 Marcus Muench, PhD
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| Title | Associate Professor |
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| School | UCSF School of Medicine |
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| Department | Laboratory Medicine |
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| Address | Blood Systems Research Inst
270 Masonic Avenue
San Francisco CA 94118
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| Phone | 415-901-0747 |
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 Overview Research in my laboratory is focused on the early development of human tissue-specific stem cells. Mostly my laboratory studies cells of the fetal liver to better understand hematopoietic, immune and hepatic development. Both hematopoietic and hepatic tissues share the same organ during fetal development but are considered to arise from separate embryological tissues. Our work has helped to identify hematopoietic and hepatic progenitor populations in the liver and some of the cytokines that regulate their growth. A driving force behind my basic research efforts is a desire for the research to be clinically applicable, particularly in the field of fetal therapy. Fetal cellular therapy, the transplantation of cells into a fetus, has the potential of ameliorating or curing a large number of birth defects. However, the current practice of in utero stem cell transplantation is not yet effective enough to treat most hematopoietic or hepatic birth defects. Work in my laboratory is using mouse models of in utero transplantation to study methods of improving engraftment of foreign cells by prenatal transplantation.
Bibliographic
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Salvador B, Sexton NR, Carrion R, Nunneley J, Patterson JL, Steffen I, Lu K, Muench MO, Lembo D, Simmons G. Filoviruses utilize glycosaminoglycans for their attachment to target cells. J Virol. 2013 Mar; 87(6):3295-304.
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Lee ST, Xiao Y, Muench MO, Xiao J, Fomin ME, Wiencke JK, Zheng S, Dou X, de Smith A, Chokkalingam A, Buffler P, Ma X, Wiemels JL. A global DNA methylation and gene expression analysis of early human B-cell development reveals a demethylation signature and transcription factor network. Nucleic Acids Res. 2012 Dec; 40(22):11339-51.
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Jackman RP, Utter GH, Muench MO, Heitman JW, Munz MM, Jackman RW, Biswas HH, Rivers RM, Tobler LH, Busch MP, Norris PJ. Distinct roles of trauma and transfusion in induction of immune modulation after injury. Transfusion. 2012 Dec; 52(12):2533-50.
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Schonemann MD, Muench MO, Tee MK, Miller WL, Mellon SH. Expression of P450c17 in the human fetal nervous system. Endocrinology. 2012 May; 153(5):2494-505.
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Bárcena A, Muench MO, Kapidzic M, Gormley M, Goldfien GA, Fisher SJ. Human placenta and chorion: potential additional sources of hematopoietic stem cells for transplantation. Transfusion. 2011 Nov; 51 Suppl 4:94S-105S.
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Muench MO, Chen JC, Beyer AI, Fomin ME. Cellular therapies supplement: the peritoneum as an ectopic site of hematopoiesis following in utero transplantation. Transfusion. 2011 Nov; 51 Suppl 4:106S-117S.
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Fomin ME, Tai LK, Bárcena A, Muench MO. Coexpression of CD14 and CD326 discriminate hepatic precursors in the human fetal liver. Stem Cells Dev. 2011 Jul; 20(7):1247-57.
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Chen JC, Kuo ML, Ou LS, Chang PY, Muench MO, Shen CR, Chang HL, Yu HY, Fu RH. Characterization of tolerance induction through prenatal marrow transplantation: the requirement for a threshold level of chimerism to establish rather than maintain postnatal skin tolerance. Cell Transplant. 2010; 19(12):1609-22.
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Erlendsson LS, Muench MO, Hellman U, Hrafnkelsdóttir SM, Jonsson A, Balmer Y, Mäntylä E, Orvar BL. Barley as a green factory for the production of functional Flt3 ligand. Biotechnol J. 2010 Feb; 5(2):163-71.
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Glowacka I, Bertram S, Herzog P, Pfefferle S, Steffen I, Muench MO, Simmons G, Hofmann H, Kuri T, Weber F, Eichler J, Drosten C, Pöhlmann S. Differential downregulation of ACE2 by the spike proteins of severe acute respiratory syndrome coronavirus and human coronavirus NL63. J Virol. 2010 Jan; 84(2):1198-205.
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Salvador B, Zhou Y, Michault A, Muench MO, Simmons G. Characterization of Chikungunya pseudotyped viruses: Identification of refractory cell lines and demonstration of cellular tropism differences mediated by mutations in E1 glycoprotein. Virology. 2009 Oct 10; 393(1):33-41.
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Bárcena A, Muench MO, Kapidzic M, Fisher SJ. A new role for the human placenta as a hematopoietic site throughout gestation. Reprod Sci. 2009 Feb; 16(2):178-87.
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Muench MO. Transplantation NK'Oed in the first trimester. Blood. 2008 Dec 15; 112(13):4790-1.
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Mold JE, Michaëlsson J, Burt TD, Muench MO, Beckerman KP, Busch MP, Lee TH, Nixon DF, McCune JM. Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero. Science. 2008 Dec 5; 322(5907):1562-5.
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Bárcena A, Kapidzic M, Muench MO, Gormley M, Scott MA, Weier JF, Ferlatte C, Fisher SJ. The human placenta is a hematopoietic organ during the embryonic and fetal periods of development. Dev Biol. 2009 Mar 1; 327(1):24-33.
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Drake PM, Nathan JK, Stock CM, Chang PV, Muench MO, Nakata D, Reader JR, Gip P, Golden KP, Weinhold B, Gerardy-Schahn R, Troy FA, Bertozzi CR. Polysialic acid, a glycan with highly restricted expression, is found on human and murine leukocytes and modulates immune responses. J Immunol. 2008 Nov 15; 181(10):6850-8.
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Chen JC, Chang ML, Huang SF, Chang PY, Muench MO, Fu RH, Ou LS, Kuo ML. Prenatal tolerance induction: relationship between cell dose, marrow T-cells, chimerism, and tolerance. Cell Transplant. 2008; 17(5):495-506.
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Chen JC, Chang ML, Muench MO. Persistence of allografts in the peritoneal cavity after prenatal transplantation in mice. Transfusion. 2008 Mar; 48(3):553-60.
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Ishimoto H, Muench MO, Higuchi T, Minegishi K, Tanaka M, Yoshimura Y, Jaffe RB. Midkine, a heparin-binding growth factor, selectively stimulates proliferation of definitive zone cells of the human fetal adrenal gland. J Clin Endocrinol Metab. 2006 Oct; 91(10):4050-6.
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Muench MO, Ohkubo T, Smith CA, Suskind DL, Bárcena A. Maintenance of proliferative capacity and retroviral transduction efficiency of human fetal CD38(-)/CD34(++) stem cells. Stem Cells Dev. 2006 Feb; 15(1):97-108.
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Muench MO. In utero transplantation: baby steps towards an effective therapy. Bone Marrow Transplant. 2005 Mar; 35(6):537-47.
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Chen JC, Chang ML, Lee H, Muench MO. Prevention of graft rejection by donor type II CD8(+) T cells (Tc2 cells) is not sufficient to improve engraftment in fetal transplantation. Fetal Diagn Ther. 2005 Jan-Feb; 20(1):35-43.
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Chen JC, Chang ML, Lee H, Muench MO. Haploidentical donor T cells fail to facilitate engraftment but lessen the immune response of host T cells in murine fetal transplantation. Br J Haematol. 2004 Aug; 126(3):377-84.
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Suskind DL, Rosenthal P, Heyman MB, Kong D, Magrane G, Baxter-Lowe LA, Muench MO. Maternal microchimerism in the livers of patients with biliary atresia. BMC Gastroenterol. 2004 Jul 31; 4:14.
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Muench MO, Bárcena A. Megakaryocyte growth and development factor is a potent growth factor for primitive hematopoietic progenitors in the human fetus. Pediatr Res. 2004 Jun; 55(6):1050-6.
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Muench MO, Bárcena A. Stem cell transplantation in the fetus. Cancer Control. 2004 Mar-Apr; 11(2):105-18.
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Suskind DL, Muench MO. Searching for common stem cells of the hepatic and hematopoietic systems in the human fetal liver: CD34+ cytokeratin 7/8+ cells express markers for stellate cells. J Hepatol. 2004 Feb; 40(2):261-8.
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Muench MO, Pott Bärtsch EM, Chen JC, Lopoo JB, Bárcena A. Ontogenic changes in CD95 expression on human leukocytes: prevalence of T-cells expressing activation markers and identification of CD95-CD45RO+ T-cells in the fetus. Dev Comp Immunol. 2003 Dec; 27(10):899-914.
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Chen JC, Chang ML, Muench MO. A kinetic study of the murine mixed lymphocyte reaction by 5,6-carboxyfluorescein diacetate succinimidyl ester labeling. J Immunol Methods. 2003 Aug; 279(1-2):123-33.
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Muench MO, Ratcliffe JV, Nakanishi M, Ishimoto H, Jaffe RB. Isolation of definitive zone and chromaffin cells based upon expression of CD56 (neural cell adhesion molecule) in the human fetal adrenal gland. J Clin Endocrinol Metab. 2003 Aug; 88(8):3921-30.
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Muench MO, Suskind DL, Bárcena A. Isolation, growth and identification of colony-forming cells with erythroid, myeloid, dendritic cell and NK-cell potential from human fetal liver. Biol Proced Online. 2002 Jun 11; 4:10-23.
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Muench MO, Bárcena A. Broad distribution of colony-forming cells with erythroid, myeloid, dendritic cell, and NK cell potential among CD34(++) fetal liver cells. J Immunol. 2001 Nov 1; 167(9):4902-9.
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Ohkubo T, Bárcena A, Smith CA, Harrison MR, Muench MO. High-efficiency retroviral transduction of fetal liver CD38-CD34++ cells: implications for in utero and ex utero gene therapy. Fetal Diagn Ther. 2001 Sep-Oct; 16(5):299-307.
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Muench MO, Namikawa R. Disparate regulation of human fetal erythropoiesis by the microenvironments of the liver and bone marrow. Blood Cells Mol Dis. 2001 Mar-Apr; 27(2):377-90.
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Huie MA, Cheung MC, Muench MO, Becerril B, Kan YW, Marks JD. Antibodies to human fetal erythroid cells from a nonimmune phage antibody library. Proc Natl Acad Sci U S A. 2001 Feb 27; 98(5):2682-7.
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Muench MO, Rae J, Bárcena A, Leemhuis T, Farrell J, Humeau L, Maxwell-Wiggins JR, Capper J, Mychaliska GB, Albanese CT, Martin T, Tsukamoto A, Curnutte JT, Harrison MR. Transplantation of a fetus with paternal Thy-1(+)CD34(+)cells for chronic granulomatous disease. Bone Marrow Transplant. 2001 Feb; 27(4):355-64.
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Oppenheim SM, Muench MO, Gutiérrez-Adán A, Moyer AL, BonDurant RH, Rowe JD, Anderson GB. Hematopoietic stem cell transplantation in utero produces sheep-goat chimeras. Blood Cells Mol Dis. 2001 Jan-Feb; 27(1):296-308.
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Muench MO, Humeau L, Paek B, Ohkubo T, Lanier LL, Albanese CT, Bárcena A. Differential effects of interleukin-3, interleukin-7, interleukin 15, and granulocyte-macrophage colony-stimulating factor in the generation of natural killer and B cells from primitive human fetal liver progenitors. Exp Hematol. 2000 Aug; 28(8):961-73.
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Golfier F, Bárcena A, Harrison MR, Muench MO. Fetal bone marrow as a source of stem cells for in utero or postnatal transplantation. Br J Haematol. 2000 Apr; 109(1):173-81.
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Golfier F, Bárcena A, Cruz J, Harrison M, Muench M. Mid-trimester fetal livers are a rich source of CD34+/++ cells for transplantation. Bone Marrow Transplant. 1999 Sep; 24(5):451-61.
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Bárcena A, Muench MO, Song KS, Ohkubo T, Harrison MR. Role of CD95/Fas and its ligand in the regulation of the growth of human CD34(++)CD38(-) fetal liver cells. Exp Hematol. 1999 Sep; 27(9):1428-39.
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Namikawa R, Muench MO, Firpo MT, Humeau L, Xu Y, Menon S, Roncarolo MG. Administration of Flk2/Flt3 ligand induces expansion of human high-proliferative potential colony-forming cells in the SCID-hu mouse. Exp Hematol. 1999 Jun; 27(6):1029-37.
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Muench MO, Bárcena A, Ohkubo T, Harrison MR. Requirement of retinoids for the expression of CD38 on human hematopoietic progenitors in vitro. Cytotherapy. 1999; 1(6):455-68.
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Mychaliska GB, Muench MO, Rice HE, Leavitt AD, Cruz J, Harrison MR. The biology and ethics of banking fetal liver hematopoietic stem cells for in utero transplantation. J Pediatr Surg. 1998 Feb; 33(2):394-9.
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Muench MO, Roncarolo MG, Rosnet O, Birnbaum D, Namikawa R. Colony-forming cells expressing high levels of CD34 are the main targets for granulocyte colony-stimulating factor and macrophage colony-stimulating factor in the human fetal liver. Exp Hematol. 1997 Apr; 25(4):277-87.
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Muench MO, Roncarolo MG, Namikawa R. Phenotypic and functional evidence for the expression of CD4 by hematopoietic stem cells isolated from human fetal liver. Blood. 1997 Feb 15; 89(4):1364-75.
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Bárcena A, Park SW, Banapour B, Muench MO, Mechetner E. Expression of Fas/CD95 and Bcl-2 by primitive hematopoietic progenitors freshly isolated from human fetal liver. Blood. 1996 Sep 15; 88(6):2013-25.
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Namikawa R, Muench MO, Roncarolo MG. Regulatory roles of the ligand for Flk2/Flt3 tyrosine kinase receptor on human hematopoiesis. Stem Cells. 1996 Jul; 14(4):388-95.
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Namikawa R, Muench MO, de Vries JE, Roncarolo MG. The FLK2/FLT3 ligand synergizes with interleukin-7 in promoting stromal-cell-independent expansion and differentiation of human fetal pro-B cells in vitro. Blood. 1996 Mar 1; 87(5):1881-90.
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Bárcena A, Muench MO, Roncarolo MG, Spits H. Tracing the expression of CD7 and other antigens during T- and myeloid-cell differentiation in the human fetal liver and thymus. Leuk Lymphoma. 1995 Mar; 17(1-2):1-11.
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Muench MO, Roncarolo MG, Menon S, Xu Y, Kastelein R, Zurawski S, Hannum CH, Culpepper J, Lee F, Namikawa R. FLK-2/FLT-3 ligand regulates the growth of early myeloid progenitors isolated from human fetal liver. Blood. 1995 Feb 15; 85(4):963-72.
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Muench MO, Roncarolo MG, Namikawa R, Bárcena A, Moore MA. Progress in the ex vivo expansion of hematopoietic progenitors. Leuk Lymphoma. 1994 Dec; 16(1-2):1-11.
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Sánchez MJ, Muench MO, Roncarolo MG, Lanier LL, Phillips JH. Identification of a common T/natural killer cell progenitor in human fetal thymus. J Exp Med. 1994 Aug 1; 180(2):569-76.
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Bárcena A, Galy AH, Punnonen J, Muench MO, Schols D, Roncarolo MG, de Vries JE, Spits H. Lymphoid and myeloid differentiation of fetal liver CD34+lineage- cells in human thymic organ culture. J Exp Med. 1994 Jul 1; 180(1):123-32.
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Muench MO, Cupp J, Polakoff J, Roncarolo MG. Expression of CD33, CD38, and HLA-DR on CD34+ human fetal liver progenitors with a high proliferative potential. Blood. 1994 Jun 1; 83(11):3170-81.
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Hannum C, Culpepper J, Campbell D, McClanahan T, Zurawski S, Bazan JF, Kastelein R, Hudak S, Wagner J, Mattson J, et al. Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs. Nature. 1994 Apr 14; 368(6472):643-8.
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Paul SR, Hayes LL, Palmer R, Morris GE, Neben TY, Loebelenz J, Pedneault G, Brooks J, Blue I, Moore MA, et al. Interleukin-11 expression in donor bone marrow cells improves hematological reconstitution in lethally irradiated recipient mice. Exp Hematol. 1994 Mar; 22(3):295-301.
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Bárcena A, Muench MO, Roncarolo MG, Spits H. In search of T-cell progenitors in the human foetal liver. Res Immunol. 1994 Feb; 145(2):120-3; discussion 155-8.
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Bárcena A, Muench MO, Galy AH, Cupp J, Roncarolo MG, Phillips JH, Spits H. Phenotypic and functional analysis of T-cell precursors in the human fetal liver and thymus: CD7 expression in the early stages of T- and myeloid-cell development. Blood. 1993 Dec 1; 82(11):3401-14.
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Muench MO, Firpo MT, Moore MA. Bone marrow transplantation with interleukin-1 plus kit-ligand ex vivo expanded bone marrow accelerates hematopoietic reconstitution in mice without the loss of stem cell lineage and proliferative potential. Blood. 1993 Jun 15; 81(12):3463-73.
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Smith C, Muench MO, Knizewski M, Gilboa E, Moore MA. Development of a lacZ marked WEHI-3B D+ murine leukemic cell line as an in-vivo model of acute non-lymphocytic leukemia. Leukemia. 1993 Feb; 7(2):310-7.
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Muench MO, Guy Z, Moore MA. Ex vivo differentiation therapy as a method of leukemic cell purging in murine bone marrow expansion cultures. Cancer Res. 1992 Dec 1; 52(23):6576-82.
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Muench MO, Gasparetto C, Moore MA. The in vitro growth of murine high proliferative potential-colony forming cells is not enhanced by growth in a low oxygen atmosphere. Cytokine. 1992 Nov; 4(6):488-94.
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Muench MO, Moore MA. Accelerated recovery of peripheral blood cell counts in mice transplanted with in vitro cytokine-expanded hematopoietic progenitors. Exp Hematol. 1992 Jun; 20(5):611-8.
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Muench MO, Schneider JG, Moore MA. Interactions among colony-stimulating factors, IL-1 beta, IL-6, and kit-ligand in the regulation of primitive murine hematopoietic cells. Exp Hematol. 1992 Mar; 20(3):339-49.
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Smith C, Gasparetto C, Collins N, Gillio A, Muench MO, O'Reilly RJ, Moore MA. Purification and partial characterization of a human hematopoietic precursor population. Blood. 1991 May 15; 77(10):2122-8.
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Moore MA, Muench MO, Warren DJ, Laver J. Cytokine networks involved in the regulation of haemopoietic stem cell proliferation and differentiation. Ciba Found Symp. 1990; 148:43-58; discussion 58-61.
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Slørdal L, Muench MO, Warren DJ, Moore MA. Radioprotection by murine and human tumor-necrosis factor: dose-dependent effects on hematopoiesis in the mouse. Eur J Haematol. 1989 Nov; 43(5):428-34.
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