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Noriko Isobe, MD, PhD

TitleResearch Associate
SchoolUCSF School of Medicine
DepartmentNeurology
Address675 Nelson Rising Lane
San Francisco CA 94158
Phone415-502-7211
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    Collapse Biography 
    Collapse Education and Training
    Kyushu University Ph.D.2010Graduate School of Medical Sciences
    Kyushu University M.D.2003School of Medicine
    Collapse Awards and Honors
    Japan Society for the Promotion of Science (JSPS)2014 - 2015Research Fellowship for Young Scientists (PD)
    JSPS2012 - 2014Postdoctoral Fellowship for Research Abroad
    23rd Annual Meeting of the Japanese Society for Neuroimmunology2011Young Neuroimmunologist Award
    4th Congress of the Pan-Asian Committee for Treatment and Research in Multiple Sclerosis (PACTRIMS)2011Young Investigator Award
    The Uehara Memorial Foundation2011Post-doctoral Fellowship
    The Association for Preventive Medicine of Japan2010 - 2011Grant for Research on Intractable diseases
    27th Congress of European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS)2010Travel grant
    26th Congress of ECTRIMS2009Travel grant

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Isobe N, Oksenberg JR, Henry RG. HLA Genetic Risk Burden in Multiple Sclerosis-Reply. JAMA Neurol. 2016 Oct 24. PMID: 27775754.
      View in: PubMed
    2. Nakamura Y, Matsushita T, Sato S, Niino M, Fukazawa T, Yoshimura S, Hisahara S, Isobe N, Shimohama S, Watanabe M, Yoshida K, Houzen H, Miyazaki Y, Yamasaki R, Kikuchi S, Kira J. Latitude and HLA-DRB1*04:05 independently influence disease severity in Japanese multiple sclerosis: a cross-sectional study. J Neuroinflammation. 2016; 13(1):239. PMID: 27599848; PMCID: PMC5013608.
    3. Isobe N, Keshavan A, Gourraud PA, Zhu AH, Datta E, Schlaeger R, Caillier SJ, Santaniello A, Lizée A, Himmelstein DS, Baranzini SE, Hollenbach J, Cree BA, Hauser SL, Oksenberg JR, Henry RG, et al. Association of HLA Genetic Risk Burden With Disease Phenotypes in Multiple Sclerosis. JAMA Neurol. 2016 Jul 1; 73(7):795-802. PMID: 27244296.
      View in: PubMed
    4. Didonna A, Isobe N, Caillier SJ, Li KH, Burlingame AL, Hauser SL, Baranzini SE, Patsopoulos NA, Oksenberg JR. A non-synonymous single-nucleotide polymorphism associated with multiple sclerosis risk affects the EVI5 interactome. Hum Mol Genet. 2015 Dec 15; 24(24):7151-8. PMID: 26433934.
      View in: PubMed
    5. Sato S, Yamamoto K, Matsushita T, Isobe N, Kawano Y, Iinuma K, Niino M, Fukazawa T, Nakamura Y, Watanabe M, Yonekawa T, Masaki K, Yoshimura S, Murai H, Yamasaki R, Kira JI. Copy number variations in multiple sclerosis and neuromyelitis optica. Ann Neurol. 2015 Nov; 78(5):762-74. PMID: 26296936.
      View in: PubMed
    6. Isobe N, Madireddy L, Khankhanian P, Matsushita T, Caillier SJ, Moré JM, Gourraud PA, McCauley JL, Beecham AH, Piccio L, Herbert J, Khan O, Cohen J, Stone L, Santaniello A, Cree BA, Onengut-Gumuscu S, Rich SS, Hauser SL, Sawcer S, Oksenberg JR. An ImmunoChip study of multiple sclerosis risk in African Americans. Brain. 2015 Jun; 138(Pt 6):1518-30. PMID: 25818868; PMCID: PMC4553906 [Available on 06/01/16].
    7. Isobe N, Yonekawa T, Matsushita T, Kawano Y, Masaki K, Yoshimura S, Murai H, Yamasaki R, Kira J. Distinct features of IgG2 aquaporin-4 antibody carriers with neuromyelitis optica. Clin Exp Neuroimmunol. 2015; 6(2):154-158.
    8. Niino M, Sato S, Fukazawa T, Yoshimura S, Hisahara S, Matsushita T, Isobe N, Yoshida K, Houzen H, Miyazaki Y, Shimohama S, Kikuchi S, Kira J. Latitude and HLA-DRB1 alleles independently affect the emergence of cerebrospinal fluid IgG abnormality in multiple sclerosis. Mult Scler. 2015 Aug; 21(9):1112-20. PMID: 25583844.
      View in: PubMed
    9. Nickles D, Madireddy L, Patel N, Isobe N, Miller BL, Baranzini SE, Kramer JH, Oksenberg JR. Whole genome sequences of 2 octogenarians with sustained cognitive abilities. Neurobiol Aging. 2015 Mar; 36(3):1435-8. PMID: 25618617; PMCID: PMC4346472 [Available on 03/01/16].
    10. Yoshimura S, Isobe N, Matsushita T, Masaki K, Sato S, Kawano Y, Ochi H, Kira J. Genetic and infectious profiles influence cerebrospinal fluid IgG abnormality in Japanese multiple sclerosis patients. PLoS One. 2014; 9(4):e95367. PMID: 24736746; PMCID: PMC3988235.
    11. Isobe N, Oksenberg JR. Clin Exp Neuroimmunol. Genetic studies of multiple sclerosis and neuromyelitis optica: current status in European, African American, and Asian populations. 2014; 5(1):61-68.
    12. Ainiding G, Kawano Y, Sato S, Isobe N, Matsushita T, Yoshimura S, Yonekawa T, Yamasaki R, Murai H, Kira J. Interleukin 2 receptor a chain gene polymorphisms and risks of multiple sclerosis and neuromyelitis optica in southern Japanese. J Neurol Sci. 2014 Feb 15; 337(1-2):147-50. PMID: 24332945.
      View in: PubMed
    13. Yonekawa T, Murai H, Utsuki S, Matsushita T, Masaki K, Isobe N, Yamasaki R, Yoshida M, Kusunoki S, Sakata K, Fujii K, Kira J. A nationwide survey of hypertrophic pachymeningitis in Japan. J Neurol Neurosurg Psychiatry. 2014 Jul; 85(7):732-9. PMID: 24273222.
      View in: PubMed
    14. Shiraishi W, Hayashi S, Kamada T, Isobe N, Yamasaki R, Murai H, Ohyagi Y, Kira J. A case of neuromyelitis optica harboring both anti-aquaporin-4 antibodies and a pathogenic mitochondrial DNA mutation for Leber's hereditary optic neuropathy. Mult Scler. 2014 Feb; 20(2):258-60. PMID: 24263387.
      View in: PubMed
    15. Harbo HF, Isobe N, Berg-Hansen P, Bos SD, Caillier SJ, Gustavsen MW, Mero IL, Celius EG, Hauser SL, Oksenberg JR, Gourraud PA. Oligoclonal bands and age at onset correlate with genetic risk score in multiple sclerosis. Mult Scler. 2014 May; 20(6):660-8. PMID: 24099750; PMCID: PMC4066985.
    16. Isobe N, Damotte V, Lo Re V, Ban M, Pappas D, Guillot-Noel L, Rebeix I, Compston A, Mack T, Cozen W, Fontaine B, Hauser SL, Oksenberg JR, Sawcer S, Gourraud PA. Genetic burden in multiple sclerosis families. Genes Immun. 2013 Oct; 14(7):434-40. PMID: 23903824; PMCID: PMC4102601.
    17. Isobe N, Gourraud PA, Harbo HF, Caillier SJ, Santaniello A, Khankhanian P, Maiers M, Spellman S, Cereb N, Yang S, Pando MJ, Piccio L, Cross AH, De Jager PL, Cree BA, Hauser SL, Oksenberg JR. Genetic risk variants in African Americans with multiple sclerosis. Neurology. 2013 Jul 16; 81(3):219-27. PMID: 23771490; PMCID: PMC3770164.
    18. Matsushita T, Tateishi T, Isobe N, Yonekawa T, Yamasaki R, Matsuse D, Murai H, Kira J. Characteristic cerebrospinal fluid cytokine/chemokine profiles in neuromyelitis optica, relapsing remitting or primary progressive multiple sclerosis. PLoS One. 2013; 8(4):e61835. PMID: 23637915; PMCID: PMC3630114.
    19. Huang J, Yoshimura S, Isobe N, Matsushita T, Yonekawa T, Sato S, Yamasaki R, Kira J. A NOTCH4 missense mutation confers resistance to multiple sclerosis in Japanese. Mult Scler. 2013 Nov; 19(13):1696-703. PMID: 23549433.
      View in: PubMed
    20. Isobe N, Yonekawa T, Matsushita T, Masaki K, Yoshimura S, Fichna J, Chen S, Furmaniak J, Smith BR, Kira J. Clinical relevance of serum aquaporin-4 antibody levels in neuromyelitis optica. Neurochem Res. 2013 May; 38(5):997-1001. PMID: 23456674.
      View in: PubMed
    21. Yoshimura S, Isobe N, Yonekawa T, Matsushita T, Masaki K, Sato S, Kawano Y, Yamamoto K, Kira J. Genetic and infectious profiles of Japanese multiple sclerosis patients. PLoS One. 2012; 7(11):e48592. PMID: 23152786; PMCID: PMC3494689.
    22. Yoshimura S, Isobe N, Matsushita T, Yonekawa T, Masaki K, Sato S, Kawano Y, Kira J. Distinct genetic and infectious profiles in Japanese neuromyelitis optica patients according to anti-aquaporin 4 antibody status. J Neurol Neurosurg Psychiatry. 2013 Jan; 84(1):29-34. PMID: 23038741.
      View in: PubMed
    23. Sato S, Isobe N, Yoshimura S, Kanamori Y, Masaki K, Matsushita T, Kira J. HLA-DPB1*0201 is associated with susceptibility to atopic myelitis in Japanese. J Neuroimmunol. 2012 Oct 15; 251(1-2):110-3. PMID: 22884298.
      View in: PubMed
    24. Isobe N, Yonekawa T, Matsushita T, Kawano Y, Masaki K, Yoshimura S, Fichna J, Chen S, Furmaniak J, Smith BR, Kira J. Quantitative assays for anti-aquaporin-4 antibody with subclass analysis in neuromyelitis optica. Mult Scler. 2012 Nov; 18(11):1541-51. PMID: 22526930.
      View in: PubMed
    25. Ainiding G, Yamashita K, Torii T, Furuta K, Isobe N, Matsushita T, Masaki K, Matsumoto S, Kira J. Clinical disability progression and platelet GP IIb/IIIa values in patients with atopic myelitis. J Neuroimmunol. 2012 May 15; 246(1-2):108-12. PMID: 22484027.
      View in: PubMed
    26. Masaki K, Suzuki SO, Matsushita T, Yonekawa T, Matsuoka T, Isobe N, Motomura K, Wu XM, Tabira T, Iwaki T, Kira J. Extensive loss of connexins in Baló's disease: evidence for an auto-antibody-independent astrocytopathy via impaired astrocyte-oligodendrocyte/myelin interaction. Acta Neuropathol. 2012 Jun; 123(6):887-900. PMID: 22438105.
      View in: PubMed
    27. Isobe N, Kanamori Y, Yonekawa T, Matsushita T, Shigeto H, Kawamura N, Kira J. First diagnostic criteria for atopic myelitis with special reference to discrimination from myelitis-onset multiple sclerosis. J Neurol Sci. 2012 May 15; 316(1-2):30-5. PMID: 22364869.
      View in: PubMed
    28. Estiasari R, Matsushita T, Masaki K, Akiyama T, Yonekawa T, Isobe N, Kira J. Comparison of clinical, immunological and neuroimaging features between anti-aquaporin-4 antibody-positive and antibody-negative Sjogren's syndrome patients with central nervous system manifestations. Mult Scler. 2012 Jun; 18(6):807-16. PMID: 22291033.
      View in: PubMed
    29. Ramagopalan S, Dyment D, Farrell R, Isobe N. Multiple sclerosis. Autoimmune Dis. 2011; 2011:248758. PMID: 21747986; PMCID: PMC3130332.
    30. Fang L, Isobe N, Yoshimura S, Yonekawa T, Matsushita T, Masaki K, Doi H, Ochi K, Miyamoto K, Kawano Y, Kira J. Interleukin-7 receptor alpha gene polymorphism influences multiple sclerosis risk in Asians. Neurology. 2011 Jun 14; 76(24):2125-7. PMID: 21670443.
      View in: PubMed
    31. McElroy JP, Isobe N, Gourraud PA, Caillier SJ, Matsushita T, Kohriyama T, Miyamoto K, Nakatsuji Y, Miki T, Hauser SL, Oksenberg JR, Kira J. SNP-based analysis of the HLA locus in Japanese multiple sclerosis patients. Genes Immun. 2011 Oct; 12(7):523-30. PMID: 21654846; PMCID: PMC3361962.
    32. Murai H, Yamashita N, Watanabe M, Nomura Y, Motomura M, Yoshikawa H, Nakamura Y, Kawaguchi N, Onodera H, Araga S, Isobe N, Nagai M, Kira J. Characteristics of myasthenia gravis according to onset-age: Japanese nationwide survey. J Neurol Sci. 2011 Jun 15; 305(1-2):97-102. PMID: 21440910.
      View in: PubMed
    33. Shinoda K, Matsushita T, Furuta K, Isobe N, Yonekawa T, Ohyagi Y, Kira J. Wall-eyed bilateral internuclear ophthalmoplegia (WEBINO) syndrome in a patient with neuromyelitis optica spectrum disorder and anti-aquaporin-4 antibody. Mult Scler. 2011 Jul; 17(7):885-7. PMID: 21300735.
      View in: PubMed
    34. Yoshimura S, Ochi H, Isobe N, Matsushita T, Motomura K, Matsuoka T, Minohara M, Kira J. Altered production of brain-derived neurotrophic factor by peripheral blood immune cells in multiple sclerosis. Mult Scler. 2010 Oct; 16(10):1178-88. PMID: 20656764.
      View in: PubMed
    35. Nakamura N, Shigeto H, Isobe N, Tanaka M, Ohyagi Y, Kira J. [A case of mononeuropathy multiplex associated with idiopathic thrombocytopenic purpura]. Rinsho Shinkeigaku. 2010 Jul; 50(7):482-4. PMID: 20681266.
      View in: PubMed
    36. Matsushita T, Isobe N, Kawajiri M, Mogi M, Tsukuda K, Horiuchi M, Ohyagi Y, Kira J. CSF angiotensin II and angiotensin-converting enzyme levels in anti-aquaporin-4 autoimmunity. J Neurol Sci. 2010 Aug 15; 295(1-2):41-5. PMID: 20541774.
      View in: PubMed
    37. Doi H, Tateishi T, Isobe N, Yamasaki R, Ohyagi Y, Kira J. [Sporadic hemiplegic migraine-like headache in a patient with systemic lupus erythematosus]. Rinsho Shinkeigaku. 2010 May; 50(5):332-4. PMID: 20535984.
      View in: PubMed
    38. Tateishi T, Yamasaki R, Tanaka M, Matsushita T, Kikuchi H, Isobe N, Ohyagi Y, Kira J. CSF chemokine alterations related to the clinical course of amyotrophic lateral sclerosis. J Neuroimmunol. 2010 May; 222(1-2):76-81. PMID: 20381883.
      View in: PubMed
    39. Matsushita T, Isobe N, Piao H, Matsuoka T, Ishizu T, Doi H, Masaki K, Yoshiura T, Yamasaki R, Ohyagi Y, Kira J. Reappraisal of brain MRI features in patients with multiple sclerosis and neuromyelitis optica according to anti-aquaporin-4 antibody status. J Neurol Sci. 2010 Apr 15; 291(1-2):37-43. PMID: 20122699.
      View in: PubMed
    40. Isobe N, Matsushita T, Yamasaki R, Ramagopalan SV, Kawano Y, Nishimura Y, Ebers GC, Kira J. Influence of HLA-DRB1 alleles on the susceptibility and resistance to multiple sclerosis in Japanese patients with respect to anti-aquaporin 4 antibody status. Mult Scler. 2010 Feb; 16(2):147-55. PMID: 20028711.
      View in: PubMed
    41. Li W, Minohara M, Piao H, Matsushita T, Masaki K, Matsuoka T, Isobe N, Su JJ, Ohyagi Y, Kira J. Association of anti-Helicobacter pylori neutrophil-activating protein antibody response with anti-aquaporin-4 autoimmunity in Japanese patients with multiple sclerosis and neuromyelitis optica. Mult Scler. 2009 Dec; 15(12):1411-21. PMID: 19965522.
      View in: PubMed
    42. Isobe N, Kira J, Kawamura N, Ishizu T, Arimura K, Kawano Y. Neural damage associated with atopic diathesis: a nationwide survey in Japan. Neurology. 2009 Sep 8; 73(10):790-7. PMID: 19738174.
      View in: PubMed
    43. Matsushita T, Isobe N, Matsuoka T, Ishizu T, Kawano Y, Yoshiura T, Ohyagi Y, Kira J. Extensive vasogenic edema of anti-aquaporin-4 antibody-related brain lesions. Mult Scler. 2009 Sep; 15(9):1113-7. PMID: 19625334.
      View in: PubMed
    44. Matsushita T, Isobe N, Matsuoka T, Shi N, Kawano Y, Wu XM, Yoshiura T, Nakao Y, Ishizu T, Kira JI. Aquaporin-4 autoimmune syndrome and anti-aquaporin-4 antibody-negative opticospinal multiple sclerosis in Japanese. Mult Scler. 2009 Jul; 15(7):834-47. PMID: 19465451.
      View in: PubMed
    45. Doi H, Matsushita T, Isobe N, Ishizu T, Ohyagi Y, Kira J. Frequency of chronic headaches in Japanese patients with multiple sclerosis: with special reference to opticospinal and common forms of multiple sclerosis. Headache. 2009 Nov-Dec; 49(10):1513-20. PMID: 19438737.
      View in: PubMed
    46. Watanabe A, Matsushita T, Doi H, Matsuoka T, Shigeto H, Isobe N, Kawano Y, Tobimatsu S, Kira J. Multimodality-evoked potential study of anti-aquaporin-4 antibody-positive and -negative multiple sclerosis patients. J Neurol Sci. 2009 Jun 15; 281(1-2):34-40. PMID: 19339021.
      View in: PubMed
    47. Matsushita T, Matsuoka T, Isobe N, Kawano Y, Minohara M, Shi N, Nishimura Y, Ochi H, Kira J. Association of the HLA-DPB1*0501 allele with anti-aquaporin-4 antibody positivity in Japanese patients with idiopathic central nervous system demyelinating disorders. Tissue Antigens. 2009 Feb; 73(2):171-6. PMID: 19140826.
      View in: PubMed
    48. Doi H, Matsushita T, Isobe N, Matsuoka T, Minohara M, Ochi H, Kira JI. Hypercomplementemia at relapse in patients with anti-aquaporin-4 antibody. Mult Scler. 2009 Mar; 15(3):304-10. PMID: 19028829.
      View in: PubMed
    49. Kuroki N, Ohyagi Y, Kawano Y, Yoshiura T, Taniwaki T, Kira J. Acute onset facial numbness. J Clin Neurosci. 2008 Sep; 15(9):1049, 1077. PMID: 18782920.
      View in: PubMed
    50. Koga Y, Isobe N, Tateishi T, Osoegawa M, Ohyagi Y, Kira J. [Case of posterior reversible encephalopathy syndrome with cerebral vasoconstriction]. Rinsho Shinkeigaku. 2008 May; 48(5):355-8. PMID: 18540385.
      View in: PubMed
    51. Kira J, Isobe N, Kawano Y, Osoegawa M, Ohyagi Y, Mihara F, Murai H. Atopic myelitis with focal amyotrophy: a possible link to Hopkins syndrome. J Neurol Sci. 2008 Jun 15; 269(1-2):143-51. PMID: 18295237.
      View in: PubMed
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