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    Michael Boettcher, PhD

    TitlePostdoctoral Scholar
    SchoolUCSF School of Medicine
    DepartmentDiabetes Center
    Address513 Parnassus Ave
    San Francisco CA 94143
    Phone415-476-1116
    EmailMichael.Boettcher@ucsf.edu
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      Collapse Overview
      I analyze the function of thousands of genes in parallel. For this purpose I developed pooled, large-scale CRISPR/Cas9 libraries. The idea is to apply this high-throughput technology in order to identify genes and genetic networks that play key roles in the development and treatment of cancer.


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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Boettcher M, McManus MT. Choosing the Right Tool for the Job: RNAi, TALEN, or CRISPR. Mol Cell. 2015 May 21; 58(4):575-85. PMID: 26000843; PMCID: PMC4441801 [Available on 05/21/16].
      2. Boettcher M, Lawson A, Ladenburger V, Fredebohm J, Wolf J, Hoheisel JD, Frezza C, Shlomi T. High throughput synthetic lethality screen reveals a tumorigenic role of adenylate cyclase in fumarate hydratase-deficient cancer cells. BMC Genomics. 2014; 15:158. PMID: 24568598; PMCID: PMC3945041.
      3. Wolf J, Müller-Decker K, Flechtenmacher C, Zhang F, Shahmoradgoli M, Mills GB, Hoheisel JD, Boettcher M. An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation. Oncogene. 2014 Aug 14; 33(33):4273-8. PMID: 24292671.
        View in: PubMed
      4. Wolf J, Dewi DL, Fredebohm J, Müller-Decker K, Flechtenmacher C, Hoheisel JD, Boettcher M. A mammosphere formation RNAi screen reveals that ATG4A promotes a breast cancer stem-like phenotype. Breast Cancer Res. 2013; 15(6):R109. PMID: 24229464; PMCID: PMC3978845.
      5. Fredebohm J, Wolf J, Hoheisel JD, Boettcher M. Depletion of RAD17 sensitizes pancreatic cancer cells to gemcitabine. J Cell Sci. 2013 Aug 1; 126(Pt 15):3380-9. PMID: 23687379.
        View in: PubMed
      6. Fredebohm J, Boettcher M, Eisen C, Gaida MM, Heller A, Keleg S, Tost J, Greulich-Bode KM, Hotz-Wagenblatt A, Lathrop M, Giese NA, Hoheisel JD. Establishment and characterization of a highly tumourigenic and cancer stem cell enriched pancreatic cancer cell line as a well defined model system. PLoS One. 2012; 7(11):e48503. PMID: 23152778; PMCID: PMC3495919.
      7. Shenfeld M, Hachmo Y, Frenkel M, Dafni N, Boettcher M, Hoheisel JD, Dotan I, Canaani D. ER-alpha-cDNA as part of a bicistronic transcript gives rise to high frequency, long term, receptor expressing cell clones. PLoS One. 2012; 7(2):e31977. PMID: 22363779; PMCID: PMC3282794.
      8. Boettcher M, Kischkel F, Hoheisel JD. High-definition DNA methylation profiles from breast and ovarian carcinoma cell lines with differing doxorubicin resistance. PLoS One. 2010; 5(6):e11002. PMID: 20544021; PMCID: PMC2882327.
      9. Boettcher M, Hoheisel JD. Pooled RNAi Screens - Technical and Biological Aspects. Curr Genomics. 2010 May; 11(3):162-7. PMID: 21037854; PMCID: PMC2878981.
      10. Boettcher M, Fredebohm J, Moghaddas Gholami A, Hachmo Y, Dotan I, Canaani D, Hoheisel JD. Decoding pooled RNAi screens by means of barcode tiling arrays. BMC Genomics. 2010; 11:7. PMID: 20051122; PMCID: PMC2824726.
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