Daniel Chan, PhD

TitlePostdoctoral Scholar
SchoolUCSF School of Pharmacy
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    Collapse Biography 
    Collapse Education and Training
    University of California San Francisco (UCSF)Postdoc2016Pharmacy
    University of New South Wales (UNSW)PhD2011Complex Systems in Biology

    Collapse Overview 
    Collapse Overview
    I aspire to impact translational research by the use of Quantitative Systems Pharmacology (QSP) modeling approaches to gain deeper mechanistic insights and support decision-making.

    Collapse Interests
    Areas of interest: Pharmacometrics / Systems Pharmacology / Precision Medicine. My current research focuses on developing a data-driven framework for precision medicine of biologics for chronic inflammatory diseases, such as inflammatory bowel diseases (IBDs) including Crohn’s disease. Using PK/PD modeling to quantify the sources of inter-subject variability in efficacy, safety and pharmacokinetics, combined with the selection of predictive biomarkers, the right treatment and the right therapeutic dose for the right patient can be identified, thus maximizing the individual patient response to biologics therapy. This research is being done in collaboration with partners from the biopharmaceutical industry.

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Petravic J, Ellenberg P, Chan ML, Paukovics G, Smyth RP, Mak J, Davenport MP. Intracellular dynamics of HIV infection. J Virol. 2014 Jan; 88(2):1113-24. PMID: 24198427; PMCID: PMC3911679.
    2. Paiardini M, Cervasi B, Reyes-Aviles E, Micci L, Ortiz AM, Chahroudi A, Vinton C, Gordon SN, Bosinger SE, Francella N, Hallberg PL, Cramer E, Schlub T, Chan ML, Riddick NE, Collman RG, Apetrei C, Pandrea I, Else J, Munch J, Kirchhoff F, Davenport MP, Brenchley JM, Silvestri G. Low levels of SIV infection in sooty mangabey central memory CD4? T cells are associated with limited CCR5 expression. Nat Med. 2011 Jul; 17(7):830-6. PMID: 21706028; PMCID: PMC3253129.
    3. Chan ML, Petravic J, Ortiz AM, Engram J, Paiardini M, Cromer D, Silvestri G, Davenport MP. Limited CD4+ T cell proliferation leads to preservation of CD4+ T cell counts in SIV-infected sooty mangabeys. Proc Biol Sci. 2010 Dec 22; 277(1701):3773-81. PMID: 20591864; PMCID: PMC2992704.
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