Kumar S, Aghi MK. PMID: 32041837; PMCID: PMC7236890.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    34. Exploring genetic interaction manifolds constructed from rich single-cell phenotypes. Science. 2019 08 23; 365(6455):786-793. Norman TM, Horlbeck MA, Replogle JM, Ge AY, Xu A, Jost M, Gilbert LA, Weissman JS. PMID: 31395745; PMCID: PMC6746554.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansCells
    35. A Bounty of New Challenging Targets in Oncology for Chemical Discovery. Biochemistry. 2019 08 06; 58(31):3328-3330. Lou K, Gilbert LA, Shokat KM. PMID: 31343870.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    36. DNA-Dependent Protein Kinase Drives Prostate Cancer Progression through Transcriptional Regulation of the Wnt Signaling Pathway. Clin Cancer Res. 2019 09 15; 25(18):5608-5622. Kothari V, Goodwin JF, Zhao SG, Drake JM, Yin Y, Chang SL, Evans JR, Wilder-Romans K, Gabbara K, Dylgjeri E, Chou J, Sun G, Tomlins SA, Mehra R, Hege K, Filvaroff EH, Schaeffer EM, Karnes RJ, Quigley DA, Rathkopf DE, He HH, Speers C, Spratt DE, Gilbert LA, Ashworth A, Chinnaiyan AM, Raj GV, Knudsen KE, Feng FY. PMID: 31266829; PMCID: PMC6744969.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    37. KRASG12C inhibition produces a driver-limited state revealing collateral dependencies. Sci Signal. 2019 05 28; 12(583). Lou K, Steri V, Ge AY, Hwang YC, Yogodzinski CH, Shkedi AR, Choi ALM, Mitchell DC, Swaney DL, Hann B, Gordan JD, Shokat KM, Gilbert LA. PMID: 31138768; PMCID: PMC6871662.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    38. Lethal clues to cancer-cell vulnerability. Nature. 2019 04; 568(7753):463-464. Feng FY, Gilbert LA. PMID: 31000834.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    39. Cellular response to small molecules that selectively stall protein synthesis by the ribosome. PLoS Genet. 2019 03; 15(3):e1008057. Liaud N, Horlbeck MA, Gilbert LA, Gjoni K, Weissman JS, Cate JHD. PMID: 30875366; PMCID: PMC6436758.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    40. Functional Genomics for Cancer Research: Applications In Vivo and In Vitro. Annual Review of Cancer Biology. 2019 Mar 4; 3(1):1-19. O'Loughlin OT, Gilbert GL. .
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    41. Finding and Interpreting Genetic Interactions using Perturb-Seq Single Cell RNA-Seq CRISPR Screens. Biophysical Journal. 2019 Feb 1; 116(3):318a. Weissman WJ, Norman NT, Horlbeck HM, Gilbert GL. .
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    42. DRES-01. ZEB1-MEDIATED INVASIVE MESENCHYMAL TRANSITION AT THE SINGLE CELL LEVEL PROMOTES ANTI-ANGIOGENIC THERAPY RESISTANCE IN GLIOBLASTOMA. Neuro-Oncology. 2018 Nov 5; 20(suppl_6):vi75-vi75. Chandra CA, Jahangiri JA, Chen CW, Yagnik YG, Garcia GJ, Nguyen NA, Weiss WJ, Wolf WK, Lin LJ, Mueller MS, Rick RJ, Diaz DA, Gilbert GL, Kumar KS, Aghi AM. .
      View in: Publisher Site   Mentions:
    43. Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer. Cell. 2018 10 18; 175(3):889. Quigley DA, Dang HX, Zhao SG, Lloyd P, Aggarwal R, Alumkal JJ, Foye A, Kothari V, Perry MD, Bailey AM, Playdle D, Barnard TJ, Zhang L, Zhang J, Youngren JF, Cieslik MP, Parolia A, Beer TM, Thomas G, Chi KN, Gleave M, Lack NA, Zoubeidi A, Reiter RE, Rettig MB, Witte O, Ryan CJ, Fong L, Kim W, Friedlander T, Chou J, Li H, Das R, Li H, Moussavi-Baygi R, Goodarzi H, Gilbert LA, Lara PN, Evans CP, Goldstein TC, Stuart JM, Tomlins SA, Spratt DE, Cheetham RK, Cheng DT, Farh K, Gehring JS, Hakenberg J, Liao A, Febbo PG, Shon J, Sickler B, Batzoglou S, Knudsen KE, He HH, Huang J, Wyatt AW, Dehm SM, Ashworth A, Chinnaiyan AM, Maher CA, Small EJ, Feng FY. PMID: 30340047.
      View in: PubMed   Mentions: 64     Fields:    
    44. A high-throughput screen of real-time ATP levels in individual cells reveals mechanisms of energy failure. PLoS Biol. 2018 08; 16(8):e2004624. Mendelsohn BA, Bennett NK, Darch MA, Yu K, Nguyen MK, Pucciarelli D, Nelson M, Horlbeck MA, Gilbert LA, Hyun W, Kampmann M, Nakamura JL, Nakamura K. PMID: 30148842; PMCID: PMC6110572.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    45. Mapping the Genetic Landscape of Human Cells. Cell. 2018 08 09; 174(4):953-967.e22. Horlbeck MA, Xu A, Wang M, Bennett NK, Park CY, Bogdanoff D, Adamson B, Chow ED, Kampmann M, Peterson TR, Nakamura K, Fischbach MA, Weissman JS, Gilbert LA. PMID: 30033366; PMCID: PMC6426455.
      View in: PubMed   Mentions: 119     Fields:    Translation:HumansCells
    46. Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer. Cell. 2018 07 26; 174(3):758-769.e9. Quigley DA, Dang HX, Zhao SG, Lloyd P, Aggarwal R, Alumkal JJ, Foye A, Kothari V, Perry MD, Bailey AM, Playdle D, Barnard TJ, Zhang L, Zhang J, Youngren JF, Cieslik MP, Parolia A, Beer TM, Thomas G, Chi KN, Gleave M, Lack NA, Zoubeidi A, Reiter RE, Rettig MB, Witte O, Ryan CJ, Fong L, Kim W, Friedlander T, Chou J, Li H, Das R, Li H, Moussavi-Baygi R, Goodarzi H, Gilbert LA, Lara PN, Evans CP, Goldstein TC, Stuart JM, Tomlins SA, Spratt DE, Cheetham RK, Cheng DT, Farh K, Gehring JS, Hakenberg J, Liao A, Febbo PG, Shon J, Sickler B, Batzoglou S, Knudsen KE, He HH, Huang J, Wyatt AW, Dehm SM, Ashworth A, Chinnaiyan AM, Maher CA, Small EJ, Feng FY. PMID: 30033370; PMCID: PMC6425931.
      View in: PubMed   Mentions: 263     Fields:    Translation:HumansCells
    47. Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein-Protein Interactions with Heat Shock Protein 70 (Hsp70). J Med Chem. 2018 Jul 26; 61(14):6163-6177. Shao H, Li X, Moses MA, Gilbert LA, Kalyanaraman C, Young ZT, Chernova M, Journey SN, Weissman JS, Hann B, Jacobson MP, Neckers L, Gestwicki JE. PMID: 29953808; PMCID: PMC6104643.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    48. Combinatorial genetics in liver repopulation and carcinogenesis with a in vivo CRISPR activation platform. Hepatology. 2018 Aug; 68(2):663-676. Wangensteen KJ, Wang YJ, Dou Z, Wang AW, Mosleh-Shirazi E, Horlbeck MA, Gilbert LA, Weissman JS, Berger SL, Kaestner KH. PMID: 29091290; PMCID: PMC5930141.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    49. The Promise and Challenge of In Vivo Delivery for Genome Therapeutics. ACS Chem Biol. 2018 02 16; 13(2):376-382. Wilson RC, Gilbert LA. PMID: 29019396; PMCID: PMC5906052.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    50. Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent. Mol Cell. 2017 Oct 05; 68(1):210-223.e6. Jost M, Chen Y, Gilbert LA, Horlbeck MA, Krenning L, Menchon G, Rai A, Cho MY, Stern JJ, Prota AE, Kampmann M, Akhmanova A, Steinmetz MO, Tanenbaum ME, Weissman JS. PMID: 28985505; PMCID: PMC5640507.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansCells
    51. CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells. Science. 2017 01 06; 355(6320). Liu SJ, Horlbeck MA, Cho SW, Birk HS, Malatesta M, He D, Attenello FJ, Villalta JE, Cho MY, Chen Y, Mandegar MA, Olvera MP, Gilbert LA, Conklin BR, Chang HY, Weissman JS, Lim DA. PMID: 27980086; PMCID: PMC5394926.
      View in: PubMed   Mentions: 328     Fields:    Translation:HumansCells
    52. A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response. Cell. 2016 Dec 15; 167(7):1867-1882.e21. Adamson B, Norman TM, Jost M, Cho MY, Nuñez JK, Chen Y, Villalta JE, Gilbert LA, Horlbeck MA, Hein MY, Pak RA, Gray AN, Gross CA, Dixit A, Parnas O, Regev A, Weissman JS. PMID: 27984733; PMCID: PMC5315571.
      View in: PubMed   Mentions: 436     Fields:    Translation:HumansAnimalsCells
    53. Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation. Elife. 2016 Sep 23; 5. Horlbeck MA, Gilbert LA, Villalta JE, Adamson B, Pak RA, Chen Y, Fields AP, Park CY, Corn JE, Kampmann M, Weissman JS. PMID: 27661255; PMCID: PMC5094855.
      View in: PubMed   Mentions: 336     Fields:    Translation:HumansAnimalsCells
    54. A senescence secretory switch mediated by PI3K/AKT/mTOR activation controls chemoprotective endothelial secretory responses. Genes Dev. 2016 08 15; 30(16):1811-21. Bent EH, Gilbert LA, Hemann MT. PMID: 27566778; PMCID: PMC5024680.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    55. Ligand-binding domains of nuclear receptors facilitate tight control of split CRISPR activity. Nat Commun. 2016 07 01; 7:12009. Nguyen DP, Miyaoka Y, Gilbert LA, Mayerl SJ, Lee BH, Weissman JS, Conklin BR, Wells JA. PMID: 27363581; PMCID: PMC4932181.
      View in: PubMed   Mentions: 45     Fields:    Translation:Cells
    56. Versatile in vivo regulation of tumor phenotypes by dCas9-mediated transcriptional perturbation. Proc Natl Acad Sci U S A. 2016 07 05; 113(27):E3892-900. Braun CJ, Bruno PM, Horlbeck MA, Gilbert LA, Weissman JS, Hemann MT. PMID: 27325776; PMCID: PMC4941480.
      View in: PubMed   Mentions: 46     Fields:    Translation:Animals
    57. Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification. Nat Chem Biol. 2016 May; 12(5):361-6. Deans RM, Morgens DW, Ökesli A, Pillay S, Horlbeck MA, Kampmann M, Gilbert LA, Li A, Mateo R, Smith M, Glenn JS, Carette JE, Khosla C, Bassik MC. PMID: 27018887; PMCID: PMC4836973.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansCells
    58. Versatile protein tagging in cells with split fluorescent protein. Nat Commun. 2016 Mar 18; 7:11046. Kamiyama D, Sekine S, Barsi-Rhyne B, Hu J, Chen B, Gilbert LA, Ishikawa H, Leonetti MD, Marshall WF, Weissman JS, Huang B. PMID: 26988139; PMCID: PMC4802074.
      View in: PubMed   Mentions: 180     Fields:    Translation:HumansCells
    59. Nucleosomes impede Cas9 access to DNA in vivo and in vitro. Elife. 2016 03 17; 5. Horlbeck MA, Witkowsky LB, Guglielmi B, Replogle JM, Gilbert LA, Villalta JE, Torigoe SE, Tjian R, Weissman JS. PMID: 26987018; PMCID: PMC4861601.
      View in: PubMed   Mentions: 195     Fields:    Translation:HumansCells
    60. CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs. Cell Stem Cell. 2016 Apr 07; 18(4):541-53. Mandegar MA, Huebsch N, Frolov EB, Shin E, Truong A, Olvera MP, Chan AH, Miyaoka Y, Holmes K, Spencer CI, Judge LM, Gordon DE, Eskildsen TV, Villalta JE, Horlbeck MA, Gilbert LA, Krogan NJ, Sheikh SP, Weissman JS, Qi LS, So PL, Conklin BR. PMID: 26971820; PMCID: PMC4830697.
      View in: PubMed   Mentions: 228     Fields:    Translation:HumansCells
    61. Abstract IA27: Retooling CRISPR to turn genes on and off. New Technologies in Cancer Research. 2016 Feb 1; ia27-ia27. Gilbert GL, Horlbeck HM, Villalta VJ, Hao HS, Gestwicki GJ, Weissman WJ. .
      View in: Publisher Site   Mentions:
    62. Unraveling the Mechanism of SBRT Response in EGFR-Addicted Pulmonary Adenocarcinoma by CRISPR/Cas9 Functional Genomics. International Journal of Radiation Oncology • Biology • Physics. 2015 Nov 1; 93(3):e519. Polishchuk PA, Flanagan FJ, Gilbert GL, Horlbeck HM, Yang YX, Olow OA, Bassik BM, Weissman WJ, Haas-Kogan HD, Wells WJ, Bivona BT. .
      View in: Publisher Site   Mentions:
    63. Next-generation libraries for robust RNA interference-based genome-wide screens. Proc Natl Acad Sci U S A. 2015 Jun 30; 112(26):E3384-91. Kampmann M, Horlbeck MA, Chen Y, Tsai JC, Bassik MC, Gilbert LA, Villalta JE, Kwon SC, Chang H, Kim VN, Weissman JS. PMID: 26080438; PMCID: PMC4491794.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimals
    64. Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds. Cell. 2015 Jan 15; 160(1-2):339-50. Zalatan JG, Lee ME, Almeida R, Gilbert LA, Whitehead EH, La Russa M, Tsai JC, Weissman JS, Dueber JE, Qi LS, Lim WA. PMID: 25533786; PMCID: PMC4297522.
      View in: PubMed   Mentions: 387     Fields:    Translation:HumansAnimalsCells
    65. Abstract IA10: Improving existing cancer therapy by targeting the tumor microenvironment. Target Discovery and Validation. 2014 Nov 1; ia10-ia10. Pallasch PC, Gilbert GL, Hemann HM. .
      View in: Publisher Site   Mentions:
    66. Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation. Cell. 2014 Oct 23; 159(3):647-61. Gilbert LA, Horlbeck MA, Adamson B, Villalta JE, Chen Y, Whitehead EH, Guimaraes C, Panning B, Ploegh HL, Bassik MC, Qi LS, Kampmann M, Weissman JS. PMID: 25307932; PMCID: PMC4253859.
      View in: PubMed   Mentions: 1187     Fields:    Translation:HumansCells
    67. A protein-tagging system for signal amplification in gene expression and fluorescence imaging. Cell. 2014 Oct 23; 159(3):635-46. Tanenbaum ME, Gilbert LA, Qi LS, Weissman JS, Vale RD. PMID: 25307933; PMCID: PMC4252608.
      View in: PubMed   Mentions: 607     Fields:    Translation:HumansAnimalsCells
    68. Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System. Cell. 2014 Jan 1; 156(1-2):373. Chen CB, Gilbert GL, Cimini CB, Schnitzbauer SJ, Zhang ZW, Li LG, Park PJ, Blackburn BE, Weissman WJ, Qi QL, Huang HB. .
      View in: Publisher Site   Mentions:
    69. Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system. Cell. 2013 Dec 19; 155(7):1479-91. Chen B, Gilbert LA, Cimini BA, Schnitzbauer J, Zhang W, Li GW, Park J, Blackburn EH, Weissman JS, Qi LS, Huang B. PMID: 24360272; PMCID: PMC3918502.
      View in: PubMed   Mentions: 888     Fields:    Translation:HumansCells
    70. CRISPR interference (CRISPRi) for sequence-specific control of gene expression. Nat Protoc. 2013 Nov; 8(11):2180-96. Larson MH, Gilbert LA, Wang X, Lim WA, Weissman JS, Qi LS. PMID: 24136345; PMCID: PMC3922765.
      View in: PubMed   Mentions: 456     Fields:    Translation:Cells
    71. Abstract PR07: Systematic genetic interaction maps reveal rewiring of the stress response network and resulting vulnerabilities in leukemia and multiple myeloma cells. Interpreting the Cancer Genome. 2013 Oct 1; pr07-pr07. Kampmann KM, Acosta-Alvear AD, Cho CM, Chen CY, Li LX, Gilbert GL, Aftab AB, Gestwicki GJ, Walter WP, Weissman WJ. .
      View in: Publisher Site   Mentions:
    72. CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes. Cell. 2013 Jul 18; 154(2):442-51. Gilbert LA, Larson MH, Morsut L, Liu Z, Brar GA, Torres SE, Stern-Ginossar N, Brandman O, Whitehead EH, Doudna JA, Lim WA, Weissman JS, Qi LS. PMID: 23849981; PMCID: PMC3770145.
      View in: PubMed   Mentions: 1615     Fields:    Translation:HumansAnimalsCells
    73. Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell. 2013 Feb 28; 152(5):1173-83. Qi LS, Larson MH, Gilbert LA, Doudna JA, Weissman JS, Arkin AP, Lim WA. PMID: 23452860; PMCID: PMC3664290.
      View in: PubMed   Mentions: 2016     Fields:    Translation:Cells
    74. Defining principles of combination drug mechanisms of action. Proc Natl Acad Sci U S A. 2013 Jan 08; 110(2):E170-9. Pritchard JR, Bruno PM, Gilbert LA, Capron KL, Lauffenburger DA, Hemann MT. PMID: 23251029; PMCID: PMC3545813.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimals
    75. Context-specific roles for paracrine IL-6 in lymphomagenesis. Genes Dev. 2012 Aug 01; 26(15):1758-68. Gilbert LA, Hemann MT. PMID: 22855834; PMCID: PMC3418592.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    76. Bcl-2 family genetic profiling reveals microenvironment-specific determinants of chemotherapeutic response. Cancer Res. 2011 Sep 01; 71(17):5850-8. Pritchard JR, Gilbert LA, Meacham CE, Ricks JL, Jiang H, Lauffenburger DA, Hemann MT. PMID: 21784872; PMCID: PMC3165087.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    77. Chemotherapeutic resistance: surviving stressful situations. Cancer Res. 2011 Aug 01; 71(15):5062-6. Gilbert LA, Hemann MT. PMID: 21771909; PMCID: PMC3148403.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    78. DNA damage-mediated induction of a chemoresistant niche. Cell. 2010 Oct 29; 143(3):355-66. Gilbert LA, Hemann MT. PMID: 21029859; PMCID: PMC2972353.
      View in: PubMed   Mentions: 212     Fields:    Translation:HumansAnimalsCells
    79. A thioredoxin family protein of the apicoplast periphery identifies abundant candidate transport vesicles in Toxoplasma gondii. Eukaryot Cell. 2008 Sep; 7(9):1518-29. DeRocher AE, Coppens I, Karnataki A, Gilbert LA, Rome ME, Feagin JE, Bradley PJ, Parsons M. PMID: 18586952; PMCID: PMC2547066.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    80. Toxoplasma gondii targets a protein phosphatase 2C to the nuclei of infected host cells. Eukaryot Cell. 2007 Jan; 6(1):73-83. Gilbert LA, Ravindran S, Turetzky JM, Boothroyd JC, Bradley PJ. PMID: 17085638; PMCID: PMC1800361.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
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