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    Mitchell Rosen, MD

    TitleAssociate Professor
    SchoolUCSF School of Medicine
    DepartmentOb/Gyn, Reproductive Sciences
    Address499 Illinois
    San Francisco CA 94158
    Phone415-885-7870
    vCardDownload vCard

      Collapse Biography 
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      St. Louis UniversityM.D.School of Medicine1998

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      Dr. Mitchell Rosen is a reproductive endocrinology and fertility expert at the UCSF Center for Reproductive Health. He also is director of the UCSF Fertillity Preservation Center, which helps patients with cancer preserve their ability to have children, despite aggressive cancer treatment.

      Rosen earned a medical degree at Saint Louis University and completed residency training in obstetrics and gynecology at the University of Texas Medical Branch in Galveston, Texas. During medical and residency training, he was named the best resident twice and received the Ortho-McNeil Best Resident Teacher Award in 2002. Rosen completed fellowship training in reproductive endocrinology and infertility at UCSF. He was trained in the UCSF embryology laboratory to qualify as a high complexity lab director (HCLD). In addition to caring for patients, he is an assistant professor of medicine at UCSF and teaches medical students, residents and fellows.

      Dr. Rosen on his research: My research focuses on Reproductive Endocrinology and Infertility, oogenesis (folliculogenesis) and early reproductive failure. During my fellowship I explored a basic research interest in a candidate gene (DAZ-L) involved in gametogenesis, and determined that this gene may be involved in the age at ovarian failure and spermatogenesis. I am actively involved in studies to better understand the impact of exogenous stimulation on in vivo and subsequent in vitro oocyte development and maturation. Of particular interest is understanding ways to optimize controlled ovarian hyperstimulation to improve pregnancy outcomes during assisted reproduction. I have recently received funding to develop a randomized trial evaluating concomitant FSH with hCG for ovulation trigger. During a spontaneous ovulatory surge, there is a rise in both FSH and LH. While hCG has been substituted for the LH surge, no studies have addressed the role of FSH on the developing oocyte during the final steps of nuclear and cytoplasmic maturation. This prospective study will compare ovarian stimulation and follicular development, along with oocyte maturation, developmental competence, and quality between those participants receiving hCG alone or combined FSH/hCG. In addition, the intrafollicular hormonal milieu, embryo quality, and pregnancy rates will be compared between the two treatment groups.

      I am also involved in several other studies, which focus on optimizing embryo selection, leading to single embryo transfer, and thereby decreasing health risks to women and their children. We have established a protocol utilizing proton magnetic spectroscopy and HPLC proteomics to compare embryos with and without known implantation. Additionally, I am a member of a research team addressing the role of methyl-tetrahydrafolate reductase in ovarian stimulation and IVF outcomes, and the effect CMV in semen has on fertilization and embryo quality. Ultimately, my goal is to promote a team effort between clinicians, basic scientists, and embryologists in order to better study folliculogenesis and apply this knowledge to understanding the process of ovarian aging and the impact of exogenous medications on follicle development.


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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Shah MS, Letourneau JM, Niemasik EE, Bleil M, McCulloch CE, Rosen MP, et al. The role of in-depth reproductive health counseling in addressing reproductive health concerns in female survivors of nongynecologic cancers. J Psychosoc Oncol. 2016 Jul-Aug; 34(4):305-17. PMID: 27144587.
        View in: PubMed
      2. Bosch E, Labarta E, Kolibianakis E, Rosen M, Meldrum D. Regimen of ovarian stimulation affects oocyte and therefore embryo quality. Fertil Steril. 2016 Mar; 105(3):560-70. PMID: 26826273.
        View in: PubMed
      3. Tran ND, Aghajanova L, Kao CN, Cedars MI, Rosen MP. Impact of pituitary suppression on antral follicle count and oocyte recovery after ovarian stimulation. Fertil Steril. 2016 Mar; 105(3):690-6. PMID: 26696299.
        View in: PubMed
      4. Han B, Herndon CN, Rosen MP, Wang ZJ, Daldrup-Link H. Uterine didelphys associated with obstructed hemivagina and ipsilateral renal anomaly (OHVIRA) syndrome. Radiol Case Rep. 2010; 5(1):327. PMID: 27307842.
        View in: PubMed
      5. Usadi RS, Diamond MP, Legro RS, Schlaff WD, Hansen KR, Casson P, Christman G, Wright Bates G, Baker V, Seungdamrong A, Rosen MP, Lucidi S, Thomas T, Huang H, Santoro N, Eisenberg E, Zhang H, Alvero R. Recruitment strategies in two reproductive medicine network infertility trials. Contemp Clin Trials. 2015 Nov; 45(Pt B):196-200. PMID: 26386293.
        View in: PubMed
      6. Chien AJ, Duralde E, Hwang R, Tsung K, Kao CN, Rugo HS, Melisko ME, Esserman LJ, Munster PN, Cedars M, Kerlikowske K, McCulloch CE, Rosen MP. Association of tamoxifen use and ovarian function in patients with invasive or pre-invasive breast cancer. Breast Cancer Res Treat. 2015 Aug; 153(1):173-81. PMID: 26208485.
        View in: PubMed
      7. Letourneau J, Chan J, Salem W, Chan SW, Shah M, Ebbel E, McCulloch C, Chen LM, Cedars M, Rosen M. Fertility Sparing Surgery for Localized Ovarian Cancers Maintains an Ability to Conceive, but is Associated With Diminished Reproductive Potential. J Surg Oncol. 2015 Jul; 112(1):26-30. PMID: 26193338.
        View in: PubMed
      8. Cakmak H, Rosen MP. Random-start ovarian stimulation in patients with cancer. Curr Opin Obstet Gynecol. 2015 Jun; 27(3):215-21. PMID: 25919235.
        View in: PubMed
      9. Smith JF, Yango P, Altman E, Choudhry S, Poelzl A, Zamah AM, Rosen M, Klatsky PC, Tran ND. Testicular niche required for human spermatogonial stem cell expansion. Stem Cells Transl Med. 2014 Sep; 3(9):1043-54. PMID: 25038247; PMCID: PMC4149303.
      10. Cakmak H, Tran ND, Zamah AM, Cedars MI, Rosen MP. A novel "delayed start" protocol with gonadotropin-releasing hormone antagonist improves outcomes in poor responders. Fertil Steril. 2014 May; 101(5):1308-14. PMID: 24636401; PMCID: PMC4604751.
      11. Quinn MM, Letourneau JM, Rosen MP. Contraception after cancer treatment: describing methods, counseling, and unintended pregnancy risk. Contraception. 2014 May; 89(5):466-71. PMID: 24576795.
        View in: PubMed
      12. Bleil ME, Gregorich SE, McConnell D, Rosen MP, Cedars MI. Does accelerated reproductive aging underlie premenopausal risk for cardiovascular disease? Menopause. 2013 Nov; 20(11):1139-46. PMID: 23591257; PMCID: PMC4123819.
      13. Bleil ME, Gregorich SE, Adler NE, Sternfeld B, Rosen MP, Cedars MI. Race/ethnic disparities in reproductive age: an examination of ovarian reserve estimates across four race/ethnic groups of healthy, regularly cycling women. Fertil Steril. 2014 Jan; 101(1):199-207. PMID: 24182412; PMCID: PMC3976042.
      14. Letourneau J, Chan SW, Rosen MP. Accelerating ovarian age: cancer treatment in the premenopausal woman. Semin Reprod Med. 2013 Nov; 31(6):462-8. PMID: 24101227.
        View in: PubMed
      15. Cakmak H, Katz A, Cedars MI, Rosen MP. Effective method for emergency fertility preservation: random-start controlled ovarian stimulation. Fertil Steril. 2013 Dec; 100(6):1673-80. PMID: 23987516.
        View in: PubMed
      16. Bleil ME, Bromberger JT, Latham MD, Adler NE, Pasch LA, Gregorich SE, Rosen MP, Cedars MI. Disruptions in ovarian function are related to depression and cardiometabolic risk during premenopause. Menopause. 2013 Jun; 20(6):631-9. PMID: 23715377; PMCID: PMC3657585.
      17. Cakmak H, Rosen MP. Ovarian stimulation in cancer patients. Fertil Steril. 2013 May; 99(6):1476-84. PMID: 23635348.
        View in: PubMed
      18. Lin WT, Beattie M, Chen LM, Oktay K, Crawford SL, Gold EB, Cedars M, Rosen M. Comparison of age at natural menopause in BRCA1/2 mutation carriers with a non-clinic-based sample of women in northern California. Cancer. 2013 May 1; 119(9):1652-9. PMID: 23362014; PMCID: PMC3634895.
      19. Bleil ME, Adler NE, Pasch LA, Sternfeld B, Gregorich SE, Rosen MP, Cedars MI. Depressive symptomatology, psychological stress, and ovarian reserve: a role for psychological factors in ovarian aging? Menopause. 2012 Nov; 19(11):1176-85. PMID: 22760086; PMCID: PMC3465629.
      20. Cakmak H, Fujimoto VY, Zamah AM, Rosen MP, Tran ND, Cedars MI, Rinaudo PF. Metaphase II (MII) oocytes obtained at different time points in the same in vitro fertilization cycle. J Assist Reprod Genet. 2012 Nov; 29(11):1203-5. PMID: 22941385; PMCID: PMC3510378.
      21. Bleil ME, Adler NE, Pasch LA, Sternfeld B, Gregorich SE, Rosen MP, Cedars MI. Psychological stress and reproductive aging among pre-menopausal women. Hum Reprod. 2012 Sep; 27(9):2720-8. PMID: 22767452; PMCID: PMC3415289.
      22. Niemasik EE, Letourneau J, Dohan D, Katz A, Melisko M, Rugo H, Rosen M. Patient perceptions of reproductive health counseling at the time of cancer diagnosis: a qualitative study of female California cancer survivors. J Cancer Surviv. 2012 Sep; 6(3):324-32. PMID: 22752834.
        View in: PubMed
      23. Schuh-Huerta SM, Johnson NA, Rosen MP, Sternfeld B, Cedars MI, Reijo Pera RA. Genetic markers of ovarian follicle number and menopause in women of multiple ethnicities. Hum Genet. 2012 Nov; 131(11):1709-24. PMID: 22696150; PMCID: PMC3470691.
      24. Letourneau JM, Smith JF, Ebbel EE, Craig A, Katz PP, Cedars MI, Rosen MP. Racial, socioeconomic, and demographic disparities in access to fertility preservation in young women diagnosed with cancer. Cancer. 2012 Sep 15; 118(18):4579-88. PMID: 22451228; PMCID: PMC3387319.
      25. Rosen MP, Meldrum DR. Can FSH co-trigger prevent OHSS? Fertil Steril. 2012 Mar; 97(3):534-5. PMID: 22285746.
        View in: PubMed
      26. Rosen MP, Johnstone E, McCulloch CE, Schuh-Huerta SM, Sternfeld B, Reijo-Pera RA, Cedars MI. A characterization of the relationship of ovarian reserve markers with age. Fertil Steril. 2012 Jan; 97(1):238-43. PMID: 22130324; PMCID: PMC3312467.
      27. Schuh-Huerta SM, Johnson NA, Rosen MP, Sternfeld B, Cedars MI, Reijo Pera RA. Genetic variants and environmental factors associated with hormonal markers of ovarian reserve in Caucasian and African American women. Hum Reprod. 2012 Feb; 27(2):594-608. PMID: 22116950; PMCID: PMC3258032.
      28. Zamah AM, Mauro MJ, Druker BJ, Oktay K, Egorin MJ, Cedars MI, Rosen MP. Will imatinib compromise reproductive capacity? Oncologist. 2011; 16(10):1422-7. PMID: 21948652; PMCID: PMC3228060.
      29. Tran ND, Cedars MI, Rosen MP. The role of anti-müllerian hormone (AMH) in assessing ovarian reserve. J Clin Endocrinol Metab. 2011 Dec; 96(12):3609-14. PMID: 21937624.
        View in: PubMed
      30. Letourneau JM, Ebbel EE, Katz PP, Katz A, Ai WZ, Chien AJ, Melisko ME, Cedars MI, Rosen MP. Pretreatment fertility counseling and fertility preservation improve quality of life in reproductive age women with cancer. Cancer. 2012 Mar 15; 118(6):1710-7. PMID: 21887678; PMCID: PMC3235264.
      31. Letourneau JM, Ebbel EE, Katz PP, Oktay KH, McCulloch CE, Ai WZ, Chien AJ, Melisko ME, Cedars MI, Rosen MP. Acute ovarian failure underestimates age-specific reproductive impairment for young women undergoing chemotherapy for cancer. Cancer. 2012 Apr 1; 118(7):1933-9. PMID: 21850728; PMCID: PMC3220922.
      32. Rugo HS, Rosen MP. Reducing the long-term effects of chemotherapy in young women with early-stage breast cancer. JAMA. 2011 Jul 20; 306(3):312-4. PMID: 21771995.
        View in: PubMed
      33. Huddleston HG, Rosen MP, Gibson M, Cedars MI, Fujimoto VY. Ethnic variation in estradiol metabolism in reproductive age Asian and white women treated with transdermal estradiol. Fertil Steril. 2011 Sep; 96(3):797-9. PMID: 21774930.
        View in: PubMed
      34. Singer ST, Vichinsky EP, Gildengorin G, van Disseldorp J, Rosen M, Cedars MI. Reproductive capacity in iron overloaded women with thalassemia major. Blood. 2011 Sep 8; 118(10):2878-81. PMID: 21757620; PMCID: PMC3172803.
      35. Lamb JD, Shen S, McCulloch C, Jalalian L, Cedars MI, Rosen MP. Follicle-stimulating hormone administered at the time of human chorionic gonadotropin trigger improves oocyte developmental competence in in vitro fertilization cycles: a randomized, double-blind, placebo-controlled trial. Fertil Steril. 2011 Apr; 95(5):1655-60. PMID: 21315341.
        View in: PubMed
      36. Rosen MP, Johnstone E, Addauan-Andersen C, Cedars MI. A lower antral follicle count is associated with infertility. Fertil Steril. 2011 May; 95(6):1950-4, 1954.e1. PMID: 21376313; PMCID: PMC3080442.
      37. Shaheen R, Slanetz PJ, Raza S, Rosen MP. Barriers and opportunities for early detection of breast cancer in Gaza women. Breast. 2011 Apr; 20 Suppl 2:S30-4. PMID: 21316968.
        View in: PubMed
      38. Rosen MP. Do oocyte quality and quantity as measured by antral follicle count decline in parallel? Fertil Steril. 2011 Feb; 95(2):482-3; discussion 484-5. PMID: 21183174.
        View in: PubMed
      39. Hotaling JM, Smith JF, Rosen M, Muller CH, Walsh TJ. The relationship between isolated teratozoospermia and clinical pregnancy after in vitro fertilization with or without intracytoplasmic sperm injection: a systematic review and meta-analysis. Fertil Steril. 2011 Mar 1; 95(3):1141-5. PMID: 21030014.
        View in: PubMed
      40. Letourneau JM, Melisko ME, Cedars MI, Rosen MP. A changing perspective: improving access to fertility preservation. Nat Rev Clin Oncol. 2011 Jan; 8(1):56-60. PMID: 20736926; PMCID: PMC3226819.
      41. Johnstone EB, Rosen MP, Neril R, Trevithick D, Sternfeld B, Murphy R, Addauan-Andersen C, McConnell D, Pera RR, Cedars MI. The polycystic ovary post-rotterdam: a common, age-dependent finding in ovulatory women without metabolic significance. J Clin Endocrinol Metab. 2010 Nov; 95(11):4965-72. PMID: 20719841; PMCID: PMC2968725.
      42. Zamah AM, Hsieh M, Chen J, Vigne JL, Rosen MP, Cedars MI, Conti M. Human oocyte maturation is dependent on LH-stimulated accumulation of the epidermal growth factor-like growth factor, amphiregulin. Hum Reprod. 2010 Oct; 25(10):2569-78. PMID: 20719813; PMCID: PMC2939758.
      43. Mucowski SJ, Herndon CN, Rosen MP. The arcuate uterine anomaly: a critical appraisal of its diagnostic and clinical relevance. Obstet Gynecol Surv. 2010 Jul; 65(7):449-54. PMID: 20723266.
        View in: PubMed
      44. Rosen MP, Sternfeld B, Schuh-Huerta SM, Reijo Pera RA, McCulloch CE, Cedars MI. Antral follicle count: absence of significant midlife decline. Fertil Steril. 2010 Nov; 94(6):2182-5. PMID: 20149366; PMCID: PMC3210029.
      45. Huddleston HG, Rosen MP, Lamb JD, Modan A, Cedars MI, Fujimoto VY. Asian ethnicity in anonymous oocyte donors is associated with increased estradiol levels but comparable recipient pregnancy rates compared with Caucasians. Fertil Steril. 2010 Nov; 94(6):2059-63. PMID: 20056204.
        View in: PubMed
      46. Rosen MP, Johnstone EB, Gillham SJ, Modan AE, Lipshutz AK, Reijo-Pera R, Cedars MI. Is antral follicle count a genetic trait? Menopause. 2010 Jan-Feb; 17(1):109-13. PMID: 19752762.
        View in: PubMed
      47. Rosen M, Breitkopf D, Waud K. Tubo-ovarian abscess management options for women who desire fertility. Obstet Gynecol Surv. 2009 Oct; 64(10):681-9. PMID: 19772677.
        View in: PubMed
      48. Lamb JD, Zamah AM, Shen S, McCulloch C, Cedars MI, Rosen MP. Follicular fluid steroid hormone levels are associated with fertilization outcome after intracytoplasmic sperm injection. Fertil Steril. 2010 Aug; 94(3):952-7. PMID: 19591987; PMCID: PMC4633089.
      49. Rosen MP, Shen S, Rinaudo PF, Huddleston HG, McCulloch CE, Cedars MI. Fertilization rate is an independent predictor of implantation rate. Fertil Steril. 2010 Sep; 94(4):1328-33. PMID: 19560757.
        View in: PubMed
      50. Rosen MP, Zamah AM, Shen S, Dobson AT, McCulloch CE, Rinaudo PF, Lamb JD, Cedars MI. The effect of follicular fluid hormones on oocyte recovery after ovarian stimulation: FSH level predicts oocyte recovery. Reprod Biol Endocrinol. 2009; 7:35. PMID: 19389255; PMCID: PMC2679036.
      51. Rosen MP, Shen S, Dobson AT, Rinaudo PF, McCulloch CE, Cedars MI. A quantitative assessment of follicle size on oocyte developmental competence. Fertil Steril. 2008 Sep; 90(3):684-90. PMID: 18249377; PMCID: PMC4624406.
      52. Jackson JE, Rosen M, McLean T, Moro J, Croughan M, Cedars MI. Prevalence of celiac disease in a cohort of women with unexplained infertility. Fertil Steril. 2008 Apr; 89(4):1002-4. PMID: 17662282.
        View in: PubMed
      53. Rosen MP, Shen S, McCulloch CE, Rinaudo PF, Cedars MI, Dobson AT. Methylenetetrahydrofolate reductase (MTHFR) is associated with ovarian follicular activity. Fertil Steril. 2007 Sep; 88(3):632-8. PMID: 17572411.
        View in: PubMed
      54. Dobson AT, Davis RM, Rosen MP, Shen S, Rinaudo PF, Chan J, Cedars MI. Methylenetetrahydrofolate reductase C677T and A1298C variants do not affect ongoing pregnancy rates following IVF. Hum Reprod. 2007 Feb; 22(2):450-6. PMID: 17053001.
        View in: PubMed
      55. Tung JY, Rosen MP, Nelson LM, Turek PJ, Witte JS, Cramer DW, Cedars MI, Reijo-Pera RA. Novel missense mutations of the Deleted-in-AZoospermia-Like (DAZL) gene in infertile women and men. Reprod Biol Endocrinol. 2006; 4:40. PMID: 16884537; PMCID: PMC1557510.
      56. Pacheco LD, Rosen MP, Gei AF, Saade GR, Hankins GD. Management of uterine hyperstimulation with concomitant use of oxytocin and terbutaline. Am J Perinatol. 2006 Aug; 23(6):377-80. PMID: 16847795.
        View in: PubMed
      57. Shen S, Rosen MP, Dobson AT, Fujimoto VY, McCulloch CE, Cedars MI. Day 2 transfer improves pregnancy outcome in in vitro fertilization cycles with few available embryos. Fertil Steril. 2006 Jul; 86(1):44-50. PMID: 16730718.
        View in: PubMed
      58. Rosen MP, Shen S, Dobson AT, Fujimoto VY, McCulloch CE, Cedars MI. Oocyte degeneration after intracytoplasmic sperm injection: a multivariate analysis to assess its importance as a laboratory or clinical marker. Fertil Steril. 2006 Jun; 85(6):1736-43. PMID: 16678177.
        View in: PubMed
      59. Rosen MP, Shen S, Dobson AT, Fujimoto VY, McCulloch CE, Cedars MI. Triploidy formation after intracytoplasmic sperm injection may be a surrogate marker for implantation. Fertil Steril. 2006 Feb; 85(2):384-90. PMID: 16595215.
        View in: PubMed
      60. Tung JY, Rosen MP, Nelson LM, Turek PJ, Witte JS, Cramer DW, Cedars MI, Pera RA. Variants in Deleted in AZoospermia-Like (DAZL) are correlated with reproductive parameters in men and women. Hum Genet. 2006 Feb; 118(6):730-40. PMID: 16328470.
        View in: PubMed
      61. Bradley RJ, Rosen MP. Subfertility and gastrointestinal disease: 'unexplained' is often undiagnosed. Obstet Gynecol Surv. 2004 Feb; 59(2):108-17. PMID: 14752299.
        View in: PubMed
      62. Rosen MP, Breitkopf DM, Nagamani M. A randomized controlled trial of second- versus third-generation oral contraceptives in the treatment of acne vulgaris. Am J Obstet Gynecol. 2003 May; 188(5):1158-60. PMID: 12748463.
        View in: PubMed
      63. Breitkopf DM, Rosen MP, Young SL, Nagamani M. Efficacy of second versus third generation oral contraceptives in the treatment of hirsutism. Contraception. 2003 May; 67(5):349-53. PMID: 12742556.
        View in: PubMed
      64. Rosen MP, Davis RB, Lesky LG. Utilization of outpatient diagnostic imaging. Does the physician's gender play a role? J Gen Intern Med. 1997 Jul; 12(7):407-11. PMID: 9229278; PMCID: PMC1497130.
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