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    Marielle Cavrois, PhD

    TitleAssistant Professor
    SchoolUCSF School of Medicine
    DepartmentMedicine
    Address1650 Owens Street
    San Francisco CA 94143
    Phone415-734-4824

       Biography 
       Education and Training
      University of California, San FranciscoPostdoctoral StudiesGraduate Division

       Overview 
       Overview
      Significance
      Mucosal transmission of HIV is a major force driving expansion of the global AIDS epidemic. Understanding the initial events in the establishment of infection in a new host is key to developing an effective vaccine and microbicides.

      Areas of Investigation
      Our main focus is to understand HIV transmission: what cells HIV initially infects in the genital mucosa and what HIV features are critical for viral transmission from one person to another. We are particularly interested in the envelope protein encoded by HIV and how it mediates fusion, the initial step of the viral life cycle. We developed a fluorometric assay to identify the most susceptible cells in vivo and characterize the strains of HIV circulating in the population.


       ORNG Applications 
       More Info

       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Cavrois M, Neidleman J, Santiago ML, Derdeyn CA, Hunter E, Greene WC. Enhanced Fusion and Virion Incorporation for HIV-1 Subtype C Envelope Glycoproteins with Compact V1/V2 Domains. J Virol. 2014 Feb; 88(4):2083-94.
        View in: PubMed
      2. Roan NR, Cavrois M, Greene WC. [Role of semen-derived amyloid fibrils as facilitators of HIV infection]. Med Sci (Paris). 2012 Apr; 28(4):358-60.
        View in: PubMed
      3. Doitsh G, Cavrois M, Lassen KG, Zepeda O, Yang Z, Santiago ML, Hebbeler AM, Greene WC. Abortive HIV infection mediates CD4 T cell depletion and inflammation in human lymphoid tissue. Cell. 2010 Nov 24; 143(5):789-801.
        View in: PubMed
      4. Cavrois M, Neidleman J, Galloway N, Derdeyn CA, Hunter E, Greene WC. Measuring HIV fusion mediated by envelopes from primary viral isolates. Methods. 2011 Jan; 53(1):34-8.
        View in: PubMed
      5. Cavrois M, Neidleman J, Greene WC. The achilles heel of the trojan horse model of HIV-1 trans-infection. PLoS Pathog. 2008 Jun; 4(6):e1000051.
        View in: PubMed
      6. Burt TD, Agan BK, Marconi VC, He W, Kulkarni H, Mold JE, Cavrois M, Huang Y, Mahley RW, Dolan MJ, McCune JM, Ahuja SK. Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4/epsilon4 genotype accelerates HIV disease progression. Proc Natl Acad Sci U S A. 2008 Jun 24; 105(25):8718-23.
        View in: PubMed
      7. Cavrois M, Neidleman J, Kreisberg JF, Greene WC. In vitro derived dendritic cells trans-infect CD4 T cells primarily with surface-bound HIV-1 virions. PLoS Pathog. 2007 Jan; 3(1):e4.
        View in: PubMed
      8. Cavrois M, Neidleman J, Kreisberg JF, Fenard D, Callebaut C, Greene WC. Human immunodeficiency virus fusion to dendritic cells declines as cells mature. J Virol. 2006 Feb; 80(4):1992-9.
        View in: PubMed
      9. Fenard D, Yonemoto W, de Noronha C, Cavrois M, Williams SA, Greene WC. Nef is physically recruited into the immunological synapse and potentiates T cell activation early after TCR engagement. J Immunol. 2005 Nov 1; 175(9):6050-7.
        View in: PubMed
      10. Yonezawa A, Cavrois M, Greene WC. Studies of ebola virus glycoprotein-mediated entry and fusion by using pseudotyped human immunodeficiency virus type 1 virions: involvement of cytoskeletal proteins and enhancement by tumor necrosis factor alpha. J Virol. 2005 Jan; 79(2):918-26.
        View in: PubMed
      11. Cavrois M, Neidleman J, Yonemoto W, Fenard D, Greene WC. HIV-1 virion fusion assay: uncoating not required and no effect of Nef on fusion. Virology. 2004 Oct 10; 328(1):36-44.
        View in: PubMed
      12. Cavrois M, Neidleman J, Bigos M, Greene WC. Fluorescence resonance energy transfer-based HIV-1 virion fusion assay. Methods Mol Biol. 2004; 263:333-44.
        View in: PubMed
      13. Cavrois M, De Noronha C, Greene WC. A sensitive and specific enzyme-based assay detecting HIV-1 virion fusion in primary T lymphocytes. Nat Biotechnol. 2002 Nov; 20(11):1151-4.
        View in: PubMed
      14. de Noronha CM, Sherman MP, Lin HW, Cavrois MV, Moir RD, Goldman RD, Greene WC. Dynamic disruptions in nuclear envelope architecture and integrity induced by HIV-1 Vpr. Science. 2001 Nov 2; 294(5544):1105-8.
        View in: PubMed
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