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Maggie Waung, MD

TitleAdjunct Instructor
SchoolUCSF School of Medicine
DepartmentNeurology
Address675 Nelson Rising Lane
San Francisco CA 94158
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    Collapse Biography 
    Collapse Education and Training
    University of California San FranciscoResidency2014Neurology
    University of Texas Southwestern Medical CenterMD, PhD2010Medicine, Neuroscience
    Wellesley CollegeB.A.2002Physics
    Collapse Awards and Honors
    University of California San Francisco2016  - 2017Weill Neuroscience Scholar
    American Headache Society2016Frontiers in Headache Medicine Scholarship Award
    San Francisco Neurological Society2016Newman Award for Best Clinical Neurology Paper
    Association of Migraine Disorders2014  - 2015Basic Headache Research Grant Recipient
    American Academy of Neurology2010Medical Student Prize for Excellence in Neurology

    Collapse Overview 
    Collapse Overview
    My career goal is to broaden the understanding of central pain processing to develop targeted, novel therapeutics for specific headache syndromes. My experiences with patients who experience migraines prompted me to think more deeply about concepts of pain and central sensitization. Migraineurs have exquisite sensitivity to external stimuli, and headaches seem to be triggered by pain pathways that may have undergone maladaptive changes. Additionally, long-term acute medication use promotes the severity and frequency of migraines, which can become refractory to treatment. Because migraines can worsen over time, this indicates plastic changes in circuitry may be potential targets for new therapies.

    I am currently employing state of the art optogenetic methods combined with ex vivo brain slice whole cell physiology and pharmacology to interrogate specific circuits implicated in migraine pathophysiology. Evaluating changes in these circuits in response to headache or analgesic use will provide much needed insight into clinical conditions such as chronic migraine and medication overuse headache, fulfilling an underserved translational need in the area of headache.


    Collapse Research 
    Collapse Research Activities and Funding
    The Role of Mesencephalic Circuits in Migraine
    NIH/NINDS K08NS097632Mar 1, 2017 - Feb 28, 2022
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Waung MW, Akerman S, Wakefield M, Keywood C, Goadsby PJ. Metabotropic glutamate receptor 5: a target for migraine therapy. Ann Clin Transl Neurol. 2016 Aug; 3(8):560-71. PMID: 27606340; PMCID: PMC4999590.
    2. Byers CE, Barylko B, Ross JA, Southworth DR, James NG, Taylor CA, Wang L, Collins KA, Estrada A, Waung M, Tassin TC, Huber KM, Jameson DM, Albanesi JP. Enhancement of dynamin polymerization and GTPase activity by Arc/Arg3.1. Biochim Biophys Acta. 2015 Jun; 1850(6):1310-8. PMID: 25783003; PMCID: PMC4398645 [Available on 06/01/16].
    3. Waung MW, Abrams GM. Combat-related headache and traumatic brain injury. Curr Pain Headache Rep. 2012 Dec; 16(6):533-8. PMID: 22956047.
      View in: PubMed
    4. Waung MW, Grossman AW, Barmada SJ, Josephson SA, Dillon WP, Ralph JW. Pearls & oy-sters: the use of CT venography in Hirayama disease. Neurology. 2012 Jul 31; 79(5):e38-40. PMID: 22851722; PMCID: PMC3405252.
    5. Waung MW, Singer MA. An unusual case of Miller Fisher syndrome presenting with proptosis and chemosis. Muscle Nerve. 2012 May; 45(5):764-6. PMID: 22499110; PMCID: PMC3335291.
    6. Waung MW, Huber KM. Protein translation in synaptic plasticity: mGluR-LTD, Fragile X. Curr Opin Neurobiol. 2009 Jun; 19(3):319-26. PMID: 19411173; PMCID: PMC2730429.
    7. Waung MW, Pfeiffer BE, Nosyreva ED, Ronesi JA, Huber KM. Rapid translation of Arc/Arg3.1 selectively mediates mGluR-dependent LTD through persistent increases in AMPAR endocytosis rate. Neuron. 2008 Jul 10; 59(1):84-97. PMID: 18614031; PMCID: PMC2580055.
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