Sign in to edit your profile (add interests, mentoring, photo, etc.)

    Marcel Alavi Alavi Khorassani Moghadam, PhD

    TitlePostdoctoral Scholar
    SchoolUCSF School of Medicine
    Address10 Koret Way
    San Francisco CA 94143

       Awards and Honors
      Foundation Fighting Blindness2014Travel Award - RD2014
      Eberhard Karls Universität, Tübingen, Germany2010PhD with the highest honors, summa cum laude
      GlaxoSmithKline2009Travel Award - ARVO 2009
      European Retinal Research Training Network RETNET2007Fellowship
      GlaxoSmithKline2007Travel Award - ARVO 2007

      My research interest is inherited blinding diseases with particular focus on mitochondria and their contribution to pathology. My enthusiasm for science arose as research assistant in Rudi Grosschedl’s lab trying to determine which amino acids of beta-catenin are acetylated. In Jürgen Soll’s lab, which I joined for my Diploma thesis, I became interested in organelle biology purifying a chloroplast protein import complex. Looking for a more translational aspect of my research I studied Dominant Optic Atrophy (DOA) for my PhD in Bernd Wissinger’s lab, where I phenotypically and molecular-biologically characterized a DOA mouse model. I was rewarded a RetNet Fellowship (Marie Curie European Retinal Research Training Network Fellowship), which I used for a 3-month sabbatical in Per Ekstöm’s lab, where I discovered increased HDAC activity in retinas of rd1 mice, a model for early retinal degeneration. I was awarded my PhD with summa cum laude and moved on to join Uwe Wolfrum’s lab for my postdoctoral training, where I studied different mouse models for Usher-Syndrome, retinal degeneration combined with deafness. I supervised a graduate student, who developed a new therapeutical approach for Usher-Syndrome using Zinc-finger nucleases. Here, I gained also profound teaching experience. After working for one year for Miltenyi Biotec deepening my project management skills, I joined Doug Gould’s lab to continue my postdoctoral training. I worked on different aspects of ER stress and its implications in retinal degeneration. I characterized a new animal model and I established and evaluated tools that allow in vivo monitoring of ER stress in the eye. I also tested new therapies for retinal degeneration.


       ORNG Applications 
       Featured Publications
       In The News

      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Ghosh R, Wang L, Wang ES, Perera BG, Igbaria A, Morita S, Prado K, Thamsen M, Caswell D, Macias H, Weiberth KF, Gliedt MJ, Alavi MV, Hari SB, Mitra AK, Bhhatarai B, Schürer SC, Snapp EL, Gould DB, German MS, Backes BJ, Maly DJ, Oakes SA, Papa FR. Allosteric inhibition of the IRE1a RNase preserves cell viability and function during endoplasmic reticulum stress. Cell. 2014 Jul 31; 158(3):534-48.
        View in: PubMed PMC4244221
      2. Alavi MV, Fuhrmann N. Dominant optic atrophy, OPA1, and mitochondrial quality control: understanding mitochondrial network dynamics. Mol Neurodegener. 2013; 8:32.
        View in: PubMed PMC3856479
      3. Caffin F, Prola A, Piquereau J, Novotova M, David DJ, Garnier A, Fortin D, Alavi MV, Veksler V, Ventura-Clapier R, Joubert F. Altered skeletal muscle mitochondrial biogenesis but improved endurance capacity in trained OPA1-deficient mice. J Physiol. 2013 Dec 1; 591(Pt 23):6017-37.
        View in: PubMed PMC3872767
      4. Piquereau J, Caffin F, Novotova M, Prola A, Garnier A, Mateo P, Fortin D, Huynh le H, Nicolas V, Alavi MV, Brenner C, Ventura-Clapier R, Veksler V, Joubert F. Down-regulation of OPA1 alters mouse mitochondrial morphology, PTP function, and cardiac adaptation to pressure overload. Cardiovasc Res. 2012 Jun 1; 94(3):408-17.
        View in: PubMed PMC3863708
      5. Nguyen D, Alavi MV, Kim KY, Kang T, Scott RT, Noh YH, Lindsey JD, Wissinger B, Ellisman MH, Weinreb RN, Perkins GA, Ju WK. A new vicious cycle involving glutamate excitotoxicity, oxidative stress and mitochondrial dynamics. Cell Death Dis. 2011; 2:e240.
        View in: PubMed PMC3252734
      6. Carelli V, Schimpf S, Fuhrmann N, Valentino ML, Zanna C, Iommarini L, Papke M, Schaich S, Tippmann S, Baumann B, Barboni P, Longanesi L, Rugolo M, Ghelli A, Alavi MV, Youle RJ, Bucchi L, Carroccia R, Giannoccaro MP, Tonon C, Lodi R, Cenacchi G, Montagna P, Liguori R, Wissinger B. A clinically complex form of dominant optic atrophy (OPA8) maps on chromosome 16. Hum Mol Genet. 2011 May 15; 20(10):1893-905.
        View in: PubMed
      7. Fuhrmann N, Schimpf S, Kamenisch Y, Leo-Kottler B, Alexander C, Auburger G, Zrenner E, Wissinger B, Alavi MV. Solving a 50 year mystery of a missing OPA1 mutation: more insights from the first family diagnosed with autosomal dominant optic atrophy. Mol Neurodegener. 2010; 5:25.
        View in: PubMed PMC2893178
      8. Sancho-Pelluz J, Alavi MV, Sahaboglu A, Kustermann S, Farinelli P, Azadi S, van Veen T, Romero FJ, Paquet-Durand F, Ekström P. Excessive HDAC activation is critical for neurodegeneration in the rd1 mouse. Cell Death Dis. 2010; 1:e24.
        View in: PubMed PMC3032332
      9. Heiduschka P, Schnichels S, Fuhrmann N, Hofmeister S, Schraermeyer U, Wissinger B, Alavi MV. Electrophysiological and histologic assessment of retinal ganglion cell fate in a mouse model for OPA1-associated autosomal dominant optic atrophy. Invest Ophthalmol Vis Sci. 2010 Mar; 51(3):1424-31.
        View in: PubMed
      10. Alavi MV, Fuhrmann N, Nguyen HP, Yu-Wai-Man P, Heiduschka P, Chinnery PF, Wissinger B. Subtle neurological and metabolic abnormalities in an Opa1 mouse model of autosomal dominant optic atrophy. Exp Neurol. 2009 Dec; 220(2):404-9.
        View in: PubMed
      11. Fuhrmann N, Alavi MV, Bitoun P, Woernle S, Auburger G, Leo-Kottler B, Yu-Wai-Man P, Chinnery P, Wissinger B. Genomic rearrangements in OPA1 are frequent in patients with autosomal dominant optic atrophy. J Med Genet. 2009 Feb; 46(2):136-44.
        View in: PubMed
      12. Weisschuh N, Alavi MV, Bonin M, Wissinger B. Identification of genes that are linked with optineurin expression using a combined RNAi--microarray approach. Exp Eye Res. 2007 Oct; 85(4):450-61.
        View in: PubMed
      13. Alavi MV, Bette S, Schimpf S, Schuettauf F, Schraermeyer U, Wehrl HF, Ruttiger L, Beck SC, Tonagel F, Pichler BJ, Knipper M, Peters T, Laufs J, Wissinger B. A splice site mutation in the murine Opa1 gene features pathology of autosomal dominant optic atrophy. Brain. 2007 Apr; 130(Pt 4):1029-42.
        View in: PubMed
      14. Alavi M, Schleiff E. Plant Science. Analysis of expression patterns of translocon subunits of chloroplasts and mitochondria. 2005; 168(6):1533-1539.
      15. Vojta A, Alavi M, Becker T, Hörmann F, Küchler M, Soll J, Thomson R, Schleiff E. The protein translocon of the plastid envelopes. J Biol Chem. 2004 May 14; 279(20):21401-5.
        View in: PubMed
      Marcel Alavi's Networks
      Related Concepts
      Derived automatically from this person's publications.
      People in Profiles who have published with this person.
      Related Authors
      People who share related concepts with this person.
      Back to TOP