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    Michael Ward, MD, PhD

    TitleAssistant Professor
    SchoolUCSF School of Medicine
    Address505 Parnassus Avenue
    San Francisco CA 94117
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      Collapse Biography 
      Collapse Awards and Honors
      National Institutes of Health2013 - 2018K08 Career Development Award
      American Brain Foundation2013Clinical Research Training Fellowship
      American Neurological Association2012ANA Travel Fellowship
      UCSF CTSI2012T1 Catalyst Award
      UCSF2010Flexible Residency in Neurology supported by the Shupin Endowment
      Washington University in St. Louis2006O'Leary Prize in Neuroscience (Finalist)
      Gordon Research Conference2004Gordon Conference Travel Fellowship
      Kenyon College1999Summa Cum Laude
      Kenyon College1999Phi Beta Kappa
      Barry Goldwater Foundation1997Barry Goldwater Scholarship

      Collapse Overview 
      Collapse Overview
      I am a behavioral neurologist who specializes in the diagnosis, treatment, and research of complex neurodegenerative diseases, such as Alzheimer's disease and frontotemporal dementia.

      My research focuses on understanding core mechanisms that underlie neurodegeneration, with an ultimate goal of developing novel early-stage diagnostics and therapeutics for these debilitating and currently untreatable diseases.

      Our group employs a combination of approaches involving non-invasive studies of human subjects with dementing illnesses and basic studies using mouse models of these diseases. We recently discovered that retinal neuron death occurs before cognitive changes in certain neurodegenerative diseases. Using the retina as a model system, we are studying basic mechanisms that underlie neuronal death and dysfunction in neurodegenerative conditions, and investigating whether new retinal imaging techniques might allow us to diagnose and monitor dementing illnesses at early stages.

      Collapse Interests
      Neurodegenerative Diseases, Retinal imaging, Microscopy, Neuroscience

      Collapse ORNG Applications 
      Collapse Awarded Grants

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Cho SH, Chen JA, Sayed F, Ward ME, Gao F, Nguyen TA, Krabbe G, Sohn PD, Lo I, Minami S, Devidze N, Zhou Y, Coppola G, Gan L. SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1ß. J Neurosci. 2015 Jan 14; 35(2):807-18. PMID: 25589773; PMCID: PMC4293425.
      2. Minami SS, Min SW, Krabbe G, Wang C, Zhou Y, Asgarov R, Li Y, Martens LH, Elia LP, Ward ME, Mucke L, Farese RV, Gan L. Progranulin protects against amyloid ß deposition and toxicity in Alzheimer's disease mouse models. Nat Med. 2014 Oct; 20(10):1157-64. PMID: 25261995; PMCID: PMC4196723.
      3. Michael E Ward, Alice Taubes, Robert Chen, Bruce L Miller, Chantelle F. Sephton, Jeffrey M Gelfand, John Boscardin, Lauren Herl Martens, William W. Seeley, Gang Yu, Joachim Herz, Anthony J. Filiano, Andrew E. Arrant, Erik D. Roberson, Timothy W. Kraft, Robert V Farese, Jr., Ari Green*, Li Gan.*. . Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD. Journal of Experimental Medicine. 2014.
      4. Ward ME, Taubes A, Chen R, Miller BL, Sephton CF, Gelfand JM, Minami S, Boscardin J, Martens LH, Seeley WW, Yu G, Herz J, Filiano AJ, Arrant AE, Roberson ED, Kraft TW, Farese RV, Green A, Gan L. Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD. J Exp Med. 2014 Sep 22; 211(10):1937-45. PMID: 25155018; PMCID: PMC4172214.
      5. Ward ME, Petersen RC. Glaucoma and dementia: more than meets the eye? Ann Neurol. 2013 Aug; 74(2):155-7. PMID: 23775919.
        View in: PubMed
      6. Feng Y, Ngu H, Alford SK, Ward M, Yin F, Longmore GD. a-actinin1 and 4 tyrosine phosphorylation is critical for stress fiber establishment, maintenance and focal adhesion maturation. Exp Cell Res. 2013 May 1; 319(8):1124-35. PMID: 23454549; PMCID: PMC4142059.
      7. Minami SS, Sun B, Popat K, Kauppinen T, Pleiss M, Zhou Y, Ward ME, Floreancig P, Mucke L, Desai T, Gan L. Selective targeting of microglia by quantum dots. J Neuroinflammation. 2012; 9:22. PMID: 22272874; PMCID: PMC3292839.
      8. Ward ME, Miller BL. Potential mechanisms of progranulin-deficient FTLD. J Mol Neurosci. 2011 Nov; 45(3):574-82. PMID: 21892758; PMCID: PMC3767571.
      9. Teoh H, Quan A, Lovren F, Wang G, Tirgari S, Szmitko PE, Szalai AJ, Ward ME, Verma S. Impaired endothelial function in C-reactive protein overexpressing mice. Atherosclerosis. 2008 Dec; 201(2):318-25. PMID: 18433756.
        View in: PubMed
      10. Ward ME, Toporsian M, Scott JA, Teoh H, Govindaraju V, Quan A, Wener AD, Wang G, Bevan SC, Newton DC, Marsden PA. Hypoxia induces a functionally significant and translationally efficient neuronal NO synthase mRNA variant. J Clin Invest. 2005 Nov; 115(11):3128-39. PMID: 16276418; PMCID: PMC1265848.
      11. Ward ME, Jiang H, Rao Y. Regulated formation and selection of neuronal processes underlie directional guidance of neuronal migration. Mol Cell Neurosci. 2005 Nov; 30(3):378-87. PMID: 16154761.
        View in: PubMed
      12. Kisseleva M, Feng Y, Ward M, Song C, Anderson RA, Longmore GD. The LIM protein Ajuba regulates phosphatidylinositol 4,5-bisphosphate levels in migrating cells through an interaction with and activation of PIPKI alpha. Mol Cell Biol. 2005 May; 25(10):3956-66. PMID: 15870270; PMCID: PMC1087706.
      13. Pratt SJ, Epple H, Ward M, Feng Y, Braga VM, Longmore GD. The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration. J Cell Biol. 2005 Feb 28; 168(5):813-24. PMID: 15728191; PMCID: PMC2171823.
      14. Ward ME, Rao Y. Investigations of neuronal migration in the central nervous system. Methods Mol Biol. 2005; 294:137-56. PMID: 15576911.
        View in: PubMed
      15. Ungewickell A, Ward ME, Ungewickell E, Majerus PW. The inositol polyphosphate 5-phosphatase Ocrl associates with endosomes that are partially coated with clathrin. Proc Natl Acad Sci U S A. 2004 Sep 14; 101(37):13501-6. PMID: 15353600; PMCID: PMC518786.
      16. Ward ME, Wu JY, Rao Y. Visualization of spatially and temporally regulated N-WASP activity during cytoskeletal reorganization in living cells. Proc Natl Acad Sci U S A. 2004 Jan 27; 101(4):970-4. PMID: 14732696; PMCID: PMC327126.
      17. Ward M, McCann C, DeWulf M, Wu JY, Rao Y. Distinguishing between directional guidance and motility regulation in neuronal migration. J Neurosci. 2003 Jun 15; 23(12):5170-7. PMID: 12832541; PMCID: PMC2041933.
      18. Rao Y, Wong K, Ward M, Jurgensen C, Wu JY. Neuronal migration and molecular conservation with leukocyte chemotaxis. Genes Dev. 2002 Dec 1; 16(23):2973-84. PMID: 12464628; PMCID: PMC2064004.
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