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    Nancy McNamara, PhD, OD

    TitleAssociate Professor
    SchoolUCSF Chancellor/EVC/FAS
    DepartmentProctor Foundation
    Address513 Parnassus Ave, Med Sci
    San Francisco CA 94143

       Education and Training
      University of California BerkeleyODSchool of Optometry1996

       ORNG Applications 
       Awarded Grants

      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Rutar T, Youm J, Porco T, Tilton N, Muskat M, McNamara N, Wara D. Ophthalmic manifestations of perinatally acquired HIV in a US cohort of long-term survivors. Br J Ophthalmol. 2015 May; 99(5):650-3.
        View in: PubMed
      2. McNamara NA, Gallup M, Porco TC. Establishing PAX6 as a Biomarker to Detect Early Loss of Ocular Phenotype in Human Patients With Sjögren's Syndrome. Invest Ophthalmol Vis Sci. 2014 Nov; 55(11):7079-84.
        View in: PubMed PMC4224577
      3. Vijmasi T, Chen FY, Balasubbu S, Gallup M, McKown RL, Laurie GW, McNamara NA. Topical administration of lacritin is a novel therapy for aqueous-deficient dry eye disease. Invest Ophthalmol Vis Sci. 2014 Aug; 55(8):5401-9.
        View in: PubMed PMC4148924
      4. Zhang L, Gallup M, Zlock L, Chen YT, Finkbeiner WE, McNamara NA. Pivotal role of MUC1 glycosylation by cigarette smoke in modulating disruption of airway adherens junctions in vitro. J Pathol. 2014 Sep; 234(1):60-73.
        View in: PubMed PMC4138268
      5. Chen YF, Zhou D, Metzger T, Gallup M, Jeanne M, Gould DB, Anderson MS, McNamara NA. Spontaneous development of autoimmune uveitis Is CCR2 dependent. Am J Pathol. 2014 Jun; 184(6):1695-705.
        View in: PubMed PMC4044718
      6. Zhou D, McNamara NA. Macrophages: important players in primary Sjögren's syndrome? Expert Rev Clin Immunol. 2014 Apr; 10(4):513-20.
        View in: PubMed
      7. Robertson DM, Alexander LJ, Bonanno JA, Fleiszig SM, McNamara N. Cornea and ocular surface disease: application of cutting-edge optometric research. Optom Vis Sci. 2014 Apr; 91(4 Suppl 1):S3-16.
        View in: PubMed PMC4090233
      8. Chen YT, Chen FY, Vijmasi T, Stephens DN, Gallup M, McNamara NA. Pax6 downregulation mediates abnormal lineage commitment of the ocular surface epithelium in aqueous-deficient dry eye disease. PLoS One. 2013; 8(10):e77286.
        View in: PubMed PMC3797128
      9. Vijmasi T, Chen FY, Chen YT, Gallup M, McNamara N. Topical administration of interleukin-1 receptor antagonist as a therapy for aqueous-deficient dry eye in autoimmune disease. Mol Vis. 2013; 19:1957-65.
        View in: PubMed PMC3782366
      10. Zhang L, Gallup M, Zlock L, Finkbeiner WE, McNamara NA. Rac1 and Cdc42 differentially modulate cigarette smoke-induced airway cell migration through p120-catenin-dependent and -independent pathways. Am J Pathol. 2013 Jun; 182(6):1986-95.
        View in: PubMed
      11. Zhang L, Gallup M, Zlock L, Basbaum C, Finkbeiner WE, McNamara NA. Cigarette smoke disrupts the integrity of airway adherens junctions through the aberrant interaction of p120-catenin with the cytoplasmic tail of MUC1. J Pathol. 2013 Jan; 229(1):74-86.
        View in: PubMed PMC4096852
      12. McNamara NA, Carbone LA, Shellhaas RA. Epilepsy characteristics and psychosocial factors associated with ketogenic diet success. J Child Neurol. 2013 Oct; 28(10):1233-7.
        View in: PubMed
      13. Zhou D, Chen YT, Chen F, Gallup M, Vijmasi T, Bahrami AF, Noble LB, van Rooijen N, McNamara NA. Critical involvement of macrophage infiltration in the development of Sjögren's syndrome-associated dry eye. Am J Pathol. 2012 Sep; 181(3):753-60.
        View in: PubMed PMC3432423
      14. Shiboski SC, Shiboski CH, Criswell L, Baer A, Challacombe S, Lanfranchi H, Schiødt M, Umehara H, Vivino F, Zhao Y, Dong Y, Greenspan D, Heidenreich AM, Helin P, Kirkham B, Kitagawa K, Larkin G, Li M, Lietman T, Lindegaard J, McNamara N, Sack K, Shirlaw P, Sugai S, Vollenweider C, Whitcher J, Wu A, Zhang S, Zhang W, Greenspan J, Daniels T. American College of Rheumatology classification criteria for Sjögren's syndrome: a data-driven, expert consensus approach in the Sjögren's International Collaborative Clinical Alliance cohort. Arthritis Care Res (Hoboken). 2012 Apr; 64(4):475-87.
        View in: PubMed PMC3349440
      15. Chen YT, Lazarev S, Bahrami AF, Noble LB, Chen FY, Zhou D, Gallup M, Yadav M, McNamara NA. Interleukin-1 receptor mediates the interplay between CD4+ T cells and ocular resident cells to promote keratinizing squamous metaplasia in Sjögren's syndrome. Lab Invest. 2012 Apr; 92(4):556-70.
        View in: PubMed PMC3725338
      16. Zhang L, Gallup M, Zlock L, Finkbeiner W, McNamara NA. p120-catenin modulates airway epithelial cell migration induced by cigarette smoke. Biochem Biophys Res Commun. 2012 Jan 6; 417(1):49-55.
        View in: PubMed PMC4066870
      17. Amburgey K, McNamara N, Bennett LR, McCormick ME, Acsadi G, Dowling JJ. Prevalence of congenital myopathies in a representative pediatric united states population. Ann Neurol. 2011 Oct; 70(4):662-5.
        View in: PubMed
      18. Chan MF, Sack R, Quigley DA, Sathe S, Vijmasi T, Li S, Holsclaw D, Strauss EC, McNamara NA. Membrane array analysis of tear proteins in ocular cicatricial pemphigoid. Optom Vis Sci. 2011 Aug; 88(8):1005-9.
        View in: PubMed PMC3667701
      19. Chen YT, Nikulina K, Lazarev S, Bahrami AF, Noble LB, Gallup M, McNamara NA. Interleukin-1 as a phenotypic immunomodulator in keratinizing squamous metaplasia of the ocular surface in Sjögren's syndrome. Am J Pathol. 2010 Sep; 177(3):1333-43.
        View in: PubMed PMC2928966
      20. Chen YT, Gallup M, Nikulina K, Lazarev S, Zlock L, Finkbeiner W, McNamara N. Cigarette smoke induces epidermal growth factor receptor-dependent redistribution of apical MUC1 and junctional beta-catenin in polarized human airway epithelial cells. Am J Pathol. 2010 Sep; 177(3):1255-64.
        View in: PubMed PMC2928959
      21. McNamara NA. Molecular mechanisms of keratinizing ocular surface disease. Optom Vis Sci. 2010 Apr; 87(4):233-8.
        View in: PubMed
      22. Li S, Gallup M, Chen YT, McNamara NA. Molecular mechanism of proinflammatory cytokine-mediated squamous metaplasia in human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2010 May; 51(5):2466-75.
        View in: PubMed PMC2868474
      23. Whitcher JP, Shiboski CH, Shiboski SC, Heidenreich AM, Kitagawa K, Zhang S, Hamann S, Larkin G, McNamara NA, Greenspan JS, Daniels TE. A simplified quantitative method for assessing keratoconjunctivitis sicca from the Sjögren's Syndrome International Registry. Am J Ophthalmol. 2010 Mar; 149(3):405-15.
        View in: PubMed PMC3459675
      24. Liu H, Begley C, Chen M, Bradley A, Bonanno J, McNamara NA, Nelson JD, Simpson T. A link between tear instability and hyperosmolarity in dry eye. Invest Ophthalmol Vis Sci. 2009 Aug; 50(8):3671-9.
        View in: PubMed
      25. Chen YT, Li S, Nikulina K, Porco T, Gallup M, McNamara N. Immune profile of squamous metaplasia development in autoimmune regulator-deficient dry eye. Mol Vis. 2009; 15:563-76.
        View in: PubMed PMC2660375
      26. Sack R, Sathe S, Beaton AR, McNamara N, Fleiszig S, Ni M. Protein array characterization of bioactive proteins secreted by immortalized human corneal epithelium in response to pseudomonas constituents. Curr Eye Res. 2009 Feb; 34(2):92-8.
        View in: PubMed
      27. Li S, Sack R, Vijmasi T, Sathe S, Beaton A, Quigley D, Gallup M, McNamara NA. Antibody protein array analysis of the tear film cytokines. Optom Vis Sci. 2008 Aug; 85(8):653-60.
        View in: PubMed PMC3786218
      28. Li S, Nikulina K, DeVoss J, Wu AJ, Strauss EC, Anderson MS, McNamara NA. Small proline-rich protein 1B (SPRR1B) is a biomarker for squamous metaplasia in dry eye disease. Invest Ophthalmol Vis Sci. 2008 Jan; 49(1):34-41.
        View in: PubMed PMC2574421
      29. Sack R, Conradi L, Beaton A, Sathe S, McNamara N, Leonardi A. Antibody array characterization of inflammatory mediators in allergic and normal tears in the open and closed eye environments. Exp Eye Res. 2007 Oct; 85(4):528-38.
        View in: PubMed
      30. Evans DJ, McNamara NA, Fleiszig SM. Life at the front: dissecting bacterial-host interactions at the ocular surface. Ocul Surf. 2007 Jul; 5(3):213-27.
        View in: PubMed
      31. Maltseva IA, Fleiszig SM, Evans DJ, Kerr S, Sidhu SS, McNamara NA, Basbaum C. Exposure of human corneal epithelial cells to contact lenses in vitro suppresses the upregulation of human beta-defensin-2 in response to antigens of Pseudomonas aeruginosa. Exp Eye Res. 2007 Jul; 85(1):142-53.
        View in: PubMed
      32. Dasari V, Gallup M, Lemjabbar H, Maltseva I, McNamara N. Epithelial-mesenchymal transition in lung cancer: is tobacco the "smoking gun"? Am J Respir Cell Mol Biol. 2006 Jul; 35(1):3-9.
        View in: PubMed
      33. McNamara N, Gallup M, Sucher A, Maltseva I, McKemy D, Basbaum C. AsialoGM1 and TLR5 cooperate in flagellin-induced nucleotide signaling to activate Erk1/2. Am J Respir Cell Mol Biol. 2006 Jun; 34(6):653-60.
        View in: PubMed PMC2644226
      34. McNamara NA, Andika R, Kwong M, Sack RA, Fleiszig SM. Interaction of Pseudomonas aeruginosa with human tear fluid components. Curr Eye Res. 2005 Jul; 30(7):517-25.
        View in: PubMed
      35. McNamara N, Gallup M, Khong A, Sucher A, Maltseva I, Fahy J, Basbaum C. Adenosine up-regulation of the mucin gene, MUC2, in asthma. FASEB J. 2004 Nov; 18(14):1770-2.
        View in: PubMed
      36. Londhe V, McNamara N, Lemjabbar H, Basbaum C. Viral dsRNA activates mucin transcription in airway epithelial cells. FEBS Lett. 2003 Oct 9; 553(1-2):33-8.
        View in: PubMed
      37. McNamara NA. Innate defense of the ocular surface. Eye Contact Lens. 2003 Jan; 29(1 Suppl):S10-3; discussion S26-9, S192-4.
        View in: PubMed
      38. Fleiszig SM, McNamara NA, Evans DJ. The tear film and defense against infection. Adv Exp Med Biol. 2002; 506(Pt A):523-30.
        View in: PubMed
      39. McNamara N, Basbaum C. Mechanism by which bacterial flagellin stimulates host mucin production. Adv Exp Med Biol. 2002; 506(Pt A):269-73.
        View in: PubMed
      40. McNamara N, Basbaum C. Signaling networks controlling mucin production in response to Gram-positive and Gram-negative bacteria. Glycoconj J. 2001 Sep; 18(9):715-22.
        View in: PubMed
      41. Fusaro RE, Polse KA, Graham AD, Gan CM, Rivera RK, Lin MC, Sanders TL, McNamara NA, Chan JS. The Berkeley Contact Lens Extended Wear Study. Part I : Study design and conduct. Ophthalmology. 2001 Aug; 108(8):1381-8.
        View in: PubMed
      42. Polse KA, Graham AD, Fusaro RE, Gan CM, Rivera RK, Lin MC, Sanders TL, McNamara NA, Chan JS. The Berkeley Contact Lens Extended Wear Study. Part II : Clinical results. Ophthalmology. 2001 Aug; 108(8):1389-99.
        View in: PubMed
      43. McNamara N, Khong A, McKemy D, Caterina M, Boyer J, Julius D, Basbaum C. ATP transduces signals from ASGM1, a glycolipid that functions as a bacterial receptor. Proc Natl Acad Sci U S A. 2001 Jul 31; 98(16):9086-91.
        View in: PubMed PMC55377
      44. Belcher CE, Drenkow J, Kehoe B, Gingeras TR, McNamara N, Lemjabbar H, Basbaum C, Relman DA. The transcriptional responses of respiratory epithelial cells to Bordetella pertussis reveal host defensive and pathogen counter-defensive strategies. Proc Natl Acad Sci U S A. 2000 Dec 5; 97(25):13847-52.
        View in: PubMed PMC17664
      45. Lin MC, Graham AD, Polse KA, McNamara NA, Tieu TG. The effects of one-hour wear of high-Dk soft contact lenses on corneal pH and epithelial permeability. CLAO J. 2000 Jul; 26(3):130-3.
        View in: PubMed
      46. McNamara NA, Sack RA, Fleiszig SM. Mucin-bacterial binding assays. Methods Mol Biol. 2000; 125:429-37.
        View in: PubMed
      47. Lin MC, Graham AD, Polse KA, Mandell RB, McNamara NA. Measurement of post-lens tear thickness. Invest Ophthalmol Vis Sci. 1999 Nov; 40(12):2833-9.
        View in: PubMed
      48. Basbaum C, Lemjabbar H, Longphre M, Li D, Gensch E, McNamara N. Control of mucin transcription by diverse injury-induced signaling pathways. Am J Respir Crit Care Med. 1999 Nov; 160(5 Pt 2):S44-8.
        View in: PubMed
      49. McNAMARA NA, Van R, Tuchin OS, Fleiszig SM. Ocular surface epithelia express mRNA for human beta defensin-2. Exp Eye Res. 1999 Nov; 69(5):483-90.
        View in: PubMed
      50. Polse KA, Graham AD, Fusaro RE, Gan CM, Rivera RK, Chan JS, McNamara NA, Sanders TS. Predicting RGP daily wear success. CLAO J. 1999 Jul; 25(3):152-8.
        View in: PubMed
      51. McNamara NA, Polse KA, Brand RJ, Graham AD, Chan JS, McKenney CD. Tear mixing under a soft contact lens: effects of lens diameter. Am J Ophthalmol. 1999 Jun; 127(6):659-65.
        View in: PubMed
      52. McNamara NA, Chan JS, Han SC, Polse KA, McKenney CD. Effects of hypoxia on corneal epithelial permeability. Am J Ophthalmol. 1999 Feb; 127(2):153-7.
        View in: PubMed
      53. McNamara NA, Polse KA, Fukunaga SA, Maebori JS, Suzuki RM. Soft lens extended wear affects epithelial barrier function. Ophthalmology. 1998 Dec; 105(12):2330-5.
        View in: PubMed
      54. McNamara NA, Polse KA, Bonanno JA. Fluorophotometry in contact lens research: the next step. Optom Vis Sci. 1998 May; 75(5):316-22.
        View in: PubMed
      55. McNamara NA, Fusaro RE, Brand RJ, Polse KA. Epithelial permeability reflects subclinical effects of contact lens wear. Br J Ophthalmol. 1998 Apr; 82(4):376-81.
        View in: PubMed PMC1722553
      56. McNamara NA, Brand RJ, Polse KA, Bourne WM. Corneal function during normal and high serum glucose levels in diabetes. Invest Ophthalmol Vis Sci. 1998 Jan; 39(1):3-17.
        View in: PubMed
      57. McNamara NA, Fleiszig SM. Human tear film components bind Pseudomonas aeruginosa. Adv Exp Med Biol. 1998; 438:653-8.
        View in: PubMed
      58. McNamara NA, Fusaro RE, Brand RJ, Polse KA, Srinivas SP. Measurement of corneal epithelial permeability to fluorescein. A repeatability study. Invest Ophthalmol Vis Sci. 1997 Aug; 38(9):1830-9.
        View in: PubMed
      59. Levy B, McNamara N, Corzine J, Abbott RL. Prospective trial of daily and extended wear disposable contact lenses. Cornea. 1997 May; 16(3):274-6.
        View in: PubMed
      60. McMahon TT, Polse KA, McNamara N, Viana MA. Recovery from induced corneal edema and endothelial morphology after long-term PMMA contact lens wear. Optom Vis Sci. 1996 Mar; 73(3):184-8.
        View in: PubMed
      61. Goldberg MA, McNamara N, Nguyen NT, Lerner L, Rosenblum LH, Park DW, Abbott RL, Levy B. Effect of diclofenac sodium (Voltaren) on hypoxia-induced corneal edema in humans. CLAO J. 1995 Jan; 21(1):61-3.
        View in: PubMed
      62. McNamara NA, Polse KA, Bonanno JA. Stromal acidosis modulates corneal swelling. Invest Ophthalmol Vis Sci. 1994 Mar; 35(3):846-50.
        View in: PubMed
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