Daniel Chan, PhD
|University of California San Francisco (UCSF)||Postdoc||2016||Pharmacy|
|University of New South Wales (UNSW)||PhD||2011||Complex Systems in Biology|
I aspire to impact translational research by the use of Quantitative Systems Pharmacology (QSP) modeling approaches to gain deeper mechanistic insights and support decision-making.
Areas of interest: Pharmacometrics / Systems Pharmacology / Precision Medicine. My current research focuses on developing a data-driven framework for precision medicine of biologics for chronic inflammatory diseases, such as inflammatory bowel diseases (IBDs) including Crohn’s disease. Using PK/PD modeling to quantify the sources of inter-subject variability in efficacy, safety and pharmacokinetics, combined with the selection of predictive biomarkers, the right treatment and the right therapeutic dose for the right patient can be identified, thus maximizing the individual patient response to biologics therapy. This research is being done in collaboration with partners from the biopharmaceutical industry.
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