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    Lynn Pulliam, PhD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentLaboratory Medicine
    Address4150 Clement St, Blg 2, Rm 259
    San Francisco CA 94121
    Phone415-221-4810x6490
    vCardDownload vCard

      Collapse Biography 
      Collapse Education and Training
      University of California, San FranciscoPh.D. Graduate Division (Experimental Pathology)1983
      California State University, Long BeachM.S.Microbiology1977
      Collapse Awards and Honors
      San Francisco Business Times2012Most Influential Women in Business
      Society for Neurovirology2010 - 2013President
      International Society for Neurovirology2009Outstanding Women in Neuroscience
      Northern California Institute for Research and Development2008Research and Leadership

      Collapse Overview 
      Collapse Overview
      Dr. Pulliam is Professor of Laboratory Medicine and Medicine at UCSF. Her research interests are in HIV-associated cognitive impairment, neuroinflammation and chronic monocyte activation. She is former President and continuing Board of Directors Member of the Society for Neurovirology as well as a member of several journal Editorial Boards. Dr. Pulliam is Director of Microbiology at the San Francisco Veterans Affairs Medical Center where she teaches microbiology to Infectious Disease and Laboratory Medicine residents and fellows.

      Collapse Interests
      HIV, HCV, neuroinflammation, cognitive impairment

      Collapse ORNG Applications 
      Collapse Websites
      Collapse Awarded Grants

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Tang N, Sun B, Gupta A, Rempel H, Pulliam L. Monocyte exosomes induce adhesion molecules and cytokines via activation of NF-?B in endothelial cells. FASEB J. 2016 Sep; 30(9):3097-106. PMID: 27226520; PMCID: PMC5001509 [Available on 09/01/17].
      2. Goetzl EJ, Goetzl L, Karliner JS, Tang N, Pulliam L. Human plasma platelet-derived exosomes: effects of aspirin. FASEB J. 2016 May; 30(5):2058-63. PMID: 26873936.
        View in: PubMed
      3. Pulliam L, Gupta A. Modulation of cellular function through immune-activated exosomes. DNA Cell Biol. 2015 Jul; 34(7):459-63. PMID: 25945690; PMCID: PMC4504252 [Available on 07/01/16].
      4. Pulliam L, Calosing C, Sun B, Grunfeld C, Rempel H. Monocyte activation from interferon-a in HIV infection increases acetylated LDL uptake and ROS production. J Interferon Cytokine Res. 2014 Oct; 34(10):822-8. PMID: 24731171; PMCID: PMC4186262.
      5. Pulliam L. Cognitive consequences of a sustained monocyte type 1 IFN response in HIV-1 infection. Curr HIV Res. 2014; 12(2):77-84. PMID: 24862334; PMCID: PMC4175740.
      6. Rempel H, Sun B, Calosing C, Abadjian L, Monto A, Pulliam L. Monocyte activation in HIV/HCV coinfection correlates with cognitive impairment. PLoS One. 2013; 8(2):e55776. PMID: 23437063; PMCID: PMC3578833.
      7. Sun B, Abadjian L, Rempel H, Monto A, Pulliam L. Differential cognitive impairment in HCV coinfected men with controlled HIV compared to HCV monoinfection. J Acquir Immune Defic Syndr. 2013 Feb 1; 62(2):190-6. PMID: 23187938; PMCID: PMC3587125.
      8. Joseph J, Achim CL, Boivin MJ, Brew BJ, Clifford DB, Colosi DA, Ellis RJ, Heaton RK, Gallo-Diop A, Grant I, Kanmogne GD, Kumar M, Letendre S, Marcotte TD, Nath A, Pardo CA, Paul RH, Pulliam L, Robertson K, Royal W, Sacktor N, Sithinamsuwan P, Smith DM, Valcour V, Wigdahl B, Wood C. Global NeuroAIDS roundtable. J Neurovirol. 2013 Feb; 19(1):1-9. PMID: 23354550; PMCID: PMC3713197.
      9. Wang Q, Na B, Ou JH, Pulliam L, Yen TS. Hepatitis B virus alters the antioxidant system in transgenic mice and sensitizes hepatocytes to Fas signaling. PLoS One. 2012; 7(5):e36818. PMID: 22606292; PMCID: PMC3350475.
      10. Pulliam L, Rempel H, Sun B, Abadjian L, Calosing C, Meyerhoff DJ. A peripheral monocyte interferon phenotype in HIV infection correlates with a decrease in magnetic resonance spectroscopy metabolite concentrations. AIDS. 2011 Sep 10; 25(14):1721-6. PMID: 21750421; PMCID: PMC4120827.
      11. O'Donovan A, Sun B, Cole S, Rempel H, Lenoci M, Pulliam L, Neylan T. Transcriptional control of monocyte gene expression in post-traumatic stress disorder. Dis Markers. 2011; 30(2-3):123-32. PMID: 21508516; PMCID: PMC3825251.
      12. Neylan TC, Sun B, Rempel H, Ross J, Lenoci M, O'Donovan A, Pulliam L. Suppressed monocyte gene expression profile in men versus women with PTSD. Brain Behav Immun. 2011 Mar; 25(3):524-31. PMID: 21145962; PMCID: PMC3039086.
      13. Rempel H, Sun B, Calosing C, Pillai SK, Pulliam L. Interferon-alpha drives monocyte gene expression in chronic unsuppressed HIV-1 infection. AIDS. 2010 Jun 19; 24(10):1415-23. PMID: 20495440; PMCID: PMC2991092.
      14. Sun B, Abadjian L, Rempel H, Calosing C, Rothlind J, Pulliam L. Peripheral biomarkers do not correlate with cognitive impairment in highly active antiretroviral therapy-treated subjects with human immunodeficiency virus type 1 infection. J Neurovirol. 2010 Mar; 16(2):115-24. PMID: 20307252.
        View in: PubMed
      15. Hans Rempel, Bing Sun, Cyrus Calosing, Satish Pillai, Lynn Pulliam. . Interferon alpha drives monocyte gene expression in chronic unsuppressed HIV-i1 infection. 2010; 24:1415-1423.
      16. Pulliam L. HIV regulation of amyloid beta production. J Neuroimmune Pharmacol. 2009 Jun; 4(2):213-7. PMID: 19288202.
        View in: PubMed
      17. Rempel H, Calosing C, Sun B, Pulliam L. Sialoadhesin expressed on IFN-induced monocytes binds HIV-1 and enhances infectivity. PLoS One. 2008; 3(4):e1967. PMID: 18414664; PMCID: PMC2288672.
      18. Price RW, Epstein LG, Becker JT, Cinque P, Gisslen M, Pulliam L, McArthur JC. Biomarkers of HIV-1 CNS infection and injury. Neurology. 2007 Oct 30; 69(18):1781-8. PMID: 17967994.
        View in: PubMed
      19. Rempel HC, Pulliam L. HIV-1 Tat inhibits neprilysin and elevates amyloid beta. AIDS. 2005 Jan 28; 19(2):127-35. PMID: 15668537.
        View in: PubMed
      20. Pulliam L, Sun B, Rempel H. Invasive chronic inflammatory monocyte phenotype in subjects with high HIV-1 viral load. J Neuroimmunol. 2004 Dec; 157(1-2):93-8. PMID: 15579285.
        View in: PubMed
      21. Sun B, Rempel HC, Pulliam L. Loss of macrophage-secreted lysozyme in HIV-1-associated dementia detected by SELDI-TOF mass spectrometry. AIDS. 2004 Apr 30; 18(7):1009-12. PMID: 15096803.
        View in: PubMed
      22. Kusdra L, McGuire D, Pulliam L. Changes in monocyte/macrophage neurotoxicity in the era of HAART: implications for HIV-associated dementia. AIDS. 2002 Jan 4; 16(1):31-8. PMID: 11741160.
        View in: PubMed
      23. Rempel H, Kusdra L, Pulliam L. Interleukin-1beta up-regulates expression of neurofilament light in human neuronal cells. J Neurochem. 2001 Aug; 78(3):640-5. PMID: 11483667.
        View in: PubMed
      24. Pulliam L, Irwin I, Kusdra L, Rempel H, Flitter WD, Garland WA. CPI-1189 attenuates effects of suspected neurotoxins associated with AIDS dementia: a possible role for ERK activation. Brain Res. 2001 Mar 2; 893(1-2):95-103. PMID: 11222997.
        View in: PubMed
      25. Kusdra L, Rempel H, Yaffe K, Pulliam L. Elevation of CD69+ monocyte/macrophages in patients with Alzheimer's disease. Immunobiology. 2000 May; 202(1):26-33. PMID: 10879686.
        View in: PubMed
      26. Pulliam L, Zhou M, Stubblebine M, Bitler CM. Differential modulation of cell death proteins in human brain cells by tumor necrosis factor alpha and platelet activating factor. J Neurosci Res. 1998 Nov 15; 54(4):530-8. PMID: 9822163.
        View in: PubMed
      27. Pulliam L, Stubblebine M, Hyun W. Quantification of neurotoxicity and identification of cellular subsets in a three-dimensional brain model. Cytometry. 1998 May 1; 32(1):66-9. PMID: 9581626.
        View in: PubMed
      28. Pulliam L, Gascon R, Stubblebine M, McGuire D, McGrath MS. Unique monocyte subset in patients with AIDS dementia. Lancet. 1997 Mar 8; 349(9053):692-5. PMID: 9078201.
        View in: PubMed
      29. Pulliam L, Clarke JA, McGrath MS, Moore D, McGuire D. Monokine products as predictors of AIDS dementia. AIDS. 1996 Nov; 10(13):1495-500. PMID: 8931783.
        View in: PubMed
      30. Pulliam L, Moore D, West DC. Human cytomegalovirus induces IL-6 and TNF alpha from macrophages and microglial cells: possible role in neurotoxicity. J Neurovirol. 1995 Jun; 1(2):219-27. PMID: 9222360.
        View in: PubMed
      31. Yeung MC, Pulliam L, Lau AS. The HIV envelope protein gp120 is toxic to human brain-cell cultures through the induction of interleukin-6 and tumor necrosis factor-alpha. AIDS. 1995 Feb; 9(2):137-43. PMID: 7536422.
        View in: PubMed
      32. Pulliam L, Clarke JA, McGuire D, McGrath MS. Investigation of HIV-infected macrophage neurotoxin production from patients with AIDS dementia. Adv Neuroimmunol. 1994; 4(3):195-8. PMID: 7874387.
        View in: PubMed
      33. Pulliam L, West D, Haigwood N, Swanson RA. HIV-1 envelope gp120 alters astrocytes in human brain cultures. AIDS Res Hum Retroviruses. 1993 May; 9(5):439-44. PMID: 8318270.
        View in: PubMed
      34. Hughes-Fulford M, McGrath MS, Hanks D, Erickson S, Pulliam L. Effects of dimethyl prostaglandin A1 on herpes simplex virus and human immunodeficiency virus replication. Antimicrob Agents Chemother. 1992 Oct; 36(10):2253-8. PMID: 1332592; PMCID: PMC245485.
      35. Pulliam L, Herndier BG, McGrath MS. Purified trichosanthin (GLQ223) exacerbation of indirect HIV-associated neurotoxicity in vitro. AIDS. 1991 Oct; 5(10):1237-42. PMID: 1786150.
        View in: PubMed
      36. Pulliam L. Cytomegalovirus preferentially infects a monocyte derived macrophage/microglial cell in human brain cultures: neuropathology differs between strains. J Neuropathol Exp Neurol. 1991 Jul; 50(4):432-40. PMID: 1648122.
        View in: PubMed
      37. Pulliam L, Herndier BG, Tang NM, McGrath MS. Human immunodeficiency virus-infected macrophages produce soluble factors that cause histological and neurochemical alterations in cultured human brains. J Clin Invest. 1991 Feb; 87(2):503-12. PMID: 1671392; PMCID: PMC296337.
      38. Cregan P, Yamamoto A, Lum A, VanDerHeide T, MacDonald M, Pulliam L. Comparison of four methods for rapid detection of Pneumocystis carinii in respiratory specimens. J Clin Microbiol. 1990 Nov; 28(11):2432-6. PMID: 1701444; PMCID: PMC268201.
      39. Pulliam L, Berens ME, Rosenblum ML. A normal human brain cell aggregate model for neurobiological studies. J Neurosci Res. 1988 Oct-Dec; 21(2-4):521-30. PMID: 3216435.
        View in: PubMed
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