Mary Helen Barcellos-Hoff, PhD
|University of Chicago||A.B.||Biopsychology||1978|
|University of California, San Francisco||Ph.D.||Experimental Pathology||1986|
|University of California, Berkeley||Postdoctoral training||Biophysics||1988|
The Barcellos-Hoff laboratory studies radiation carcinogenesis and biologically augmented radiotherapy. Dr. Barcellos-Hoff received an undergraduate degree from the University of Chicago and earned a doctoral degree in experimental pathology from the University of California, San Francisco. She conducted postdoctoral research on extracellular matrix mediated functional differentiation with Mina Bissell at the Lawrence Berkeley National Laboratory (LBNL). She joined LBNL as a staff scientist, where she rose from postdoctoral fellow to Senior Scientist and Associate Director of the Life Sciences Division. She joined New York University School of Medicine in 2008 as Director of Radiation Biology in the Department of Radiation Oncology. She moved to UCSF as Professor and Vice Chair of Research in the Department of Radiation Oncology in 2015.
Dr. Barcellos-Hoff promotes the application of systems biology approaches to problems in radiation research. She was Chief Scientist for the Low Dose Radiation Research program in the Department of Energy (DOE) from 2006-2010. Her studies funded by DOE and NASA describe the complexity of radiation effects on biological systems and have generated new perspectives on mechanisms underlying radiation carcinogenesis.
Translational research based on aspects of these low dose studies provides a rationale for implementing TGFß inhibition during radiotherapy. TGF? is activated by radiation and mediates the DNA damage response as well as the composition of the tumor microenvironment, particularly tumor immunological responses. Detailed understanding of its contributions to tumor response may motivate clinical trials of TGF? inhibitors in radiotherapy.
Dr. Barcellos-Hoff is a member of AAAS and the American Association of Cancer Research. She is member of the AACR Tumor Microenvironment Working Group, which she chaired from 2012 to 2014, and a founding member of the AACR committee for Radiation Science and Medicine Working Group. She is a long-standing member of the Radiation Research Society and President of the International Association of Radiation Research (2014-2019).
TGFß, Radiation biology, mammary biology, carcinogenesis, systems biology, TGFß, lung cancer, glioblastoma, breast cancer, radiotherapy, charged particle radiobiology, DNA damage response, tumor microenvironment, tumor immunology, BRCA1
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