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    Megan Mayerle, PhD

    TitlePostdoctoral Scholar
    SchoolUCSF School of Medicine
    DepartmentBiochemistry and Biophysics
    Address600 16th Street
    San Francisco CA 94158
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      Collapse Biography 
      Collapse Education and Training
      The Johns Hopkins UniversityPhDBiology2012
      Marquette UniversityBSBiology and English Literature2004
      Collapse Awards and Honors
      University of California San Francisco2016 - 2016RNA Society Travel Award
      Johns Hopkins University2009 - 2010Deans Teaching Fellowship
      Marquette University2004Alpha Sigma Nu Membership
      Johns Hopkins University2010 - 2010Graduate Representative Organization Travel Grant
      Marquette University2000 - 2004Ignatius Scholarship

      Collapse Overview 
      Collapse Overview
      Cells have developed elaborate mechanisms to minimize errors in gene expression. These fall into two broad categories: 1) fidelity mechanisms intrinsic to the gene expression machinery that minimize errors during transcription, RNA pro-cessing, and translation, and 2) surveillance mechanisms that scan the products of the gene expression machinery for errors and correct them. I am broadly interested the mechanistic basis of how the components of the large, RNA-protein complexes involved in gene expression maintain fidelity, and how aberrant versions of these complexes can cause and contribute to human diseases.

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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Mayerle M, Guthrie C. Prp8 retinitis pigmentosa mutants cause defects in the transition between the catalytic steps of splicing. RNA. 2016 May; 22(5):793-809. PMID: 26968627.
        View in: PubMed
      2. Mayerle M, Guthrie C. A new communication hub in the RNA world. Nat Struct Mol Biol. 2016 Mar 2; 23(3):189-90. PMID: 26931416.
        View in: PubMed
      3. Kim H, Abeysirigunawarden SC, Chen K, Mayerle M, Ragunathan K, Luthey-Schulten Z, Ha T, Woodson SA. Protein-guided RNA dynamics during early ribosome assembly. Nature. 2014 Feb 20; 506(7488):334-8. PMID: 24522531; PMCID: PMC3968076.
      4. Mayerle M, Woodson SA. Specific contacts between protein S4 and ribosomal RNA are required at multiple stages of ribosome assembly. RNA. 2013 Apr; 19(4):574-85. PMID: 23431409; PMCID: PMC3677267.
      5. Chen K, Eargle J, Lai J, Kim H, Abeysirigunawardena S, Mayerle M, Woodson S, Ha T, Luthey-Schulten Z. Assembly of the five-way junction in the ribosomal small subunit using hybrid MD-Go simulations. J Phys Chem B. 2012 Jun 14; 116(23):6819-31. PMID: 22458631; PMCID: PMC3422213.
      6. Mayerle M, Bellur DL, Woodson SA. Slow formation of stable complexes during coincubation of minimal rRNA and ribosomal protein S4. J Mol Biol. 2011 Sep 23; 412(3):453-65. PMID: 21821049; PMCID: PMC3167742.
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