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    Marcel Alavi Khorassani Moghadam, PhD

    TitlePostdoctoral Scholar
    SchoolUCSF School of Medicine
    Address10 Koret Way
    San Francisco CA 94117
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      Collapse Biography 
      Collapse Awards and Honors
      Foundation Fighting Blindness2014Travel Award - RD2014
      Eberhard Karls Universität, Tübingen, Germany2010PhD with the highest honors, summa cum laude
      GlaxoSmithKline2009Travel Award - ARVO 2009
      European Retinal Research Training Network RETNET2007Fellowship
      GlaxoSmithKline2007Travel Award - ARVO 2007

      Collapse Overview 
      Collapse Overview
      I am a PhD level scientist studying pre-clinical models for eye diseases with a good understanding of the big picture from basic research, to clinical approval, to commercialization. I have been working on projects that involved studies of disease etiology (mechanism of action), biomarker identification, therapy development, and drug delivery. I have also expertise in marketing and communications, business development, and the drug approval process.

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      Collapse In The News
      Collapse Featured Publications

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Alavi MV, Mao M, Pawlikowski BT, Kvezereli M, Duncan JL, Libby RT, John SW, Gould DB. Col4a1 mutations cause progressive retinal neovascular defects and retinopathy. Sci Rep. 2016; 6:18602. PMID: 26813606.
        View in: PubMed
      2. Alavi MV. Aging and Vision. Adv Exp Med Biol. 2016; 854:393-9. PMID: 26427437.
        View in: PubMed
      3. Mao M, Alavi MV, Labelle-Dumais C, Gould DB. Type IV Collagens and Basement Membrane Diseases: Cell Biology and Pathogenic Mechanisms. Curr Top Membr. 2015; 76:61-116. PMID: 26610912.
        View in: PubMed
      4. Mao M, Smith RS, Alavi MV, Marchant JK, Cosma M, Libby RT, John SW, Gould DB. Strain-Dependent Anterior Segment Dysgenesis and Progression to Glaucoma in Col4a1 Mutant Mice. Invest Ophthalmol Vis Sci. 2015 Oct 1; 56(11):6823-31. PMID: 26567795; PMCID: PMC4627250 [Available on 04/01/16].
      5. Alavi MV, Chiang WC, Kroeger H, Yasumura D, Matthes MT, Iwawaki T, LaVail MM, Gould DB, Lin JH. In Vivo Visualization of Endoplasmic Reticulum Stress in the Retina Using the ERAI Reporter Mouse. Invest Ophthalmol Vis Sci. 2015 Oct 1; 56(11):6961-70. PMID: 26513501; PMCID: PMC4627472 [Available on 04/01/16].
      6. Ghosh R, Wang L, Wang ES, Perera BG, Igbaria A, Morita S, Prado K, Thamsen M, Caswell D, Macias H, Weiberth KF, Gliedt MJ, Alavi MV, Hari SB, Mitra AK, Bhhatarai B, Schürer SC, Snapp EL, Gould DB, German MS, Backes BJ, Maly DJ, Oakes SA, Papa FR. Allosteric inhibition of the IRE1a RNase preserves cell viability and function during endoplasmic reticulum stress. Cell. 2014 Jul 31; 158(3):534-48. PMID: 25018104; PMCID: PMC4244221.
      7. Alavi MV, Fuhrmann N. Dominant optic atrophy, OPA1, and mitochondrial quality control: understanding mitochondrial network dynamics. Mol Neurodegener. 2013; 8:32. PMID: 24067127; PMCID: PMC3856479.
      8. Caffin F, Prola A, Piquereau J, Novotova M, David DJ, Garnier A, Fortin D, Alavi MV, Veksler V, Ventura-Clapier R, Joubert F. Altered skeletal muscle mitochondrial biogenesis but improved endurance capacity in trained OPA1-deficient mice. J Physiol. 2013 Dec 1; 591(Pt 23):6017-37. PMID: 24042504; PMCID: PMC3872767.
      9. Piquereau J, Caffin F, Novotova M, Prola A, Garnier A, Mateo P, Fortin D, Huynh le H, Nicolas V, Alavi MV, Brenner C, Ventura-Clapier R, Veksler V, Joubert F. Down-regulation of OPA1 alters mouse mitochondrial morphology, PTP function, and cardiac adaptation to pressure overload. Cardiovasc Res. 2012 Jun 1; 94(3):408-17. PMID: 22406748; PMCID: PMC3863708.
      10. Nguyen D, Alavi MV, Kim KY, Kang T, Scott RT, Noh YH, Lindsey JD, Wissinger B, Ellisman MH, Weinreb RN, Perkins GA, Ju WK. A new vicious cycle involving glutamate excitotoxicity, oxidative stress and mitochondrial dynamics. Cell Death Dis. 2011; 2:e240. PMID: 22158479; PMCID: PMC3252734.
      11. Carelli V, Schimpf S, Fuhrmann N, Valentino ML, Zanna C, Iommarini L, Papke M, Schaich S, Tippmann S, Baumann B, Barboni P, Longanesi L, Rugolo M, Ghelli A, Alavi MV, Youle RJ, Bucchi L, Carroccia R, Giannoccaro MP, Tonon C, Lodi R, Cenacchi G, Montagna P, Liguori R, Wissinger B. A clinically complex form of dominant optic atrophy (OPA8) maps on chromosome 16. Hum Mol Genet. 2011 May 15; 20(10):1893-905. PMID: 21349918.
        View in: PubMed
      12. Fuhrmann N, Schimpf S, Kamenisch Y, Leo-Kottler B, Alexander C, Auburger G, Zrenner E, Wissinger B, Alavi MV. Solving a 50 year mystery of a missing OPA1 mutation: more insights from the first family diagnosed with autosomal dominant optic atrophy. Mol Neurodegener. 2010; 5:25. PMID: 20546606; PMCID: PMC2893178.
      13. Sancho-Pelluz J, Alavi MV, Sahaboglu A, Kustermann S, Farinelli P, Azadi S, van Veen T, Romero FJ, Paquet-Durand F, Ekström P. Excessive HDAC activation is critical for neurodegeneration in the rd1 mouse. Cell Death Dis. 2010; 1:e24. PMID: 21364632; PMCID: PMC3032332.
      14. Heiduschka P, Schnichels S, Fuhrmann N, Hofmeister S, Schraermeyer U, Wissinger B, Alavi MV. Electrophysiological and histologic assessment of retinal ganglion cell fate in a mouse model for OPA1-associated autosomal dominant optic atrophy. Invest Ophthalmol Vis Sci. 2010 Mar; 51(3):1424-31. PMID: 19834041.
        View in: PubMed
      15. Alavi MV, Fuhrmann N, Nguyen HP, Yu-Wai-Man P, Heiduschka P, Chinnery PF, Wissinger B. Subtle neurological and metabolic abnormalities in an Opa1 mouse model of autosomal dominant optic atrophy. Exp Neurol. 2009 Dec; 220(2):404-9. PMID: 19815013.
        View in: PubMed
      16. Fuhrmann N, Alavi MV, Bitoun P, Woernle S, Auburger G, Leo-Kottler B, Yu-Wai-Man P, Chinnery P, Wissinger B. Genomic rearrangements in OPA1 are frequent in patients with autosomal dominant optic atrophy. J Med Genet. 2009 Feb; 46(2):136-44. PMID: 19181907.
        View in: PubMed
      17. Weisschuh N, Alavi MV, Bonin M, Wissinger B. Identification of genes that are linked with optineurin expression using a combined RNAi--microarray approach. Exp Eye Res. 2007 Oct; 85(4):450-61. PMID: 17663987.
        View in: PubMed
      18. Alavi MV, Bette S, Schimpf S, Schuettauf F, Schraermeyer U, Wehrl HF, Ruttiger L, Beck SC, Tonagel F, Pichler BJ, Knipper M, Peters T, Laufs J, Wissinger B. A splice site mutation in the murine Opa1 gene features pathology of autosomal dominant optic atrophy. Brain. 2007 Apr; 130(Pt 4):1029-42. PMID: 17314202.
        View in: PubMed
      19. Alavi M, Schleiff E. . Plant Science. Analysis of expression patterns of translocon subunits of chloroplasts and mitochondria. 2005; 168(6):1533-1539.
      20. Vojta A, Alavi M, Becker T, Hörmann F, Küchler M, Soll J, Thomson R, Schleiff E. The protein translocon of the plastid envelopes. J Biol Chem. 2004 May 14; 279(20):21401-5. PMID: 15033972.
        View in: PubMed
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