Michael Fischbach, PhD
|School||UCSF School of Pharmacy|
|Address||1700 4th Street|
San Francisco CA 94158
School or Department
|University of California, San Francisco||Residency |
||2015||Opportunity Award, Program for Breakthrough Biomedical Research|
|Global Probiotics Council||2010||Young Investigator Grant For Probiotics Research|
||2016||New Innovator Award|
|W.M. Keck Foundation||2011
||2014||Medical Research Award|
|David and Lucile Packard Foundation||2011
||2016||Fellowship for Science and Engineering|
Natural products -- small molecules from microbes -- are used widely in the clinic as antibiotics, anticancer agents, immunosuppressants, and cholesterol-lowering drugs. Dr. Michael Fischbach focuses on three emerging principles that are changing our understanding of which microbes make natural products, what roles they play in the biology of their producers, and how best to discover them:
1) Natural products are produced by the human microbiome. He is currently mining gut- and skin-associated bacteria for natural products that play important roles in human physiology and disease.
2) Natural products mediate interactions among microbial species and between microbes and multicellular organisms. Michael is particularly interested in the mechanisms by which natural products from the human microbiome mediate interspecies interactions.
3) Connecting natural products to the genes that encode them accelerates discovery. Michael is developing a bioinformatic algorithm that automatically identifies clusters of small molecule- producing genes in bacterial genomes.
Chemistry, Chemical Biology, Microbiology, Human Microbiome, Genetics, Genomics, Biochemistry, Natural Products, Drug Discovery, Antibiotics, Biosynthesis, Metabolism, Bioengineering, Therapeutics
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