Min Kyu Kim, PhD, MS
|School||UCSF School of Medicine|
|Department||Cellular Molecular Pharmacology|
|Address||1700 4th Street|
San Francisco CA 94158
|Seoul National University||M.S.||Molecular Biology||1995|
|Seoul National University||Ph.D.||Biological Sciences||2000|
|Seoul National University ||PostDoc||Biological Sciences||2001|
|Harvard Medical School||PostDoc||Biological Chemistry and Molecular Pharmacology||2009|
|Korea Research Foundation||1995
||1996||Pre-doctoral Fellowship for Future Researchers|
|Harvard Medical School||2004||BCMP Discovery of the Year|
|The Medical Foundation||2005
||2007||Charles A. King Trust Postdoctoral Fellowship|
Protein Interaction Networks Governing Cell Differentiation
Stem cells are pluripotent to differentiate into various cell types in the body. Thus, analyzing each differentiation process using stem cells is fundamental not only to understand its basic mechanisms but also to take advantage of stem cells for therapeutic purposes. My research will investigate protein differential regulation and protein-protein interactions, using the large-scale proteomics and genomics, to dissect functions of protein complexes during cellular differentiation as they are formed and expressed. This study may allow us to identify a novel key regulator(s) of significant medical relevance for multiple cellular differentiation pathways (especially for cancer research and treatment).
Transcription Termination and RNA Processing
Proteins of different activities are often derived from a single gene by alternative polyadenylation and termination, and many bacterial operons are controlled by attenuation, which manifest the importance of transcription termination in gene regulation. However, the mechanisms that terminate transcription are less well understood. The goal of this research is to define the functional interactions between various protein factors and RNA polymerases to understand the regulation of transcription termination and its fundamental roles in gene expression and RNA 3’-end processing. Ultimately, this study may be able to lead us to manipulate termination, so that we can develop potential therapies for genetic disorders caused by aberrant termination.
Eukaryotic gene expression, RNA Processing & Transcriptional Termination, Chromatin Modification and Epigenetics, Large-scale Proteomics and Genomics, Stem Cells, Cancer, Personalized Medicine
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