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    Michael Humphreys, MD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentMedicine
    Address1001 Potrero Ave, SFGH 100
    San Francisco CA 94110
    Phone415-502-3834
    vCardDownload vCard

      Collapse Biography 
      Collapse Education and Training
      University of California, San FranciscoResidency School of Medicine
      Collapse Awards and Honors
      American Heart Association1999John Alexander, MD Research Award
      1991Elected to American Clinical and Climatological Association
      Case Western Reserve University1965Alpha Omega Alpha Society

      Collapse Overview 
      Collapse Overview
      Dr. Humphreys' primary research interest has been in sodium metabolism and the pathophysiology of edema formation and salt-sensitive hypertension. He and his colleagues identified that rodent models of sodium retention like nephrotic syndrome, liver cirrhosis, and pregnancy are characterized by resistance to the natriuretic actions of atrial natriuretic peptide (ANP), and this in turn is caused by a heightened activity of Type V phosphodiesterase (PDE), which catabolizes cGMP formed normally in renal collecting duct cells when ANP interacts with its renal receptors. Inhibition of Type V PDE restores ANP responsiveness in these models. His group has also identified a novel hormonal system involved in normal sodium metabolism in rodents. It involves a peptide hormone gamma-melanocyte stimulating hormone (g-MSH) released from the pituitary ACTH precursor proopiomelanocortin. When animals are fed a high salt diet, g-MSH synthesis and secretion are up-regulated; it acts on the kidneys to increase sodium excretion, and on the brain to dampen down sympathetic excitation which occurs with high sodium intakes. When rodents have impaired ability to increase g-MSH secretion during ingestion of the high sodium diet, or lack the melanocortinr receptor with which it interacts, marked hypertension develops, and is accompanied by insulin resistance.
      Dr. Humphreys has also done clinical research in these areas and has studied the occurrence of HIV-associated nephropathy in patients at San Francisco General Hospital. He participated in early studies measuring nitrogen balance in ESRD patients treated with hemodialysis, and was for a short time a site director for the Frequent Hemodialysis Network clinical trial.


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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Humphreys MH. Renal nerves and CKD: is renal denervation the answer? J Am Soc Nephrol. 2012 Jul; 23(7):1132-5. PMID: 22677558.
        View in: PubMed
      2. Humphreys MH. The brain splits obesity and hypertension. Nat Med. 2011 Jul; 17(7):782-3. PMID: 21738154.
        View in: PubMed
      3. Humphreys MH, Ni XP, Pearce D. Cardiovascular effects of melanocortins. Eur J Pharmacol. 2011 Jun 11; 660(1):43-52. PMID: 21199648; PMCID: PMC3086937.
      4. Sasser JM, Ni XP, Humphreys MH, Baylis C. Increased renal phosphodiesterase-5 activity mediates the blunted natriuretic response to a nitric oxide donor in the pregnant rat. Am J Physiol Renal Physiol. 2010 Oct; 299(4):F810-4. PMID: 20668100; PMCID: PMC2957261.
      5. Chen S, Grigsby CL, Law CS, Ni X, Nekrep N, Olsen K, Humphreys MH, Gardner DG. Tonicity-dependent induction of Sgk1 expression has a potential role in dehydration-induced natriuresis in rodents. J Clin Invest. 2009 Jun; 119(6):1647-58. PMID: 19436108; PMCID: PMC2689130.
      6. Ni XP, van Dijk C, Pearce D, Humphreys MH. Evidence for a noradrenergic mechanism causing hypertension and abnormal glucose metabolism in rats with relative deficiency of gamma-melanocyte-stimulating hormone. Exp Physiol. 2009 Aug; 94(8):867-76. PMID: 19429645; PMCID: PMC2853237.
      7. Ni XP, Humphreys MH. Abnormal glucose metabolism in hypertensive mice with genetically interrupted gamma-melanocyte stimulating hormone signaling fed a high-sodium diet. Am J Hypertens. 2008 Dec; 21(12):1284-7. PMID: 18802429; PMCID: PMC3035849.
      8. Ni XP, Humphreys MH. Prevention of salt-induced hypertension by an analog of gamma-melanocyte-stimulating hormone in the rat. Am J Hypertens. 2007 Aug; 20(8):862-5. PMID: 17679034.
        View in: PubMed
      9. Humphreys MH. Cardiovascular and renal actions of melanocyte-stimulating hormone peptides. Curr Opin Nephrol Hypertens. 2007 Jan; 16(1):32-8. PMID: 17143069.
        View in: PubMed
      10. Ni XP, Butler AA, Cone RD, Humphreys MH. Central receptors mediating the cardiovascular actions of melanocyte stimulating hormones. J Hypertens. 2006 Nov; 24(11):2239-46. PMID: 17053546.
        View in: PubMed
      11. Knight S, Snellen H, Humphreys M, Baylis C. Increased renal phosphodiesterase-5 activity mediates the blunted natriuretic response to ANP in the pregnant rat. Am J Physiol Renal Physiol. 2007 Feb; 292(2):F655-9. PMID: 17003222; PMCID: PMC2765210.
      12. Ni XP, Bhargava A, Pearce D, Humphreys MH. Modulation by dietary sodium intake of melanocortin 3 receptor mRNA and protein abundance in the rat kidney. Am J Physiol Regul Integr Comp Physiol. 2006 Mar; 290(3):R560-7. PMID: 16195498.
        View in: PubMed
      13. Chen S, Ni XP, Humphreys MH, Gardner DG. 1,25 dihydroxyvitamin d amplifies type a natriuretic peptide receptor expression and activity in target cells. J Am Soc Nephrol. 2005 Feb; 16(2):329-39. PMID: 15590756.
        View in: PubMed
      14. Kalantar-Zadeh K, Block G, McAllister CJ, Humphreys MH, Kopple JD. Appetite and inflammation, nutrition, anemia, and clinical outcome in hemodialysis patients. Am J Clin Nutr. 2004 Aug; 80(2):299-307. PMID: 15277149.
        View in: PubMed
      15. Ni XP, Safai M, Rishi R, Baylis C, Humphreys MH. Increased activity of cGMP-specific phosphodiesterase (PDE5) contributes to resistance to atrial natriuretic peptide natriuresis in the pregnant rat. J Am Soc Nephrol. 2004 May; 15(5):1254-60. PMID: 15100365; PMCID: PMC2756797.
      16. Kalantar-Zadeh K, Kopple JD, Humphreys MH, Block G. Comparing outcome predictability of markers of malnutrition-inflammation complex syndrome in haemodialysis patients. Nephrol Dial Transplant. 2004 Jun; 19(6):1507-19. PMID: 15069177.
        View in: PubMed
      17. Humphreys MH. Gamma-MSH, sodium metabolism, and salt-sensitive hypertension. Am J Physiol Regul Integr Comp Physiol. 2004 Mar; 286(3):R417-30. PMID: 14761863.
        View in: PubMed
      18. Kalantar-Zadeh K, Block G, Humphreys MH, McAllister CJ, Kopple JD. A low, rather than a high, total plasma homocysteine is an indicator of poor outcome in hemodialysis patients. J Am Soc Nephrol. 2004 Feb; 15(2):442-53. PMID: 14747392.
        View in: PubMed
      19. Kalantar-Zadeh K, Rodriguez RA, Humphreys MH. Association between serum ferritin and measures of inflammation, nutrition and iron in haemodialysis patients. Nephrol Dial Transplant. 2004 Jan; 19(1):141-9. PMID: 14671049.
        View in: PubMed
      20. Mayan H, Ni XP, Almog S, Humphreys MH. Suppression of gamma-melanocyte-stimulating hormone secretion is accompanied by salt-sensitive hypertension in the rat. Hypertension. 2003 Nov; 42(5):962-7. PMID: 14568996.
        View in: PubMed
      21. Ni XP, Pearce D, Butler AA, Cone RD, Humphreys MH. Genetic disruption of gamma-melanocyte-stimulating hormone signaling leads to salt-sensitive hypertension in the mouse. J Clin Invest. 2003 Apr; 111(8):1251-8. PMID: 12697744; PMCID: PMC152936.
      22. Kalantar-Zadeh K, Block G, Humphreys MH, Kopple JD. Reverse epidemiology of cardiovascular risk factors in maintenance dialysis patients. Kidney Int. 2003 Mar; 63(3):793-808. PMID: 12631061.
        View in: PubMed
      23. Chen S, Cao L, Intengan HD, Humphreys M, Gardner DG. Osmoregulation of endothelial nitric-oxide synthase gene expression in inner medullary collecting duct cells. Role in activation of the type A natriuretic peptide receptor. J Biol Chem. 2002 Sep 6; 277(36):32498-504. PMID: 12082097.
        View in: PubMed
      24. Kalantar-Zadeh K, Kopple JD, Block G, Humphreys MH. Association among SF36 quality of life measures and nutrition, hospitalization, and mortality in hemodialysis. J Am Soc Nephrol. 2001 Dec; 12(12):2797-806. PMID: 11729250.
        View in: PubMed
      25. Kalantar-Zadeh K, Kopple JD, Block G, Humphreys MH. A malnutrition-inflammation score is correlated with morbidity and mortality in maintenance hemodialysis patients. Am J Kidney Dis. 2001 Dec; 38(6):1251-63. PMID: 11728958.
        View in: PubMed
      26. Chandramohan G, Ni XP, Kalinyak JE, Humphreys MH. Dietary sodium modulates mRNA abundance of enzymes involved in pituitary processing of proopiomelanocortin. Pituitary. 2001 Sep; 4(4):231-7. PMID: 12501973.
        View in: PubMed
      27. Ni XP, Safai M, Gardner DG, Humphreys MH. Increased cGMP phosphodiesterase activity mediates renal resistance to ANP in rats with bile duct ligation. Kidney Int. 2001 Apr; 59(4):1264-73. PMID: 11260387.
        View in: PubMed
      28. Humphreys MH. Salt intake and body fluid volumes: have we learned all there is to know? Am J Kidney Dis. 2001 Mar; 37(3):648-52. PMID: 11228194.
        View in: PubMed
      29. Kalantar-Zadeh K, Don BR, Rodriguez RA, Humphreys MH. Serum ferritin is a marker of morbidity and mortality in hemodialysis patients. Am J Kidney Dis. 2001 Mar; 37(3):564-72. PMID: 11228181.
        View in: PubMed
      30. Berkhin EB, Humphreys MH. Regulation of renal tubular secretion of organic compounds. Kidney Int. 2001 Jan; 59(1):17-30. PMID: 11135053.
        View in: PubMed
      31. Kalantar-Zadeh K, Block G, Kelly MP, Schroepfer C, Rodriguez RA, Humphreys MH. Near infra-red interactance for longitudinal assessment of nutrition in dialysis patients. J Ren Nutr. 2001 Jan; 11(1):23-31. PMID: 11172450.
        View in: PubMed
      32. Facchini FS, Humphreys MH, DoNascimento CA, Abbasi F, Reaven GM. Relation between insulin resistance and plasma concentrations of lipid hydroperoxides, carotenoids, and tocopherols. Am J Clin Nutr. 2000 Sep; 72(3):776-9. PMID: 10966898.
        View in: PubMed
      33. Abbasi F, Facchini F, Humphreys MH, Reaven GM. Plasma homocysteine concentrations in healthy volunteers are not related to differences in insulin-mediated glucose disposal. Atherosclerosis. 1999 Sep; 146(1):175-8. PMID: 10487501.
        View in: PubMed
      34. Jayasekara D, Aweeka FT, Rodriguez R, Kalayjian RC, Humphreys MH, Gambertoglio JG. Antiviral therapy for HIV patients with renal insufficiency. J Acquir Immune Defic Syndr. 1999 Aug 15; 21(5):384-95. PMID: 10458619.
        View in: PubMed
      35. Kalantar-Zadeh K, Luft FC, Humphreys MH. Moderately high serum ferritin concentration is not a sign of iron overload in dialysis patients. Kidney Int. 1999 Aug; 56(2):758-9. PMID: 10432420.
        View in: PubMed
      36. Facchini F, Humphreys MH, Jeppesen J, Reaven GM. Measurements of insulin-mediated glucose disposal are stable over time. J Clin Endocrinol Metab. 1999 May; 84(5):1567-9. PMID: 10323381.
        View in: PubMed
      37. Facchini FS, DoNascimento C, Reaven GM, Yip JW, Ni XP, Humphreys MH. Blood pressure, sodium intake, insulin resistance, and urinary nitrate excretion. Hypertension. 1999 Apr; 33(4):1008-12. PMID: 10205239.
        View in: PubMed
      38. Brody SR, Humphreys MH, Gambertoglio JG, Schoenfeld P, Cundy KC, Aweeka FT. Pharmacokinetics of cidofovir in renal insufficiency and in continuous ambulatory peritoneal dialysis or high-flux hemodialysis. Clin Pharmacol Ther. 1999 Jan; 65(1):21-8. PMID: 9951427.
        View in: PubMed
      39. Cao L, Chen SC, Cheng T, Humphreys MH, Gardner DG. Ligand-dependent regulation of NPR-A gene expression in inner medullary collecting duct cells. Am J Physiol. 1998 Jul; 275(1 Pt 2):F119-25. PMID: 9689013.
        View in: PubMed
      40. Ni XP, Kesterson RA, Sharma SD, Hruby VJ, Cone RD, Wiedemann E, Humphreys MH. Prevention of reflex natriuresis after acute unilateral nephrectomy by melanocortin receptor antagonists. Am J Physiol. 1998 Apr; 274(4 Pt 2):R931-8. PMID: 9575953.
        View in: PubMed
      41. Valentin JP, Ying WZ, Couser WG, Humphreys MH. Extrarenal resistance to atrial natriuretic peptide in rats with experimental nephrotic syndrome. Am J Physiol. 1998 Mar; 274(3 Pt 2):F556-63. PMID: 9530272.
        View in: PubMed
      42. Valentin JP, Mazbar SA, Humphreys MH. Long-term captopril treatment restores natriuresis after carotid baroreceptor activation in the SHR. Am J Physiol. 1997 Jul; 273(1 Pt 2):R70-9. PMID: 9249534.
        View in: PubMed
      43. Chen XW, Ying WZ, Valentin JP, Ling KT, Lin SY, Wiedemann E, Humphreys MH. Mechanism of the natriuretic action of gamma-melanocyte-stimulating hormone. Am J Physiol. 1997 Jun; 272(6 Pt 2):R1946-53. PMID: 9227612.
        View in: PubMed
      44. Valentin JP, Sechi LA, Griffin CA, Humphreys MH, Schambelan M. The renin-angiotensin system and compensatory renal hypertrophy in the rat. Am J Hypertens. 1997 Apr; 10(4 Pt 1):397-402. PMID: 9128205.
        View in: PubMed
      45. Ni X, Cheng Y, Cao L, Gardner DG, Humphreys MH. Mechanisms contributing to renal resistance to atrial natriuretic peptide in rats with common bile-duct ligation. J Am Soc Nephrol. 1996 Oct; 7(10):2110-8. PMID: 8915970.
        View in: PubMed
      46. Mayan H, Ling KT, Lee EY, Wiedemann E, Kalinyak JE, Humphreys MH. Dietary sodium intake modulates pituitary proopiomelanocortin mRNA abundance. Hypertension. 1996 Aug; 28(2):244-9. PMID: 8707389.
        View in: PubMed
      47. Lee EY, Humphreys MH. Phosphodiesterase activity as a mediator of renal resistance to ANP in pathological salt retention. Am J Physiol. 1996 Jul; 271(1 Pt 2):F3-6. PMID: 8760236.
        View in: PubMed
      48. Valentin JP, Ying WZ, Sechi LA, Ling KT, Qiu C, Couser WG, Humphreys MH. Phosphodiesterase inhibitors correct resistance to natriuretic peptides in rats with Heymann Nephritis. J Am Soc Nephrol. 1996 Apr; 7(4):582-93. PMID: 8724892.
        View in: PubMed
      49. Humphreys MH. Human immunodeficiency virus-associated glomerulosclerosis. Kidney Int. 1995 Aug; 48(2):311-20. PMID: 7564098.
        View in: PubMed
      50. Sechi LA, Valentin JP, Griffin CA, Lee E, Bartoli E, Humphreys MH, Schambelan M. Receptors for atrial natriuretic peptide are decreased in the kidney of rats with streptozotocin-induced diabetes mellitus. J Clin Invest. 1995 Jun; 95(6):2451-7. PMID: 7769090; PMCID: PMC295920.
      51. Valentin JP, Qiu C, Wiedemann E, Gardner DG, Humphreys MH. Modulation of ANP-dependent effects of endothelin by inhibitors of neutral endopeptidase and cGMP phosphodiesterase. J Pharmacol Exp Ther. 1995 May; 273(2):744-52. PMID: 7752077.
        View in: PubMed
      52. Valentin JP, Sechi LA, Humphreys MH. [Resistance to hemoconcentration but non hypotensive action of atrial natriuretic peptide in diabetes mellitus induced by streptozocin in the rat]. Arch Mal Coeur Vaiss. 1994 Aug; 87(8):1119-23. PMID: 7755472.
        View in: PubMed
      53. Valentin JP, Sechi LA, Griffin CA, Humphreys MH, Schambelan M. [Gene expression of the renin-angiotensin system in compensatory renal hypertrophy secondary to contralateral nephrectomy]. Arch Mal Coeur Vaiss. 1994 Aug; 87(8):1115-7. PMID: 7755471.
        View in: PubMed
      54. Valentin JP, Ying WZ, Sechi LA, Humphreys MH. [Resistance to the action of atrial natriuretic peptide and urodilatin in Heymann nephritis in vitro]. Arch Mal Coeur Vaiss. 1994 Aug; 87(8):1125-9. PMID: 7755473.
        View in: PubMed
      55. Valentin JP, Sechi LA, Humphreys MH. Blunted effect of ANP on hematocrit and plasma volume in streptozotocin-induced diabetes mellitus in rats. Am J Physiol. 1994 Feb; 266(2 Pt 2):R584-91. PMID: 8141419.
        View in: PubMed
      56. Humphreys MH. Mechanisms and management of nephrotic edema. Kidney Int. 1994 Jan; 45(1):266-81. PMID: 8127018.
        View in: PubMed
      57. Humphreys MH, Lin SY, Ying WZ, Wiedemann E. A gamma-melanocyte stimulating hormone and postnephrectomy natriuresis. Hypertension. 1993 Dec; 22(6):934-5. PMID: 8244525.
        View in: PubMed
      58. Valentin JP, Sechi LA, Griffin CA, Humphreys MH, Schambelan M. Renin-angiotensin system gene expression during compensatory renal hypertrophy in the rat. J Hypertens Suppl. 1993 Dec; 11(5):S236-7. PMID: 8158362.
        View in: PubMed
      59. Valentin JP, Ying WZ, Sechi LA, Humphreys MH. Atrial natriuretic peptide and blunted renal responses to volume expansion in rats with Heymann nephritis. J Hypertens Suppl. 1993 Dec; 11(5):S218-9. PMID: 8158353.
        View in: PubMed
      60. Humphreys MH, Wiedemann E, Valentin JP, Chen XW, Ying WZ. Natriuretic actions of gamma-melanocyte-stimulating hormone. Ann N Y Acad Sci. 1993 May 31; 680:545-8. PMID: 8390189.
        View in: PubMed
      61. Valentin JP, Sechi LA, Qui C, Schambelan M, Humphreys MH. Urodilatin binds to and activates renal receptors for atrial natriuretic peptide. Hypertension. 1993 Apr; 21(4):432-8. PMID: 8384600.
        View in: PubMed
      62. Humphreys MH, Valentin JP, Qiu C, Ying WZ, Muldowney WP, Gardner DG. Underfill and overflow revisited: mechanisms of nephrotic edema. Trans Am Clin Climatol Assoc. 1993; 104:47-59; discussion 59-60. PMID: 1343447; PMCID: PMC2376618.
      63. Valentin JP, Wiedemann E, Humphreys MH. Natriuretic properties of melanocyte-stimulating hormones. J Cardiovasc Pharmacol. 1993; 22 Suppl 2:S114-8. PMID: 7508015.
        View in: PubMed
      64. Valentin JP, Humphreys MH. Urodilatin: a paracrine renal natriuretic peptide. Semin Nephrol. 1993 Jan; 13(1):61-70. PMID: 8434187.
        View in: PubMed
      65. Qiu C, Valentin JP, Chen XW, Wiedemann E, Humphreys MH. Acute unilateral nephrectomy elicits a specific increase in plasma of peptides derived from the N-terminal region of proopiomelanocortin. J Am Soc Nephrol. 1992 Nov; 3(5):1105-12. PMID: 1336405.
        View in: PubMed
      66. Valentin JP, Qiu C, Muldowney WP, Ying WZ, Gardner DG, Humphreys MH. Cellular basis for blunted volume expansion natriuresis in experimental nephrotic syndrome. J Clin Invest. 1992 Oct; 90(4):1302-12. PMID: 1328296; PMCID: PMC443174.
      67. Valentin JP, Humphreys MH. [Modulating effects of atrial natriuretic peptide on vascular permeability and blood pressure by inhibition of cyclic phosphodiesterase GMP in the rat]. Arch Mal Coeur Vaiss. 1992 Aug; 85(8):1219-22. PMID: 1336359.
        View in: PubMed
      68. Valentin JP, Qiu CB, Wiedemann E, Gardner D, Humphreys MH. Inhibition of neutral endopeptidase amplifies the effects of endogenous atrial natriuretic peptide on blood pressure and fluid partition. Am J Hypertens. 1992 Feb; 5(2):88-91. PMID: 1532317.
        View in: PubMed
      69. Vannucchi MT, Vannucchi H, Humphreys M. Serum levels of vitamin A and retinol binding protein in chronic renal patients treated by continuous ambulatorial peritoneal dialysis. Int J Vitam Nutr Res. 1992; 62(2):107-12. PMID: 1517032.
        View in: PubMed
      70. Valentin JP, Mazbar SA, Humphreys MH. Natriuretic effect of intermittent bilateral carotid artery traction in the rat. J Hypertens Suppl. 1991 Dec; 9(6):S86-7. PMID: 1819022.
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      71. Frassetto L, Schoenfeld PY, Humphreys MH. Increasing incidence of human immunodeficiency virus-associated nephropathy at San Francisco General Hospital. Am J Kidney Dis. 1991 Dec; 18(6):655-9. PMID: 1962649.
        View in: PubMed
      72. Valentin JP, Gardner DG, Ribstein J, Mimran A, Humphreys MH. [Extravascular transfer of fluids and proteins induced by endothelin in the binephrectomized rat]. Arch Mal Coeur Vaiss. 1991 Aug; 84(8):1159-62. PMID: 1835358.
        View in: PubMed
      73. Valentin JP, Gardner DG, Wiedemann E, Humphreys MH. Modulation of endothelin effects on blood pressure and hematocrit by atrial natriuretic peptide. Hypertension. 1991 Jun; 17(6 Pt 2):864-9. PMID: 1828459.
        View in: PubMed
      74. Humphreys MH. Urodilatin--renal natriuretic peptide? J Am Soc Nephrol. 1991 Mar; 1(9):1057-9. PMID: 1832981.
        View in: PubMed
      75. Humphreys MH, Lin SY, Wiedemann E. Renal nerves and the natriuresis following unilateral renal exclusion in the rat. Kidney Int. 1991 Jan; 39(1):63-70. PMID: 2002634.
        View in: PubMed
      76. Mazbar SA, Wiedemann E, Humphreys MH. Mechanism of the natriuretic effect of unilateral carotid artery traction in the rat. J Am Soc Nephrol. 1990 Sep; 1(3):266-71. PMID: 2104270.
        View in: PubMed
      77. Mazbar SA, Schoenfeld PY, Humphreys MH. Renal involvement in patients infected with HIV: experience at San Francisco General Hospital. Kidney Int. 1990 May; 37(5):1325-32. PMID: 2345428.
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      78. Humphreys MH. Human immunodeficiency virus-associated nephropathy. East is east and west is west? Arch Intern Med. 1990 Feb; 150(2):253-5. PMID: 2405796.
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      79. Humphreys MH, Etheredge SB, Lin SY, Ribstein J, Marton LJ. Renal ornithine decarboxylase activity, polyamines, and compensatory renal hypertrophy in the rat. Am J Physiol. 1988 Aug; 255(2 Pt 2):F270-7. PMID: 3136663.
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      80. Humphreys MH, Lin SY. Peptide hormones and the regulation of sodium excretion. Hypertension. 1988 May; 11(5):397-410. PMID: 2966767.
        View in: PubMed
      81. Chaves C, Humphreys MH. Amplification of the natriuretic response to acute unilateral nephrectomy by volume expansion. Miner Electrolyte Metab. 1988; 14(5):277-82. PMID: 3173265.
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      82. Lin SY, Chaves C, Wiedemann E, Humphreys MH. A gamma-melanocyte stimulating hormone-like peptide causes reflex natriuresis after acute unilateral nephrectomy. Hypertension. 1987 Dec; 10(6):619-27. PMID: 3692573.
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      83. Lin SY, Wiedemann E, Deschepper CF, Alper RH, Humphreys MH. Prevention of reflex natriuresis after acute unilateral nephrectomy by neonatal administration of MSG. Am J Physiol. 1987 Feb; 252(2 Pt 2):F276-82. PMID: 3812742.
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      84. Humphreys MH, Schoenfeld PY. Renal complications in patients with the acquired immune deficiency syndrome (AIDS). Am J Nephrol. 1987; 7(1):1-7. PMID: 3555070.
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      85. Al-Bander HA, Mock DM, Etheredge SB, Paukert TT, Humphreys MH, Morris RC. Coordinately increased lysozymuria and lysosomal enzymuria induced by maleic acid. Kidney Int. 1986 Dec; 30(6):804-12. PMID: 3102828.
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      86. Humphreys MH, Lin SY, Ribstein J, Wiedemann E. Reflex responses to reductions in functioning renal mass. Fed Proc. 1985 Oct; 44(13):2840-5. PMID: 2995143.
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      87. Lin SY, Humphreys MH. Centrally administered naloxone blocks reflex natriuresis after acute unilateral nephrectomy. Am J Physiol. 1985 Sep; 249(3 Pt 2):F390-5. PMID: 3929623.
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      88. Lin SY, Wiedemann E, Humphreys MH. Role of the pituitary in reflex natriuresis following acute unilateral nephrectomy. Am J Physiol. 1985 Aug; 249(2 Pt 2):F282-90. PMID: 3161342.
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      89. Al-Bander H, Etheredge SB, Paukert T, Humphreys MH, Morris RC. Phosphate loading attenuates renal tubular dysfunction induced by maleic acid in the dog. Am J Physiol. 1985 Apr; 248(4 Pt 2):F513-21. PMID: 3985158.
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      90. Kaysen GA, Paukert TT, Menke DJ, Couser WG, Humphreys MH. Plasma volume expansion is necessary for edema formation in the rate with Heymann nephritis. Am J Physiol. 1985 Feb; 248(2 Pt 2):F247-53. PMID: 3970214.
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      91. Al-Bander H, Court SB, Humphreys MH. Determinants of the kaliuresis after acute unilateral nephrectomy in the dog. Miner Electrolyte Metab. 1985; 11(5):287-94. PMID: 4047005.
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      92. Ribstein J, Humphreys MH. Renal nerves and cation excretion after acute reduction in functioning renal mass in the rat. Am J Physiol. 1984 Mar; 246(3 Pt 2):F260-5. PMID: 6703059.
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      93. Ribstein J, Humphreys MH. Endogenous opioids and electrolyte excretion after contralateral renal exclusion. Am J Physiol. 1983 Apr; 244(4):F392-8. PMID: 6837737.
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      94. Humphreys MH, Chou LY. Anion effects on fluid absorption from rat jejunum perfused in vivo. Am J Physiol. 1983 Jan; 244(1):G33-9. PMID: 6295185.
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      95. Al-Bander HA, Weiss RA, Humphreys MH, Morris RC. Dysfunction of the proximal tubule underlies maleic acid-induced type II renal tubular acidosis. Am J Physiol. 1982 Dec; 243(6):F604-11. PMID: 7149027.
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      96. Ayus JC, Humphreys MH. Hemodynamic and renal functional changes after acute unilateral nephrectomy in the dog: role of carotid sinus baroreceptors. Am J Physiol. 1982 Feb; 242(2):F181-9. PMID: 7065134.
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      97. Cogan JJ, Humphreys MH, Carlson CJ, Benowitz NL, Rapaport E. Acute vasodilator therapy increases renal clearance of digoxin in patients with congestive heart failure. Circulation. 1981 Nov; 64(5):973-6. PMID: 7285311.
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      98. Humphreys MH, Al-Bander H, Eneas JF, Schambelan M. Factors determining electrolyte excretion and renin secretion after closure of an arteriovenous fistula in the dog. J Lab Clin Med. 1981 Jul; 98(1):89-98. PMID: 7019367.
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      99. Humphreys MH, Ayus JC, Stanton CJ. Prevention by vagotomy or atropine administration of the hemodynamic changes occurring after acute unilateral nephrectomy in the dog. Circ Res. 1980 Apr; 46(4):575-80. PMID: 7357705.
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      100. Benowitz N, Abolin C, Tozer T, Rosenberg J, Rogers W, Pond S, Schoenfeld P, Humphreys M. Resin hemoperfusion in ethychlorvynol overdose. Clin Pharmacol Ther. 1980 Feb; 27(2):236-42. PMID: 7353346.
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      101. Humphreys MH, Kaysen GA, Chou LY, Watson JB. Anion-stimulated phosphohydrolase activity of intestinal alkaline phosphatase. Am J Physiol. 1980 Jan; 238(1):G3-9. PMID: 6153512.
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      102. Andrew OT, Schoenfeld PY, Hopewell PC, Humphreys MH. Tuberculosis in patients with end-stage renal disease. Am J Med. 1980 Jan; 68(1):59-65. PMID: 7350806.
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      103. Eneas JF, Schoenfeld PY, Humphreys MH. The effect of infusion of mannitol-sodium bicarbonate on the clinical course of myoglobinuria. Arch Intern Med. 1979 Jul; 139(7):801-5. PMID: 454069.
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      104. Ayus JC, Eneas JF, Tong TG, Benowitz NL, Schoenfeld PY, Hadley KL, Becker CE, Humphreys MH. Peritoneal clearance and total body elimination of vancomycin during chronic intermittent peritoneal dialysis. Clin Nephrol. 1979 Mar; 11(3):129-32. PMID: 436339.
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      105. Humphreys MH, Reid IA. Effects of clonidine on glucose and phosphate metabolism in the anesthetized dog. J Pharmacol Exp Ther. 1979 Feb; 208(2):243-7. PMID: 762655.
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      106. Humphreys MH, Chou LY. Anion-stimulated ATPase activity of brush border from rat small intestine. Am J Physiol. 1979 Jan; 236(1):E70-6. PMID: 155403.
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      107. Borah MF, Schoenfeld PY, Gotch FA, Sargent JA, Wolfsen M, Humphreys MH. Nitrogen balance during intermittent dialysis therapy of uremia. Kidney Int. 1978 Nov; 14(5):491-500. PMID: 750694.
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      108. Sargent J, Gotch F, Borah M, Piercy L, Spinozzi N, Schoenfeld P, Humphreys M. Urea kinetics: a guide to nutritional management of renal failure. Am J Clin Nutr. 1978 Sep; 31(9):1696-702. PMID: 99022.
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      109. Humphreys MH, Ayus JC. Role of hemodynamic changes in the increased cation excretion after acute unilateral nephrectomy in the anesthetized dog. J Clin Invest. 1978 Mar; 61(3):590-6. PMID: 641140; PMCID: PMC372571.
      110. Humphreys MH. Inhibition of NaCl absorption from perfused rat ileum by furosemide. Am J Physiol. 1976 Jun; 230(6):1517-23. PMID: 937541.
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      111. Beallo R, Dallman PR, Schoenfeld PY, Humphreys MH. Serum ferritin and iron deficiency in patients on chronic hemodialysis. Trans Am Soc Artif Intern Organs. 1976; 22:73-9. PMID: 951893.
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      112. Humphreys MH, Reid IA, Ufferman RC, Lieberman RA, Earley LE. The relationship between sodium excretion and renin secretion by the perfused kidney. Proc Soc Exp Biol Med. 1975 Dec; 150(3):728-34. PMID: 1208596.
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      113. Humphreys MH, Reid IA, Chou LY. Suppression of antidiuretic hormone secretion by clonidine in the anesthetized dog. Kidney Int. 1975 Jun; 7(6):405-12. PMID: 1167185.
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      114. Earley LE, Humphreys MH, Bartoli E. Capillary circulation as a regulator of sodium reabsorption and excretion. Circ Res. 1972 Sep; 31(9):Suppl 2:1-18. PMID: 5057027.
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      115. Schrier RW, Humphreys MH. Role of distal reabsorption and peritubular environment in glomerulotubular balance. Am J Physiol. 1972 Feb; 222(2):379-87. PMID: 5058378.
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      116. Schrier RW, Humphreys MH, Ufferman RC. Role of cardiac output and the autonomic nervous system in the antinatriuretic response to acute constriction of the thoracic superior vena cava. Circ Res. 1971 Nov; 29(5):490-8. PMID: 5120614.
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      117. Schrier RW, Humphreys MH. Factors involved in antinatriuretic effects of acute constriction of the thoracic and abdominal inferior vena cava. Circ Res. 1971 Nov; 29(5):479-89. PMID: 5120613.
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      118. Humphreys MH, Earley LE. The mechanism of decreased intestinal sodium and water absorption after acute volume expansion in the rat. J Clin Invest. 1971 Nov; 50(11):2355-67. PMID: 5096520; PMCID: PMC292178.
      119. Humphreys MH, Friedler RM, Earley LE. Natrriuresis produced by vasopressin or hemorrhage during water diuresis in the dog. Am J Physiol. 1970 Sep; 219(3):658-65. PMID: 5450867.
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