Marcus Fischer, PhD

TitlePostdoctoral Scholar
SchoolUCSF School of Pharmacy
DepartmentPharmaceutical Chemistry
Address1700 4th St
San Francisco CA 94158
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    1. Lee H, Fischer M, Shoichet BK, Liu SY. Hydrogen Bonding of 1,2-Azaborines in the Binding Cavity of T4 Lysozyme Mutants: Structures and Thermodynamics. J Am Chem Soc. 2016 Sep 21; 138(37):12021-4. PMID: 27603116.
      View in: PubMed
    2. Fischer M, Hopkins AP, Severi E, Hawkhead J, Bawdon D, Watts AG, Hubbard RE, Thomas GH. Tripartite ATP-independent Periplasmic (TRAP) Transporters Use an Arginine-mediated Selectivity Filter for High Affinity Substrate Binding. J Biol Chem. 2015 Nov 6; 290(45):27113-23. PMID: 26342690; PMCID: PMC4646407.
    3. Fischer M, Shoichet BK, Fraser JS. One Crystal, Two Temperatures: Cryocooling Penalties Alter Ligand Binding to Transient Protein Sites. Chembiochem. 2015 Jul 27; 16(11):1560-4. PMID: 26032594; PMCID: PMC4539595.
    4. Merski M, Fischer M, Balius TE, Eidam O, Shoichet BK. Homologous ligands accommodated by discrete conformations of a buried cavity. Proc Natl Acad Sci U S A. 2015 Apr 21; 112(16):5039-44. PMID: 25847998; PMCID: PMC4413287.
    5. Nicholls RA, Fischer M, McNicholas S, Murshudov GN. Conformation-independent structural comparison of macromolecules with ProSMART. Acta Crystallogr D Biol Crystallogr. 2014 Sep; 70(Pt 9):2487-99. PMID: 25195761; PMCID: PMC4157452.
    6. Fischer M, Coleman RG, Fraser JS, Shoichet BK. Incorporation of protein flexibility and conformational energy penalties in docking screens to improve ligand discovery. Nat Chem. 2014 Jul; 6(7):575-83. PMID: 24950326; PMCID: PMC4144196.
    7. Rocklin GJ, Boyce SE, Fischer M, Fish I, Mobley DL, Shoichet BK, Dill KA. Blind prediction of charged ligand binding affinities in a model binding site. J Mol Biol. 2013 Nov 15; 425(22):4569-83. PMID: 23896298; PMCID: PMC3962782.
    8. Barelier S, Boyce SE, Fish I, Fischer M, Goodin DB, Shoichet BK. Roles for ordered and bulk solvent in ligand recognition and docking in two related cavities. PLoS One. 2013; 8(7):e69153. PMID: 23874896; PMCID: PMC3715451.
    9. Fischer M, Leech AP, Hubbard RE. Comparative assessment of different histidine-tags for immobilization of protein onto surface plasmon resonance sensorchips. Anal Chem. 2011 Mar 1; 83(5):1800-7. PMID: 21314134.
      View in: PubMed
    10. Mulligan C, Fischer M, Thomas GH. Tripartite ATP-independent periplasmic (TRAP) transporters in bacteria and archaea. FEMS Microbiol Rev. 2011 Jan; 35(1):68-86. PMID: 20584082.
      View in: PubMed
    11. Fischer M, Zhang QY, Hubbard RE, Thomas GH. Caught in a TRAP: substrate-binding proteins in secondary transport. Trends Microbiol. 2010 Oct; 18(10):471-8. PMID: 20656493.
      View in: PubMed
    12. Fischer M, Hubbard RE. Fragment-based ligand discovery. Mol Interv. 2009 Feb; 9(1):22-30. PMID: 19299661.
      View in: PubMed
    13. Liashenko VL, Aleksander SK, Vaneeva LI, Semenova GB. [Immunogenicity of H-antigen polymers obtained by different methods]. Biull Eksp Biol Med. 1978 May; 85(5):551-4. PMID: 656603.
      View in: PubMed
    14. Renaud LP, Kelly JS. Proceedings: Response of identified ventromedial hypothalamic nucleus neurons to putative neurotransmitters applied by microiontophoresis. Br J Pharmacol. 1975 Oct; 55(2):277P-278P. PMID: 115; PMCID: PMC1666801.
    15. Schmoldt A, Benthe HF, Haberland G. Digitoxin metabolism by rat liver microsomes. Biochem Pharmacol. 1975 Sep 1; 24(17):1639-41. PMID: 10.
      View in: PubMed
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