Manasi Bhate, PhD

TitlePostdoctoral Scholar
SchoolUCSF School of Pharmacy
DepartmentPharmaceutical Chemistry
Address555 Mission Bay Blvd South
San Francisco CA 94158
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    1. Bhate MP, Molnar KS, Goulian M, DeGrado WF. Signal transduction in histidine kinases: insights from new structures. Structure. 2015 Jun 2; 23(6):981-94. PMID: 25982528; PMCID: PMC4456306 [Available on 06/02/16].
    2. Joh NH, Wang T, Bhate MP, Acharya R, Wu Y, Grabe M, Hong M, Grigoryan G, DeGrado WF. De novo design of a transmembrane ZnĀ²?-transporting four-helix bundle. Science. 2014 Dec 19; 346(6216):1520-4. PMID: 25525248; PMCID: PMC4400864.
    3. Wylie BJ, Bhate MP, McDermott AE. Transmembrane allosteric coupling of the gates in a potassium channel. Proc Natl Acad Sci U S A. 2014 Jan 7; 111(1):185-90. PMID: 24344306; PMCID: PMC3890889.
    4. Bhate MP, Wylie BJ, Thompson A, Tian L, Nimigean C, McDermott AE. Preparation of uniformly isotope labeled KcsA for solid state NMR: expression, purification, reconstitution into liposomes and functional assay. Protein Expr Purif. 2013 Oct; 91(2):119-24. PMID: 23916531; PMCID: PMC3805054.
    5. Yamada T, Bhate MP, Strange K. Regulatory phosphorylation induces extracellular conformational changes in a CLC anion channel. Biophys J. 2013 May 7; 104(9):1893-904. PMID: 23663832; PMCID: PMC3647193.
    6. Bhate MP, McDermott AE. Protonation state of E71 in KcsA and its role for channel collapse and inactivation. Proc Natl Acad Sci U S A. 2012 Sep 18; 109(38):15265-70. PMID: 22942391; PMCID: PMC3458351.
    7. Bhate MP, Wylie BJ, Tian L, McDermott AE. Conformational dynamics in the selectivity filter of KcsA in response to potassium ion concentration. J Mol Biol. 2010 Aug 13; 401(2):155-66. PMID: 20600123; PMCID: PMC2937177.
    8. Bhate MP, Woodard JC, Mehta MA. Solvation and hydrogen bonding in alanine- and glycine-containing dipeptides probed using solution- and solid-state NMR spectroscopy. J Am Chem Soc. 2009 Jul 15; 131(27):9579-89. PMID: 19537718.
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