Nancy Boudreau, PhD

SchoolUCSF School of Medicine
Address1001 Potrero Ave, SFGH 1
San Francisco CA 94110
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    Inside-Out Approaches to Improve Wound Repair by HoxB3
    NIH R21AR069495Jul 15, 2016 - Apr 30, 2018
    Role: Principal Investigator
    The Regulation of Tumor Progression by Endothelial HoxA5
    NIH R01CA140655May 7, 2010 - Feb 28, 2015
    Role: Principal Investigator
    Improved Drug Delivery to Tumors Using Novel Tissue Perfusion Approaches
    NIH R01CA140943Jul 15, 2009 - May 31, 2014
    Role: Principal Investigator
    Integrative Study of Brain Vascular Malformations
    NIH P01NS044155Jul 1, 2002 - Mar 31, 2014
    Role: Co-Investigator
    NIH R01CA085249Mar 1, 2000 - Feb 28, 2005
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Daldrup-Link HE, Mohanty S, Ansari C, Lenkov O, Shaw A, Ito K, Hong SH, Hoffmann M, Pisani L, Boudreau N, Gambhir SS, Coussens LM. Alk5 inhibition increases delivery of macromolecular and protein-bound contrast agents to tumors. JCI Insight. 2016 May 6; 1(6). PMID: 27182558.
      View in: PubMed
    2. Cuevas I, Layman H, Coussens L, Boudreau N. Correction: Sustained Endothelial Expression of HoxA5 In Vivo Impairs Pathological Angiogenesis And Tumor Progression. PLoS One. 2016; 11(2):e0148833. PMID: 26839951.
      View in: PubMed
    3. Han BW, Layman H, Rode NA, Conway A, Schaffer DV, Boudreau NJ, Jackson WM, Healy KE. Multivalent Conjugates of Sonic Hedgehog Accelerate Diabetic Wound Healing. Tissue Eng Part A. 2015 Sep; 21(17-18):2366-78. PMID: 26154888; PMCID: PMC4554933 [Available on 09/01/16].
    4. Cuevas I, Layman H, Coussens L, Boudreau N. Sustained endothelial expression of HoxA5 in vivo impairs pathological angiogenesis and tumor progression. PLoS One. 2015; 10(3):e0121720. PMID: 25821967; PMCID: PMC4379087.
    5. Kachgal S, Mace KA, Boudreau NJ. The dual roles of homeobox genes in vascularization and wound healing. Cell Adh Migr. 2012 Nov-Dec; 6(6):457-70. PMID: 23076135; PMCID: PMC3547888.
    6. Bahrami SB, Veiseh M, Boudreau NJ. Isolation and expansion of endothelial progenitor cells derived from mouse embryonic stem cells. Methods Mol Biol. 2012; 916:81-96. PMID: 22914934; PMCID: PMC3733326.
    7. Bahrami SB, Veiseh M, Dunn AA, Boudreau NJ. Temporal changes in Hox gene expression accompany endothelial cell differentiation of embryonic stem cells. Cell Adh Migr. 2011 Mar-Apr; 5(2):133-41. PMID: 21200152; PMCID: PMC3084978.
    8. Gilbert PM, Mouw JK, Unger MA, Lakins JN, Gbegnon MK, Clemmer VB, Benezra M, Licht JD, Boudreau NJ, Tsai KK, Welm AL, Feldman MD, Weber BL, Weaver VM. HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype. J Clin Invest. 2010 May; 120(5):1535-50. PMID: 20389018; PMCID: PMC2860938.
    9. Sounni NE, Dehne K, van Kempen L, Egeblad M, Affara NI, Cuevas I, Wiesen J, Junankar S, Korets L, Lee J, Shen J, Morrison CJ, Overall CM, Krane SM, Werb Z, Boudreau N, Coussens LM. Stromal regulation of vessel stability by MMP14 and TGFbeta. Dis Model Mech. 2010 May-Jun; 3(5-6):317-32. PMID: 20223936; PMCID: PMC2860851.
    10. Chen A, Cuevas I, Kenny PA, Miyake H, Mace K, Ghajar C, Boudreau A, Bissell MJ, Bissell M, Boudreau N. Endothelial cell migration and vascular endothelial growth factor expression are the result of loss of breast tissue polarity. Cancer Res. 2009 Aug 15; 69(16):6721-9. PMID: 19654314; PMCID: PMC2760003.
    11. Mace KA, Restivo TE, Rinn JL, Paquet AC, Chang HY, Young DM, Boudreau NJ. HOXA3 modulates injury-induced mobilization and recruitment of bone marrow-derived cells. Stem Cells. 2009 Jul; 27(7):1654-65. PMID: 19544454; PMCID: PMC2733377.
    12. Zhu Y, Cuevas IC, Gabriel RA, Su H, Nishimura S, Gao P, Fields A, Hao Q, Young WL, Yang GY, Boudreau NJ. Restoring transcription factor HoxA5 expression inhibits the growth of experimental hemangiomas in the brain. J Neuropathol Exp Neurol. 2009 Jun; 68(6):626-32. PMID: 19458547; PMCID: PMC2728585.
    13. Cuevas I, Boudreau N. Managing tumor angiogenesis: lessons from VEGF-resistant tumors and wounds. Adv Cancer Res. 2009; 103:25-42. PMID: 19854351.
      View in: PubMed
    14. Arderiu G, Cuevas I, Chen A, Carrio M, East L, Boudreau NJ. HoxA5 stabilizes adherens junctions via increased Akt1. Cell Adh Migr. 2007 Oct-Dec; 1(4):185-95. PMID: 19262140; PMCID: PMC2634105.
    15. Yu DH, Mace KA, Hansen SL, Boudreau N, Young DM. Effects of decreased insulin-like growth factor-1 stimulation on hypoxia inducible factor 1-alpha protein synthesis and function during cutaneous repair in diabetic mice. Wound Repair Regen. 2007 Sep-Oct; 15(5):628-35. PMID: 17971008.
      View in: PubMed
    16. Mace KA, Yu DH, Paydar KZ, Boudreau N, Young DM. Sustained expression of Hif-1alpha in the diabetic environment promotes angiogenesis and cutaneous wound repair. Wound Repair Regen. 2007 Sep-Oct; 15(5):636-45. PMID: 17971009.
      View in: PubMed
    17. Vlahakis NE, Young BA, Atakilit A, Hawkridge AE, Issaka RB, Boudreau N, Sheppard D. Integrin alpha9beta1 directly binds to vascular endothelial growth factor (VEGF)-A and contributes to VEGF-A-induced angiogenesis. J Biol Chem. 2007 May 18; 282(20):15187-96. PMID: 17363377.
      View in: PubMed
    18. Hansen SL, Dosanjh A, Young DM, Boudreau N, Hoffman WY. Hemangiomas and homeobox gene expression. J Craniofac Surg. 2006 Jul; 17(4):767-71. PMID: 16877932.
      View in: PubMed
    19. Boudreau N, Weaver V. Forcing the third dimension. Cell. 2006 May 5; 125(3):429-31. PMID: 16678088.
      View in: PubMed
    20. Charboneau A, East L, Mulholland N, Rohde M, Boudreau N. Pbx1 is required for Hox D3-mediated angiogenesis. Angiogenesis. 2005; 8(4):289-96. PMID: 16328158.
      View in: PubMed
    21. Morimoto-Tomita M, Uchimura K, Bistrup A, Lum DH, Egeblad M, Boudreau N, Werb Z, Rosen SD. Sulf-2, a proangiogenic heparan sulfate endosulfatase, is upregulated in breast cancer. Neoplasia. 2005 Nov; 7(11):1001-10. PMID: 16331886; PMCID: PMC1502017.
    22. Carrio M, Arderiu G, Myers C, Boudreau NJ. Homeobox D10 induces phenotypic reversion of breast tumor cells in a three-dimensional culture model. Cancer Res. 2005 Aug 15; 65(16):7177-85. PMID: 16103068.
      View in: PubMed
    23. Cambier S, Gline S, Mu D, Collins R, Araya J, Dolganov G, Einheber S, Boudreau N, Nishimura SL. Integrin alpha(v)beta8-mediated activation of transforming growth factor-beta by perivascular astrocytes: an angiogenic control switch. Am J Pathol. 2005 Jun; 166(6):1883-94. PMID: 15920172; PMCID: PMC1602409.
    24. Mace KA, Hansen SL, Myers C, Young DM, Boudreau N. HOXA3 induces cell migration in endothelial and epithelial cells promoting angiogenesis and wound repair. J Cell Sci. 2005 Jun 15; 118(Pt 12):2567-77. PMID: 15914537.
      View in: PubMed
    25. Rhoads K, Arderiu G, Charboneau A, Hansen SL, Hoffman W, Boudreau N. A role for Hox A5 in regulating angiogenesis and vascular patterning. Lymphat Res Biol. 2005; 3(4):240-52. PMID: 16379594.
      View in: PubMed
    26. Chen Y, Xu B, Arderiu G, Hashimoto T, Young WL, Boudreau N, Yang GY. Retroviral delivery of homeobox D3 gene induces cerebral angiogenesis in mice. J Cereb Blood Flow Metab. 2004 Nov; 24(11):1280-7. PMID: 15545924.
      View in: PubMed
    27. Heckman CA, Urban JM, Cayer M, Li Y, Boudreau N, Barnes J, Plummer HK, Hall C, Kozma R, Lim L. Novel p21-activated kinase-dependent protrusions characteristically formed at the edge of transformed cells. Exp Cell Res. 2004 May 1; 295(2):432-47. PMID: 15093742.
      View in: PubMed
    28. Hashimoto T, Wu Y, Boudreau N, Li J, Matsumoto M, Young W. Regulation of tie2 expression by angiopoietin--potential feedback system. Endothelium. 2004 May-Aug; 11(3-4):207-10. PMID: 15370298.
      View in: PubMed
    29. Hansen SL, Myers CA, Charboneau A, Young DM, Boudreau N. HoxD3 accelerates wound healing in diabetic mice. Am J Pathol. 2003 Dec; 163(6):2421-31. PMID: 14633614; PMCID: PMC1892363.
    30. Boudreau NJ, Varner JA. The homeobox transcription factor Hox D3 promotes integrin alpha5beta1 expression and function during angiogenesis. J Biol Chem. 2004 Feb 6; 279(6):4862-8. PMID: 14610084.
      View in: PubMed
    31. Hansen SL, Young DM, Boudreau NJ. HoxD3 expression and collagen synthesis in diabetic fibroblasts. Wound Repair Regen. 2003 Nov-Dec; 11(6):474-80. PMID: 14617289.
      View in: PubMed
    32. Boudreau NJ. Organized living: from cell surfaces to basement membranes. Sci STKE. 2003 Aug 19; 2003(196):pe34. PMID: 12928524.
      View in: PubMed
    33. Zhong J, Eliceiri B, Stupack D, Penta K, Sakamoto G, Quertermous T, Coleman M, Boudreau N, Varner JA. Neovascularization of ischemic tissues by gene delivery of the extracellular matrix protein Del-1. J Clin Invest. 2003 Jul; 112(1):30-41. PMID: 12840057; PMCID: PMC162283.
    34. Hashimoto T, Wen G, Lawton MT, Boudreau NJ, Bollen AW, Yang GY, Barbaro NM, Higashida RT, Dowd CF, Halbach VV, Young WL. Abnormal expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in brain arteriovenous malformations. Stroke. 2003 Apr; 34(4):925-31. PMID: 12649522.
      View in: PubMed
    35. Boudreau N, Myers C. Breast cancer-induced angiogenesis: multiple mechanisms and the role of the microenvironment. Breast Cancer Res. 2003; 5(3):140-6. PMID: 12793895; PMCID: PMC165004.
    36. Myers C, Charboneau A, Cheung I, Hanks D, Boudreau N. Sustained expression of homeobox D10 inhibits angiogenesis. Am J Pathol. 2002 Dec; 161(6):2099-109. PMID: 12466126; PMCID: PMC1850921.
    37. Uyeno LA, Newman-Keagle JA, Cheung I, Hunt TK, Young DM, Boudreau N. Hox D3 expression in normal and impaired wound healing. J Surg Res. 2001 Sep; 100(1):46-56. PMID: 11516204.
      View in: PubMed
    38. Hashimoto T, Lam T, Boudreau NJ, Bollen AW, Lawton MT, Young WL. Abnormal balance in the angiopoietin-tie2 system in human brain arteriovenous malformations. Circ Res. 2001 Jul 20; 89(2):111-3. PMID: 11463715.
      View in: PubMed
    39. Myers C, Charboneau A, Boudreau N. Homeobox B3 promotes capillary morphogenesis and angiogenesis. J Cell Biol. 2000 Jan 24; 148(2):343-51. PMID: 10648567; PMCID: PMC2174277.
    40. Boudreau NJ, Jones PL. Extracellular matrix and integrin signalling: the shape of things to come. Biochem J. 1999 May 1; 339 ( Pt 3):481-8. PMID: 10215583; PMCID: PMC1220180.
    41. Boudreau N, Bissell MJ. Extracellular matrix signaling: integration of form and function in normal and malignant cells. Curr Opin Cell Biol. 1998 Oct; 10(5):640-6. PMID: 9818175; PMCID: PMC2933204.
    42. Zhou B, Boudreau N, Coulber C, Hammarback J, Rabinovitch M. Microtubule-associated protein 1 light chain 3 is a fibronectin mRNA-binding protein linked to mRNA translation in lamb vascular smooth muscle cells. J Clin Invest. 1997 Dec 15; 100(12):3070-82. PMID: 9399954; PMCID: PMC508520.
    43. Boudreau N, Andrews C, Srebrow A, Ravanpay A, Cheresh DA. Induction of the angiogenic phenotype by Hox D3. J Cell Biol. 1997 Oct 6; 139(1):257-64. PMID: 9314544; PMCID: PMC2139816.
    44. Boudreau N, Werb Z, Bissell MJ. Suppression of apoptosis by basement membrane requires three-dimensional tissue organization and withdrawal from the cell cycle. Proc Natl Acad Sci U S A. 1996 Apr 16; 93(8):3509-13. PMID: 8622967; PMCID: PMC39640.
    45. Boudreau N, Sympson CJ, Werb Z, Bissell MJ. Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix. Science. 1995 Feb 10; 267(5199):891-3. PMID: 7531366; PMCID: PMC3004777.
    46. Jones PL, Boudreau N, Myers CA, Erickson HP, Bissell MJ. Tenascin-C inhibits extracellular matrix-dependent gene expression in mammary epithelial cells. Localization of active regions using recombinant tenascin fragments. J Cell Sci. 1995 Feb; 108 ( Pt 2):519-27. PMID: 7539436.
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    47. Boudreau N, Myers C, Bissell MJ. From laminin to lamin: regulation of tissue-specific gene expression by the ECM. Trends Cell Biol. 1995 Jan; 5(1):1-4. PMID: 14731421.
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    48. Martins-Green M, Boudreau N, Bissell MJ. Inflammation is responsible for the development of wound-induced tumors in chickens infected with Rous sarcoma virus. Cancer Res. 1994 Aug 15; 54(16):4334-41. PMID: 7519120.
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    49. Boudreau N, Clausell N, Boyle J, Rabinovitch M. Transforming growth factor-beta regulates increased ductus arteriosus endothelial glycosaminoglycan synthesis and a post-transcriptional mechanism controls increased smooth muscle fibronectin, features associated with intimal proliferation. Lab Invest. 1992 Sep; 67(3):350-9. PMID: 1405493.
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    50. Boudreau N, Rabinovitch M. Developmentally regulated changes in extracellular matrix in endothelial and smooth muscle cells in the ductus arteriosus may be related to intimal proliferation. Lab Invest. 1991 Feb; 64(2):187-99. PMID: 1997732.
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    51. Boudreau N, Turley E, Rabinovitch M. Fibronectin, hyaluronan, and a hyaluronan binding protein contribute to increased ductus arteriosus smooth muscle cell migration. Dev Biol. 1991 Feb; 143(2):235-47. PMID: 1703972.
      View in: PubMed
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