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    Millie Hughes-Fulford, PhD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentMedicine
    Address1001 Potrero Ave
    San Francisco CA 94110
    Phone415-750-6940
    vCardDownload vCard

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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Grenon SM, Owens CD, Nosova EV, Hughes-Fulford M, Alley HF, Chong K, Perez S, Yen PK, Boscardin J, Hellmann J, Spite M, Conte MS. Short-Term, High-Dose Fish Oil Supplementation Increases the Production of Omega-3 Fatty Acid-Derived Mediators in Patients With Peripheral Artery Disease (the OMEGA-PAD I Trial). J Am Heart Assoc. 2015; 4(8). PMID: 26296857.
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      2. Hughes-Fulford M, Chang TT, Martinez EM, Li CF. Spaceflight alters expression of microRNA during T-cell activation. FASEB J. 2015 Dec; 29(12):4893-900. PMID: 26276131.
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      3. Chang TT, Spurlock SM, Candelario TL, Grenon SM, Hughes-Fulford M. Spaceflight impairs antigen-specific tolerance induction in vivo and increases inflammatory cytokines. FASEB J. 2015 Oct; 29(10):4122-32. PMID: 26085131.
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      4. Martinez EM, Yoshida MC, Candelario TL, Hughes-Fulford M. Spaceflight and simulated microgravity cause a significant reduction of key gene expression in early T-cell activation. Am J Physiol Regul Integr Comp Physiol. 2015 Mar 15; 308(6):R480-8. PMID: 25568077.
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      5. Chang TT, Hughes-Fulford M. Molecular mechanisms underlying the enhanced functions of three-dimensional hepatocyte aggregates. Biomaterials. 2014 Feb; 35(7):2162-71. PMID: 24332390; PMCID: PMC4012541 [Available on 02/01/15].
      6. Grenon SM, Owens CD, Alley H, Chong K, Yen PK, Harris W, Hughes-Fulford M, Conte MS. n-3 Polyunsaturated fatty acids supplementation in peripheral artery disease: the OMEGA-PAD trial. Vasc Med. 2013 Oct; 18(5):263-74. PMID: 24052491; PMCID: PMC4074651.
      7. Grenon SM, Jeanne M, Aguado-Zuniga J, Conte MS, Hughes-Fulford M. Effects of gravitational mechanical unloading in endothelial cells: association between caveolins, inflammation and adhesion molecules. Sci Rep. 2013; 3:1494. PMID: 23511048; PMCID: PMC3603133.
      8. Grenon SM, Saary J, Gray G, Vanderploeg JM, Hughes-Fulford M. Can I take a space flight? Considerations for doctors. BMJ. 2012; 345:e8124. PMID: 23241271.
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      9. Chang TT, Walther I, Li CF, Boonyaratanakornkit J, Galleri G, Meloni MA, Pippia P, Cogoli A, Hughes-Fulford M. The Rel/NF-?B pathway and transcription of immediate early genes in T cell activation are inhibited by microgravity. J Leukoc Biol. 2012 Dec; 92(6):1133-45. PMID: 22750545; PMCID: PMC3501893.
      10. Grenon SM, Aguado-Zuniga J, Hatton JP, Owens CD, Conte MS, Hughes-Fulford M. Effects of fatty acids on endothelial cells: inflammation and monocyte adhesion. J Surg Res. 2012 Sep; 177(1):e35-43. PMID: 22572621; PMCID: PMC3756552.
      11. Grenon SM, Hughes-Fulford M, Rapp J, Conte MS. Polyunsaturated fatty acids and peripheral artery disease. Vasc Med. 2012 Feb; 17(1):51-63. PMID: 22363018.
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      12. Magbanua MJ, Roy R, Sosa EV, Weinberg V, Federman S, Mattie MD, Hughes-Fulford M, Simko J, Shinohara K, Haqq CM, Carroll PR, Chan JM. Gene expression and biological pathways in tissue of men with prostate cancer in a randomized clinical trial of lycopene and fish oil supplementation. PLoS One. 2011; 6(9):e24004. PMID: 21912659; PMCID: PMC3164676.
      13. Hughes-Fulford M. To infinity ... and beyond! Human spaceflight and life science. FASEB J. 2011 Sep; 25(9):2858-64. PMID: 21880668.
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      14. Hughes-Fulford M, Li CF. The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization. J Orthop Surg Res. 2011; 6:8. PMID: 21306641; PMCID: PMC3044105.
      15. Chan JM, Weinberg V, Magbanua MJ, Sosa E, Simko J, Shinohara K, Federman S, Mattie M, Hughes-Fulford M, Haqq C, Carroll PR. Nutritional supplements, COX-2 and IGF-1 expression in men on active surveillance for prostate cancer. Cancer Causes Control. 2011 Jan; 22(1):141-50. PMID: 21103921; PMCID: PMC3002170.
      16. Chang TT, Hughes-Fulford M. Monolayer and spheroid culture of human liver hepatocellular carcinoma cell line cells demonstrate distinct global gene expression patterns and functional phenotypes. Tissue Eng Part A. 2009 Mar; 15(3):559-67. PMID: 18724832.
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      17. Sevigny MB, Li CF, Alas M, Hughes-Fulford M. Glycosylation regulates turnover of cyclooxygenase-2. FEBS Lett. 2006 Dec 11; 580(28-29):6533-6. PMID: 17113084.
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      18. Hughes-Fulford M, Rodenacker K, J├╝tting U. Reduction of anabolic signals and alteration of osteoblast nuclear morphology in microgravity. J Cell Biochem. 2006 Oct 1; 99(2):435-49. PMID: 16619267.
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      19. Li CF, Hughes-Fulford M. Fibroblast growth factor-2 is an immediate-early gene induced by mechanical stress in osteogenic cells. J Bone Miner Res. 2006 Jun; 21(6):946-55. PMID: 16753025.
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      20. Hughes-Fulford M, Li CF, Boonyaratanakornkit J, Sayyah S. Arachidonic acid activates phosphatidylinositol 3-kinase signaling and induces gene expression in prostate cancer. Cancer Res. 2006 Feb 1; 66(3):1427-33. PMID: 16452198.
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      21. Boonyaratanakornkit JB, Cogoli A, Li CF, Schopper T, Pippia P, Galleri G, Meloni MA, Hughes-Fulford M. Key gravity-sensitive signaling pathways drive T cell activation. FASEB J. 2005 Dec; 19(14):2020-2. PMID: 16210397.
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      22. Hughes-Fulford M, Tjandrawinata RR, Li CF, Sayyah S. Arachidonic acid, an omega-6 fatty acid, induces cytoplasmic phospholipase A2 in prostate carcinoma cells. Carcinogenesis. 2005 Sep; 26(9):1520-6. PMID: 15878913.
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      23. Hughes-Fulford M, Sugano E, Schopper T, Li CF, Boonyaratanakornkit JB, Cogoli A. Early immune response and regulation of IL-2 receptor subunits. Cell Signal. 2005 Sep; 17(9):1111-24. PMID: 15993752.
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      24. Hughes-Fulford M. Signal transduction and mechanical stress. Sci STKE. 2004 Sep 7; 2004(249):RE12. PMID: 15353762.
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      25. Hughes-Fulford M. Lessons learned about spaceflight and cell biology experiments. J Gravit Physiol. 2004 Mar; 11(1):105-9. PMID: 16145818.
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      26. Hughes-Fulford M. Function of the cytoskeleton in gravisensing during spaceflight. Adv Space Res. 2003; 32(8):1585-93. PMID: 15002415.
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      27. Hatton JP, Pooran M, Li CF, Luzzio C, Hughes-Fulford M. A short pulse of mechanical force induces gene expression and growth in MC3T3-E1 osteoblasts via an ERK 1/2 pathway. J Bone Miner Res. 2003 Jan; 18(1):58-66. PMID: 12510806.
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      28. Hughes-Fulford M. The role of signaling pathways in osteoblast gravity perception. J Gravit Physiol. 2002 Jul; 9(1):P257-60. PMID: 15002570.
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      29. Hughes-Fulford M. Physiological effects of microgravity on osteoblast morphology and cell biology. Adv Space Biol Med. 2002; 8:129-57. PMID: 12951695.
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      30. Hughes-Fulford M. Changes in gene expression and signal transduction in microgravity. J Gravit Physiol. 2001 Jul; 8(1):P1-4. PMID: 12638602.
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      31. Hughes-Fulford M, Chen Y, Tjandrawinata RR. Fatty acid regulates gene expression and growth of human prostate cancer PC-3 cells. Carcinogenesis. 2001 May; 22(5):701-7. PMID: 11323387.
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      32. Chen Y, Hughes-Fulford M. Human prostate cancer cells lack feedback regulation of low-density lipoprotein receptor and its regulator, SREBP2. Int J Cancer. 2001 Jan 1; 91(1):41-5. PMID: 11149418.
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      33. Chen Y, Hughes-Fulford M. Prostaglandin E2 and the protein kinase A pathway mediate arachidonic acid induction of c-fos in human prostate cancer cells. Br J Cancer. 2000 Jun; 82(12):2000-6. PMID: 10864209; PMCID: PMC2363249.
      34. Lewis ML, Hughes-Fulford M. Regulation of heat shock protein message in Jurkat cells cultured under serum-starved and gravity-altered conditions. J Cell Biochem. 2000 Feb; 77(1):127-34. PMID: 10679823.
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      35. Fitzgerald J, Dietz TJ, Hughes-Fulford M. Prostaglandin E2-induced up-regulation of c-fos messenger ribonucleic acid is primarily mediated by 3',5'-cyclic adenosine monophosphate in MC3T3-E1 osteoblasts. Endocrinology. 2000 Jan; 141(1):291-8. PMID: 10614650.
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      36. Lum DF, McQuaid KR, Gilbertson VL, Hughes-Fulford M. Coordinate up-regulation of low-density lipoprotein receptor and cyclo-oxygenase-2 gene expression in human colorectal cells and in colorectal adenocarcinoma biopsies. Int J Cancer. 1999 Oct 8; 83(2):162-6. PMID: 10471521.
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      37. Fitzgerald J, Hughes-Fulford M. Mechanically induced c-fos expression is mediated by cAMP in MC3T3-E1 osteoblasts. FASEB J. 1999 Mar; 13(3):553-7. PMID: 10064622.
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      38. Hughes-Fulford M, Gilbertson V. Osteoblast fibronectin mRNA, protein synthesis, and matrix are unchanged after exposure to microgravity. FASEB J. 1999; 13 Suppl:S121-7. PMID: 10352153.
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      39. Hughes-Fulford M, Tjandrawinata R, Fitzgerald J, Gasuad K, Gilbertson V. Effects of microgravity on osteoblast growth. Gravit Space Biol Bull. 1998 May; 11(2):51-60. PMID: 11540639.
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      40. Tjandrawinata RR, Vincent VL, Hughes-Fulford M. Vibrational force alters mRNA expression in osteoblasts. FASEB J. 1997 May; 11(6):493-7. PMID: 9194530.
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      41. Tjandrawinata RR, Hughes-Fulford M. Up-regulation of cyclooxygenase-2 by product-prostaglandin E2. Adv Exp Med Biol. 1997; 407:163-70. PMID: 9321948.
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      42. Hughes-Fulford M. Prostaglandin regulation of gene expression and growth in normal and malignant tissues. Adv Exp Med Biol. 1997; 400A:269-78. PMID: 9547568.
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      43. Tjandrawinata RR, Dahiya R, Hughes-Fulford M. Induction of cyclo-oxygenase-2 mRNA by prostaglandin E2 in human prostatic carcinoma cells. Br J Cancer. 1997; 75(8):1111-8. PMID: 9099957; PMCID: PMC2222782.
      44. Hughes-Fulford M, Boman B. Growth regulation of Gardner's syndrome colorectal cancer cells by NSAIDs. Adv Exp Med Biol. 1997; 407:433-41. PMID: 9321987.
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      45. Fitzgerald J, Hughes-Fulford M. Gravitational loading of a simulated launch alters mRNA expression in osteoblasts. Exp Cell Res. 1996 Oct 10; 228(1):168-71. PMID: 8892985.
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      46. Hughes-Fulford M, Lewis ML. Effects of microgravity on osteoblast growth activation. Exp Cell Res. 1996 Apr 10; 224(1):103-9. PMID: 8612673.
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      47. Leong J, Hughes-Fulford M, Rakhlin N, Habib A, Maclouf J, Goldyne ME. Cyclooxygenases in human and mouse skin and cultured human keratinocytes: association of COX-2 expression with human keratinocyte differentiation. Exp Cell Res. 1996 Apr 10; 224(1):79-87. PMID: 8612694.
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      48. Hughes-Fulford M. Cell cycle arrest by prostaglandin A1 at the G1/S phase interface with up-regulation of oncogenes in S-49 cyc- cells. J Cell Biochem. 1994 Mar; 54(3):265-72. PMID: 8200906.
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      49. Lin HS, Hughes-Fulford M, Kumegawa M, Pitts AC, Snowdowne KW. Cytoplasmic pH influences cytoplasmic calcium in MC3T3-E1 osteoblast cells. J Bone Miner Res. 1993 Jun; 8(6):725-32. PMID: 8328315.
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      50. Hughes-Fulford M. Review of the biological effects of weightlessness on the human endocrine system. Receptor. 1993; 3(3):145-54. PMID: 8167565.
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      51. Hughes-Fulford M, Fukushima M. Control of cell cycle by metabolites of prostaglandin D2 through a non-cAMP mediated mechanism. Life Sci Adv Exp Clin Endocrinol. 1993; 12:57-64. PMID: 11539936.
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      52. Hughes-Fulford M, Appel R, Kumegawa M, Schmidt J. Effect of dexamethasone on proliferating osteoblasts: inhibition of prostaglandin E2 synthesis, DNA synthesis, and alterations in actin cytoskeleton. Exp Cell Res. 1992 Nov; 203(1):150-6. PMID: 1426038.
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      53. Rossberg Walker K, Hughes-Fulford M, Schmidt G. KC-135 flights for life science activities. ASGSB Bull. 1992 Oct; 6(1):107-12. PMID: 11537651.
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      54. Hughes-Fulford M, McGrath MS, Hanks D, Erickson S, Pulliam L. Effects of dimethyl prostaglandin A1 on herpes simplex virus and human immunodeficiency virus replication. Antimicrob Agents Chemother. 1992 Oct; 36(10):2253-8. PMID: 1332592; PMCID: PMC245485.
      55. Hughes-Fulford M. Altered cell function in microgravity. Exp Gerontol. 1991; 26(2-3):247-56. PMID: 1915694.
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      56. Demeure MJ, Hughes-Fulford M, Goretzki PE, Duh QY, Clark OH. Actin architecture of cultured human thyroid cancer cells: predictor of differentiation? Surgery. 1990 Dec; 108(6):986-92; discussion 992-3. PMID: 2247845.
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      57. Hughes-Fulford M, Scheld HW. Thin film bioreactors in space. Adv Space Res. 1989; 9(11):111-7. PMID: 11537324.
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      58. Erickson SK, Cooper AD, Barnard GF, Havel CM, Watson JA, Feingold KR, Moser AH, Hughes-Fulford M, Siperstein MD. Regulation of cholesterol metabolism in a slow-growing hepatoma in vivo. Biochim Biophys Acta. 1988 May 22; 960(2):131-8. PMID: 2835108.
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      59. Hughes-Fulford M, Feingold KR, Searle GL, Wu J, Siperstein MD, Schoenfeld PY, Kaysen G. Role of the kidneys in the metabolism of circulating mevalonate in humans. J Clin Endocrinol Metab. 1986 Jun; 62(6):1227-31. PMID: 3084536.
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      60. Feingold KR, Zsigmond G, Hughes-Fulford M, Lear SR, Moser AH. The effect of diabetes mellitus on the lymphatic transport of intestinal sterols. Metabolism. 1985 Dec; 34(12):1105-9. PMID: 4069009.
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      61. Williams ML, Hughes-Fulford M, Elias PM. Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and sterol synthesis by cholesterol sulfate in cultured fibroblasts. Biochim Biophys Acta. 1985 Jun 30; 845(3):349-57. PMID: 3859337.
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      62. Hughes-Fulford M, Wu J, Kato T, Fukushima M. Inhibition of DNA synthesis and cell cycle by prostaglandins independent of cyclic AMP. Adv Prostaglandin Thromboxane Leukot Res. 1985; 15:401-4. PMID: 3004144.
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      63. Trentalance A, Leoni S, Mangiantini MT, Spagnuolo S, Feingold K, Hughes-Fulford M, Siperstein M, Cooper AD, Erickson SK. Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and cholesterol synthesis and esterification during the first cell cycle of liver regeneration. Biochim Biophys Acta. 1984 Jun 6; 794(1):142-51. PMID: 6733123.
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