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    Michael Grabe, PhD

    TitleAssociate Professor
    SchoolUCSF School of Medicine
    DepartmentCardiovascular Research Inst
    Address555 Mission Bay Blvd South
    San Francisco CA 94158
    Phone415-502-2874
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      Collapse Biography 
      Collapse Awards and Honors
      Oakland Planning and Development Corporation, Pittsburgh, PA2012Shining Star Award (for community service)
      University of Pittsburgh2011Senior Vice Chancellor's Research Seminar
      NSF2009 - 2014CAREER Award
      Sloan Foundation2009 - 2011Alfred P. Sloan Research Fellow in Molecular Biology
      University of California, Berkeley1997 - 1998Outstanding Graduate Student Instructor

      Collapse Overview 
      Collapse Overview
      The Grabe lab uses computational methods to understand biological phenomena. We are primarily interested in ion and small molecule transport across cellular membranes. We wish to understand the molecular workings of ion channels and transporters as well as how these proteins work together to regulate ion homeostasis in excitable cells and intracellular organelles such as the lysosome. We are also interested in the role that membrane proteins play in controlling the intrinsic shape of organelles.


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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Bethel NP, Grabe M. Atomistic insight into lipid translocation by a TMEM16 scramblase. Proc Natl Acad Sci U S A. 2016 Nov 21. PMID: 27872308.
        View in: PubMed
      2. Adelman JL, Ghezzi C, Bisignano P, Loo DD, Choe S, Abramson J, Rosenberg JM, Wright EM, Grabe M. Stochastic steps in secondary active sugar transport. Proc Natl Acad Sci U S A. 2016 Jul 5; 113(27):E3960-6. PMID: 27325773.
        View in: PubMed
      3. Veshaguri S, Christensen SM, Kemmer GC, Ghale G, Møller MP, Lohr C, Christensen AL, Justesen BH, Jørgensen IL, Schiller J, Hatzakis NS, Grabe M, Pomorski TG, Stamou D. Direct observation of proton pumping by a eukaryotic P-type ATPase. Science. 2016 Mar 25; 351(6280):1469-73. PMID: 27013734.
        View in: PubMed
      4. Argudo D, Bethel NP, Marcoline FV, Grabe M. Continuum descriptions of membranes and their interaction with proteins: Towards chemically accurate models. Biochim Biophys Acta. 2016 Jul; 1858(7 Pt B):1619-34. PMID: 26853937.
        View in: PubMed
      5. Marcoline FV, Bethel N, Guerriero CJ, Brodsky JL, Grabe M. Membrane Protein Properties Revealed through Data-Rich Electrostatics Calculations. Structure. 2015 Aug 4; 23(8):1526-37. PMID: 26118532; PMCID: PMC4527966 [Available on 08/04/16].
      6. Adelman JL, Grabe M. Simulating Current-Voltage Relationships for a Narrow Ion Channel Using the Weighted Ensemble Method. J Chem Theory Comput. 2015 Apr 14; 11(4):1907-18. PMID: 26392816.
        View in: PubMed
      7. Zwier MC, Adelman JL, Kaus JW, Pratt AJ, Wong KF, Rego NB, Suárez E, Lettieri S, Wang DW, Grabe M, Zuckerman DM, Chong LT. WESTPA: an interoperable, highly scalable software package for weighted ensemble simulation and analysis. J Chem Theory Comput. 2015 Feb 10; 11(2):800-9. PMID: 26392815; PMCID: PMC4573570.
      8. Joh NH, Wang T, Bhate MP, Acharya R, Wu Y, Grabe M, Hong M, Grigoryan G, DeGrado WF. De novo design of a transmembrane Zn²?-transporting four-helix bundle. Science. 2014 Dec 19; 346(6216):1520-4. PMID: 25525248; PMCID: PMC4400864.
      9. Choudhary OP, Paz A, Adelman JL, Colletier JP, Abramson J, Grabe M. Structure-guided simulations illuminate the mechanism of ATP transport through VDAC1. Nat Struct Mol Biol. 2014 Jul; 21(7):626-32. PMID: 24908397; PMCID: PMC4157756.
      10. Hong T, Yang H, Zhang SS, Cho HC, Kalashnikova M, Sun B, Zhang H, Bhargava A, Grabe M, Olgin J, Gorelik J, Marbán E, Jan LY, Shaw RM. Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia. Nat Med. 2014 Jun; 20(6):624-32. PMID: 24836577; PMCID: PMC4048325.
      11. Latorraca NR, Callenberg KM, Boyle JP, Grabe M. Continuum approaches to understanding ion and peptide interactions with the membrane. J Membr Biol. 2014 May; 247(5):395-408. PMID: 24652510; PMCID: PMC4096575.
      12. Adelman JL, Sheng Y, Choe S, Abramson J, Wright EM, Rosenberg JM, Grabe M. Structural determinants of water permeation through the sodium-galactose transporter vSGLT. Biophys J. 2014 Mar 18; 106(6):1280-9. PMID: 24655503; PMCID: PMC3984995.
      13. Mukherjee S, Zheng H, Derebe MG, Callenberg KM, Partch CL, Rollins D, Propheter DC, Rizo J, Grabe M, Jiang QX, Hooper LV. Antibacterial membrane attack by a pore-forming intestinal C-type lectin. Nature. 2014 Jan 2; 505(7481):103-7. PMID: 24256734; PMCID: PMC4160023.
      14. Ishida Y, Nayak S, Mindell JA, Grabe M. A model of lysosomal pH regulation. J Gen Physiol. 2013 Jun; 141(6):705-20. PMID: 23712550; PMCID: PMC3664703.
      15. Adelman JL, Grabe M. Simulating rare events using a weighted ensemble-based string method. J Chem Phys. 2013 Jan 28; 138(4):044105. PMID: 23387566; PMCID: PMC3568092.
      16. Callenberg KM, Latorraca NR, Grabe M. Membrane bending is critical for the stability of voltage sensor segments in the membrane. J Gen Physiol. 2012 Jul; 140(1):55-68. PMID: 22732310; PMCID: PMC3382720.
      17. Adelman JL, Dale AL, Zwier MC, Bhatt D, Chong LT, Zuckerman DM, Grabe M. Simulations of the alternating access mechanism of the sodium symporter Mhp1. Biophys J. 2011 Nov 16; 101(10):2399-407. PMID: 22098738; PMCID: PMC3218348.
      18. Cantalupo PG, Calgua B, Zhao G, Hundesa A, Wier AD, Katz JP, Grabe M, Hendrix RW, Girones R, Wang D, Pipas JM. Raw sewage harbors diverse viral populations. MBio. 2011; 2(5). PMID: 21972239; PMCID: PMC3187576.
      19. Watanabe A, Choe S, Chaptal V, Rosenberg JM, Wright EM, Grabe M, Abramson J. The mechanism of sodium and substrate release from the binding pocket of vSGLT. Nature. 2010 Dec 16; 468(7326):988-91. PMID: 21131949; PMCID: PMC3736980.
      20. Kashlan OB, Adelman JL, Okumura S, Blobner BM, Zuzek Z, Hughey RP, Kleyman TR, Grabe M. Constraint-based, homology model of the extracellular domain of the epithelial Na+ channel a subunit reveals a mechanism of channel activation by proteases. J Biol Chem. 2011 Jan 7; 286(1):649-60. PMID: 20974852; PMCID: PMC3013024.
      21. Choe S, Rosenberg JM, Abramson J, Wright EM, Grabe M. Water permeation through the sodium-dependent galactose cotransporter vSGLT. Biophys J. 2010 Oct 6; 99(7):L56-8. PMID: 20923633; PMCID: PMC3042592.
      22. Callenberg KM, Choudhary OP, de Forest GL, Gohara DW, Baker NA, Grabe M. APBSmem: a graphical interface for electrostatic calculations at the membrane. PLoS One. 2010; 5(9). PMID: 20949122; PMCID: PMC2947494.
      23. Bailey MA, Grabe M, Devor DC. Characterization of the PCMBS-dependent modification of KCa3.1 channel gating. J Gen Physiol. 2010 Oct; 136(4):367-87. PMID: 20837673; PMCID: PMC2947057.
      24. Kashlan OB, Boyd CR, Argyropoulos C, Okumura S, Hughey RP, Grabe M, Kleyman TR. Allosteric inhibition of the epithelial Na+ channel through peptide binding at peripheral finger and thumb domains. J Biol Chem. 2010 Nov 5; 285(45):35216-23. PMID: 20817728; PMCID: PMC2966135.
      25. Choudhary OP, Ujwal R, Kowallis W, Coalson R, Abramson J, Grabe M. The electrostatics of VDAC: implications for selectivity and gating. J Mol Biol. 2010 Feb 26; 396(3):580-92. PMID: 20005234; PMCID: PMC3736979.
      26. Choe S, Grabe M. Conformational dynamics of the inner pore helix of voltage-gated potassium channels. J Chem Phys. 2009 Jun 7; 130(21):215103. PMID: 19508102.
        View in: PubMed
      27. Choe S, Hecht KA, Grabe M. A continuum method for determining membrane protein insertion energies and the problem of charged residues. J Gen Physiol. 2008 Jun; 131(6):563-73. PMID: 18474636; PMCID: PMC2391250.
      28. Krzysiak TC, Grabe M, Gilbert SP. Getting in sync with dimeric Eg5. Initiation and regulation of the processive run. J Biol Chem. 2008 Jan 25; 283(4):2078-87. PMID: 18037705; PMCID: PMC2265775.
      29. Grabe M, Lai HC, Jain M, Jan YN, Jan LY. Structure prediction for the down state of a potassium channel voltage sensor. Nature. 2007 Feb 1; 445(7127):550-3. PMID: 17187053.
        View in: PubMed
      30. Bichet D, Grabe M, Jan YN, Jan LY. Electrostatic interactions in the channel cavity as an important determinant of potassium channel selectivity. Proc Natl Acad Sci U S A. 2006 Sep 26; 103(39):14355-60. PMID: 16983069; PMCID: PMC1570129.
      31. Grabe M, Bichet D, Qian X, Jan YN, Jan LY. K+ channel selectivity depends on kinetic as well as thermodynamic factors. Proc Natl Acad Sci U S A. 2006 Sep 26; 103(39):14361-6. PMID: 16983068; PMCID: PMC1570128.
      32. Nayak S, Olkin I, Liu H, Grabe M, Gould MK, Allen IE, Owens DK, Bravata DM. Meta-analysis: accuracy of quantitative ultrasound for identifying patients with osteoporosis. Ann Intern Med. 2006 Jun 6; 144(11):832-41. PMID: 16754925.
        View in: PubMed
      33. Lai HC, Grabe M, Jan YN, Jan LY. The S4 voltage sensor packs against the pore domain in the KAT1 voltage-gated potassium channel. Neuron. 2005 Aug 4; 47(3):395-406. PMID: 16055063.
        View in: PubMed
      34. Grabe M, Lecar H, Jan YN, Jan LY. A quantitative assessment of models for voltage-dependent gating of ion channels. Proc Natl Acad Sci U S A. 2004 Dec 21; 101(51):17640-5. PMID: 15591352; PMCID: PMC539724.
      35. Lecar H, Larsson HP, Grabe M. Electrostatic model of S4 motion in voltage-gated ion channels. Biophys J. 2003 Nov; 85(5):2854-64. PMID: 14581190; PMCID: PMC1303566.
      36. Cohen BE, Grabe M, Jan LY. Answers and questions from the KvAP structures. Neuron. 2003 Jul 31; 39(3):395-400. PMID: 12895415.
        View in: PubMed
      37. Grabe M, Neu J, Oster G, Nollert P. Protein interactions and membrane geometry. Biophys J. 2003 Feb; 84(2 Pt 1):854-68. PMID: 12547769; PMCID: PMC1302665.
      38. Curry WB, Grabe MD, Kurnikov IV, Skourtis SS, Beratan DN, Regan JJ, Aquino AJ, Beroza P, Onuchic JN. Pathways, pathway tubes, pathway docking, and propagators in electron transfer proteins. J Bioenerg Biomembr. 1995 Jun; 27(3):285-93. PMID: 8847342.
        View in: PubMed
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