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    Noriko Isobe, MD, PhD

    TitleSpecialist
    SchoolUCSF School of Medicine
    DepartmentNeurology
    Address675 Nelson Rising Lane
    San Francisco CA 94158
    Phone415-502-7211
    vCardDownload vCard

      Collapse Biography 
      Collapse Education and Training
      Kyushu University Ph.D.Graduate School of Medical Sciences2010
      Kyushu University M.D.School of Medicine2003
      Collapse Awards and Honors
      Japan Society for the Promotion of Science (JSPS)2014 - 2015Research Fellowship for Young Scientists (PD)
      JSPS2012 - 2014Postdoctoral Fellowship for Research Abroad
      23rd Annual Meeting of the Japanese Society for Neuroimmunology2011Young Neuroimmunologist Award
      4th Congress of the Pan-Asian Committee for Treatment and Research in Multiple Sclerosis (PACTRIMS)2011Young Investigator Award
      The Uehara Memorial Foundation2011Post-doctoral Fellowship
      The Association for Preventive Medicine of Japan2010 - 2011Grant for Research on Intractable diseases
      27th Congress of European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS)2010Travel grant
      26th Congress of ECTRIMS2009Travel grant

      Collapse ORNG Applications 
      Collapse Websites

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Isobe N, Oksenberg JR, Henry RG. HLA Genetic Risk Burden in Multiple Sclerosis-Reply. JAMA Neurol. 2016 Oct 24. PMID: 27775754.
        View in: PubMed
      2. Nakamura Y, Matsushita T, Sato S, Niino M, Fukazawa T, Yoshimura S, Hisahara S, Isobe N, Shimohama S, Watanabe M, Yoshida K, Houzen H, Miyazaki Y, Yamasaki R, Kikuchi S, Kira J. Latitude and HLA-DRB1*04:05 independently influence disease severity in Japanese multiple sclerosis: a cross-sectional study. J Neuroinflammation. 2016; 13(1):239. PMID: 27599848; PMCID: PMC5013608.
      3. Isobe N, Keshavan A, Gourraud PA, Zhu AH, Datta E, Schlaeger R, Caillier SJ, Santaniello A, Lizée A, Himmelstein DS, Baranzini SE, Hollenbach J, Cree BA, Hauser SL, Oksenberg JR, Henry RG, et al. Association of HLA Genetic Risk Burden With Disease Phenotypes in Multiple Sclerosis. JAMA Neurol. 2016 Jul 1; 73(7):795-802. PMID: 27244296.
        View in: PubMed
      4. Didonna A, Isobe N, Caillier SJ, Li KH, Burlingame AL, Hauser SL, Baranzini SE, Patsopoulos NA, Oksenberg JR. A non-synonymous single-nucleotide polymorphism associated with multiple sclerosis risk affects the EVI5 interactome. Hum Mol Genet. 2015 Dec 15; 24(24):7151-8. PMID: 26433934.
        View in: PubMed
      5. Sato S, Yamamoto K, Matsushita T, Isobe N, Kawano Y, Iinuma K, Niino M, Fukazawa T, Nakamura Y, Watanabe M, Yonekawa T, Masaki K, Yoshimura S, Murai H, Yamasaki R, Kira JI. Copy number variations in multiple sclerosis and neuromyelitis optica. Ann Neurol. 2015 Nov; 78(5):762-74. PMID: 26296936.
        View in: PubMed
      6. Isobe N, Madireddy L, Khankhanian P, Matsushita T, Caillier SJ, Moré JM, Gourraud PA, McCauley JL, Beecham AH, Piccio L, Herbert J, Khan O, Cohen J, Stone L, Santaniello A, Cree BA, Onengut-Gumuscu S, Rich SS, Hauser SL, Sawcer S, Oksenberg JR. An ImmunoChip study of multiple sclerosis risk in African Americans. Brain. 2015 Jun; 138(Pt 6):1518-30. PMID: 25818868; PMCID: PMC4553906 [Available on 06/01/16].
      7. Isobe N, Yonekawa T, Matsushita T, Kawano Y, Masaki K, Yoshimura S, Murai H, Yamasaki R, Kira J. . Distinct features of IgG2 aquaporin-4 antibody carriers with neuromyelitis optica. Clin Exp Neuroimmunol. 2015; 6(2):154-158.
      8. Niino M, Sato S, Fukazawa T, Yoshimura S, Hisahara S, Matsushita T, Isobe N, Yoshida K, Houzen H, Miyazaki Y, Shimohama S, Kikuchi S, Kira J. Latitude and HLA-DRB1 alleles independently affect the emergence of cerebrospinal fluid IgG abnormality in multiple sclerosis. Mult Scler. 2015 Aug; 21(9):1112-20. PMID: 25583844.
        View in: PubMed
      9. Nickles D, Madireddy L, Patel N, Isobe N, Miller BL, Baranzini SE, Kramer JH, Oksenberg JR. Whole genome sequences of 2 octogenarians with sustained cognitive abilities. Neurobiol Aging. 2015 Mar; 36(3):1435-8. PMID: 25618617; PMCID: PMC4346472 [Available on 03/01/16].
      10. Yoshimura S, Isobe N, Matsushita T, Masaki K, Sato S, Kawano Y, Ochi H, Kira J. Genetic and infectious profiles influence cerebrospinal fluid IgG abnormality in Japanese multiple sclerosis patients. PLoS One. 2014; 9(4):e95367. PMID: 24736746; PMCID: PMC3988235.
      11. Isobe N, Oksenberg JR. . Clin Exp Neuroimmunol. Genetic studies of multiple sclerosis and neuromyelitis optica: current status in European, African American, and Asian populations. 2014; 5(1):61-68.
      12. Ainiding G, Kawano Y, Sato S, Isobe N, Matsushita T, Yoshimura S, Yonekawa T, Yamasaki R, Murai H, Kira J. Interleukin 2 receptor a chain gene polymorphisms and risks of multiple sclerosis and neuromyelitis optica in southern Japanese. J Neurol Sci. 2014 Feb 15; 337(1-2):147-50. PMID: 24332945.
        View in: PubMed
      13. Yonekawa T, Murai H, Utsuki S, Matsushita T, Masaki K, Isobe N, Yamasaki R, Yoshida M, Kusunoki S, Sakata K, Fujii K, Kira J. A nationwide survey of hypertrophic pachymeningitis in Japan. J Neurol Neurosurg Psychiatry. 2014 Jul; 85(7):732-9. PMID: 24273222.
        View in: PubMed
      14. Shiraishi W, Hayashi S, Kamada T, Isobe N, Yamasaki R, Murai H, Ohyagi Y, Kira J. A case of neuromyelitis optica harboring both anti-aquaporin-4 antibodies and a pathogenic mitochondrial DNA mutation for Leber's hereditary optic neuropathy. Mult Scler. 2014 Feb; 20(2):258-60. PMID: 24263387.
        View in: PubMed
      15. Harbo HF, Isobe N, Berg-Hansen P, Bos SD, Caillier SJ, Gustavsen MW, Mero IL, Celius EG, Hauser SL, Oksenberg JR, Gourraud PA. Oligoclonal bands and age at onset correlate with genetic risk score in multiple sclerosis. Mult Scler. 2014 May; 20(6):660-8. PMID: 24099750; PMCID: PMC4066985.
      16. Isobe N, Damotte V, Lo Re V, Ban M, Pappas D, Guillot-Noel L, Rebeix I, Compston A, Mack T, Cozen W, Fontaine B, Hauser SL, Oksenberg JR, Sawcer S, Gourraud PA. Genetic burden in multiple sclerosis families. Genes Immun. 2013 Oct; 14(7):434-40. PMID: 23903824; PMCID: PMC4102601.
      17. Zhang GW, Zhang WX, Chen SY, Yoshimura Y, Isobe N, Lai SJ. Dectin-1 gene polymorphism is associated with susceptibility to nonspecific digestive disorders and cytokine expression in rabbits. J Anim Sci. 2013 Sep; 91(9):4051-9. PMID: 23893974.
        View in: PubMed
      18. Isobe N, Gourraud PA, Harbo HF, Caillier SJ, Santaniello A, Khankhanian P, Maiers M, Spellman S, Cereb N, Yang S, Pando MJ, Piccio L, Cross AH, De Jager PL, Cree BA, Hauser SL, Oksenberg JR. Genetic risk variants in African Americans with multiple sclerosis. Neurology. 2013 Jul 16; 81(3):219-27. PMID: 23771490; PMCID: PMC3770164.
      19. Matsushita T, Tateishi T, Isobe N, Yonekawa T, Yamasaki R, Matsuse D, Murai H, Kira J. Characteristic cerebrospinal fluid cytokine/chemokine profiles in neuromyelitis optica, relapsing remitting or primary progressive multiple sclerosis. PLoS One. 2013; 8(4):e61835. PMID: 23637915; PMCID: PMC3630114.
      20. Huang J, Yoshimura S, Isobe N, Matsushita T, Yonekawa T, Sato S, Yamasaki R, Kira J. A NOTCH4 missense mutation confers resistance to multiple sclerosis in Japanese. Mult Scler. 2013 Nov; 19(13):1696-703. PMID: 23549433.
        View in: PubMed
      21. Isobe N, Yonekawa T, Matsushita T, Masaki K, Yoshimura S, Fichna J, Chen S, Furmaniak J, Smith BR, Kira J. Clinical relevance of serum aquaporin-4 antibody levels in neuromyelitis optica. Neurochem Res. 2013 May; 38(5):997-1001. PMID: 23456674.
        View in: PubMed
      22. Yoshimura S, Isobe N, Yonekawa T, Matsushita T, Masaki K, Sato S, Kawano Y, Yamamoto K, Kira J. Genetic and infectious profiles of Japanese multiple sclerosis patients. PLoS One. 2012; 7(11):e48592. PMID: 23152786; PMCID: PMC3494689.
      23. Yoshimura S, Isobe N, Matsushita T, Yonekawa T, Masaki K, Sato S, Kawano Y, Kira J. Distinct genetic and infectious profiles in Japanese neuromyelitis optica patients according to anti-aquaporin 4 antibody status. J Neurol Neurosurg Psychiatry. 2013 Jan; 84(1):29-34. PMID: 23038741.
        View in: PubMed
      24. Sato S, Isobe N, Yoshimura S, Kanamori Y, Masaki K, Matsushita T, Kira J. HLA-DPB1*0201 is associated with susceptibility to atopic myelitis in Japanese. J Neuroimmunol. 2012 Oct 15; 251(1-2):110-3. PMID: 22884298.
        View in: PubMed
      25. Isobe N, Yonekawa T, Matsushita T, Kawano Y, Masaki K, Yoshimura S, Fichna J, Chen S, Furmaniak J, Smith BR, Kira J. Quantitative assays for anti-aquaporin-4 antibody with subclass analysis in neuromyelitis optica. Mult Scler. 2012 Nov; 18(11):1541-51. PMID: 22526930.
        View in: PubMed
      26. Ainiding G, Yamashita K, Torii T, Furuta K, Isobe N, Matsushita T, Masaki K, Matsumoto S, Kira J. Clinical disability progression and platelet GP IIb/IIIa values in patients with atopic myelitis. J Neuroimmunol. 2012 May 15; 246(1-2):108-12. PMID: 22484027.
        View in: PubMed
      27. Masaki K, Suzuki SO, Matsushita T, Yonekawa T, Matsuoka T, Isobe N, Motomura K, Wu XM, Tabira T, Iwaki T, Kira J. Extensive loss of connexins in Baló's disease: evidence for an auto-antibody-independent astrocytopathy via impaired astrocyte-oligodendrocyte/myelin interaction. Acta Neuropathol. 2012 Jun; 123(6):887-900. PMID: 22438105.
        View in: PubMed
      28. Isobe N, Kanamori Y, Yonekawa T, Matsushita T, Shigeto H, Kawamura N, Kira J. First diagnostic criteria for atopic myelitis with special reference to discrimination from myelitis-onset multiple sclerosis. J Neurol Sci. 2012 May 15; 316(1-2):30-5. PMID: 22364869.
        View in: PubMed
      29. Estiasari R, Matsushita T, Masaki K, Akiyama T, Yonekawa T, Isobe N, Kira J. Comparison of clinical, immunological and neuroimaging features between anti-aquaporin-4 antibody-positive and antibody-negative Sjogren's syndrome patients with central nervous system manifestations. Mult Scler. 2012 Jun; 18(6):807-16. PMID: 22291033.
        View in: PubMed
      30. Ramagopalan S, Dyment D, Farrell R, Isobe N. Multiple sclerosis. Autoimmune Dis. 2011; 2011:248758. PMID: 21747986; PMCID: PMC3130332.
      31. Fang L, Isobe N, Yoshimura S, Yonekawa T, Matsushita T, Masaki K, Doi H, Ochi K, Miyamoto K, Kawano Y, Kira J. Interleukin-7 receptor alpha gene polymorphism influences multiple sclerosis risk in Asians. Neurology. 2011 Jun 14; 76(24):2125-7. PMID: 21670443.
        View in: PubMed
      32. McElroy JP, Isobe N, Gourraud PA, Caillier SJ, Matsushita T, Kohriyama T, Miyamoto K, Nakatsuji Y, Miki T, Hauser SL, Oksenberg JR, Kira J. SNP-based analysis of the HLA locus in Japanese multiple sclerosis patients. Genes Immun. 2011 Oct; 12(7):523-30. PMID: 21654846; PMCID: PMC3361962.
      33. Murai H, Yamashita N, Watanabe M, Nomura Y, Motomura M, Yoshikawa H, Nakamura Y, Kawaguchi N, Onodera H, Araga S, Isobe N, Nagai M, Kira J. Characteristics of myasthenia gravis according to onset-age: Japanese nationwide survey. J Neurol Sci. 2011 Jun 15; 305(1-2):97-102. PMID: 21440910.
        View in: PubMed
      34. Shinoda K, Matsushita T, Furuta K, Isobe N, Yonekawa T, Ohyagi Y, Kira J. Wall-eyed bilateral internuclear ophthalmoplegia (WEBINO) syndrome in a patient with neuromyelitis optica spectrum disorder and anti-aquaporin-4 antibody. Mult Scler. 2011 Jul; 17(7):885-7. PMID: 21300735.
        View in: PubMed
      35. Yoshimura S, Ochi H, Isobe N, Matsushita T, Motomura K, Matsuoka T, Minohara M, Kira J. Altered production of brain-derived neurotrophic factor by peripheral blood immune cells in multiple sclerosis. Mult Scler. 2010 Oct; 16(10):1178-88. PMID: 20656764.
        View in: PubMed
      36. Nakamura N, Shigeto H, Isobe N, Tanaka M, Ohyagi Y, Kira J. [A case of mononeuropathy multiplex associated with idiopathic thrombocytopenic purpura]. Rinsho Shinkeigaku. 2010 Jul; 50(7):482-4. PMID: 20681266.
        View in: PubMed
      37. Matsushita T, Isobe N, Kawajiri M, Mogi M, Tsukuda K, Horiuchi M, Ohyagi Y, Kira J. CSF angiotensin II and angiotensin-converting enzyme levels in anti-aquaporin-4 autoimmunity. J Neurol Sci. 2010 Aug 15; 295(1-2):41-5. PMID: 20541774.
        View in: PubMed
      38. Doi H, Tateishi T, Isobe N, Yamasaki R, Ohyagi Y, Kira J. [Sporadic hemiplegic migraine-like headache in a patient with systemic lupus erythematosus]. Rinsho Shinkeigaku. 2010 May; 50(5):332-4. PMID: 20535984.
        View in: PubMed
      39. Tateishi T, Yamasaki R, Tanaka M, Matsushita T, Kikuchi H, Isobe N, Ohyagi Y, Kira J. CSF chemokine alterations related to the clinical course of amyotrophic lateral sclerosis. J Neuroimmunol. 2010 May; 222(1-2):76-81. PMID: 20381883.
        View in: PubMed
      40. Matsushita T, Isobe N, Piao H, Matsuoka T, Ishizu T, Doi H, Masaki K, Yoshiura T, Yamasaki R, Ohyagi Y, Kira J. Reappraisal of brain MRI features in patients with multiple sclerosis and neuromyelitis optica according to anti-aquaporin-4 antibody status. J Neurol Sci. 2010 Apr 15; 291(1-2):37-43. PMID: 20122699.
        View in: PubMed
      41. Isobe N, Matsushita T, Yamasaki R, Ramagopalan SV, Kawano Y, Nishimura Y, Ebers GC, Kira J. Influence of HLA-DRB1 alleles on the susceptibility and resistance to multiple sclerosis in Japanese patients with respect to anti-aquaporin 4 antibody status. Mult Scler. 2010 Feb; 16(2):147-55. PMID: 20028711.
        View in: PubMed
      42. Li W, Minohara M, Piao H, Matsushita T, Masaki K, Matsuoka T, Isobe N, Su JJ, Ohyagi Y, Kira J. Association of anti-Helicobacter pylori neutrophil-activating protein antibody response with anti-aquaporin-4 autoimmunity in Japanese patients with multiple sclerosis and neuromyelitis optica. Mult Scler. 2009 Dec; 15(12):1411-21. PMID: 19965522.
        View in: PubMed
      43. Isobe N, Kira J, Kawamura N, Ishizu T, Arimura K, Kawano Y. Neural damage associated with atopic diathesis: a nationwide survey in Japan. Neurology. 2009 Sep 8; 73(10):790-7. PMID: 19738174.
        View in: PubMed
      44. Matsushita T, Isobe N, Matsuoka T, Ishizu T, Kawano Y, Yoshiura T, Ohyagi Y, Kira J. Extensive vasogenic edema of anti-aquaporin-4 antibody-related brain lesions. Mult Scler. 2009 Sep; 15(9):1113-7. PMID: 19625334.
        View in: PubMed
      45. Matsushita T, Isobe N, Matsuoka T, Shi N, Kawano Y, Wu XM, Yoshiura T, Nakao Y, Ishizu T, Kira JI. Aquaporin-4 autoimmune syndrome and anti-aquaporin-4 antibody-negative opticospinal multiple sclerosis in Japanese. Mult Scler. 2009 Jul; 15(7):834-47. PMID: 19465451.
        View in: PubMed
      46. Doi H, Matsushita T, Isobe N, Ishizu T, Ohyagi Y, Kira J. Frequency of chronic headaches in Japanese patients with multiple sclerosis: with special reference to opticospinal and common forms of multiple sclerosis. Headache. 2009 Nov-Dec; 49(10):1513-20. PMID: 19438737.
        View in: PubMed
      47. Watanabe A, Matsushita T, Doi H, Matsuoka T, Shigeto H, Isobe N, Kawano Y, Tobimatsu S, Kira J. Multimodality-evoked potential study of anti-aquaporin-4 antibody-positive and -negative multiple sclerosis patients. J Neurol Sci. 2009 Jun 15; 281(1-2):34-40. PMID: 19339021.
        View in: PubMed
      48. Matsushita T, Matsuoka T, Isobe N, Kawano Y, Minohara M, Shi N, Nishimura Y, Ochi H, Kira J. Association of the HLA-DPB1*0501 allele with anti-aquaporin-4 antibody positivity in Japanese patients with idiopathic central nervous system demyelinating disorders. Tissue Antigens. 2009 Feb; 73(2):171-6. PMID: 19140826.
        View in: PubMed
      49. Doi H, Matsushita T, Isobe N, Matsuoka T, Minohara M, Ochi H, Kira JI. Hypercomplementemia at relapse in patients with anti-aquaporin-4 antibody. Mult Scler. 2009 Mar; 15(3):304-10. PMID: 19028829.
        View in: PubMed
      50. Kuroki N, Ohyagi Y, Kawano Y, Yoshiura T, Taniwaki T, Kira J. Acute onset facial numbness. J Clin Neurosci. 2008 Sep; 15(9):1049, 1077. PMID: 18782920.
        View in: PubMed
      51. Koga Y, Isobe N, Tateishi T, Osoegawa M, Ohyagi Y, Kira J. [Case of posterior reversible encephalopathy syndrome with cerebral vasoconstriction]. Rinsho Shinkeigaku. 2008 May; 48(5):355-8. PMID: 18540385.
        View in: PubMed
      52. Kira J, Isobe N, Kawano Y, Osoegawa M, Ohyagi Y, Mihara F, Murai H. Atopic myelitis with focal amyotrophy: a possible link to Hopkins syndrome. J Neurol Sci. 2008 Jun 15; 269(1-2):143-51. PMID: 18295237.
        View in: PubMed
      53. Yang W, Arii S, Mori A, Furumoto K, Nakao T, Isobe N, Murata T, Onodera H, Imamura M. sFlt-1 gene-transfected fibroblasts: a wound-specific gene therapy inhibits local cancer recurrence. Cancer Res. 2001 Nov 1; 61(21):7840-5. PMID: 11691801.
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      54. Furumoto K, Arii S, Yamasaki S, Mizumoto M, Mori A, Inoue N, Isobe N, Imamura M. Spleen-derived dendritic cells engineered to enhance interleukin-12 production elicit therapeutic antitumor immune responses. Int J Cancer. 2000 Sep 1; 87(5):665-72. PMID: 10925360.
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      55. Nakamura Y, Higaki T, Kato H, Kishida F, Kogiso S, Isobe N, Kaneko H. A quantitative comparison of induction and challenge concentrations inducing a 50% positive response in three skin sensitization tests; the guinea pig maximization test, adjuvant and patch test and Buehler test. J Toxicol Sci. 1999 May; 24(2):123-31. PMID: 10349614.
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      56. Nakamura I, Isobe N, Nakamura N, Kamihara T, Fukui S. Mechanism of thiamine-induced respiratory deficiency in Saccharomyces carlsbergensis. J Bacteriol. 1981 Sep; 147(3):954-61. PMID: 7275938; PMCID: PMC216134.
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