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    Matthew Larson, PhD

    TitleResearch Associate
    SchoolUCSF School of Medicine
    DepartmentHoward Hughes Medical Instit
    Address1700 4th Street
    San Francisco CA 94158
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Peters JM, Colavin A, Shi H, Czarny TL, Larson MH, Wong S, Hawkins JS, Lu CH, Koo BM, Marta E, Shiver AL, Whitehead EH, Weissman JS, Brown ED, Qi LS, Huang KC, Gross CA. A Comprehensive, CRISPR-based Functional Analysis of Essential Genes in Bacteria. Cell. 2016 Jun 2; 165(6):1493-506. PMID: 27238023.
        View in: PubMed
      2. Shen PS, Park J, Qin Y, Li X, Parsawar K, Larson MH, Cox J, Cheng Y, Lambowitz AM, Weissman JS, Brandman O, Frost A. Protein synthesis. Rqc2p and 60S ribosomal subunits mediate mRNA-independent elongation of nascent chains. Science. 2015 Jan 2; 347(6217):75-8. PMID: 25554787; PMCID: PMC4451101.
      3. Larson MH, Mooney RA, Peters JM, Windgassen T, Nayak D, Gross CA, Block SM, Greenleaf WJ, Landick R, Weissman JS. A pause sequence enriched at translation start sites drives transcription dynamics in vivo. Science. 2014 May 30; 344(6187):1042-7. PMID: 24789973; PMCID: PMC4108260.
      4. Larson MH, Gilbert LA, Wang X, Lim WA, Weissman JS, Qi LS. CRISPR interference (CRISPRi) for sequence-specific control of gene expression. Nat Protoc. 2013 Nov; 8(11):2180-96. PMID: 24136345; PMCID: PMC3922765.
      5. Gilbert LA, Larson MH, Morsut L, Liu Z, Brar GA, Torres SE, Stern-Ginossar N, Brandman O, Whitehead EH, Doudna JA, Lim WA, Weissman JS, Qi LS. CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes. Cell. 2013 Jul 18; 154(2):442-51. PMID: 23849981; PMCID: PMC3770145.
      6. Qi LS, Larson MH, Gilbert LA, Doudna JA, Weissman JS, Arkin AP, Lim WA. Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell. 2013 Feb 28; 152(5):1173-83. PMID: 23452860; PMCID: PMC3664290.
      7. Palangat M, Larson MH, Hu X, Gnatt A, Block SM, Landick R. Efficient reconstitution of transcription elongation complexes for single-molecule studies of eukaryotic RNA polymerase II. Transcription. 2012 May-Jun; 3(3):146-53. PMID: 22771949; PMCID: PMC3616084.
      8. Larson MH, Zhou J, Kaplan CD, Palangat M, Kornberg RD, Landick R, Block SM. Trigger loop dynamics mediate the balance between the transcriptional fidelity and speed of RNA polymerase II. Proc Natl Acad Sci U S A. 2012 Apr 24; 109(17):6555-60. PMID: 22493230; PMCID: PMC3340090.
      9. Larson MH, Landick R, Block SM. Single-molecule studies of RNA polymerase: one singular sensation, every little step it takes. Mol Cell. 2011 Feb 4; 41(3):249-62. PMID: 21292158; PMCID: PMC3056354.
      10. Larson MH, Greenleaf WJ, Landick R, Block SM. Applied force reveals mechanistic and energetic details of transcription termination. Cell. 2008 Mar 21; 132(6):971-82. PMID: 18358810; PMCID: PMC2295211.
      11. Block SM, Larson MH, Greenleaf WJ, Herbert KM, Guydosh NR, Anthony PC. Molecule by molecule, the physics and chemistry of life: SMB 2007. Nat Chem Biol. 2007 Apr; 3(4):193-7. PMID: 17372599; PMCID: PMC1865523.
      12. Dalal RV, Larson MH, Neuman KC, Gelles J, Landick R, Block SM. Pulling on the nascent RNA during transcription does not alter kinetics of elongation or ubiquitous pausing. Mol Cell. 2006 Jul 21; 23(2):231-9. PMID: 16857589; PMCID: PMC1513632.
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