Margaret Feeney, MD
|School||UCSF School of Medicine|
|Address||1001 Potrero Ave|
San Francisco CA 94110
My research interests center on the immunopathogenesis of HIV and malaria in childhood. The broad goals of my research program are to elucidate the developmental differences between T cell responses in children and adults, and to identify correlates of protective immune responses to HIV and malaria in order to guide the rational design of vaccines and immunomodulatory therapies.
While great strides have been made in the prevention of pediatric HIV infection in the U.S., mother-to-child transmission of HIV remains a major cause of pediatric morbidity and mortality worldwide and one HIV-infected infant is born each minute. Children infected with HIV display tremendous variability in their clinical course and rate of progression to AIDS. My laboratory seeks to identify immunologic and genetic factors underlying the high variability in the rate of progression to AIDS among children. Current studies focus on characterization of the T cell response to acute perinatal infection in infants, viral evolution following mother-to-child transmission, and the impact of HLA-associated viral mutations on the infant immune response. These translational immunology studies are conducted in collaboration with clinical sites in the Caribbean and Africa.
A more recent focus of my laboratory is the human immune response to childhood malaria. We are conducting longitudinal investigations of the cellular immune response to malaria, including immunoregulatory mechanisms that may interfere with the development of durable immunity, in a region of high endemnicity in Tororo, Uganda. We are also investigating whether prenatal exposure to malaria antigens resulting from placental malaria may result in immune tolerance to malaria antigens encountered during infancy. These studies are based on a collaboration with malaria epidemiologists and clinical investigators in the Infectious Disease Division at SFGH and our Ugandan colleagues based at the Infectious Disease Research Collaboration (IDRC).
In addition to my laboratory research, I serve as the Director for the Philani Program, a clinical care, research, and teaching initiative in KwaZulu Natal, South Africa which serves an umbrella for clinical and translational research addressing pediatric HIV and tuberculosis co-infection.
EDUCATION AND TRAINING
Dartmouth College, BA, 1992
U. Pennsylvania School of Medicine, MD, 1996
Residency in Pediatrics, UCSF, 1996-1999
Harvard Medical School, MMSc., 2001
Fellowship in Pediatric Infectious Diseases, 1999-2002
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