Sign in to see private stats on your profile page — or add photo, interests, videos, mentoring, etc.

    Michael Boettcher, PhD

    TitlePostdoctoral Scholar
    SchoolUCSF School of Medicine
    DepartmentDiabetes Center
    Address513 Parnassus Ave
    San Francisco CA 94143
    vCardDownload vCard

      Collapse Overview 
      Collapse Overview
      I analyze the function of thousands of genes in parallel. For this purpose I developed pooled, large-scale CRISPR/Cas9 libraries. The idea is to apply this high-throughput technology in order to identify genes and genetic networks that play key roles in the development and treatment of cancer.

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Boettcher M, McManus MT. Choosing the Right Tool for the Job: RNAi, TALEN, or CRISPR. Mol Cell. 2015 May 21; 58(4):575-85. PMID: 26000843; PMCID: PMC4441801 [Available on 05/21/16].
      2. Boettcher M, Lawson A, Ladenburger V, Fredebohm J, Wolf J, Hoheisel JD, Frezza C, Shlomi T. High throughput synthetic lethality screen reveals a tumorigenic role of adenylate cyclase in fumarate hydratase-deficient cancer cells. BMC Genomics. 2014; 15:158. PMID: 24568598; PMCID: PMC3945041.
      3. Wolf J, Müller-Decker K, Flechtenmacher C, Zhang F, Shahmoradgoli M, Mills GB, Hoheisel JD, Boettcher M. An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation. Oncogene. 2014 Aug 14; 33(33):4273-8. PMID: 24292671.
        View in: PubMed
      4. Wolf J, Dewi DL, Fredebohm J, Müller-Decker K, Flechtenmacher C, Hoheisel JD, Boettcher M. A mammosphere formation RNAi screen reveals that ATG4A promotes a breast cancer stem-like phenotype. Breast Cancer Res. 2013; 15(6):R109. PMID: 24229464; PMCID: PMC3978845.
      5. Fredebohm J, Wolf J, Hoheisel JD, Boettcher M. Depletion of RAD17 sensitizes pancreatic cancer cells to gemcitabine. J Cell Sci. 2013 Aug 1; 126(Pt 15):3380-9. PMID: 23687379.
        View in: PubMed
      6. Fredebohm J, Boettcher M, Eisen C, Gaida MM, Heller A, Keleg S, Tost J, Greulich-Bode KM, Hotz-Wagenblatt A, Lathrop M, Giese NA, Hoheisel JD. Establishment and characterization of a highly tumourigenic and cancer stem cell enriched pancreatic cancer cell line as a well defined model system. PLoS One. 2012; 7(11):e48503. PMID: 23152778; PMCID: PMC3495919.
      7. Shenfeld M, Hachmo Y, Frenkel M, Dafni N, Boettcher M, Hoheisel JD, Dotan I, Canaani D. ER-alpha-cDNA as part of a bicistronic transcript gives rise to high frequency, long term, receptor expressing cell clones. PLoS One. 2012; 7(2):e31977. PMID: 22363779; PMCID: PMC3282794.
      8. Boettcher M, Kischkel F, Hoheisel JD. High-definition DNA methylation profiles from breast and ovarian carcinoma cell lines with differing doxorubicin resistance. PLoS One. 2010; 5(6):e11002. PMID: 20544021; PMCID: PMC2882327.
      9. Boettcher M, Hoheisel JD. Pooled RNAi Screens - Technical and Biological Aspects. Curr Genomics. 2010 May; 11(3):162-7. PMID: 21037854; PMCID: PMC2878981.
      10. Boettcher M, Fredebohm J, Moghaddas Gholami A, Hachmo Y, Dotan I, Canaani D, Hoheisel JD. Decoding pooled RNAi screens by means of barcode tiling arrays. BMC Genomics. 2010; 11:7. PMID: 20051122; PMCID: PMC2824726.
      Michael's Networks
      Related Concepts
      Derived automatically from this person's publications.
      People in Profiles who have published with this person.
      Related Authors
      People who share related concepts with this person.
      Back to TOP