Sign in to edit your profile (add interests, mentoring, photo, etc.)

    Nadia Roan, PhD

    TitleAssistant Professor
    SchoolUCSF School of Medicine
    Address1450 3rd Street
    San Francisco CA 94158
    vCardDownload vCard

      Collapse Biography 
      Collapse Awards and Honors
      UCSF, NIH2016 - 2017NCTRI P50 Pilot Grant Award
      NIH2015 - 2017R21 (R21AI116252)
      UCSF2014 - 2015Center for AIDS Research Basic Science HIV/AIDS grant
      NIH2013 - 2016K99/R00 (K99AI103262, R00AI104262)
      UCSF2013 - 2015Hellman Award for Early-Career Faculty
      Dept. of Urology, UCSF2012 - 2013KURe K12
      The J. David Gladstone Institute, UCSF2012Centers for AIDS Research Early Career Award of Excellence in Basic Research
      The J. David Gladstone Institute, UCSF2012Gladstone Institute of Virology and Immunology Award for Scientific Excellence
      The J. David Gladstone Institute, UCSF2008 - 2010A.P. Giannini Foundation Postdoctoral Fellowship
      NIH2006Travel Award for the 11th International Symposium on Human Chlamydial Infections
      Harvard Medical School2004Manfred Karnovsky Fellowship Award
      U.C. Berkeley2001Outstanding Scholar Award
      Harvard Medical School2001 - 2004National Science Foundation Pre-Doctoral Fellowship
      U.C. Berkeley2001University Medal Finalist
      U.C. Berkeley2001F.H. Carpenter Memorial Price in Biochemistry

      Collapse Overview 
      Collapse Overview
      Dr. Roan has had a long-standing interest in understanding the effect of host factors on microbial pathogens of the genital mucosa. Her research as a graduate student led to new insights into the nature of the mucosal immune response directed against the most common sexually transmitted bacterium C. trachomatis. She created and characterized C. trachomatis-specific TCR transgenic and retrogenic mice, and used these mice as tools to understand the inflammatory response to C. trachomatis within the upper female reproductive tract (FRT). During her postdoctoral years, Dr. Roan continued her studies on sexually transmitted microbes, but transitioned to studying HIV-1, a viral pathogen with a devastating effect on global health. She focused on understanding the effect of semen components on HIV-1 infection. She identified and characterized amyloid fibrils made up of peptides derived from the major components of the semen coagulum. These amyloids markedly enhance HIV infection, in part by promoting the attachment of HIV-1 to their cellular targets.

      Dr. Roan’s current research interest focuses on two major areas. First, she is investigating the mechanisms by which semen components such as coagulum-derived amyloids promote HIV transmission, and the effects of these components on the effectiveness of currently available anti-HIV microbicides. This understanding will help the development of a new class of “combination microbicides” that contain components targeting both HIV-1 and naturally-occurring factors that promote HIV-1 infectivity. In parallel, a high-thoroughput screen is currently being conducted to identify compounds that inhibit the activity of viral-enhancing factors in semen. Dr. Roan’s second line of research is to understand the physiological functions of semen amyloids and their effects on cells present in the genital mucosa. This understanding will reveal insights into the roles of these semen factors in reproduction, which can lead to novel ways to enhance fertility or to the development of a new class of contraceptives.

      Collapse ORNG Applications 
      Collapse Websites
      Collapse NIH Awarded Grants
      Collapse Global Health

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. French KC, Roan NR, Makhatadze GI. Structural characterization of semen coagulum-derived SEM1(86-107) amyloid fibrils that enhance HIV-1 infection. Biochemistry. 2014 May 27; 53(20):3267-77.
        View in: PubMed PMC4039337
      2. Roan NR, Liu H, Usmani SM, Neidleman J, Müller JA, Avila-Herrera A, Gawanbacht A, Zirafi O, Chu S, Dong M, Kumar ST, Smith JF, Pollard KS, Fändrich M, Kirchhoff F, Münch J, Witkowska HE, Greene WC. Liquefaction of semen generates and later degrades a conserved semenogelin peptide that enhances HIV infection. J Virol. 2014 Jul; 88(13):7221-34.
        View in: PubMed PMC4054457
      3. Roan NR, Chu S, Liu H, Neidleman J, Witkowska HE, Greene WC. Interaction of fibronectin with semen amyloids synergistically enhances HIV infection. J Infect Dis. 2014 Oct 1; 210(7):1062-6.
        View in: PubMed PMC4168303
      4. Usmani SM, Zirafi O, Müller JA, Sandi-Monroy NL, Yadav JK, Meier C, Weil T, Roan NR, Greene WC, Walther P, Nilsson KP, Hammarström P, Wetzel R, Pilcher CD, Gagsteiger F, Fändrich M, Kirchhoff F, Münch J. Direct visualization of HIV-enhancing endogenous amyloid fibrils in human semen. Nat Commun. 2014; 5:3508.
        View in: PubMed PMC4129123
      5. Chen JC, Johnson BA, Erikson DW, Piltonen TT, Barragan F, Chu S, Kohgadai N, Irwin JC, Greene WC, Giudice LC, Roan NR. Seminal plasma induces global transcriptomic changes associated with cell migration, proliferation and viability in endometrial epithelial cells and stromal fibroblasts. Hum Reprod. 2014 Jun; 29(6):1255-70.
        View in: PubMed PMC4017943
      Nadia's Networks
      Related Concepts
      Derived automatically from this person's publications.
      People in Profiles who have published with this person.
      Related Authors
      People who share related concepts with this person.
      Back to TOP