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    Mary Helen Barcellos-Hoff, PhD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentRadiation Oncology
    Address2340 Sutter Street
    San Francisco CA 94115
    Phone415-476-8091
    EmailMary.Barcellos-Hoff@ucsf.edu
    vCardDownload vCard

      Collapse Biography 
      Collapse Education and Training
      University of ChicagoA.B.Biopsychology1978
      University of California, San FranciscoPh.D.Experimental Pathology1986
      University of California, BerkeleyPostdoctoral trainingBiophysics1988

      Collapse Overview 
      Collapse Overview
      The Barcellos-Hoff laboratory studies radiation carcinogenesis and biologically augmented radiotherapy. Dr. Barcellos-Hoff received an undergraduate degree from the University of Chicago and earned a doctoral degree in experimental pathology from the University of California, San Francisco. She conducted postdoctoral research on extracellular matrix mediated functional differentiation with Mina Bissell at the Lawrence Berkeley National Laboratory (LBNL). She joined LBNL as a staff scientist, where she rose from postdoctoral fellow to Senior Scientist and Associate Director of the Life Sciences Division. She joined New York University School of Medicine in 2008 as Director of Radiation Biology in the Department of Radiation Oncology. She moved to UCSF as Professor and Vice Chair of Research in the Department of Radiation Oncology in 2015.

      Dr. Barcellos-Hoff promotes the application of systems biology approaches to problems in radiation research. She was Chief Scientist for the Low Dose Radiation Research program in the Department of Energy (DOE) from 2006-2010. Her studies funded by DOE and NASA describe the complexity of radiation effects on biological systems and have generated new perspectives on mechanisms underlying radiation carcinogenesis.

      Translational research based on aspects of these low dose studies provides a rationale for implementing TGFß inhibition during radiotherapy. TGF? is activated by radiation and mediates the DNA damage response as well as the composition of the tumor microenvironment, particularly tumor immunological responses. Detailed understanding of its contributions to tumor response may motivate clinical trials of TGF? inhibitors in radiotherapy.

      Dr. Barcellos-Hoff is a member of AAAS and the American Association of Cancer Research. She is member of the AACR Tumor Microenvironment Working Group, which she chaired from 2012 to 2014, and a founding member of the AACR committee for Radiation Science and Medicine Working Group. She is a long-standing member of the Radiation Research Society and President of the International Association of Radiation Research (2014-2019).

      Collapse Interests
      TGFß, Radiation biology, mammary biology, carcinogenesis, systems biology, TGFß, lung cancer, glioblastoma, breast cancer, radiotherapy, charged particle radiobiology, DNA damage response, tumor microenvironment, tumor immunology, BRCA1

      Collapse ORNG Applications 
      Collapse Awarded Grants

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Formenti SC, Demaria S, Barcellos-Hoff MH, McBride WH. Subverting misconceptions about radiation therapy. Nat Immunol. 2016 Mar 22; 17(4):345. PMID: 27002831.
        View in: PubMed
      2. Barcellos-Hoff MH, Mao JH. HZE Radiation Non-Targeted Effects on the Microenvironment That Mediate Mammary Carcinogenesis. Front Oncol. 2016; 6:57. PMID: 27014632.
        View in: PubMed
      3. Hendry JH, Niwa O, Barcellos-Hoff MH, Globus RK, Harrison JD, Martin MT, Seed TM, Shay JW, Story MD, Suzuki K, Yamashita S. ICRP Publication 131: Stem cell biology with respect to carcinogenesis aspects of radiological protection. Ann ICRP. 2016 Jun; 45(1 Suppl):239-52. PMID: 26956677.
        View in: PubMed
      4. Mittal V, El Rayes T, Narula N, McGraw TE, Altorki NK, Barcellos-Hoff MH. The Microenvironment of Lung Cancer and Therapeutic Implications. Adv Exp Med Biol. 2016; 890:75-110. PMID: 26703800.
        View in: PubMed
      5. Niwa O, Barcellos-Hoff MH, Globus RK, Harrison JD, Hendry JH, Jacob P, Martin MT, Seed TM, Shay JW, Story MD, Suzuki K, Yamashita S. ICRP Publication 131: Stem Cell Biology with Respect to Carcinogenesis Aspects of Radiological Protection. Ann ICRP. 2015 Dec; 44(3-4):7-357. PMID: 26637346.
        View in: PubMed
      6. Barcellos-Hoff MH, Iliakis G, Jeggo P, McKenna G, O'Neil P, Wallace S. "Praising What Is Lost. . . Radiat Res. 2015 Dec; 184(6):563-4. PMID: 27064149.
        View in: PubMed
      7. Brown M, Held K, Mason K, McBride B, Willey J, Williams J, Barcellos-Hoff MH, Iliakis G, Jeggo P, McKenna G, O'Neil P, Wallace S. Two Perspectives. Radiat Res. 2015 Dec; 184(6):563-4. PMID: 26600171.
        View in: PubMed
      8. Qiang L, Shah P, Barcellos-Hoff MH, He YY. TGF-ß signaling links E-cadherin loss to suppression of nucleotide excision repair. Oncogene. 2016 Jun 23; 35(25):3293-302. PMID: 26477308.
        View in: PubMed
      9. Barcellos-Hoff MH, Blakely EA, Burma S, Fornace AJ, Gerson S, Hlatky L, Kirsch DG, Luderer U, Shay J, Wang Y, Weil MM. Concepts and challenges in cancer risk prediction for the space radiation environment. Life Sci Space Res (Amst). 2015 Jul; 6:92-103. PMID: 26256633.
        View in: PubMed
      10. Casey SC, Vaccari M, Al-Mulla F, Al-Temaimi R, Amedei A, Barcellos-Hoff MH, Brown DG, Chapellier M, Christopher J, Curran CS, Forte S, Hamid RA, Heneberg P, Koch DC, Krishnakumar PK, Laconi E, Maguer-Satta V, Marongiu F, Memeo L, Mondello C, Raju J, Roman J, Roy R, Ryan EP, Ryeom S, Salem HK, Scovassi AI, Singh N, Soucek L, Vermeulen L, Whitfield JR, Woodrick J, Colacci A, Bisson WH, Felsher DW. The effect of environmental chemicals on the tumor microenvironment. Carcinogenesis. 2015 Jun; 36 Suppl 1:S160-83. PMID: 26106136; PMCID: PMC4565612 [Available on 06/01/16].
      11. Decarlo L, Mestel C, Barcellos-Hoff MH, Schneider RJ. Eukaryotic Translation Initiation Factor 4E Is a Feed-Forward Translational Coactivator of Transforming Growth Factor ß Early Protransforming Events in Breast Epithelial Cells. Mol Cell Biol. 2015 Aug; 35(15):2597-609. PMID: 25986608; PMCID: PMC4524117 [Available on 02/01/16].
      12. Vanpouille-Box C, Diamond JM, Pilones KA, Zavadil J, Babb JS, Formenti SC, Barcellos-Hoff MH, Demaria S. TGFß Is a Master Regulator of Radiation Therapy-Induced Antitumor Immunity. Cancer Res. 2015 Jun 1; 75(11):2232-42. PMID: 25858148; PMCID: PMC4522159 [Available on 06/01/16].
      13. Zhang P, Lo A, Huang Y, Huang G, Liang G, Mott J, Karpen GH, Blakely EA, Bissell MJ, Barcellos-Hoff MH, Snijders AM, Mao JH. Identification of genetic loci that control mammary tumor susceptibility through the host microenvironment. Sci Rep. 2015; 5:8919. PMID: 25747469; PMCID: PMC4352890.
      14. Barcellos-Hoff MH. BUB1-bling over with possibilities. Neoplasia. 2015 Feb; 17(2):153-4. PMID: 25748233; PMCID: PMC4351292.
      15. Huh SJ, Clement K, Jee D, Merlini A, Choudhury S, Maruyama R, Yoo R, Chytil A, Boyle P, Ran FA, Moses HL, Barcellos-Hoff MH, Jackson-Grusby L, Meissner A, Polyak K. Age- and pregnancy-associated DNA methylation changes in mammary epithelial cells. Stem Cell Reports. 2015 Feb 10; 4(2):297-311. PMID: 25619437; PMCID: PMC4325231.
      16. Pellicciotta I, Marciscano AE, Hardee ME, Francis D, Formenti S, Barcellos-Hoff MH. Development of a novel multiplexed assay for quantification of transforming growth factor-ß (TGF-ß). Growth Factors. 2015 Apr; 33(2):79-91. PMID: 25586866.
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      17. Du S, Bouquet S, Lo CH, Pellicciotta I, Bolourchi S, Parry R, Barcellos-Hoff MH. Attenuation of the DNA damage response by transforming growth factor-beta inhibitors enhances radiation sensitivity of non-small-cell lung cancer cells in vitro and in vivo. Int J Radiat Oncol Biol Phys. 2015 Jan 1; 91(1):91-9. PMID: 25835621.
        View in: PubMed
      18. Kim MR, Lee J, An YS, Jin YB, Park IC, Chung E, Shin I, Barcellos-Hoff MH, Yi JY. TGFß1 protects cells from ?-IR by enhancing the activity of the NHEJ repair pathway. Mol Cancer Res. 2015 Feb; 13(2):319-29. PMID: 25319009.
        View in: PubMed
      19. Illa-Bochaca I, Ouyang H, Tang J, Sebastiano C, Mao JH, Costes SV, Demaria S, Barcellos-Hoff MH. Densely ionizing radiation acts via the microenvironment to promote aggressive Trp53-null mammary carcinomas. Cancer Res. 2014 Dec 1; 74(23):7137-48. PMID: 25304265.
        View in: PubMed
      20. Nguyen DH, Ouyang H, Mao JH, Hlatky L, Barcellos-Hoff MH. Distinct luminal-type mammary carcinomas arise from orthotopic Trp53-null mammary transplantation of juvenile versus adult mice. Cancer Res. 2014 Dec 1; 74(23):7149-58. PMID: 25281718; PMCID: PMC4252877 [Available on 12/01/15].
      21. Barcellos-Hoff MH, Cucinotta FA. New tricks for an old fox: impact of TGFß on the DNA damage response and genomic stability. Sci Signal. 2014 Sep 2; 7(341):re5. PMID: 25185158.
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      22. Isacke CM, Barcellos-Hoff MH. Soil amendments that slow cancer growth. Cancer Discov. 2014 Jun; 4(6):637-9. PMID: 24891361.
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      23. Arany PR, Cho A, Hunt TD, Sidhu G, Shin K, Hahm E, Huang GX, Weaver J, Chen AC, Padwa BL, Hamblin MR, Barcellos-Hoff MH, Kulkarni AB, J Mooney D. Photoactivation of endogenous latent transforming growth factor-ß1 directs dental stem cell differentiation for regeneration. Sci Transl Med. 2014 May 28; 6(238):238ra69. PMID: 24871130; PMCID: PMC4113395.
      24. Tang J, Fernandez-Garcia I, Vijayakumar S, Martinez-Ruis H, Illa-Bochaca I, Nguyen DH, Mao JH, Costes SV, Barcellos-Hoff MH. Irradiation of juvenile, but not adult, mammary gland increases stem cell self-renewal and estrogen receptor negative tumors. Stem Cells. 2014 Mar; 32(3):649-61. PMID: 24038768.
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      25. Bassani L, Graffeo CS, Behrooz N, Tyagi V, Wilson T, Penaranda S, Zagzag D, Rifkin DB, Barcellos-Hoff MH, Fatterpekar G, Placantonakis D. Noninvasive diagnosis and management of spontaneous intracranial hypotension in patients with marfan syndrome: Case Report and Review of the Literature. Surg Neurol Int. 2014; 5:8. PMID: 24575323; PMCID: PMC3927088.
      26. Barcellos-Hoff MH, Kleinberg DL. Breast cancer risk in BRCA1 mutation carriers: insight from mouse models. Ann Oncol. 2013 Nov; 24 Suppl 8:viii8-viii12. PMID: 24131977.
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      27. Du S, Barcellos-Hoff MH. Tumors as organs: biologically augmenting radiation therapy by inhibiting transforming growth factor ß activity in carcinomas. Semin Radiat Oncol. 2013 Oct; 23(4):242-51. PMID: 24012338; PMCID: PMC3951811.
      28. Barcellos-Hoff MH, Lyden D, Wang TC. The evolution of the cancer niche during multistage carcinogenesis. Nat Rev Cancer. 2013 Jul; 13(7):511-8. PMID: 23760023.
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      29. Nguyen DH, Fredlund E, Zhao W, Perou CM, Balmain A, Mao JH, Barcellos-Hoff MH. Murine microenvironment metaprofiles associate with human cancer etiology and intrinsic subtypes. Clin Cancer Res. 2013 Mar 15; 19(6):1353-62. PMID: 23339125; PMCID: PMC3732211.
      30. Barcellos-Hoff MH. New biological insights on the link between radiation exposure and breast cancer risk. J Mammary Gland Biol Neoplasia. 2013 Mar; 18(1):3-13. PMID: 23325014.
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      31. Barcellos-Hoff MH. Does microenvironment contribute to the etiology of estrogen receptor-negative breast cancer? Clin Cancer Res. 2013 Feb 1; 19(3):541-8. PMID: 23325583.
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      32. Golden EB, Pellicciotta I, Demaria S, Barcellos-Hoff MH, Formenti SC. The convergence of radiation and immunogenic cell death signaling pathways. Front Oncol. 2012; 2:88. PMID: 22891162; PMCID: PMC3413017.
      33. Hardee ME, Marciscano AE, Medina-Ramirez CM, Zagzag D, Narayana A, Lonning SM, Barcellos-Hoff MH. Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-ß. Cancer Res. 2012 Aug 15; 72(16):4119-29. PMID: 22693253; PMCID: PMC3538149.
      34. Maxwell CA, Benítez J, Gómez-Baldó L, Osorio A, Bonifaci N, Fernández-Ramires R, Costes SV, Guinó E, Chen H, Evans GJ, Mohan P, Català I, Petit A, Aguilar H, Villanueva A, Aytes A, Serra-Musach J, Rennert G, Lejbkowicz F, Peterlongo P, Manoukian S, Peissel B, Ripamonti CB, Bonanni B, Viel A, Allavena A, Bernard L, Radice P, Friedman E, Kaufman B, Laitman Y, Dubrovsky M, Milgrom R, Jakubowska A, Cybulski C, Gorski B, Jaworska K, Durda K, Sukiennicki G, Lubinski J, Shugart YY, Domchek SM, Letrero R, Weber BL, Hogervorst FB, Rookus MA, Collee JM, Devilee P, Ligtenberg MJ, Luijt RB, Aalfs CM, Waisfisz Q, Wijnen J, Roozendaal CE, Easton DF, Peock S, Cook M, Oliver C, Frost D, Harrington P, Evans DG, Lalloo F, Eeles R, Izatt L, Chu C, Eccles D, Douglas F, Brewer C, Nevanlinna H, Heikkinen T, Couch FJ, Lindor NM, Wang X, Godwin AK, Caligo MA, Lombardi G, Loman N, Karlsson P, Ehrencrona H, Wachenfeldt Av, Barkardottir RB, Hamann U, Rashid MU, Lasa A, Caldés T, Andrés R, Schmitt M, Assmann V, Stevens K, Offit K, Curado J, Tilgner H, Guigó R, Aiza G, Brunet J, Castellsagué J, Martrat G, Urruticoechea A, Blanco I, Tihomirova L, Goldgar DE, Buys S, John EM, Miron A, Southey M, Daly MB, Schmutzler RK, Wappenschmidt B, Meindl A, Arnold N, Deissler H, Varon-Mateeva R, Sutter C, Niederacher D, Imyamitov E, Sinilnikova OM, Stoppa-Lyonne D, Mazoyer S, Verny-Pierre C, Castera L, de Pauw A, Bignon YJ, Uhrhammer N, Peyrat JP, Vennin P, Fert Ferrer S, Collonge-Rame MA, Mortemousque I, Spurdle AB, Beesley J, Chen X, Healey S, Barcellos-Hoff MH, Vidal M, Gruber SB, Lázaro C, Capellá G, McGuffog L, Nathanson KL, Antoniou AC, Chenevix-Trench G, Fleisch MC, Moreno V, Pujana MA. Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer. PLoS Biol. 2011 Nov; 9(11):e1001199. PMID: 22110403; PMCID: PMC3217025.
      35. Bouquet F, Pal A, Pilones KA, Demaria S, Hann B, Akhurst RJ, Babb JS, Lonning SM, DeWyngaert JK, Formenti SC, Barcellos-Hoff MH. TGFß1 inhibition increases the radiosensitivity of breast cancer cells in vitro and promotes tumor control by radiation in vivo. Clin Cancer Res. 2011 Nov 1; 17(21):6754-65. PMID: 22028490; PMCID: PMC3724539.
      36. Kleinberg DL, Barcellos-Hoff MH. The pivotal role of insulin-like growth factor I in normal mammary development. Endocrinol Metab Clin North Am. 2011 Sep; 40(3):461-71, vii. PMID: 21889714.
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      37. Barcellos-Hoff MH. TGFß biology in breast: 15 years on. J Mammary Gland Biol Neoplasia. 2011 Jun; 16(2):65-6. PMID: 21534008.
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      38. Nguyen DH, Martinez-Ruiz H, Barcellos-Hoff MH. Consequences of epithelial or stromal TGFß1 depletion in the mammary gland. J Mammary Gland Biol Neoplasia. 2011 Jun; 16(2):147-55. PMID: 21590374.
        View in: PubMed
      39. Nguyen DH, Oketch-Rabah HA, Illa-Bochaca I, Geyer FC, Reis-Filho JS, Mao JH, Ravani SA, Zavadil J, Borowsky AD, Jerry DJ, Dunphy KA, Seo JH, Haslam S, Medina D, Barcellos-Hoff MH. Radiation acts on the microenvironment to affect breast carcinogenesis by distinct mechanisms that decrease cancer latency and affect tumor type. Cancer Cell. 2011 May 17; 19(5):640-51. PMID: 21575864; PMCID: PMC3110779.
      40. Barcellos-Hoff MH, Brenner DJ, Brooks AL, Formenti S, Hlatky L, Locke PA, Shore R, Tenforde T, Travis EL, Williams J. Low-dose radiation knowledge worth the cost. Science. 2011 Apr 15; 332(6027):305-6. PMID: 21493843.
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      41. Andarawewa KL, Costes SV, Fernandez-Garcia I, Chou WS, Ravani SA, Park H, Barcellos-Hoff MH. Lack of radiation dose or quality dependence of epithelial-to-mesenchymal transition (EMT) mediated by transforming growth factor ß. Int J Radiat Oncol Biol Phys. 2011 Apr 1; 79(5):1523-31. PMID: 21310544.
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      42. Barcellos-Hoff MH. In honor of Mina J. Bissell. Integr Biol (Camb). 2011 Apr; 3(4):253-4. PMID: 21448491.
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      43. Barcellos-Hoff MH. What is the use of systems biology approaches in radiation biology? Health Phys. 2011 Mar; 100(3):272-3. PMID: 21595065.
        View in: PubMed
      44. Moses H, Barcellos-Hoff MH. TGF-beta biology in mammary development and breast cancer. Cold Spring Harb Perspect Biol. 2011 Jan; 3(1):a003277. PMID: 20810549; PMCID: PMC3003461.
      45. Barcellos-Hoff MH. Stromal mediation of radiation carcinogenesis. J Mammary Gland Biol Neoplasia. 2010 Dec; 15(4):381-7. PMID: 21181431; PMCID: PMC3068291.
      46. Han J, Chang H, Yang Q, Fontenay G, Groesser T, Barcellos-Hoff MH, Parvin B. Multiscale iterative voting for differential analysis of stress response for 2D and 3D cell culture models. J Microsc. 2011 Mar; 241(3):315-26. PMID: 21118235.
        View in: PubMed
      47. Mukhopadhyay R, Costes SV, Bazarov AV, Hines WC, Barcellos-Hoff MH, Yaswen P. Promotion of variant human mammary epithelial cell outgrowth by ionizing radiation: an agent-based model supported by in vitro studies. Breast Cancer Res. 2010; 12(1):R11. PMID: 20146798; PMCID: PMC2880432.
      48. Costes SV, Chiolo I, Pluth JM, Barcellos-Hoff MH, Jakob B. Spatiotemporal characterization of ionizing radiation induced DNA damage foci and their relation to chromatin organization. Mutat Res. 2010 Apr-Jun; 704(1-3):78-87. PMID: 20060491; PMCID: PMC3951968.
      49. Shelton DN, Fernandez-Gonzalez R, Illa-Bochaca I, Ortiz-de-Solorzano C, Barcellos-Hoff MH, Welm BE. Use of stem cell markers in dissociated mammary populations. Methods Mol Biol. 2010; 621:49-55. PMID: 20405358.
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      50. Illa-Bochaca I, Fernandez-Gonzalez R, Shelton DN, Welm BE, Ortiz-de-Solorzano C, Barcellos-Hoff MH. Limiting-dilution transplantation assays in mammary stem cell studies. Methods Mol Biol. 2010; 621:29-47. PMID: 20405357.
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      51. Fernandez-Gonzalez R, Illa-Bochaca I, Shelton DN, Welm BE, Barcellos-Hoff MH, Ortiz-de-Solorzano C. In situ analysis of cell populations: long-term label-retaining cells. Methods Mol Biol. 2010; 621:1-28. PMID: 20405356.
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      52. Han J, Chang H, Andarawewa K, Yaswen P, Barcellos-Hoff MH, Parvin B. Multidimensional profiling of cell surface proteins and nuclear markers. IEEE/ACM Trans Comput Biol Bioinform. 2010 Jan-Mar; 7(1):80-90. PMID: 20150670.
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      53. Barcellos-Hoff MH, Cordes N. Resistance to radio- and chemotherapy and the tumour microenvironment. Int J Radiat Biol. 2009 Nov; 85(11):920-2. PMID: 19895267.
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      54. Barcellos-Hoff MH, Nguyen DH. Radiation carcinogenesis in context: how do irradiated tissues become tumors? Health Phys. 2009 Nov; 97(5):446-57. PMID: 19820454; PMCID: PMC2761885.
      55. Barcellos-Hoff MH, Newcomb EW, Zagzag D, Narayana A. Therapeutic targets in malignant glioblastoma microenvironment. Semin Radiat Oncol. 2009 Jul; 19(3):163-70. PMID: 19464631; PMCID: PMC3538148.
      56. Barcellos-Hoff MH, Akhurst RJ. Transforming growth factor-beta in breast cancer: too much, too late. Breast Cancer Res. 2009; 11(1):202. PMID: 19291273; PMCID: PMC2687712.
      57. Beebe D, Barcellos-Hoff MH. The development of integrative biology: bridging the gap--a view from the Scientific Editors. [An interview with David Beebe and Mary Helen Barcellos-Hoff by Kathleen Too]. Integr Biol (Camb). 2009 Feb; 1(2):145-7. PMID: 20023799.
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      58. Barcellos-Hoff MH, Beebe D. Integrating biology and technology. Integr Biol (Camb). 2009 Jan; 1(1):14. PMID: 20023786.
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      59. Simian M, Bissell MJ, Barcellos-Hoff MH, Shyamala G. Estrogen and progesterone receptors have distinct roles in the establishment of the hyperplastic phenotype in PR-A transgenic mice. Breast Cancer Res. 2009; 11(5):R72. PMID: 19788752; PMCID: PMC2790852.
      60. Fernandez-Gonzalez R, Illa-Bochaca I, Welm BE, Fleisch MC, Werb Z, Ortiz-de-Solorzano C, Barcellos-Hoff MH. Mapping mammary gland architecture using multi-scale in situ analysis. Integr Biol (Camb). 2009 Jan; 1(1):80-9. PMID: 20023794; PMCID: PMC2847439.
      61. Maxwell CA, Fleisch MC, Costes SV, Erickson AC, Boissière A, Gupta R, Ravani SA, Parvin B, Barcellos-Hoff MH. Targeted and nontargeted effects of ionizing radiation that impact genomic instability. Cancer Res. 2008 Oct 15; 68(20):8304-11. PMID: 18922902.
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      62. Sudo H, Garbe J, Stampfer MR, Barcellos-Hoff MH, Kronenberg A. Karyotypic instability and centrosome aberrations in the progeny of finite life-span human mammary epithelial cells exposed to sparsely or densely ionizing radiation. Radiat Res. 2008 Jul; 170(1):23-32. PMID: 18582160.
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      63. Barcellos-Hoff MH. Cancer as an emergent phenomenon in systems radiation biology. Radiat Environ Biophys. 2008 Feb; 47(1):33-8. PMID: 18026977.
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      64. Andarawewa KL, Paupert J, Pal A, Barcellos-Hoff MH. New rationales for using TGFbeta inhibitors in radiotherapy. Int J Radiat Biol. 2007 Nov-Dec; 83(11-12):803-11. PMID: 18058368.
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      65. Barcellos-Hoff MH, Cordes N. Radiation therapy and the microenvironment. Int J Radiat Biol. 2007 Nov-Dec; 83(11-12):723-5. PMID: 18058363.
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      66. Andarawewa KL, Erickson AC, Chou WS, Costes SV, Gascard P, Mott JD, Bissell MJ, Barcellos-Hoff MH. Ionizing radiation predisposes nonmalignant human mammary epithelial cells to undergo transforming growth factor beta induced epithelial to mesenchymal transition. Cancer Res. 2007 Sep 15; 67(18):8662-70. PMID: 17875706.
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      67. Costes SV, Ponomarev A, Chen JL, Nguyen D, Cucinotta FA, Barcellos-Hoff MH. Image-based modeling reveals dynamic redistribution of DNA damage into nuclear sub-domains. PLoS Comput Biol. 2007 Aug; 3(8):e155. PMID: 17676951; PMCID: PMC1937017.
      68. Kenny PA, Lee GY, Myers CA, Neve RM, Semeiks JR, Spellman PT, Lorenz K, Lee EH, Barcellos-Hoff MH, Petersen OW, Gray JW, Bissell MJ. The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression. Mol Oncol. 2007 Jun; 1(1):84-96. PMID: 18516279.
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      69. Parvin B, Yang Q, Han J, Chang H, Rydberg B, Barcellos-Hoff MH. Iterative voting for inference of structural saliency and characterization of subcellular events. IEEE Trans Image Process. 2007 Mar; 16(3):615-23. PMID: 17357723.
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      70. Raman S, Maxwell CA, Barcellos-Hoff MH, Parvin B. Geometric approach to segmentation and protein localization in cell culture assays. J Microsc. 2007 Jan; 225(Pt 1):22-30. PMID: 17286692.
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      71. Jobling MF, Mott JD, Finnegan MT, Jurukovski V, Erickson AC, Walian PJ, Taylor SE, Ledbetter S, Lawrence CM, Rifkin DB, Barcellos-Hoff MH. Isoform-specific activation of latent transforming growth factor beta (LTGF-beta) by reactive oxygen species. Radiat Res. 2006 Dec; 166(6):839-48. PMID: 17149983.
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      72. Fleisch MC, Maxwell CA, Kuper CK, Brown ET, Barcellos-Hoff MH, Costes SV. Intensity-based signal separation algorithm for accurate quantification of clustered centrosomes in tissue sections. Microsc Res Tech. 2006 Dec; 69(12):964-72. PMID: 16941664.
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      73. Kirshner J, Jobling MF, Pajares MJ, Ravani SA, Glick AB, Lavin MJ, Koslov S, Shiloh Y, Barcellos-Hoff MH. Inhibition of transforming growth factor-beta1 signaling attenuates ataxia telangiectasia mutated activity in response to genotoxic stress. Cancer Res. 2006 Nov 15; 66(22):10861-9. PMID: 17090522.
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      74. Fernández-González R, Muñoz-Barrutia A, Barcellos-Hoff MH, Ortiz-de-Solorzano C. Quantitative in vivo microscopy: the return from the 'omics'. Curr Opin Biotechnol. 2006 Oct; 17(5):501-10. PMID: 16899361.
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      75. Fleisch MC, Maxwell CA, Barcellos-Hoff MH. The pleiotropic roles of transforming growth factor beta in homeostasis and carcinogenesis of endocrine organs. Endocr Relat Cancer. 2006 Jun; 13(2):379-400. PMID: 16728569.
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      76. Costes SV, Boissière A, Ravani S, Romano R, Parvin B, Barcellos-Hoff MH. Imaging features that discriminate between foci induced by high- and low-LET radiation in human fibroblasts. Radiat Res. 2006 May; 165(5):505-15. PMID: 16669704.
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      77. Barcellos-Hoff MH, Costes SV. A systems biology approach to multicellular and multi-generational radiation responses. Mutat Res. 2006 May 11; 597(1-2):32-8. PMID: 16417910.
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      78. Barcellos-Hoff MH, Park C, Wright EG. Radiation and the microenvironment - tumorigenesis and therapy. Nat Rev Cancer. 2005 Nov; 5(11):867-75. PMID: 16327765.
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      79. Muraoka-Cook RS, Shin I, Yi JY, Easterly E, Barcellos-Hoff MH, Yingling JM, Zent R, Arteaga CL. Activated type I TGFbeta receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progression. Oncogene. 2006 Jun 8; 25(24):3408-23. PMID: 16186809.
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      80. Fernandez-Gonzalez R, Barcellos-Hoff MH, Ortiz-de-Solórzano C. A tool for the quantitative spatial analysis of complex cellular systems. IEEE Trans Image Process. 2005 Sep; 14(9):1300-13. PMID: 16190466.
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      81. Grimm SL, Contreras A, Barcellos-Hoff MH, Rosen JM. Cell cycle defects contribute to a block in hormone-induced mammary gland proliferation in CCAAT/enhancer-binding protein (C/EBPbeta)-null mice. J Biol Chem. 2005 Oct 28; 280(43):36301-9. PMID: 16120603.
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      82. Ewan KB, Oketch-Rabah HA, Ravani SA, Shyamala G, Moses HL, Barcellos-Hoff MH. Proliferation of estrogen receptor-alpha-positive mammary epithelial cells is restrained by transforming growth factor-beta1 in adult mice. Am J Pathol. 2005 Aug; 167(2):409-17. PMID: 16049327; PMCID: PMC1603552.
      83. Barcellos-Hoff MH. Integrative radiation carcinogenesis: interactions between cell and tissue responses to DNA damage. Semin Cancer Biol. 2005 Apr; 15(2):138-48. PMID: 15652459.
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      84. Muraoka-Cook RS, Kurokawa H, Koh Y, Forbes JT, Roebuck LR, Barcellos-Hoff MH, Moody SE, Chodosh LA, Arteaga CL. Conditional overexpression of active transforming growth factor beta1 in vivo accelerates metastases of transgenic mammary tumors. Cancer Res. 2004 Dec 15; 64(24):9002-11. PMID: 15604265.
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      85. Stone HB, Moulder JE, Coleman CN, Ang KK, Anscher MS, Barcellos-Hoff MH, Dynan WS, Fike JR, Grdina DJ, Greenberger JS, Hauer-Jensen M, Hill RP, Kolesnick RN, Macvittie TJ, Marks C, McBride WH, Metting N, Pellmar T, Purucker M, Robbins ME, Schiestl RH, Seed TM, Tomaszewski JE, Travis EL, Wallner PE, Wolpert M, Zaharevitz D. Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI Workshop, December 3-4, 2003. Radiat Res. 2004 Dec; 162(6):711-28. PMID: 15548121.
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      86. Barcellos-Hoff MH, Medina D. New highlights on stroma-epithelial interactions in breast cancer. Breast Cancer Res. 2005; 7(1):33-6. PMID: 15642180; PMCID: PMC1064117.
      87. Fernandez-Gonzalez R, Barcellos-Hoff MH, Ortiz-de-Solórzano C. Quantitative image analysis in mammary gland biology. J Mammary Gland Biol Neoplasia. 2004 Oct; 9(4):343-59. PMID: 15838604.
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      88. Coleman CN, Stone HB, Alexander GA, Barcellos-Hoff MH, Bedford JS, Bristow RG, Dynlacht JR, Fuks Z, Gorelic LS, Hill RP, Joiner MC, Liu FF, McBride WH, McKenna WG, Powell SN, Robbins ME, Rockwell S, Schiff PB, Shaw EG, Siemann DW, Travis EL, Wallner PE, Wong RS, Zeman EM. Education and training for radiation scientists: radiation research program and American Society of Therapeutic Radiology and Oncology Workshop, Bethesda, Maryland, May 12-14, 2003. Radiat Res. 2003 Dec; 160(6):729-37. PMID: 14640790.
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      89. Park CC, Henshall-Powell RL, Erickson AC, Talhouk R, Parvin B, Bissell MJ, Barcellos-Hoff MH. Ionizing radiation induces heritable disruption of epithelial cell interactions. Proc Natl Acad Sci U S A. 2003 Sep 16; 100(19):10728-33. PMID: 12960393; PMCID: PMC196872.
      90. Erickson AC, Barcellos-Hoff MH. The not-so innocent bystander: the microenvironment as a therapeutic target in cancer. Expert Opin Ther Targets. 2003 Feb; 7(1):71-88. PMID: 12556204.
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      91. Parvin B, Yang Q, Fontenay G, Barcellos-Hoff MH. BioSig: an imaging bioinformatics system for phenotypic analysis. IEEE Trans Syst Man Cybern B Cybern. 2003; 33(5):814-24. PMID: 18238234.
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      92. Fernandez-Gonzalez R, Jones A, Garcia-Rodriguez E, Chen PY, Idica A, Lockett SJ, Barcellos-Hoff MH, Ortiz-De-Solorzano C. System for combined three-dimensional morphological and molecular analysis of thick tissue specimens. Microsc Res Tech. 2002 Dec 15; 59(6):522-30. PMID: 12467029.
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      93. Ewan KB, Henshall-Powell RL, Ravani SA, Pajares MJ, Arteaga C, Warters R, Akhurst RJ, Barcellos-Hoff MH. Transforming growth factor-beta1 mediates cellular response to DNA damage in situ. Cancer Res. 2002 Oct 15; 62(20):5627-31. PMID: 12384514.
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      94. Ortiz De Solórzano C, Costes S, Callahan DE, Parvin B, Barcellos-Hoff MH. Applications of quantitative digital image analysis to breast cancer research. Microsc Res Tech. 2002 Oct 15; 59(2):119-27. PMID: 12373722.
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      95. Wang F, Hansen RK, Radisky D, Yoneda T, Barcellos-Hoff MH, Petersen OW, Turley EA, Bissell MJ. Phenotypic reversion or death of cancer cells by altering signaling pathways in three-dimensional contexts. J Natl Cancer Inst. 2002 Oct 2; 94(19):1494-503. PMID: 12359858; PMCID: PMC2975573.
      96. Ewan KB, Shyamala G, Ravani SA, Tang Y, Akhurst R, Wakefield L, Barcellos-Hoff MH. Latent transforming growth factor-beta activation in mammary gland: regulation by ovarian hormones affects ductal and alveolar proliferation. Am J Pathol. 2002 Jun; 160(6):2081-93. PMID: 12057913; PMCID: PMC1850834.
      97. Costes S, Barcellos-Hoff MH. Radiation quality and tissue-specific microenvironments following exposure to 1 GeV/amu Fe. Adv Space Res. 2002; 30(4):865-70. PMID: 12530433.
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      98. Girault I, Karu AE, Schaper M, Barcellos-Hoff MH, Hagen T, Vogel DS, Ames BN, Christen S, Shigenaga MK. Immunodetection of 3-nitrotyrosine in the liver of zymosan-treated rats with a new monoclonal antibody: comparison to analysis by HPLC. Free Radic Biol Med. 2001 Dec 1; 31(11):1375-87. PMID: 11728809.
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      99. Barcellos-Hoff MH, Brooks AL. Extracellular signaling through the microenvironment: a hypothesis relating carcinogenesis, bystander effects, and genomic instability. Radiat Res. 2001 Nov; 156(5 Pt 2):618-27. PMID: 11604083.
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      100. Barcellos-Hoff MH. It takes a tissue to make a tumor: epigenetics, cancer and the microenvironment. J Mammary Gland Biol Neoplasia. 2001 Apr; 6(2):213-21. PMID: 11501581.
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      101. Asch BB, Barcellos-Hoff MH. Epigenetics and breast cancer. J Mammary Gland Biol Neoplasia. 2001 Apr; 6(2):151-2. PMID: 11501575.
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      102. Barcellos-Hoff MH. Three down and counting: the transformation of human mammary cells from normal to malignant in three steps. Trends Mol Med. 2001 Apr; 7(4):142-3. PMID: 11286925.
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      103. Kong FM, Anscher MS, Sporn TA, Washington MK, Clough R, Barcellos-Hoff MH, Jirtle RL. Loss of heterozygosity at the mannose 6-phosphate insulin-like growth factor 2 receptor (M6P/IGF2R) locus predisposes patients to radiation-induced lung injury. Int J Radiat Oncol Biol Phys. 2001 Jan 1; 49(1):35-41. PMID: 11163495.
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      104. Chang PY, Bjornstad K A, Chang E, McNamara M, Barcellos-Hoff MH, Lin SP, Aragon G, Polansky JR, Lui GM, Blakely EA. Particle irradiation induces FGF2 expression in normal human lens cells. Radiat Res. 2000 Nov; 154(5):477-84. PMID: 11025644.
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      105. Costes S, Streuli CH, Barcellos-Hoff MH. Quantitative image analysis of laminin immunoreactivity in skin basement membrane irradiated with 1 GeV/nucleon iron particles. Radiat Res. 2000 Oct; 154(4):389-97. PMID: 11023602.
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      106. Park CC, Bissell MJ, Barcellos-Hoff MH. The influence of the microenvironment on the malignant phenotype. Mol Med Today. 2000 Aug; 6(8):324-9. PMID: 10904250.
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      107. Barcellos-Hoff MH, Ravani SA. Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells. Cancer Res. 2000 Mar 1; 60(5):1254-60. PMID: 10728684.
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      108. Barcellos-Hoff MH, Ewan KB. Transforming growth factor-beta and breast cancer: Mammary gland development. Breast Cancer Res. 2000; 2(2):92-9. PMID: 11250698; PMCID: PMC139430.
      109. O'Malley Y, Zhao W, Barcellos-Hoff MH, Robbins ME. Radiation-induced alterations in rat mesangial cell Tgfb1 and Tgfb3 gene expression are not associated with altered secretion of active Tgfb isoforms. Radiat Res. 1999 Dec; 152(6):622-8. PMID: 10581532.
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      110. Vodovotz Y, Mitchell JB, Lucia MS, McKinney L, Kollum M, Cottin Y, Chan RC, Barcellos-Hoff MH, Waksman R. Modulation of protein expression and activity by radiation: relevance to intracoronary radiation for the prevention of restenosis. Cardiovasc Radiat Med. 1999 Oct-Dec; 1(4):336-43. PMID: 10828563.
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      111. Tribble DL, Barcellos-Hoff MH, Chu BM, Gong EL. Ionizing radiation accelerates aortic lesion formation in fat-fed mice via SOD-inhibitable processes. Arterioscler Thromb Vasc Biol. 1999 Jun; 19(6):1387-92. PMID: 10364068.
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      112. Vodovotz Y, Chesler L, Chong H, Kim SJ, Simpson JT, DeGraff W, Cox GW, Roberts AB, Wink DA, Barcellos-Hoff MH. Regulation of transforming growth factor beta1 by nitric oxide. Cancer Res. 1999 May 1; 59(9):2142-9. PMID: 10232601.
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      113. Chong H, Vodovotz Y, Cox GW, Barcellos-Hoff MH. Immunocytochemical localization of latent transforming growth factor-beta1 activation by stimulated macrophages. J Cell Physiol. 1999 Mar; 178(3):275-83. PMID: 9989773.
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      114. Barcellos-Hoff MH. How do tissues respond to damage at the cellular level? The role of cytokines in irradiated tissues. Radiat Res. 1998 Nov; 150(5 Suppl):S109-20. PMID: 9806614.
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      115. Barcellos-Hoff MH. The potential influence of radiation-induced microenvironments in neoplastic progression. J Mammary Gland Biol Neoplasia. 1998 Apr; 3(2):165-75. PMID: 10819525.
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      116. Shyamala G, Yang X, Silberstein G, Barcellos-Hoff MH, Dale E. Transgenic mice carrying an imbalance in the native ratio of A to B forms of progesterone receptor exhibit developmental abnormalities in mammary glands. Proc Natl Acad Sci U S A. 1998 Jan 20; 95(2):696-701. PMID: 9435255; PMCID: PMC18483.
      117. Shyamala G, Barcellos-Hoff MH, Toft D, Yang X. In situ localization of progesterone receptors in normal mouse mammary glands: absence of receptors in the connective and adipose stroma and a heterogeneous distribution in the epithelium. J Steroid Biochem Mol Biol. 1997 Nov-Dec; 63(4-6):251-9. PMID: 9459191.
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      118. Ehrhart EJ, Segarini P, Tsang ML, Carroll AG, Barcellos-Hoff MH. Latent transforming growth factor beta1 activation in situ: quantitative and functional evidence after low-dose gamma-irradiation. FASEB J. 1997 Oct; 11(12):991-1002. PMID: 9337152.
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      119. Reiss M, Barcellos-Hoff MH. Transforming growth factor-beta in breast cancer: a working hypothesis. Breast Cancer Res Treat. 1997 Aug; 45(1):81-95. PMID: 9285120.
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      120. Franko AJ, Sharplin J, Ghahary A, Barcellos-Hoff MH. Immunohistochemical localization of transforming growth factor beta and tumor necrosis factor alpha in the lungs of fibrosis-prone and "non-fibrosing" mice during the latent period and early phase after irradiation. Radiat Res. 1997 Feb; 147(2):245-56. PMID: 9008217.
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      121. Barcellos-Hoff MH. Latency and activation in the control of TGF-beta. J Mammary Gland Biol Neoplasia. 1996 Oct; 1(4):353-63. PMID: 10887509.
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      122. Barcellos-Hoff MH, Dix TA. Redox-mediated activation of latent transforming growth factor-beta 1. Mol Endocrinol. 1996 Sep; 10(9):1077-83. PMID: 8885242.
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      123. Ehrhart EJ, Gillette EL, Barcellos-Hoff MH. Immunohistochemical evidence of rapid extracellular matrix remodeling after iron-particle irradiation of mouse mammary gland. Radiat Res. 1996 Feb; 145(2):157-62. PMID: 8606925.
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      124. Barcellos-Hoff MH. Latency and activation in the control of TGF-beta. J Mammary Gland Biol Neoplasia. 1996; 1(4):353-63. PMID: 11543607.
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      125. Barcellos-Hoff MH, Ehrhart EJ, Kalia M, Jirtle R, Flanders K, Tsang ML. Immunohistochemical detection of active transforming growth factor-beta in situ using engineered tissue. Am J Pathol. 1995 Nov; 147(5):1228-37. PMID: 7485387; PMCID: PMC1869520.
      126. Barcellos-Hoff MH, Derynck R, Tsang ML, Weatherbee JA. Transforming growth factor-beta activation in irradiated murine mammary gland. J Clin Invest. 1994 Feb; 93(2):892-9. PMID: 8113421; PMCID: PMC293960.
      127. Barcellos-Hoff MH. Radiation-induced transforming growth factor beta and subsequent extracellular matrix reorganization in murine mammary gland. Cancer Res. 1993 Sep 1; 53(17):3880-6. PMID: 8358713.
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      128. Barcellos-Hoff MH, Linfoot PA, Marton LJ, Deen DF. Production of stable phenotypes from 9L rat brain tumor multicellular spheroids treated with 1,3-bis(2-chloroethyl)-1-nitrosourea. Int J Cancer. 1992 Sep 30; 52(3):409-13. PMID: 1399117.
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      129. Barcellos-Hoff MH. Mammary epithelial reorganization on extracellular matrix is mediated by cell surface galactosyltransferase. Exp Cell Res. 1992 Jul; 201(1):225-34. PMID: 1612125.
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      130. Aggeler J, Ward J, Blackie LM, Barcellos-Hoff MH, Streuli CH, Bissell MJ. Cytodifferentiation of mouse mammary epithelial cells cultured on a reconstituted basement membrane reveals striking similarities to development in vivo. J Cell Sci. 1991 Jun; 99 ( Pt 2):407-17. PMID: 1885677.
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      131. Barcellos-Hoff MH, Marton LJ, Deen DF. Differential drug sensitivity conferred by growth status detected in a mixed population of cycling and noncycling cells. Cancer Res. 1990 Jun 15; 50(12):3551-5. PMID: 2340503.
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      132. Barcellos-Hoff MH, Aggeler J, Ram TG, Bissell MJ. Functional differentiation and alveolar morphogenesis of primary mammary cultures on reconstituted basement membrane. Development. 1989 Feb; 105(2):223-35. PMID: 2806122; PMCID: PMC2948482.
      133. Deen DF, Morgan WF, Tofilon PJ, Barcellos-Hoff MH. Measurement of sister chromatid exchanges and their relationship to DNA damage, repair and cell killing. Pharmacol Ther. 1989; 42(3):349-60. PMID: 2672050.
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      134. Linfoot PA, Barcellos-Hoff MH, Brent TP, Marton LJ, Deen DF. Cell-cycle, phase-specific cell killing by carmustine in sensitive and resistant cells. NCI Monogr. 1988; (6):183-6. PMID: 3352762.
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      135. Lee EY, Barcellos-Hoff MH, Chen LH, Parry G, Bissell MJ. Transferrin is a major mouse milk protein and is synthesized by mammary epithelial cells. In Vitro Cell Dev Biol. 1987 Mar; 23(3):221-6. PMID: 3549678.
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      136. Bissell MJ, Barcellos-Hoff MH. The influence of extracellular matrix on gene expression: is structure the message? J Cell Sci Suppl. 1987; 8:327-43. PMID: 3332665.
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      137. Jostes RF, Williams ME, Barcellos-Hoff MH, Hoshino T, Deen DF. Growth delay in 9L rat brain tumor spheroids after irradiation with single and split doses of X rays. Radiat Res. 1985 May; 102(2):182-9. PMID: 4070541.
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      138. da Silva V, Gutin PH, Barcellos-Hoff MH, Bernstein MA, Deen DF, Weaver KA. The effect of combination treatment with cis-platinum and low dose rate 125I radiation in a murine brachytherapy model. Int J Radiat Oncol Biol Phys. 1984 Aug; 10(8):1471-2. PMID: 6540767.
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