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    Marcus Fischer, PhD

    TitlePostdoctoral Scholar
    SchoolUCSF School of Pharmacy
    DepartmentPharmaceutical Chemistry
    Address1700 4th St
    San Francisco CA 94158
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Fischer M, Shoichet BK, Fraser JS. One Crystal, Two Temperatures: Cryocooling Penalties Alter Ligand Binding to Transient Protein Sites. Chembiochem. 2015 Jul 27; 16(11):1560-4. PMID: 26032594; PMCID: PMC4539595.
      2. Merski M, Fischer M, Balius TE, Eidam O, Shoichet BK. Homologous ligands accommodated by discrete conformations of a buried cavity. Proc Natl Acad Sci U S A. 2015 Apr 21; 112(16):5039-44. PMID: 25847998; PMCID: PMC4413287.
      3. Nicholls RA, Fischer M, McNicholas S, Murshudov GN. Conformation-independent structural comparison of macromolecules with ProSMART. Acta Crystallogr D Biol Crystallogr. 2014 Sep; 70(Pt 9):2487-99. PMID: 25195761; PMCID: PMC4157452.
      4. Fischer M, Coleman RG, Fraser JS, Shoichet BK. Incorporation of protein flexibility and conformational energy penalties in docking screens to improve ligand discovery. Nat Chem. 2014 Jul; 6(7):575-83. PMID: 24950326; PMCID: PMC4144196.
      5. Rocklin GJ, Boyce SE, Fischer M, Fish I, Mobley DL, Shoichet BK, Dill KA. Blind prediction of charged ligand binding affinities in a model binding site. J Mol Biol. 2013 Nov 15; 425(22):4569-83. PMID: 23896298; PMCID: PMC3962782.
      6. Barelier S, Boyce SE, Fish I, Fischer M, Goodin DB, Shoichet BK. Roles for ordered and bulk solvent in ligand recognition and docking in two related cavities. PLoS One. 2013; 8(7):e69153. PMID: 23874896; PMCID: PMC3715451.
      7. Fischer M, Leech AP, Hubbard RE. Comparative assessment of different histidine-tags for immobilization of protein onto surface plasmon resonance sensorchips. Anal Chem. 2011 Mar 1; 83(5):1800-7. PMID: 21314134.
        View in: PubMed
      8. Mulligan C, Fischer M, Thomas GH. Tripartite ATP-independent periplasmic (TRAP) transporters in bacteria and archaea. FEMS Microbiol Rev. 2011 Jan; 35(1):68-86. PMID: 20584082.
        View in: PubMed
      9. Fischer M, Zhang QY, Hubbard RE, Thomas GH. Caught in a TRAP: substrate-binding proteins in secondary transport. Trends Microbiol. 2010 Oct; 18(10):471-8. PMID: 20656493.
        View in: PubMed
      10. Fischer M, Hubbard RE. Fragment-based ligand discovery. Mol Interv. 2009 Feb; 9(1):22-30. PMID: 19299661.
        View in: PubMed
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