Sign in to edit your profile (add interests, mentoring, photo, etc.)

    Margaret Feeney, MD

    TitleAssociate Professor
    SchoolUCSF School of Medicine
    DepartmentPediatrics
    Address1001 Potrero Ave, SFGH 3
    San Francisco CA 94143
    Phone415-206-8218

       Overview 
       Overview
      RESEARCH INTERESTS
      My research interests center on the immunopathogenesis of HIV and malaria in childhood. The broad goals of my research program are to elucidate the developmental differences between T cell responses in children and adults, and to identify correlates of protective immune responses to HIV and malaria in order to guide the rational design of vaccines and immunomodulatory therapies.

      While great strides have been made in the prevention of pediatric HIV infection in the U.S., mother-to-child transmission of HIV remains a major cause of pediatric morbidity and mortality worldwide and one HIV-infected infant is born each minute. Children infected with HIV display tremendous variability in their clinical course and rate of progression to AIDS. My laboratory seeks to identify immunologic and genetic factors underlying the high variability in the rate of progression to AIDS among children. Current studies focus on characterization of the T cell response to acute perinatal infection in infants, viral evolution following mother-to-child transmission, and the impact of HLA-associated viral mutations on the infant immune response. These translational immunology studies are conducted in collaboration with clinical sites in the Caribbean and Africa.

      A more recent focus of my laboratory is the human immune response to childhood malaria. We are conducting longitudinal investigations of the cellular immune response to malaria, including immunoregulatory mechanisms that may interfere with the development of durable immunity, in a region of high endemnicity in Tororo, Uganda. We are also investigating whether prenatal exposure to malaria antigens resulting from placental malaria may result in immune tolerance to malaria antigens encountered during infancy. These studies are based on a collaboration with malaria epidemiologists and clinical investigators in the Infectious Disease Division at SFGH and our Ugandan colleagues based at the Infectious Disease Research Collaboration (IDRC).

      In addition to my laboratory research, I serve as the Director for the Philani Program, a clinical care, research, and teaching initiative in KwaZulu Natal, South Africa which serves an umbrella for clinical and translational research addressing pediatric HIV and tuberculosis co-infection.


      EDUCATION AND TRAINING
      Dartmouth College, BA, 1992
      U. Pennsylvania School of Medicine, MD, 1996
      Residency in Pediatrics, UCSF, 1996-1999
      Harvard Medical School, MMSc., 2001
      Fellowship in Pediatric Infectious Diseases, 1999-2002


       ORNG Applications 
       Websites
       Faculty Mentoring
       Awarded Grants
       Global Health
       More Info

       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Jagannathan P, Eccles-James I, Bowen K, Nankya F, Auma A, Wamala S, Ebusu C, Muhindo MK, Arinaitwe E, Briggs J, Greenhouse B, Tappero JW, Kamya MR, Dorsey G, Feeney ME. IFN?/IL-10 Co-producing Cells Dominate the CD4 Response to Malaria in Highly Exposed Children. PLoS Pathog. 2014 Jan; 10(1):e1003864.
        View in: PubMed
      2. Zanoni BC, Sunpath H, Feeney ME. Pediatric response to second-line antiretroviral therapy in South Africa. PLoS One. 2012; 7(11):e49591.
        View in: PubMed
      3. Zanoni BC, Phungula T, Zanoni HM, France H, Cook EF, Feeney ME. Predictors of poor CD4 and weight recovery in HIV-infected children initiating ART in South Africa. PLoS One. 2012; 7(3):e33611.
        View in: PubMed
      4. Ruel TD, Zanoni BC, Ssewanyana I, Cao H, Havlir DV, Kamya M, Achan J, Charlebois ED, Feeney ME. Sex differences in HIV RNA level and CD4 cell percentage during childhood. Clin Infect Dis. 2011 Sep; 53(6):592-9.
        View in: PubMed
      5. Zanoni BC, Phungula T, Zanoni HM, France H, Feeney ME. Risk factors associated with increased mortality among HIV infected children initiating antiretroviral therapy (ART) in South Africa. PLoS One. 2011; 6(7):e22706.
        View in: PubMed
      6. Zanoni BC, Phungula T, Zanoni HM, France H, Feeney ME. Impact of tuberculosis cotreatment on viral suppression rates among HIV-positive children initiating HAART. AIDS. 2011 Jan 2; 25(1):49-55.
        View in: PubMed
      7. Ryland EG, Tang Y, Christie CD, Feeney ME. Sequence evolution of HIV-1 following mother-to-child transmission. J Virol. 2010 Dec; 84(23):12437-44.
        View in: PubMed
      8. Tang Y, Huang S, Dunkley-Thompson J, Steel-Duncan JC, Ryland EG, St John MA, Hazra R, Christie CD, Feeney ME. Correlates of spontaneous viral control among long-term survivors of perinatal HIV-1 infection expressing human leukocyte antigen-B57. AIDS. 2010 Jun 19; 24(10):1425-35.
        View in: PubMed
      9. Schneidewind A, Tang Y, Brockman MA, Ryland EG, Dunkley-Thompson J, Steel-Duncan JC, St John MA, Conrad JA, Kalams SA, Noel F, Allen TM, Christie CD, Feeney ME. Maternal transmission of human immunodeficiency virus escape mutations subverts HLA-B57 immunodominance but facilitates viral control in the haploidentical infant. J Virol. 2009 Sep; 83(17):8616-27.
        View in: PubMed
      10. Huang S, Dunkley-Thompson J, Tang Y, Macklin EA, Steel-Duncan J, Singh-Minott I, Ryland EG, Smikle M, Walker BD, Christie CD, Feeney ME. Deficiency of HIV-Gag-specific T cells in early childhood correlates with poor viral containment. J Immunol. 2008 Dec 1; 181(11):8103-11.
        View in: PubMed
      11. Lichterfeld M, Kavanagh DG, Williams KL, Moza B, Mui SK, Miura T, Sivamurthy R, Allgaier R, Pereyra F, Trocha A, Feeney M, Gandhi RT, Rosenberg ES, Altfeld M, Allen TM, Allen R, Walker BD, Sundberg EJ, Yu XG. A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cells. J Exp Med. 2007 Nov 26; 204(12):2813-24.
        View in: PubMed
      12. Yu XG, Lichterfeld M, Chetty S, Williams KL, Mui SK, Miura T, Frahm N, Feeney ME, Tang Y, Pereyra F, Labute MX, Pfafferott K, Leslie A, Crawford H, Allgaier R, Hildebrand W, Kaslow R, Brander C, Allen TM, Rosenberg ES, Kiepiela P, Vajpayee M, Goepfert PA, Altfeld M, Goulder PJ, Walker BD. Mutually exclusive T-cell receptor induction and differential susceptibility to human immunodeficiency virus type 1 mutational escape associated with a two-amino-acid difference between HLA class I subtypes. J Virol. 2007 Feb; 81(4):1619-31.
        View in: PubMed
      13. Feeney ME, Tang Y, Rathod A, Kneut C, McIntosh K. Absence of detectable viremia in a perinatally HIV-1-infected teenager after discontinuation of antiretroviral therapy. J Allergy Clin Immunol. 2006 Aug; 118(2):324-30.
        View in: PubMed
      14. Frahm N, Kiepiela P, Adams S, Linde CH, Hewitt HS, Sango K, Feeney ME, Addo MM, Lichterfeld M, Lahaie MP, Pae E, Wurcel AG, Roach T, St John MA, Altfeld M, Marincola FM, Moore C, Mallal S, Carrington M, Heckerman D, Allen TM, Mullins JI, Korber BT, Goulder PJ, Walker BD, Brander C. Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes. Nat Immunol. 2006 Feb; 7(2):173-8.
        View in: PubMed
      15. Allen TM, Altfeld M, Geer SC, Kalife ET, Moore C, O'sullivan KM, Desouza I, Feeney ME, Eldridge RL, Maier EL, Kaufmann DE, Lahaie MP, Reyor L, Tanzi G, Johnston MN, Brander C, Draenert R, Rockstroh JK, Jessen H, Rosenberg ES, Mallal SA, Walker BD. Selective escape from CD8+ T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution. J Virol. 2005 Nov; 79(21):13239-49.
        View in: PubMed
      16. Pillay T, Zhang HT, Drijfhout JW, Robinson N, Brown H, Khan M, Moodley J, Adhikari M, Pfafferott K, Feeney ME, St John A, Holmes EC, Coovadia HM, Klenerman P, Goulder PJ, Phillips RE. Unique acquisition of cytotoxic T-lymphocyte escape mutants in infant human immunodeficiency virus type 1 infection. J Virol. 2005 Sep; 79(18):12100-5.
        View in: PubMed
      17. Frahm N, Adams S, Kiepiela P, Linde CH, Hewitt HS, Lichterfeld M, Sango K, Brown NV, Pae E, Wurcel AG, Altfeld M, Feeney ME, Allen TM, Roach T, St John MA, Daar ES, Rosenberg E, Korber B, Marincola F, Walker BD, Goulder PJ, Brander C. HLA-B63 presents HLA-B57/B58-restricted cytotoxic T-lymphocyte epitopes and is associated with low human immunodeficiency virus load. J Virol. 2005 Aug; 79(16):10218-25.
        View in: PubMed
      18. Feeney ME, Tang Y, Pfafferott K, Roosevelt KA, Draenert R, Trocha A, Yu XG, Verrill C, Allen T, Moore C, Mallal S, Burchett S, McIntosh K, Pelton SI, St John MA, Hazra R, Klenerman P, Altfeld M, Walker BD, Goulder PJ. HIV-1 viral escape in infancy followed by emergence of a variant-specific CTL response. J Immunol. 2005 Jun 15; 174(12):7524-30.
        View in: PubMed
      19. Feeney ME. HIV and children: the developing immune system fights back. West Indian Med J. 2004 Oct; 53(5):359-62.
        View in: PubMed
      20. Feeney ME, Tang Y, Roosevelt KA, Leslie AJ, McIntosh K, Karthas N, Walker BD, Goulder PJ. Immune escape precedes breakthrough human immunodeficiency virus type 1 viremia and broadening of the cytotoxic T-lymphocyte response in an HLA-B27-positive long-term-nonprogressing child. J Virol. 2004 Aug; 78(16):8927-30.
        View in: PubMed
      21. Draenert R, Brander C, Yu XG, Altfeld M, Verrill CL, Feeney ME, Walker BD, Goulder PJ. Impact of intrapeptide epitope location on CD8 T cell recognition: implications for design of overlapping peptide panels. AIDS. 2004 Apr 9; 18(6):871-6.
        View in: PubMed
      22. Draenert R, Le Gall S, Pfafferott KJ, Leslie AJ, Chetty P, Brander C, Holmes EC, Chang SC, Feeney ME, Addo MM, Ruiz L, Ramduth D, Jeena P, Altfeld M, Thomas S, Tang Y, Verrill CL, Dixon C, Prado JG, Kiepiela P, Martinez-Picado J, Walker BD, Goulder PJ. Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection. J Exp Med. 2004 Apr 5; 199(7):905-15.
        View in: PubMed
      23. Frahm N, Korber BT, Adams CM, Szinger JJ, Draenert R, Addo MM, Feeney ME, Yusim K, Sango K, Brown NV, SenGupta D, Piechocka-Trocha A, Simonis T, Marincola FM, Wurcel AG, Stone DR, Russell CJ, Adolf P, Cohen D, Roach T, StJohn A, Khatri A, Davis K, Mullins J, Goulder PJ, Walker BD, Brander C. Consistent cytotoxic-T-lymphocyte targeting of immunodominant regions in human immunodeficiency virus across multiple ethnicities. J Virol. 2004 Mar; 78(5):2187-200.
        View in: PubMed
      24. Leslie AJ, Pfafferott KJ, Chetty P, Draenert R, Addo MM, Feeney M, Tang Y, Holmes EC, Allen T, Prado JG, Altfeld M, Brander C, Dixon C, Ramduth D, Jeena P, Thomas SA, St John A, Roach TA, Kupfer B, Luzzi G, Edwards A, Taylor G, Lyall H, Tudor-Williams G, Novelli V, Martinez-Picado J, Kiepiela P, Walker BD, Goulder PJ. HIV evolution: CTL escape mutation and reversion after transmission. Nat Med. 2004 Mar; 10(3):282-9.
        View in: PubMed
      25. Feeney ME, Draenert R, Roosevelt KA, Pelton SI, McIntosh K, Burchett SK, Mao C, Walker BD, Goulder PJ. Reconstitution of virus-specific CD4 proliferative responses in pediatric HIV-1 infection. J Immunol. 2003 Dec 15; 171(12):6968-75.
        View in: PubMed
      26. Altfeld M, Addo MM, Rosenberg ES, Hecht FM, Lee PK, Vogel M, Yu XG, Draenert R, Johnston MN, Strick D, Allen TM, Feeney ME, Kahn JO, Sekaly RP, Levy JA, Rockstroh JK, Goulder PJ, Walker BD. Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection. AIDS. 2003 Dec 5; 17(18):2581-91.
        View in: PubMed
      27. Feeney ME, Roosevelt KA, Tang Y, Pfafferott KJ, McIntosh K, Burchett SK, Mao C, Walker BD, Goulder PJ. Comprehensive screening reveals strong and broadly directed human immunodeficiency virus type 1-specific CD8 responses in perinatally infected children. J Virol. 2003 Jul; 77(13):7492-501.
        View in: PubMed
      28. Addo MM, Yu XG, Rathod A, Cohen D, Eldridge RL, Strick D, Johnston MN, Corcoran C, Wurcel AG, Fitzpatrick CA, Feeney ME, Rodriguez WR, Basgoz N, Draenert R, Stone DR, Brander C, Goulder PJ, Rosenberg ES, Altfeld M, Walker BD. Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load. J Virol. 2003 Feb; 77(3):2081-92.
        View in: PubMed
      29. Altfeld M, van Lunzen J, Frahm N, Yu XG, Schneider C, Eldridge RL, Feeney ME, Meyer-Olson D, Stellbrink HJ, Walker BD. Expansion of pre-existing, lymph node-localized CD8+ T cells during supervised treatment interruptions in chronic HIV-1 infection. J Clin Invest. 2002 Mar; 109(6):837-43.
        View in: PubMed
      30. Yu XG, Shang H, Addo MM, Eldridge RL, Phillips MN, Feeney ME, Strick D, Brander C, Goulder PJ, Rosenberg ES, Walker BD, Altfeld M. Important contribution of p15 Gag-specific responses to the total Gag-specific CTL responses. AIDS. 2002 Feb 15; 16(3):321-8.
        View in: PubMed
      Back to TOP