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    Michael Matthes, PhD

    TitleSpecialist
    SchoolUCSF School of Medicine
    DepartmentOphthalmology
    Address10 Koret Way
    San Francisco CA 94143
    Phone415-514-4238
    vCardDownload vCard

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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Stiles M, Qi H, Sun E, Tan J, Porter H, Allegood J, Chalfant CE, Yasumura D, Matthes MT, LaVail MM, Mandal NA. Sphingolipid profile alters in retinal dystrophic P23H-1 rats and systemic FTY720 can delay retinal degeneration. J Lipid Res. 2016 May; 57(5):818-31. PMID: 26947037.
        View in: PubMed
      2. LaVail MM, Yasumura D, Matthes MT, Yang H, Hauswirth WW, Deng WT, Vollrath D. Gene Therapy for MERTK-Associated Retinal Degenerations. Adv Exp Med Biol. 2016; 854:487-93. PMID: 26427450.
        View in: PubMed
      3. Chiang WC, Joseph V, Yasumura D, Matthes MT, Lewin AS, Gorbatyuk MS, Ahern K, LaVail MM, Lin JH. Ablation of Chop Transiently Enhances Photoreceptor Survival but Does Not Prevent Retinal Degeneration in Transgenic Mice Expressing Human P23H Rhodopsin. Adv Exp Med Biol. 2016; 854:185-91. PMID: 26427410.
        View in: PubMed
      4. Vollrath D, Yasumura D, Benchorin G, Matthes MT, Feng W, Nguyen NM, Sedano CD, Calton MA, LaVail MM. Tyro3 Modulates Mertk-Associated Retinal Degeneration. PLoS Genet. 2015 Dec; 11(12):e1005723. PMID: 26656104.
        View in: PubMed
      5. Murray SF, Jazayeri A, Matthes MT, Yasumura D, Yang H, Peralta R, Watt A, Freier S, Hung G, Adamson PS, Guo S, Monia BP, LaVail MM, McCaleb ML. Allele-Specific Inhibition of Rhodopsin With an Antisense Oligonucleotide Slows Photoreceptor Cell Degeneration. Invest Ophthalmol Vis Sci. 2015 Oct 1; 56(11):6362-75. PMID: 26436889.
        View in: PubMed
      6. Alavi MV, Chiang WC, Kroeger H, Yasumura D, Matthes MT, Iwawaki T, LaVail MM, Gould DB, Lin JH. In Vivo Visualization of Endoplasmic Reticulum Stress in the Retina Using the ERAI Reporter Mouse. Invest Ophthalmol Vis Sci. 2015 Oct 1; 56(11):6961-70. PMID: 26513501; PMCID: PMC4627472 [Available on 04/01/16].
      7. Chiang WC, Kroeger H, Sakami S, Messah C, Yasumura D, Matthes MT, Coppinger JA, Palczewski K, LaVail MM, Lin JH. Robust Endoplasmic Reticulum-Associated Degradation of Rhodopsin Precedes Retinal Degeneration. Mol Neurobiol. 2015 Aug; 52(1):679-95. PMID: 25270370; PMCID: PMC4383737 [Available on 08/01/16].
      8. Li M, Yasumura D, Ma AA, Matthes MT, Yang H, Nielson G, Huang Y, Szoka FC, Lavail MM, Diamond MI. Intravitreal administration of HA-1077, a ROCK inhibitor, improves retinal function in a mouse model of huntington disease. PLoS One. 2013; 8(2):e56026. PMID: 23409115; PMCID: PMC3569418.
      9. Kroeger H, Messah C, Ahern K, Gee J, Joseph V, Matthes MT, Yasumura D, Gorbatyuk MS, Chiang WC, LaVail MM, Lin JH. Induction of endoplasmic reticulum stress genes, BiP and chop, in genetic and environmental models of retinal degeneration. Invest Ophthalmol Vis Sci. 2012 Nov; 53(12):7590-9. PMID: 23074209; PMCID: PMC3495601.
      10. McGill TJ, Prusky GT, Douglas RM, Yasumura D, Matthes MT, Lowe RJ, Duncan JL, Yang H, Ahern K, Daniello KM, Silver B, LaVail MM. Discordant anatomical, electrophysiological, and visual behavioral profiles of retinal degeneration in rat models of retinal degenerative disease. Invest Ophthalmol Vis Sci. 2012; 53(10):6232-44. PMID: 22899760; PMCID: PMC3444210.
      11. Deng WT, Dinculescu A, Li Q, Boye SL, Li J, Gorbatyuk MS, Pang J, Chiodo VA, Matthes MT, Yasumura D, Liu L, Alkuraya FS, Zhang K, Vollrath D, LaVail MM, Hauswirth WW. Tyrosine-mutant AAV8 delivery of human MERTK provides long-term retinal preservation in RCS rats. Invest Ophthalmol Vis Sci. 2012 Apr; 53(4):1895-904. PMID: 22408006; PMCID: PMC3995567.
      12. Roddy GW, Rosa RH, Oh JY, Ylostalo JH, Bartosh TJ, Choi H, Lee RH, Yasumura D, Ahern K, Nielsen G, Matthes MT, LaVail MM, Prockop DJ. Stanniocalcin-1 rescued photoreceptor degeneration in two rat models of inherited retinal degeneration. Mol Ther. 2012 Apr; 20(4):788-97. PMID: 22294148; PMCID: PMC3321604.
      13. Chen H, Tran JT, Brush RS, Saadi A, Rahman AK, Yu M, Yasumura D, Matthes MT, Ahern K, Yang H, LaVail MM, Mandal MN. Ceramide signaling in retinal degeneration. Adv Exp Med Biol. 2012; 723:553-8. PMID: 22183377; PMCID: PMC3552639.
      14. Petrs-Silva H, Yasumura D, Matthes MT, LaVail MM, Lewin AS, Hauswirth WW. Suppression of rds expression by siRNA and gene replacement strategies for gene therapy using rAAV vector. Adv Exp Med Biol. 2012; 723:215-23. PMID: 22183336; PMCID: PMC3556273.
      15. Zhao C, Yasumura D, Li X, Matthes M, Lloyd M, Nielsen G, Ahern K, Snyder M, Bok D, Dunaief JL, LaVail MM, Vollrath D. mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice. J Clin Invest. 2011 Jan; 121(1):369-83. PMID: 21135502; PMCID: PMC3007156.
      16. Duncan KG, Hosseini K, Bailey KR, Yang H, Lowe RJ, Matthes MT, Kane JP, LaVail MM, Schwartz DM, Duncan JL. Expression of reverse cholesterol transport proteins ATP-binding cassette A1 (ABCA1) and scavenger receptor BI (SR-BI) in the retina and retinal pigment epithelium. Br J Ophthalmol. 2009 Aug; 93(8):1116-20. PMID: 19304587; PMCID: PMC3541028.
      17. Lavail MM, Nishikawa S, Duncan JL, Yang H, Matthes MT, Yasumura D, Vollrath D, Overbeek PA, Ash JD, Robinson ML. Sustained delivery of NT-3 from lens fiber cells in transgenic mice reveals specificity of neuroprotection in retinal degenerations. J Comp Neurol. 2008 Dec 20; 511(6):724-35. PMID: 18925574; PMCID: PMC2702994.
      18. Pennesi ME, Nishikawa S, Matthes MT, Yasumura D, LaVail MM. The relationship of photoreceptor degeneration to retinal vascular development and loss in mutant rhodopsin transgenic and RCS rats. Exp Eye Res. 2008 Dec; 87(6):561-70. PMID: 18848932; PMCID: PMC3541029.
      19. Danciger M, Ogando D, Yang H, Matthes MT, Yu N, Ahern K, Yasumura D, Williams RW, Lavail MM. Genetic modifiers of retinal degeneration in the rd3 mouse. Invest Ophthalmol Vis Sci. 2008 Jul; 49(7):2863-9. PMID: 18344445; PMCID: PMC2574750.
      20. McGill TJ, Prusky GT, Douglas RM, Yasumura D, Matthes MT, Nune G, Donohue-Rolfe K, Yang H, Niculescu D, Hauswirth WW, Girman SV, Lund RD, Duncan JL, LaVail MM. Intraocular CNTF reduces vision in normal rats in a dose-dependent manner. Invest Ophthalmol Vis Sci. 2007 Dec; 48(12):5756-66. PMID: 18055829.
        View in: PubMed
      21. Danciger M, Yang H, Ralston R, Liu Y, Matthes MT, Peirce J, Lavail MM. Quantitative genetics of age-related retinal degeneration: a second F1 intercross between the A/J and C57BL/6 strains. Mol Vis. 2007; 13:79-85. PMID: 17277741; PMCID: PMC2503185.
      22. Paskowitz DM, Donohue-Rolfe KM, Yang H, Yasumura D, Matthes MT, Hosseini K, Graybeal CM, Nune G, Zarbin MA, Lavail MM, Duncan JL. Neurotrophic factors minimize the retinal toxicity of verteporfin photodynamic therapy. Invest Ophthalmol Vis Sci. 2007 Jan; 48(1):430-7. PMID: 17197564.
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      23. Duncan JL, Paskowitz DM, Nune GC, Yasumura D, Yang H, Matthes MT, Zarbin MA, LaVail MM. Retinal damage caused by photodynamic therapy can be reduced using BDNF. Adv Exp Med Biol. 2006; 572:297-302. PMID: 17249587.
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      24. Paskowitz DM, Nune G, Yasumura D, Yang H, Bhisitkul RB, Sharma S, Matthes MT, Zarbin MA, Lavail MM, Duncan JL. BDNF reduces the retinal toxicity of verteporfin photodynamic therapy. Invest Ophthalmol Vis Sci. 2004 Nov; 45(11):4190-6. PMID: 15505074.
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      25. Duncan JL, LaVail MM, Yasumura D, Matthes MT, Yang H, Trautmann N, Chappelow AV, Feng W, Earp HS, Matsushima GK, Vollrath D. An RCS-like retinal dystrophy phenotype in mer knockout mice. Invest Ophthalmol Vis Sci. 2003 Feb; 44(2):826-38. PMID: 12556419.
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      26. Rohrer B, Matthes MT, LaVail MM, Reichardt LF. Lack of p75 receptor does not protect photoreceptors from light-induced cell death. Exp Eye Res. 2003 Jan; 76(1):125-9. PMID: 12589782; PMCID: PMC2710113.
      27. Duncan JL, Yang H, Vollrath D, Yasumura D, Matthes MT, Trautmann N, Chappelow AV, Feng W, Earp HS, Matsushima GK, LaVail MM. Inherited retinal dystrophy in Mer knockout mice. Adv Exp Med Biol. 2003; 533:165-72. PMID: 15180261.
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      28. Anderson RE, Maude MB, McClellan M, Matthes MT, Yasumura D, LaVail MM. Low docosahexaenoic acid levels in rod outer segments of rats with P23H and S334ter rhodopsin mutations. Mol Vis. 2002 Sep 23; 8:351-8. PMID: 12355064.
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      29. Bok D, Yasumura D, Matthes MT, Ruiz A, Duncan JL, Chappelow AV, Zolutukhin S, Hauswirth W, LaVail MM. Effects of adeno-associated virus-vectored ciliary neurotrophic factor on retinal structure and function in mice with a P216L rds/peripherin mutation. Exp Eye Res. 2002 Jun; 74(6):719-35. PMID: 12126945.
        View in: PubMed
      30. Feng W, Yasumura D, Matthes MT, LaVail MM, Vollrath D. Mertk triggers uptake of photoreceptor outer segments during phagocytosis by cultured retinal pigment epithelial cells. J Biol Chem. 2002 May 10; 277(19):17016-22. PMID: 11861639.
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      31. Vollrath D, Feng W, Duncan JL, Yasumura D, D'Cruz PM, Chappelow A, Matthes MT, Kay MA, LaVail MM. Correction of the retinal dystrophy phenotype of the RCS rat by viral gene transfer of Mertk. Proc Natl Acad Sci U S A. 2001 Oct 23; 98(22):12584-9. PMID: 11592982; PMCID: PMC60097.
      32. Ren JC, Stubbs EB, Matthes MT, Yasumura D, Naash MI, LaVail MM, Peachey NS. Retinal degeneration in the nervous mutant mouse. IV. Inner retinal changes. Exp Eye Res. 2001 Mar; 72(3):243-52. PMID: 11180973.
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      33. LaVail MM, Yasumura D, Matthes MT, Drenser KA, Flannery JG, Lewin AS, Hauswirth WW. Ribozyme rescue of photoreceptor cells in P23H transgenic rats: long-term survival and late-stage therapy. Proc Natl Acad Sci U S A. 2000 Oct 10; 97(21):11488-93. PMID: 11005848; PMCID: PMC17227.
      34. Danciger M, Matthes MT, Yasamura D, Akhmedov NB, Rickabaugh T, Gentleman S, Redmond TM, La Vail MM, Farber DB. A QTL on distal chromosome 3 that influences the severity of light-induced damage to mouse photoreceptors. Mamm Genome. 2000 Jun; 11(6):422-7. PMID: 10818205.
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      35. D'Cruz PM, Yasumura D, Weir J, Matthes MT, Abderrahim H, LaVail MM, Vollrath D. Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat. Hum Mol Genet. 2000 Mar 1; 9(4):645-51. PMID: 10699188.
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      36. Chen J, Simon MI, Matthes MT, Yasumura D, LaVail MM. Increased susceptibility to light damage in an arrestin knockout mouse model of Oguchi disease (stationary night blindness) Invest Ophthalmol Vis Sci. 1999 Nov; 40(12):2978-82. PMID: 10549660.
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      37. LaVail MM, Gorrin GM, Yasumura D, Matthes MT. Increased susceptibility to constant light in nr and pcd mice with inherited retinal degenerations. Invest Ophthalmol Vis Sci. 1999 Apr; 40(5):1020-4. PMID: 10102304.
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      38. Wen R, Cheng T, Song Y, Matthes MT, Yasumura D, LaVail MM, Steinberg RH. Continuous exposure to bright light upregulates bFGF and CNTF expression in the rat retina. Curr Eye Res. 1998 May; 17(5):494-500. PMID: 9617544.
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      39. LaVail MM, Yasumura D, Matthes MT, Lau-Villacorta C, Unoki K, Sung CH, Steinberg RH. Protection of mouse photoreceptors by survival factors in retinal degenerations. Invest Ophthalmol Vis Sci. 1998 Mar; 39(3):592-602. PMID: 9501871.
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      40. LaVail MM, Matthes MT, Yasumura D, Steinberg RH. Variability in rate of cone degeneration in the retinal degeneration (rd/rd) mouse. Exp Eye Res. 1997 Jul; 65(1):45-50. PMID: 9237863.
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      41. Wen R, Song Y, Cheng T, Matthes MT, Yasumura D, LaVail MM, Steinberg RH. Injury-induced upregulation of bFGF and CNTF mRNAS in the rat retina. J Neurosci. 1995 Nov; 15(11):7377-85. PMID: 7472491.
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      42. LaVail MM, Unoki K, Yasumura D, Matthes MT, Yancopoulos GD, Steinberg RH. Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light. Proc Natl Acad Sci U S A. 1992 Dec 1; 89(23):11249-53. PMID: 1454803; PMCID: PMC50527.
      43. Faktorovich EG, Steinberg RH, Yasumura D, Matthes MT, LaVail MM. Basic fibroblast growth factor and local injury protect photoreceptors from light damage in the rat. J Neurosci. 1992 Sep; 12(9):3554-67. PMID: 1527595.
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      44. LaVail MM, Faktorovich EG, Hepler JM, Pearson KL, Yasumura D, Matthes MT, Steinberg RH. Basic fibroblast growth factor protects photoreceptors from light-induced degeneration in albino rats. Ann N Y Acad Sci. 1991; 638:341-7. PMID: 1785811.
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      45. Faktorovich EG, Steinberg RH, Yasumura D, Matthes MT, LaVail MM. Photoreceptor degeneration in inherited retinal dystrophy delayed by basic fibroblast growth factor. Nature. 1990 Sep 6; 347(6288):83-6. PMID: 2168521.
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      46. Uehara F, Matthes MT, Yasumura D, LaVail MM. Light-evoked changes in the interphotoreceptor matrix. Science. 1990 Jun 29; 248(4963):1633-6. PMID: 2194288.
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      47. Matthes MT, LaVail MM. Inherited retinal dystrophy in the RCS rat: composition of the outer segment debris zone. Prog Clin Biol Res. 1989; 314:315-30. PMID: 2608665.
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      48. Bellhorn RW, Rheinhardt JM, Burns MS, Matthes MT. Retinal degeneration in the WKY rat. Prog Clin Biol Res. 1987; 247:317-31. PMID: 3685032.
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      49. Matthes MT, Bok D. Blood vascular abnormalities in the degenerative mouse retina (C57BL/6J-rd le). Invest Ophthalmol Vis Sci. 1984 Mar; 25(3):364-9. PMID: 6698754.
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      50. Matthes MT, Basinger SF. Myeloid body associations in the frog pigment epithelium. Invest Ophthalmol Vis Sci. 1980 Mar; 19(3):298-302. PMID: 6244230.
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      51. Basinger SF, Matthes MT. The effect of long-term constant light on the frog pigment epithelium. Vision Res. 1980; 20(12):1143-9. PMID: 6973875.
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      52. Basinger S, Hoffman R, Matthes M. Photoreceptor shedding is initiated by light in the frog retina. Science. 1976 Dec 3; 194(4269):1074-6. PMID: 1086510.
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      53. Anderson RE, Lissandrello PM, Maude MB, Matthes MT. Lipids of bovine retinal pigment epithelium. Exp Eye Res. 1976 Aug; 23(2):149-57. PMID: 976364.
        View in: PubMed
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