Mark Schumacher, MD, PhD

Title(s)Professor, Anesthesia
SchoolSchool of Medicine
Address513 Parnassus Ave, MSB, #436D
San Francisco CA 94117
Phone415-502-7022
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    Dr. Schumacher is Professor and Chief of the Division of Pain Medicine in the Department of Anesthesia and Perioperative Care, University of California, San Francisco. He has a clinical, research and educational focus on pain medicine with an emphasis on the development of evidence – based pain care into general clinical practice that utilize non-addictive modalities to improve both the quality and safety of analgesic care. Dr. Schumacher is also the Director of the UCSF Pain and Addiction Research Center (PARC) and served on the National Academies of Science Engineering and Medicine Committee, co-authoring the report on “Pain Management and the Opioid Epidemic.” Scientifically, following his collaboration in the cloning of the Capsaicin Receptor (TRPV1), he has led a laboratory dedicated to non-addictive strategies to block the transition from acute to chronic pain through transcriptional blockade. His current NIH-funded research includes: Study of painful Chemotherapy-Induced Peripheral Neuropathy (CIPN) with the aim to develop novel therapeutics and studying Neuro-immune Mechanisms of Analgesia of the Minor Cannabinoids such as CBD as well as its developmental effects on sensory neurons. Throughout his career, he has sought ways to communicate the science and practice of pain medicine including previously directing an NIH Center of Excellence in Pain Education at UCSF.

    Collapse Research 
    Collapse Research Activities and Funding
    Neuro-immune mechanisms of minor cannabinoids in inflammatory and neuropathic pain
    NIH R01AT010757Sep 15, 2019 - Aug 31, 2024
    Role: Co-Principal Investigator
    Capsaicin receptor subtypes in pain transduction
    NIH R01NS038737Apr 1, 1999 - Jun 30, 2013
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Peripheral Neuroinflammation and Pain: How Acute Pain Becomes Chronic. Curr Neuropharmacol. 2024; 22(1):6-14. Schumacher MA. PMID: 37559537; PMCID: PMC10716877.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    2. Chemotherapy for pain: reversing inflammatory and neuropathic pain with the anticancer agent mithramycin A. Pain. 2024 Jan 01; 165(1):54-74. Xu Z, Lee MC, Sheehan K, Fujii K, Rabl K, Rader G, Varney S, Sharma M, Eilers H, Kober K, Miaskowski C, Levine JD, Schumacher MA. PMID: 37366593; PMCID: PMC10723648.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    3. N-Oleoyl dopamine induces IL-10 via central nervous system TRPV1 and improves endotoxemia and sepsis outcomes. J Neuroinflammation. 2022 May 24; 19(1):118. Joffre J, Wong E, Lawton S, Lloyd E, Nguyen N, Xu F, Sempio C, Kobzik L, Zlatanova I, Schumacher M, Klawitter J, Su H, Rabl K, Wilhelmsen K, Yeh CC, Hellman J. PMID: 35610647; PMCID: PMC9131699.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    4. Long-Term Trends in Postoperative Opioid Prescribing, 1994 to 2014. J Am Acad Orthop Surg Glob Res Rev. 2020 01; 4(1). Chen CL, Jeffery MM, Krebs EE, Thiels CA, Schumacher MA, Schwartz AJ, Thombley R, Finlayson E, Rodriguez-Monguio R, Ward D, Dudley RA. PMID: 32159068; PMCID: PMC7028788.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    5. Differential methylation and expression of genes in the hypoxia-inducible factor 1 signaling pathway are associated with paclitaxel-induced peripheral neuropathy in breast cancer survivors and with preclinical models of chemotherapy-induced neuropathic pain. Mol Pain. 2020 Jan-Dec; 16:1744806920936502. Kober KM, Lee MC, Olshen A, Conley YP, Sirota M, Keiser M, Hammer MJ, Abrams G, Schumacher M, Levine JD, Miaskowski C. PMID: 32586194; PMCID: PMC7322824.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    6. Perturbations in neuroinflammatory pathways are associated with paclitaxel-induced peripheral neuropathy in breast cancer survivors. J Neuroimmunol. 2019 10 15; 335:577019. Miaskowski C, Topp K, Conley YP, Paul SM, Melisko M, Schumacher M, Chesney M, Abrams G, Levine JD, Kober KM. PMID: 31401418; PMCID: PMC6788784.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    7. Deleterious Effects of Higher Body Mass Index on Subjective and Objective Measures of Chemotherapy-Induced Peripheral Neuropathy in Cancer Survivors. J Pain Symptom Manage. 2019 08; 58(2):252-263. Petrovchich I, Kober KM, Wagner L, Paul SM, Abrams G, Chesney MA, Topp K, Smoot B, Schumacher M, Conley YP, Hammer M, Levine JD, Miaskowski C. PMID: 31047960; PMCID: PMC6679783.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    8. Transcription factor Sp4 is required for hyperalgesic state persistence. PLoS One. 2019; 14(2):e0211349. Sheehan K, Lee J, Chong J, Zavala K, Sharma M, Philipsen S, Maruyama T, Xu Z, Guan Z, Eilers H, Kawamata T, Schumacher M. PMID: 30811405; PMCID: PMC6392229.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    9. Age-related differences in patient-reported and objective measures of chemotherapy-induced peripheral neuropathy among cancer survivors. Support Care Cancer. 2019 Oct; 27(10):3905-3912. Wong ML, Cooper BA, Paul SM, Abrams G, Topp K, Kober KM, Chesney MA, Mazor M, Schumacher MA, Conley YP, Levine JD, Miaskowski C. PMID: 30770977; PMCID: PMC6697247.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    10. Signaling pathways and gene co-expression modules associated with cytoskeleton and axon morphology in breast cancer survivors with chronic paclitaxel-induced peripheral neuropathy. Mol Pain. 2019 Jan-Dec; 15:1744806919878088. Kober KM, Schumacher M, Conley YP, Topp K, Mazor M, Hammer MJ, Paul SM, Levine JD, Miaskowski C. PMID: 31486345; PMCID: PMC6755139.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    11. Pain Management and Opioid Regulation: Continuing Public Health Challenges. Am J Public Health. 2019 Jan; 109(1):31-34. Bonnie RJ, Schumacher MA, Clark JD, Kesselheim AS. PMID: 32941766; PMCID: PMC6301400.
      View in: PubMed   Mentions: 12     Fields:    
    12. Expression of mitochondrial dysfunction-related genes and pathways in paclitaxel-induced peripheral neuropathy in breast cancer survivors. Mol Pain. 2018 Jan-Dec; 14:1744806918816462. Kober KM, Olshen A, Conley YP, Schumacher M, Topp K, Smoot B, Mazor M, Chesney M, Hammer M, Paul SM, Levine JD, Miaskowski C. PMID: 30426838; PMCID: PMC6293373.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    13. Phenotypic Characterization of Paclitaxel-Induced Peripheral Neuropathy in Cancer Survivors. J Pain Symptom Manage. 2018 12; 56(6):908-919.e3. Kober KM, Mazor M, Abrams G, Olshen A, Conley YP, Hammer M, Schumacher M, Chesney M, Smoot B, Mastick J, Paul SM, Levine JD, Miaskowski C. PMID: 30172061; PMCID: PMC6289693.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    14. Associations Between Perceived Stress and Chemotherapy-Induced Peripheral Neuropathy and Otoxicity in Adult Cancer Survivors. J Pain Symptom Manage. 2018 07; 56(1):88-97. Miaskowski C, Paul SM, Mastick J, Abrams G, Topp K, Smoot B, Kober KM, Chesney M, Mazor M, Mausisa G, Schumacher M, Conley YP, Sabes JH, Cheung S, Wallhagen M, Levine JD. PMID: 29524582; PMCID: PMC6015523.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    15. Impact of chemotherapy-induced neurotoxicities on adult cancer survivors' symptom burden and quality of life. J Cancer Surviv. 2018 04; 12(2):234-245. Miaskowski C, Mastick J, Paul SM, Abrams G, Cheung S, Sabes JH, Kober KM, Schumacher M, Conley YP, Topp K, Smoot B, Mausisa G, Mazor M, Wallhagen M, Levine JD. PMID: 29159795; PMCID: PMC5886787.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    16. Hearing loss and tinnitus in survivors with chemotherapy-induced neuropathy. Eur J Oncol Nurs. 2018 Feb; 32:1-11. Miaskowski C, Paul SM, Mastick J, Schumacher M, Conley YP, Smoot B, Abrams G, Kober KM, Cheung S, Henderson-Sabes J, Chesney M, Mazor M, Wallhagen M, Levine JD. PMID: 29353626; PMCID: PMC5783195.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    17. America's Opioid Epidemic: Supply and Demand Considerations. Anesth Analg. 2017 11; 125(5):1667-1674. Clark DJ, Schumacher MA. PMID: 29049112.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansPHPublic Health
    18. N-Arachidonoyl Dopamine Modulates Acute Systemic Inflammation via Nonhematopoietic TRPV1. J Immunol. 2017 08 15; 199(4):1465-1475. Lawton SK, Xu F, Tran A, Wong E, Prakash A, Schumacher M, Hellman J, Wilhelmsen K. PMID: 28701511; PMCID: PMC5544930.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    19. (431) Characteristics of chemotherapy induced neuropathy (CIN) in cancer survivors who received taxol. Journal of Pain. 2017 Apr 1; 18(4):s82. Kober KK, Mastick MJ, Paul PS, Topp TK, Smoot SB, Abrams AG, Chen CL, Conley CY, Chesney CM, Bolla BK, Mausisa MG, Azor AM, Wong WM, Schumacher SM, Levine LJ, Miaskowski MC. .
      View in: Publisher Site   Mentions:
    20. Chemotherapy-Induced Neuropathy in Cancer Survivors. J Pain Symptom Manage. 2017 08; 54(2):204-218.e2. Miaskowski C, Mastick J, Paul SM, Topp K, Smoot B, Abrams G, Chen LM, Kober KM, Conley YP, Chesney M, Bolla K, Mausisa G, Mazor M, Wong M, Schumacher M, Levine JD. PMID: 28063866; PMCID: PMC5496793.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    21. Contemporary views on inflammatory pain mechanisms: TRPing over innate and microglial pathways. F1000Res. 2016; 5. Guan Z, Hellman J, Schumacher M. PMID: 27781082; PMCID: PMC5054801.
      View in: PubMed   Mentions: 10     Fields:    
    22. The anticancer antibiotic mithramycin-A inhibits TRPV1 expression in dorsal root ganglion neurons. Neurosci Lett. 2014 Aug 22; 578:211-6. Zavala K, Lee J, Chong J, Sharma M, Eilers H, Schumacher MA. PMID: 24468003.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    23. Back pain and the mineralocorticoid receptor: is there a connection? Anesthesiology. 2012 Nov; 117(5):951-2. Schumacher MA. PMID: 23042224.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    24. Pain Management for the Obese Sleep Apnea Patient. ICU Director. 2012 Mar 1; 3(2):80-84. Schumacher SM. .
      View in: Publisher Site   Mentions:
    25. Transcription factors Sp1 and Sp4 regulate TRPV1 gene expression in rat sensory neurons. Mol Pain. 2011 Jun 06; 7:44. Chu C, Zavala K, Fahimi A, Lee J, Xue Q, Eilers H, Schumacher MA. PMID: 21645329; PMCID: PMC3121596.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    26. Cutaneous nerve transection for the management of intractable upper extremity pain caused by invasive squamous cell carcinoma. J Pain Symptom Manage. 2011 Jul; 42(1):126-33. Turnbull JH, Gebauer SL, Miller BL, Barbaro NM, Blanc PD, Schumacher MA. PMID: 21306862.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    27. Pungent general anesthetics activate transient receptor potential-A1 to produce hyperalgesia and neurogenic bronchoconstriction. Anesthesiology. 2010 Jun; 112(6):1452-63. Eilers H, Cattaruzza F, Nassini R, Materazzi S, Andre E, Chu C, Cottrell GS, Schumacher M, Geppetti P, Bunnett NW. PMID: 20463581.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    28. TRPV1 splice variants: structure and function. Front Biosci (Landmark Ed). 2010 06 01; 15(3):872-82. Schumacher MA, Eilers H. PMID: 20515731; PMCID: PMC3888216.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    29. Transient receptor potential channels in pain and inflammation: therapeutic opportunities. Pain Pract. 2010 May-Jun; 10(3):185-200. Schumacher MA. PMID: 20230457; PMCID: PMC3112370.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    30. The rat vanilloid receptor splice variant VR.5'sv blocks TRPV1 activation. Neuroreport. 2007 Jul 02; 18(10):969-73. Eilers H, Lee SY, Hau CW, Logvinova A, Schumacher MA. PMID: 17558279.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    31. Determinants of the anesthetic sensitivity of two-pore domain acid-sensitive potassium channels: molecular cloning of an anesthetic-activated potassium channel from Lymnaea stagnalis. J Biol Chem. 2007 Jul 20; 282(29):20977-90. Andres-Enguix I, Caley A, Yustos R, Schumacher MA, Spanu PD, Dickinson R, Maze M, Franks NP. PMID: 17548360.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    32. Transcription of rat TRPV1 utilizes a dual promoter system that is positively regulated by nerve growth factor. J Neurochem. 2007 Apr; 101(1):212-22. Xue Q, Jong B, Chen T, Schumacher MA. PMID: 17217411.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    33. Isolation of an mRNA binding protein homologue that is expressed in nociceptors. Eur J Neurosci. 2004 Nov; 20(9):2283-93. Eilers H, Trilk SL, Lee SY, Xue Q, Jong BE, Moff I, Levine JD, Schumacher MA. PMID: 15525270.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    34. Opioid-induced respiratory depression: are 5-HT4a receptor agonists the cure? Mol Interv. 2004 Aug; 4(4):197-9. Eilers H, Schumacher MA. PMID: 15304555.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    35. The genomic organization of the gene encoding the vanilloid receptor: evidence for multiple splice variants. Genomics. 2001 Aug; 76(1-3):14-20. Xue Q, Yu Y, Trilk SL, Jong BE, Schumacher MA. PMID: 11549313.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    36. The reversal of fentanyl-induced tolerance by administration of "small-dose" ketamine. Anesth Analg. 2001 Jul; 93(1):213-4. Eilers H, Philip LA, Bickler PE, McKay WR, Schumacher MA. PMID: 11429368.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    37. Room B, 10/16/2000 2: 00 PM - 4: 00 PM (PS) The Capsaicin Receptor Variant, Stretch-inactivated Channel, Is Expressed in Small-Diameter Sensory Neurons. Anesthesiology. 2000 Sep 1; 93(3A):a-928. Schumacher SM, Jong JB, Frey FS, Capra CN, Levine LJ. .
      View in: Publisher Site   Mentions:
    38. The stretch-inactivated channel, a vanilloid receptor variant, is expressed in small-diameter sensory neurons in the rat. Neurosci Lett. 2000 Jun 30; 287(3):215-8. Schumacher MA, Jong BE, Frey SL, Sudanagunta SP, Capra NF, Levine JD. PMID: 10863033.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    39. Molecular cloning of an N-terminal splice variant of the capsaicin receptor. Loss of N-terminal domain suggests functional divergence among capsaicin receptor subtypes. J Biol Chem. 2000 Jan 28; 275(4):2756-62. Schumacher MA, Moff I, Sudanagunta SP, Levine JD. PMID: 10644739.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    40. ISOLATION OF NERVE GROWTH FACTOR (NGF) REGULATED GENES IN PRIMARY AFFERENT NEURONS. Anesthesiology. 1998 Sep 1; 89(Supplement):1093a. Schumacher SM, Moff MI, Levine LJ. .
      View in: Publisher Site   Mentions:
    41. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature. 1997 Oct 23; 389(6653):816-24. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. PMID: 9349813.
      View in: PubMed   Mentions: 2926     Fields:    Translation:HumansAnimalsCells
    42. ATP receptors in sickness, pain and death. Chem Biol. 1996 Apr; 3(4):229-32. Brake A, Schumacher M, Julius D. PMID: 8807849.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
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