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    Michael Fischbach, PhD

    TitleAssociate Professor
    SchoolUCSF School of Pharmacy
    Address1700 4th Street
    San Francisco CA 94158
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      Collapse Biography 
      Collapse Awards and Honors
      Sandler Foundation2010 - 2015Opportunity Award, Program for Breakthrough Biomedical Research
      Global Probiotics Council2010Young Investigator Grant For Probiotics Research
      NIH2011 - 2016New Innovator Award
      W.M. Keck Foundation2011 - 2014Medical Research Award
      David and Lucile Packard Foundation2011 - 2016Fellowship for Science and Engineering

      Collapse Overview 
      Collapse Overview
      Michael Fischbach is an Associate Professor in the Department of Bioengineering and Therapeutic Sciences at UCSF and a member of the California Institute for Quantitative Biosciences (QB3). Fischbach is a recipient of the NIH Director's New Innovator Award, a Fellowship for Science and Engineering from the David and Lucille Packard Foundation, a Medical Research Award from the W.M. Keck Foundation, a Burroughs Wellcome Fund Investigators in the Pathogenesis of Infectious Disease award, a Glenn Award for Research in Biological Mechanisms of Aging, and the Young Investigator Grant for Probiotics Research from the Global Probiotics Council. His laboratory uses a combination of genomics and chemistry to identify and characterize small molecules from microbes, with an emphasis on the human microbiome. Fischbach received his Ph.D. as a John and Fannie Hertz Foundation Fellow in chemistry from Harvard in 2007, where he studied the role of iron acquisition in bacterial pathogenesis and the biosynthesis of antibiotics. Before coming to UCSF, he spent two years as an independent fellow at Massachusetts General Hospital coordinating a collaborative effort based at the Broad Institute to develop genomics-based approaches to the discovery of small molecules from microbes. Fischbach is a member of the scientific advisory boards of NGM Biopharmaceuticals, Reckitt Benckiser, Symbiota, and Warp Drive Bio, and a member of Genentech's Scientific Resource Board.

      Collapse Interests
      Chemistry, Chemical Biology, Microbiology, Human Microbiome, Genetics, Genomics, Biochemistry, Natural Products, Drug Discovery, Antibiotics, Biosynthesis, Metabolism, Bioengineering, Therapeutics

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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Wilks J, Lien E, Jacobson AN, Fischbach MA, Qureshi N, Chervonsky AV, Golovkina TV. Mammalian Lipopolysaccharide Receptors Incorporated into the Retroviral Envelope Augment Virus Transmission. Cell Host Microbe. 2015 Oct 14; 18(4):456-62.
        View in: PubMed
      2. Taketani M, Donia MS, Jacobson AN, Lambris JD, Fischbach MA. A Phase-Variable Surface Layer from the Gut Symbiont Bacteroides thetaiotaomicron. MBio. 2015; 6(5).
        View in: PubMed
      3. Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJ, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kötter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nützmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gómez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, van der Donk WA, Dorrestein PC, Doyle S, Driessen AJ, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick WH, Gross H, Gust B, Hertweck C, Höfte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell DA, Moore BS, Moreira LM, Müller R, Neilan BA, Nett M, Nielsen J, O'Gara F, Oikawa H, Osbourn A, Osburne MS, Ostash B, Payne SM, Pernodet JL, Petricek M, Piel J, Ploux O, Raaijmakers JM, Salas JA, Schmitt EK, Scott B, Seipke RF, Shen B, Sherman DH, Sivonen K, Smanski MJ, Sosio M, Stegmann E, Süssmuth RD, Tahlan K, Thomas CM, Tang Y, Truman AW, Viaud M, Walton JD, Walsh CT, Weber T, van Wezel GP, Wilkinson B, Willey JM, Wohlleben W, Wright GD, Ziemert N, Zhang C, Zotchev SB, Breitling R, Takano E, Glöckner FO. Minimum Information about a Biosynthetic Gene cluster. Nat Chem Biol. 2015 Aug 18; 11(9):625-31.
        View in: PubMed
      4. Medema MH, Fischbach MA. Computational approaches to natural product discovery. Nat Chem Biol. 2015 Aug 18; 11(9):639-48.
        View in: PubMed
      5. Schulze CJ, Donia MS, Siqueira-Neto JL, Ray D, Raskatov JA, Green RE, McKerrow JH, Fischbach MA, Linington RG. Genome-Directed Lead Discovery: Biosynthesis, Structure Elucidation, and Biological Evaluation of Two Families of Polyene Macrolactams against Trypanosoma brucei. ACS Chem Biol. 2015 Oct 16; 10(10):2373-81.
        View in: PubMed
      6. Donia MS, Fischbach MA. HUMAN MICROBIOTA. Small molecules from the human microbiota. Science. 2015 Jul 24; 349(6246):1254766.
        View in: PubMed
      7. Devlin AS, Fischbach MA. A biosynthetic pathway for a prominent class of microbiota-derived bile acids. Nat Chem Biol. 2015 Sep; 11(9):685-90.
        View in: PubMed
      8. Hadjithomas M, Chen IM, Chu K, Ratner A, Palaniappan K, Szeto E, Huang J, Reddy TB, Cimermancic P, Fischbach MA, Ivanova NN, Markowitz VM, Kyrpides NC, Pati A. IMG-ABC: A Knowledge Base To Fuel Discovery of Biosynthetic Gene Clusters and Novel Secondary Metabolites. MBio. 2015; 6(4).
        View in: PubMed
      9. Nayfach S, Fischbach MA, Pollard KS. MetaQuery: a web server for rapid annotation and quantitative analysis of specific genes in the human gut microbiome. Bioinformatics. 2015 Jun 22.
        View in: PubMed
      10. Weber T, Blin K, Duddela S, Krug D, Kim HU, Bruccoleri R, Lee SY, Fischbach MA, Müller R, Wohlleben W, Breitling R, Takano E, Medema MH. antiSMASH 3.0-a comprehensive resource for the genome mining of biosynthetic gene clusters. Nucleic Acids Res. 2015 Jul 1; 43(W1):W237-43.
        View in: PubMed
      11. Medema MH, Cimermancic P, Sali A, Takano E, Fischbach MA. A systematic computational analysis of biosynthetic gene cluster evolution: lessons for engineering biosynthesis. PLoS Comput Biol. 2014 Dec; 10(12):e1004016.
        View in: PubMed
      12. Williams BB, Van Benschoten AH, Cimermancic P, Donia MS, Zimmermann M, Taketani M, Ishihara A, Kashyap PC, Fraser JS, Fischbach MA. Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine. Cell Host Microbe. 2014 Oct 8; 16(4):495-503.
        View in: PubMed PMC4260654
      13. Donia MS, Cimermancic P, Schulze CJ, Wieland Brown LC, Martin J, Mitreva M, Clardy J, Linington RG, Fischbach MA. A systematic analysis of biosynthetic gene clusters in the human microbiome reveals a common family of antibiotics. Cell. 2014 Sep 11; 158(6):1402-14.
        View in: PubMed PMC4164201
      14. Claesen J, Fischbach MA. Synthetic microbes as drug delivery systems. ACS Synth Biol. 2015 Apr 17; 4(4):358-64.
        View in: PubMed
      15. Wollenberg MS, Claesen J, Escapa IF, Aldridge KL, Fischbach MA, Lemon KP. Propionibacterium-produced coproporphyrin III induces Staphylococcus aureus aggregation and biofilm formation. MBio. 2014; 5(4):e01286-14.
        View in: PubMed PMC4120196
      16. Cimermancic P, Medema MH, Claesen J, Kurita K, Wieland Brown LC, Mavrommatis K, Pati A, Godfrey PA, Koehrsen M, Clardy J, Birren BW, Takano E, Sali A, Linington RG, Fischbach MA. Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters. Cell. 2014 Jul 17; 158(2):412-21.
        View in: PubMed PMC4123684
      17. Lau W, Fischbach MA, Osbourn A, Sattely ES. Key applications of plant metabolic engineering. PLoS Biol. 2014 Jun; 12(6):e1001879.
        View in: PubMed PMC4051588
      18. Kraal L, Abubucker S, Kota K, Fischbach MA, Mitreva M. The prevalence of species and strains in the human microbiome: a resource for experimental efforts. PLoS One. 2014; 9(5):e97279.
        View in: PubMed PMC4020798
      19. David LA, Maurice CF, Carmody RN, Gootenberg DB, Button JE, Wolfe BE, Ling AV, Devlin AS, Varma Y, Fischbach MA, Biddinger SB, Dutton RJ, Turnbaugh PJ. Diet rapidly and reproducibly alters the human gut microbiome. Nature. 2014 Jan 23; 505(7484):559-63.
        View in: PubMed PMC3957428
      20. Wieland Brown LC, Penaranda C, Kashyap PC, Williams BB, Clardy J, Kronenberg M, Sonnenburg JL, Comstock LE, Bluestone JA, Fischbach MA. Production of a-galactosylceramide by a prominent member of the human gut microbiota. PLoS Biol. 2013 Jul; 11(7):e1001610.
        View in: PubMed PMC3712910
      21. Marcobal A, Kashyap PC, Nelson TA, Aronov PA, Donia MS, Spormann A, Fischbach MA, Sonnenburg JL. A metabolomic view of how the human gut microbiota impacts the host metabolome using humanized and gnotobiotic mice. ISME J. 2013 Oct; 7(10):1933-43.
        View in: PubMed PMC3965317
      22. Blin K, Medema MH, Kazempour D, Fischbach MA, Breitling R, Takano E, Weber T. antiSMASH 2.0--a versatile platform for genome mining of secondary metabolite producers. Nucleic Acids Res. 2013 Jul; 41(Web Server issue):W204-12.
        View in: PubMed PMC3692088
      23. Fischbach MA, Bluestone JA, Lim WA. Cell-based therapeutics: the next pillar of medicine. Sci Transl Med. 2013 Apr 3; 5(179):179ps7.
        View in: PubMed PMC3772767
      24. Djonovic S, Urbach JM, Drenkard E, Bush J, Feinbaum R, Ausubel JL, Traficante D, Risech M, Kocks C, Fischbach MA, Priebe GP, Ausubel FM. Trehalose biosynthesis promotes Pseudomonas aeruginosa pathogenicity in plants. PLoS Pathog. 2013 Mar; 9(3):e1003217.
        View in: PubMed PMC3591346
      25. Donia MS, Fischbach MA. Dyeing to learn more about the gut microbiota. Cell Host Microbe. 2013 Feb 13; 13(2):119-20.
        View in: PubMed PMC3690940
      26. Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, Dorrestein PC, Entian KD, Fischbach MA, Garavelli JS, Göransson U, Gruber CW, Haft DH, Hemscheidt TK, Hertweck C, Hill C, Horswill AR, Jaspars M, Kelly WL, Klinman JP, Kuipers OP, Link AJ, Liu W, Marahiel MA, Mitchell DA, Moll GN, Moore BS, Müller R, Nair SK, Nes IF, Norris GE, Olivera BM, Onaka H, Patchett ML, Piel J, Reaney MJ, Rebuffat S, Ross RP, Sahl HG, Schmidt EW, Selsted ME, Severinov K, Shen B, Sivonen K, Smith L, Stein T, Süssmuth RD, Tagg JR, Tang GL, Truman AW, Vederas JC, Walsh CT, Walton JD, Wenzel SC, Willey JM, van der Donk WA. Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep. 2013 Jan; 30(1):108-60.
        View in: PubMed PMC3954855
      27. Rath CM, Alexandrov T, Higginbottom SK, Song J, Milla ME, Fischbach MA, Sonnenburg JL, Dorrestein PC. Molecular analysis of model gut microbiotas by imaging mass spectrometry and nanodesorption electrospray ionization reveals dietary metabolite transformations. Anal Chem. 2012 Nov 6; 84(21):9259-67.
        View in: PubMed PMC3711173
      28. Holmes TC, May AE, Zaleta-Rivera K, Ruby JG, Skewes-Cox P, Fischbach MA, DeRisi JL, Iwatsuki M, Omura S, Khosla C. Molecular insights into the biosynthesis of guadinomine: a type III secretion system inhibitor. J Am Chem Soc. 2012 Oct 24; 134(42):17797-806.
        View in: PubMed PMC3483642
      29. Lemon KP, Armitage GC, Relman DA, Fischbach MA. Microbiota-targeted therapies: an ecological perspective. Sci Transl Med. 2012 Jun 6; 4(137):137rv5.
        View in: PubMed
      30. Gonzalez DJ, Xu Y, Yang YL, Esquenazi E, Liu WT, Edlund A, Duong T, Du L, Molnár I, Gerwick WH, Jensen PR, Fischbach M, Liaw CC, Straight P, Nizet V, Dorrestein PC. Observing the invisible through imaging mass spectrometry, a window into the metabolic exchange patterns of microbes. J Proteomics. 2012 Aug 30; 75(16):5069-76.
        View in: PubMed PMC3543690
      31. Fischbach MA, Sonnenburg JL. Eating for two: how metabolism establishes interspecies interactions in the gut. Cell Host Microbe. 2011 Oct 20; 10(4):336-47.
        View in: PubMed PMC3225337
      32. Assassi S, Leyva AL, Mayes MD, Sharif R, Nair DK, Fischbach M, Nguyen N, Reveille JD, Gonzalez EB, McNearney TA. Predictors of fatigue severity in early systemic sclerosis: a prospective longitudinal study of the GENISOS cohort. PLoS One. 2011; 6(10):e26061.
        View in: PubMed PMC3193535
      33. Kersten RD, Yang YL, Xu Y, Cimermancic P, Nam SJ, Fenical W, Fischbach MA, Moore BS, Dorrestein PC. A mass spectrometry-guided genome mining approach for natural product peptidogenomics. Nat Chem Biol. 2011 Nov; 7(11):794-802.
        View in: PubMed PMC3258187
      34. Fischbach MA. Combination therapies for combating antimicrobial resistance. Curr Opin Microbiol. 2011 Oct; 14(5):519-23.
        View in: PubMed PMC3196371
      35. Medema MH, Blin K, Cimermancic P, de Jager V, Zakrzewski P, Fischbach MA, Weber T, Takano E, Breitling R. antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences. Nucleic Acids Res. 2011 Jul; 39(Web Server issue):W339-46.
        View in: PubMed PMC3125804
      36. Sonnenburg JL, Fischbach MA. Community health care: therapeutic opportunities in the human microbiome. Sci Transl Med. 2011 Apr 13; 3(78):78ps12.
        View in: PubMed PMC3287364
      37. Fischbach M, Voigt CA. Prokaryotic gene clusters: a rich toolbox for synthetic biology. Biotechnol J. 2010 Dec; 5(12):1277-96.
        View in: PubMed PMC3904232
      38. Song JY, Jeong H, Yu DS, Fischbach MA, Park HS, Kim JJ, Seo JS, Jensen SE, Oh TK, Lee KJ, Kim JF. Draft genome sequence of Streptomyces clavuligerus NRRL 3585, a producer of diverse secondary metabolites. J Bacteriol. 2010 Dec; 192(23):6317-8.
        View in: PubMed PMC2981214
      39. Zimmermann M, Fischbach MA. A family of pyrazinone natural products from a conserved nonribosomal peptide synthetase in Staphylococcus aureus. Chem Biol. 2010 Sep 24; 17(9):925-30.
        View in: PubMed
      40. Fischbach MA, Krogan NJ. The next frontier of systems biology: higher-order and interspecies interactions. Genome Biol. 2010; 11(5):208.
        View in: PubMed PMC2898071
      41. Sharma SV, Lee DY, Li B, Quinlan MP, Takahashi F, Maheswaran S, McDermott U, Azizian N, Zou L, Fischbach MA, Wong KK, Brandstetter K, Wittner B, Ramaswamy S, Classon M, Settleman J. A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations. Cell. 2010 Apr 2; 141(1):69-80.
        View in: PubMed PMC2851638
      42. Dawlaty J, Zhang X, Fischbach MA, Clardy J. Dapdiamides, tripeptide antibiotics formed by unconventional amide ligases. J Nat Prod. 2010 Mar 26; 73(3):441-6.
        View in: PubMed PMC2846032
      43. Walsh CT, Fischbach MA. Natural products version 2.0: connecting genes to molecules. J Am Chem Soc. 2010 Mar 3; 132(8):2469-93.
        View in: PubMed PMC2828520
      44. Haas BJ, Kamoun S, Zody MC, Jiang RH, Handsaker RE, Cano LM, Grabherr M, Kodira CD, Raffaele S, Torto-Alalibo T, Bozkurt TO, Ah-Fong AM, Alvarado L, Anderson VL, Armstrong MR, Avrova A, Baxter L, Beynon J, Boevink PC, Bollmann SR, Bos JI, Bulone V, Cai G, Cakir C, Carrington JC, Chawner M, Conti L, Costanzo S, Ewan R, Fahlgren N, Fischbach MA, Fugelstad J, Gilroy EM, Gnerre S, Green PJ, Grenville-Briggs LJ, Griffith J, Grünwald NJ, Horn K, Horner NR, Hu CH, Huitema E, Jeong DH, Jones AM, Jones JD, Jones RW, Karlsson EK, Kunjeti SG, Lamour K, Liu Z, Ma L, Maclean D, Chibucos MC, McDonald H, McWalters J, Meijer HJ, Morgan W, Morris PF, Munro CA, O'Neill K, Ospina-Giraldo M, Pinzón A, Pritchard L, Ramsahoye B, Ren Q, Restrepo S, Roy S, Sadanandom A, Savidor A, Schornack S, Schwartz DC, Schumann UD, Schwessinger B, Seyer L, Sharpe T, Silvar C, Song J, Studholme DJ, Sykes S, Thines M, van de Vondervoort PJ, Phuntumart V, Wawra S, Weide R, Win J, Young C, Zhou S, Fry W, Meyers BC, van West P, Ristaino J, Govers F, Birch PR, Whisson SC, Judelson HS, Nusbaum C. Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans. Nature. 2009 Sep 17; 461(7262):393-8.
        View in: PubMed
      45. Fischbach MA, Walsh CT. Antibiotics for emerging pathogens. Science. 2009 Aug 28; 325(5944):1089-93.
        View in: PubMed PMC2802854
      46. Fischbach MA. Antibiotics from microbes: converging to kill. Curr Opin Microbiol. 2009 Oct; 12(5):520-7.
        View in: PubMed PMC3176294
      47. Walsh CT, Fischbach MA. New ways to squash superbugs. Sci Am. 2009 Jul; 301(1):44-51.
        View in: PubMed
      48. Clardy J, Fischbach MA, Currie CR. The natural history of antibiotics. Curr Biol. 2009 Jun 9; 19(11):R437-41.
        View in: PubMed PMC2731226
      49. Wieland Brown LC, Acker MG, Clardy J, Walsh CT, Fischbach MA. Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2549-53.
        View in: PubMed PMC2650375
      50. Walsh CT, Fischbach MA. Repurposing libraries of eukaryotic protein kinase inhibitors for antibiotic discovery. Proc Natl Acad Sci U S A. 2009 Feb 10; 106(6):1689-90.
        View in: PubMed PMC2644097
      51. López D, Fischbach MA, Chu F, Losick R, Kolter R. Structurally diverse natural products that cause potassium leakage trigger multicellularity in Bacillus subtilis. Proc Natl Acad Sci U S A. 2009 Jan 6; 106(1):280-5.
        View in: PubMed PMC2629187
      52. Sattely ES, Fischbach MA, Walsh CT. Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways. Nat Prod Rep. 2008 Aug; 25(4):757-93.
        View in: PubMed
      53. Stinear TP, Seemann T, Harrison PF, Jenkin GA, Davies JK, Johnson PD, Abdellah Z, Arrowsmith C, Chillingworth T, Churcher C, Clarke K, Cronin A, Davis P, Goodhead I, Holroyd N, Jagels K, Lord A, Moule S, Mungall K, Norbertczak H, Quail MA, Rabbinowitsch E, Walker D, White B, Whitehead S, Small PL, Brosch R, Ramakrishnan L, Fischbach MA, Parkhill J, Cole ST. Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis. Genome Res. 2008 May; 18(5):729-41.
        View in: PubMed PMC2336800
      54. Fischbach MA, Walsh CT, Clardy J. The evolution of gene collectives: How natural selection drives chemical innovation. Proc Natl Acad Sci U S A. 2008 Mar 25; 105(12):4601-8.
        View in: PubMed PMC2290807
      55. Walsh CT, Fischbach MA. Inhibitors of sterol biosynthesis as Staphylococcus aureus antibiotics. Angew Chem Int Ed Engl. 2008; 47(31):5700-2.
        View in: PubMed PMC2603329
      56. Nolan EM, Fischbach MA, Koglin A, Walsh CT. Biosynthetic tailoring of microcin E492m: post-translational modification affords an antibacterial siderophore-peptide conjugate. J Am Chem Soc. 2007 Nov 21; 129(46):14336-47.
        View in: PubMed PMC2522288
      57. Fischbach MA, Lai JR, Roche ED, Walsh CT, Liu DR. Directed evolution can rapidly improve the activity of chimeric assembly-line enzymes. Proc Natl Acad Sci U S A. 2007 Jul 17; 104(29):11951-6.
        View in: PubMed PMC1924594
      58. Fischbach MA, Clardy J. One pathway, many products. Nat Chem Biol. 2007 Jul; 3(7):353-5.
        View in: PubMed
      59. Butcher RA, Schroeder FC, Fischbach MA, Straight PD, Kolter R, Walsh CT, Clardy J. The identification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis. Proc Natl Acad Sci U S A. 2007 Jan 30; 104(5):1506-9.
        View in: PubMed PMC1785240
      60. Straight PD, Fischbach MA, Walsh CT, Rudner DZ, Kolter R. A singular enzymatic megacomplex from Bacillus subtilis. Proc Natl Acad Sci U S A. 2007 Jan 2; 104(1):305-10.
        View in: PubMed PMC1765455
      61. Clardy J, Fischbach MA, Walsh CT. New antibiotics from bacterial natural products. Nat Biotechnol. 2006 Dec; 24(12):1541-50.
        View in: PubMed
      62. Fischbach MA, Walsh CT. Biochemistry. Directing biosynthesis. Science. 2006 Oct 27; 314(5799):603-5.
        View in: PubMed
      63. Fischbach MA, Lin H, Zhou L, Yu Y, Abergel RJ, Liu DR, Raymond KN, Wanner BL, Strong RK, Walsh CT, Aderem A, Smith KD. The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2. Proc Natl Acad Sci U S A. 2006 Oct 31; 103(44):16502-7.
        View in: PubMed PMC1637611
      64. Lai JR, Fischbach MA, Liu DR, Walsh CT. Localized protein interaction surfaces on the EntB carrier protein revealed by combinatorial mutagenesis and selection. J Am Chem Soc. 2006 Aug 30; 128(34):11002-3.
        View in: PubMed
      65. Larsen NA, Lin H, Wei R, Fischbach MA, Walsh CT. Structural characterization of enterobactin hydrolase IroE. Biochemistry. 2006 Aug 29; 45(34):10184-90.
        View in: PubMed
      66. Jin M, Fischbach MA, Clardy J. A biosynthetic gene cluster for the acetyl-CoA carboxylase inhibitor andrimid. J Am Chem Soc. 2006 Aug 23; 128(33):10660-1.
        View in: PubMed PMC2529255
      67. Fischbach MA, Walsh CT. Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms. Chem Rev. 2006 Aug; 106(8):3468-96.
        View in: PubMed
      68. Lin H, Fischbach MA, Gatto GJ, Liu DR, Walsh CT. Bromoenterobactins as potent inhibitors of a pathogen-associated, siderophore-modifying C-glycosyltransferase. J Am Chem Soc. 2006 Jul 26; 128(29):9324-5.
        View in: PubMed
      69. Sharma SV, Fischbach MA, Haber DA, Settleman J. "Oncogenic shock": explaining oncogene addiction through differential signal attenuation. Clin Cancer Res. 2006 Jul 15; 12(14 Pt 2):4392s-4395s.
        View in: PubMed
      70. Lai JR, Fischbach MA, Liu DR, Walsh CT. A protein interaction surface in nonribosomal peptide synthesis mapped by combinatorial mutagenesis and selection. Proc Natl Acad Sci U S A. 2006 Apr 4; 103(14):5314-9.
        View in: PubMed PMC1459352
      71. Fischbach MA, Lin H, Liu DR, Walsh CT. How pathogenic bacteria evade mammalian sabotage in the battle for iron. Nat Chem Biol. 2006 Mar; 2(3):132-8.
        View in: PubMed
      72. Luo M, Lin H, Fischbach MA, Liu DR, Walsh CT, Groves JT. Enzymatic tailoring of enterobactin alters membrane partitioning and iron acquisition. ACS Chem Biol. 2006 Feb 17; 1(1):29-32.
        View in: PubMed
      73. Dorrestein PC, Blackhall J, Straight PD, Fischbach MA, Garneau-Tsodikova S, Edwards DJ, McLaughlin S, Lin M, Gerwick WH, Kolter R, Walsh CT, Kelleher NL. Activity screening of carrier domains within nonribosomal peptide synthetases using complex substrate mixtures and large molecule mass spectrometry. Biochemistry. 2006 Feb 14; 45(6):1537-46.
        View in: PubMed PMC2565507
      74. Fischbach MA, Settleman J. Regulation of the nucleotide state of oncogenic ras proteins by nucleoside diphosphate kinase. Methods Enzymol. 2006; 407:33-45.
        View in: PubMed
      75. Garstecki P, J Fuerstman M, Fischbach MA, Sia SK, Whitesides GM. Mixing with bubbles: a practical technology for use with portable microfluidic devices. Lab Chip. 2006 Feb; 6(2):207-12.
        View in: PubMed
      76. Lin H, Fischbach MA, Liu DR, Walsh CT. In vitro characterization of salmochelin and enterobactin trilactone hydrolases IroD, IroE, and Fes. J Am Chem Soc. 2005 Aug 10; 127(31):11075-84.
        View in: PubMed PMC2536649
      77. Fischbach MA, Lin H, Liu DR, Walsh CT. In vitro characterization of IroB, a pathogen-associated C-glycosyltransferase. Proc Natl Acad Sci U S A. 2005 Jan 18; 102(3):571-6.
        View in: PubMed PMC545562
      78. Wolfe DB, Conroy RS, Garstecki P, Mayers BT, Fischbach MA, Paul KE, Prentiss M, Whitesides GM. Dynamic control of liquid-core/liquid-cladding optical waveguides. Proc Natl Acad Sci U S A. 2004 Aug 24; 101(34):12434-8.
        View in: PubMed PMC515079
      79. Fischbach MA, Settleman J. Specific biochemical inactivation of oncogenic Ras proteins by nucleoside diphosphate kinase. Cancer Res. 2003 Jul 15; 63(14):4089-94.
        View in: PubMed
      80. Pouchot J, Ruperto N, Lemelle I, Sommelet D, Grouteau E, David L, Duquesne A, Job Deslandre C, Kone Paut I, Pillet P, Goumy L, Barbier C, Guyot MH, Mazingue F, Gandon Laloum S, Fischbach M, Quartier P, Guyot C, Jean S, Le Gall E, Plouvier E, Bost M, de Lumley L, LePlège A, Larbre JP, Guillemin F, Coste J, Landgraf JM, Prieur AM. The French version of the Childhood Health Assessment Questionnaire (CHAQ) and the Child Health Questionnaire (CHQ). Clin Exp Rheumatol. 2001 Jul-Aug; 19(4 Suppl 23):S60-5.
        View in: PubMed
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