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    Mark Looney, MD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentMedicine
    Address513 Parnassus Ave
    San Francisco CA 94143
    Phone415-476-9563
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      Collapse Biography 
      Collapse Education and Training
      University of California, San FranciscoResidency Internal Medicine2001
      University of TennesseeM.D.School of Medicine1998

      Collapse Overview 
      Collapse Overview
      Mark R. Looney, MD is a Professor of Medicine and Laboratory Medicine and Attending Physician on the Pulmonary Consult Service and the Intensive Care Units at UCSF. He received his undergraduate degree from Lipscomb University in Nashville, Tennessee in 1994 and his medical degree from the University of Tennessee, Memphis in 1998. He then came to UCSF where he completed his residency in Internal Medicine and a fellowship in Pulmonary and Critical Care Medicine. He received his research training in the Cardiovascular Research Institute at UCSF under the direction of Dr. Michael Matthay (2003-2008) and started his own laboratory at UCSF in 2008.

      Research Interests

      My laboratory conducts research on acute lung injury (ALI) and we have focused our interests on the role of the innate immune response in producing lung endothelial and epithelial permeability. Using mouse models of ALI and two-photon intravital microscopy in the lung, we are investigating the interactions between neutrophils, platelets, and other immune cells in the lung microcirculation. Platelets are increasingly recognized as critical mediators of inflammation and injury, and we are using anti-platelet therapies as novel approaches to the prevention and treatment of ALI. We have also found that activated platelets can trigger neutrophil extracellular trap (NET) formation in the lung, and we are investigating the significance of NET formation in infectious and non-infectious models of ALI.

      Finally, we are one of the few centers in the U.S. to establish a mouse lung transplantation model that we are using to study mechanisms of both early graft dysfunction (ischemia-reperfusion injury) and late graft dysfunction (obliterative bronchiolitis). Lung transplantation has one of the lowest median survivals among all solid organ transplantations and we are dedicated to defining the lung-specific alloimmune responses that are responsible for graft dysfunction.


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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Rossaint J, Kühne K, Skupski J, Van Aken H, Looney MR, Hidalgo A, Zarbock A. Directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response. Nat Commun. 2016 Nov 15; 7:13464. PMID: 27845343.
        View in: PubMed
      2. Chong SZ, Evrard M, Devi S, Chen J, Lim JY, See P, Zhang Y, Adrover JM, Lee B, Tan L, Li JL, Liong KH, Phua C, Balachander A, Boey A, Liebl D, Tan SM, Chan JK, Balabanian K, Harris JE, Bianchini M, Weber C, Duchene J, Lum J, Poidinger M, Chen Q, Rénia L, Wang CI, Larbi A, Randolph GJ, Weninger W, Looney MR, Krummel MF, Biswas SK, Ginhoux F, Hidalgo A, Bachelerie F, Ng LG. CXCR4 identifies transitional bone marrow premonocytes that replenish the mature monocyte pool for peripheral responses. J Exp Med. 2016 Oct 17; 213(11):2293-2314. PMID: 27811056.
        View in: PubMed
      3. Henry TS, Naeger DM, Looney MR, Elicker BM. Dyspnea and Pulmonary Hypertension with Diffuse Centrilobular Nodules. Ann Am Thorac Soc. 2016 Oct; 13(10):1858-1860. PMID: 27726440.
        View in: PubMed
      4. Panka BA, de Grooth HJ, Spoelstra-de Man A, Looney M, Tuinman PR. Prevention or Treatment of ARDS with Aspirin: A Review of Preclinical Models and Meta-Analysis of Clinical Studies. Shock. 2016 Sep 19. PMID: 27648700.
        View in: PubMed
      5. Toy P, Kleinman SH, Looney MR. Reply to concerns regarding dropping the term "possible TRALI". Transfusion. 2016 Sep; 56(9):2394-5. PMID: 27624212.
        View in: PubMed
      6. Headley MB, Bins A, Nip A, Roberts EW, Looney MR, Gerard A, Krummel MF. Visualization of immediate immune responses to pioneer metastatic cells in the lung. Nature. 2016 Mar 24; 531(7595):513-7. PMID: 26982733.
        View in: PubMed
      7. Mallavia B, Liu F, Sheppard D, Looney MR. Inhibiting Integrin avß5 Reduces Ischemia-Reperfusion Injury in an Orthotopic Lung Transplant Model in Mice. Am J Transplant. 2016 Apr; 16(4):1306-11. PMID: 26602748.
        View in: PubMed
      8. Caudrillier A, Mallavia B, Rouse L, Marschner S, Looney MR. Transfusion of Human Platelets Treated with Mirasol Pathogen Reduction Technology Does Not Induce Acute Lung Injury in Mice. PLoS One. 2015; 10(7):e0133022. PMID: 26176623; PMCID: PMC4503436.
      9. Looney MR. Selectin' for NETs. Blood. 2015 Jul 9; 126(2):129-30. PMID: 26160186.
        View in: PubMed
      10. Ortiz-Muñoz G, Looney MR. Non-invasive Intratracheal Instillation in Mice. Bio Protoc. 2015; 5(12). PMID: 27390765.
        View in: PubMed
      11. Sayah DM, Mallavia B, Looney MR. Reply: neutrophil extracellular traps in primary graft dysfunction after lung transplantation. Am J Respir Crit Care Med. 2015 May 1; 191(9):1089. PMID: 25932769.
        View in: PubMed
      12. Bose O, Baluk P, Looney MR, Cheng LE, McDonald DM, Caughey GH, Krummel MF. Mast cells present protrusions into blood vessels upon tracheal allergen challenge in mice. PLoS One. 2015; 10(3):e0118513. PMID: 25789765; PMCID: PMC4366375.
      13. Roubinian NH, Looney MR, Kor DJ, Lowell CA, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson GA, Matthay MA, Toy P, Murphy EL. Cytokines and clinical predictors in distinguishing pulmonary transfusion reactions. Transfusion. 2015 Aug; 55(8):1838-46. PMID: 25702590; PMCID: PMC4536135 [Available on 08/01/16].
      14. Sayah DM, Mallavia B, Liu F, Ortiz-Muñoz G, Caudrillier A, DerHovanessian A, Ross DJ, Lynch Iii JP, Saggar R, Ardehali A, Ware LB, Christie JD, Belperio JA, Looney MR. Neutrophil extracellular traps are pathogenic in primary graft dysfunction after lung transplantation. Am J Respir Crit Care Med. 2015 Feb 15; 191(4):455-63. PMID: 25485813; PMCID: PMC4351593 [Available on 02/15/16].
      15. Vaughan AE, Brumwell AN, Xi Y, Gotts JE, Brownfield DG, Treutlein B, Tan K, Tan V, Liu FC, Looney MR, Matthay MA, Rock JR, Chapman HA. Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury. Nature. 2015 Jan 29; 517(7536):621-5. PMID: 25533958; PMCID: PMC4312207.
      16. Toy P, Bacchetti P, Grimes B, Gajic O, Murphy EL, Winters JL, Gropper MA, Hubmayr RD, Matthay MA, Wilson G, Koenigsberg M, Lee DC, Hirschler NV, Lowell CA, Schuller RM, Gandhi MJ, Norris PJ, Mair DC, Sanchez Rosen R, Looney MR. Recipient clinical risk factors predominate in possible transfusion-related acute lung injury. Transfusion. 2015 May; 55(5):947-52. PMID: 25488517; PMCID: PMC4428945 [Available on 05/01/16].
      17. Ortiz-Muñoz G, Mallavia B, Bins A, Headley M, Krummel MF, Looney MR. Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice. Blood. 2014 Oct 23; 124(17):2625-34. PMID: 25143486; PMCID: PMC4208278.
      18. Greenland JR, Xu X, Sayah DM, Liu FC, Jones KD, Looney MR, Caughey GH. Mast cells in a murine lung ischemia-reperfusion model of primary graft dysfunction. Respir Res. 2014; 15:95. PMID: 25115556; PMCID: PMC4151192.
      19. Looney MR, Roubinian N, Gajic O, Gropper MA, Hubmayr RD, Lowell CA, Bacchetti P, Wilson G, Koenigsberg M, Lee DC, Wu P, Grimes B, Norris PJ, Murphy EL, Gandhi MJ, Winters JL, Mair DC, Schuller RM, Hirschler NV, Rosen RS, Matthay MA, Toy P. Prospective study on the clinical course and outcomes in transfusion-related acute lung injury*. Crit Care Med. 2014 Jul; 42(7):1676-87. PMID: 24776608; PMCID: PMC4284060.
      20. Lelkes E, Headley MB, Thornton EE, Looney MR, Krummel MF. The spatiotemporal cellular dynamics of lung immunity. Trends Immunol. 2014 Aug; 35(8):379-86. PMID: 24974157; PMCID: PMC4124173.
      21. Looney MR, Bhattacharya J. Live imaging of the lung. Annu Rev Physiol. 2014; 76:431-45. PMID: 24245941; PMCID: PMC4501380.
      22. Murphy EL, Kwaan N, Looney MR, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson G, Matthay M, Bacchetti P, Toy P. Risk factors and outcomes in transfusion-associated circulatory overload. Am J Med. 2013 Apr; 126(4):357.e29-38. PMID: 23357450; PMCID: PMC3652681.
      23. Sayah DM, Looney MR, Toy P. Transfusion reactions: newer concepts on the pathophysiology, incidence, treatment, and prevention of transfusion-related acute lung injury. Crit Care Clin. 2012 Jul; 28(3):363-72, v. PMID: 22713611; PMCID: PMC3380279.
      24. Caudrillier A, Kessenbrock K, Gilliss BM, Nguyen JX, Marques MB, Monestier M, Toy P, Werb Z, Looney MR. Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury. J Clin Invest. 2012 Jul; 122(7):2661-71. PMID: 22684106; PMCID: PMC3386815.
      25. Thornton EE, Looney MR, Bose O, Sen D, Sheppard D, Locksley R, Huang X, Krummel MF. Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung. J Exp Med. 2012 Jun 4; 209(6):1183-99. PMID: 22585735; PMCID: PMC3371730.
      26. Thornton EE, Krummel MF, Looney MR. Live imaging of the lung. Curr Protoc Cytom. 2012 Apr; Chapter 12:Unit12.28. PMID: 22470155.
        View in: PubMed
      27. Weiskopf RB, Feiner J, Toy P, Twiford J, Shimabukuro D, Lieberman J, Looney MR, Lowell CA, Gropper MA. Fresh and stored red blood cell transfusion equivalently induce subclinical pulmonary gas exchange deficit in normal humans. Anesth Analg. 2012 Mar; 114(3):511-9. PMID: 22262647; PMCID: PMC3927839.
      28. Caudrillier A, Looney MR. Platelet-neutrophil interactions as a target for prevention and treatment of transfusion-related acute lung injury. Curr Pharm Des. 2012; 18(22):3260-6. PMID: 22621270.
        View in: PubMed
      29. Toy P, Gajic O, Bacchetti P, Looney MR, Gropper MA, Hubmayr R, Lowell CA, Norris PJ, Murphy EL, Weiskopf RB, Wilson G, Koenigsberg M, Lee D, Schuller R, Wu P, Grimes B, Gandhi MJ, Winters JL, Mair D, Hirschler N, Sanchez Rosen R, Matthay MA. Transfusion-related acute lung injury: incidence and risk factors. Blood. 2012 Feb 16; 119(7):1757-67. PMID: 22117051; PMCID: PMC3286351.
      30. Gilliss BM, Looney MR, Gropper MA. Reducing noninfectious risks of blood transfusion. Anesthesiology. 2011 Sep; 115(3):635-49. PMID: 21792054; PMCID: PMC3162102.
      31. Kleinman SH, Triulzi DJ, Murphy EL, Carey PM, Gottschall JL, Roback JD, Carrick D, Mathew S, Wright DJ, Cable R, Ness P, Gajic O, Hubmayr RD, Looney MR, Kakaiya RM. The Leukocyte Antibody Prevalence Study-II (LAPS-II): a retrospective cohort study of transfusion-related acute lung injury in recipients of high-plasma-volume human leukocyte antigen antibody-positive or -negative components. Transfusion. 2011 Oct; 51(10):2078-91. PMID: 21446938; PMCID: PMC3606005.
      32. Su X, Looney MR, Su HE, Lee JW, Song Y, Matthay MA. Role of CFTR expressed by neutrophils in modulating acute lung inflammation and injury in mice. Inflamm Res. 2011 Jul; 60(7):619-32. PMID: 21301926; PMCID: PMC3116128.
      33. Gilliss BM, Looney MR. Experimental models of transfusion-related acute lung injury. Transfus Med Rev. 2011 Jan; 25(1):1-11. PMID: 21134622; PMCID: PMC3011933.
      34. Looney MR, Thornton EE, Sen D, Lamm WJ, Glenny RW, Krummel MF. Stabilized imaging of immune surveillance in the mouse lung. Nat Methods. 2011 Jan; 8(1):91-6. PMID: 21151136; PMCID: PMC3076005.
      35. Looney MR, Gilliss BM, Matthay MA. Pathophysiology of transfusion-related acute lung injury. Curr Opin Hematol. 2010 Sep; 17(5):418-23. PMID: 20601870.
        View in: PubMed
      36. Miniati D, Jelin EB, Ng J, Wu J, Carlson TR, Wu X, Looney MR, Wang RA. Constitutively active endothelial Notch4 causes lung arteriovenous shunts in mice. Am J Physiol Lung Cell Mol Physiol. 2010 Feb; 298(2):L169-77. PMID: 19933399; PMCID: PMC2822562.
      37. Looney MR, Nguyen JX, Hu Y, Van Ziffle JA, Lowell CA, Matthay MA. Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury. J Clin Invest. 2009 Nov; 119(11):3450-61. PMID: 19809160.
        View in: PubMed
      38. Liu KD, Looney MR, Matthay MA. Inhaled activated protein C: a novel therapy for acute lung injury? Crit Care. 2009; 13(3):150. PMID: 19519935; PMCID: PMC2717421.
      39. Su X, Looney MR, Gupta N, Matthay MA. Receptor for advanced glycation end-products (RAGE) is an indicator of direct lung injury in models of experimental lung injury. Am J Physiol Lung Cell Mol Physiol. 2009 Jul; 297(1):L1-5. PMID: 19411309; PMCID: PMC2711813.
      40. Looney MR, Matthay MA. Neutrophil sandwiches injure the microcirculation. Nat Med. 2009 Apr; 15(4):364-6. PMID: 19350004; PMCID: PMC2719794.
      41. Looney MR, Esmon CT, Matthay MA. Role of coagulation pathways and treatment with activated protein C in hyperoxic lung injury. Thorax. 2009 Feb; 64(2):114-20. PMID: 19008297; PMCID: PMC4459744.
      42. Looney MR. Acute lung injury after blood product transfusion: are the times changing? Crit Care Med. 2008 Jun; 36(6):1968-70. PMID: 18520657.
        View in: PubMed
      43. Su X, Johansen M, Looney MR, Brown EJ, Matthay MA. CD47 deficiency protects mice from lipopolysaccharide-induced acute lung injury and Escherichia coli pneumonia. J Immunol. 2008 May 15; 180(10):6947-53. PMID: 18453616; PMCID: PMC2771449.
      44. Looney MR, Matthay MA. The role of protein C in sepsis. Curr Infect Dis Rep. 2007 Oct; 3(5):413-8. PMID: 24395479.
        View in: PubMed
      45. Looney MR. Newly recognized causes of acute lung injury: transfusion of blood products, severe acute respiratory syndrome, and avian influenza. Clin Chest Med. 2006 Dec; 27(4):591-600; abstract viii. PMID: 17085248.
        View in: PubMed
      46. Church GD, Price C, Sanchez R, Looney MR. Transfusion-related acute lung injury in the paediatric patient: Two case reports and a review of the literature. Transfus Med. 2006 Oct; 16(5):343-8. PMID: 16999757.
        View in: PubMed
      47. Looney MR, Su X, Van Ziffle JA, Lowell CA, Matthay MA. Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury. J Clin Invest. 2006 Jun; 116(6):1615-23. PMID: 16710475; PMCID: PMC1462945.
      48. Looney MR, Matthay MA. Animal models of transfusion-related acute lung injury. Crit Care Med. 2006 May; 34(5 Suppl):S132-6. PMID: 16617257.
        View in: PubMed
      49. Looney MR, Matthay MA. Bench-to-bedside review: the role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injury. Crit Care. 2006; 10(6):239. PMID: 17169139; PMCID: PMC1794467.
      50. Looney MR, Sartori C, Chakraborty S, James PF, Lingrel JB, Matthay MA. Decreased expression of both the alpha1- and alpha2-subunits of the Na-K-ATPase reduces maximal alveolar epithelial fluid clearance. Am J Physiol Lung Cell Mol Physiol. 2005 Jul; 289(1):L104-10. PMID: 15781423.
        View in: PubMed
      51. Su X, Looney M, Robriquet L, Fang X, Matthay MA. Direct visual instillation as a method for efficient delivery of fluid into the distal airspaces of anesthetized mice. Exp Lung Res. 2004 Sep; 30(6):479-93. PMID: 15524406.
        View in: PubMed
      52. Looney MR, Gropper MA, Matthay MA. Transfusion-related acute lung injury: a review. Chest. 2004 Jul; 126(1):249-58. PMID: 15249468.
        View in: PubMed
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