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    Olivier Julien, PhD

    SchoolUCSF School of Pharmacy
    DepartmentPharmaceutical Chemistry
    Address1700 4th Street
    San Francisco CA 94158
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Seaman JE, Julien O, Lee PS, Rettenmaier TJ, Thomsen ND, Wells JA. Cacidases: caspases can cleave after aspartate, glutamate and phosphoserine residues. Cell Death Differ. 2016 Oct; 23(10):1717-26. PMID: 27367566.
        View in: PubMed
      2. Hill ME, MacPherson DJ, Wu P, Julien O, Wells JA, Hardy JA. Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition. ACS Chem Biol. 2016 Jun 17; 11(6):1603-12. PMID: 27032039.
        View in: PubMed
      3. Julien O, Zhuang M, Wiita AP, O'Donoghue AJ, Knudsen GM, Craik CS, Wells JA. Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles. Proc Natl Acad Sci U S A. 2016 Apr 5; 113(14):E2001-10. PMID: 27006500.
        View in: PubMed
      4. Lee D, Kraus A, Prins D, Groenendyk J, Aubry I, Liu WX, Li HD, Julien O, Touret N, Sykes BD, Tremblay ML, Michalak M. UBC9-dependent association between calnexin and protein tyrosine phosphatase 1B (PTP1B) at the endoplasmic reticulum. J Biol Chem. 2015 Feb 27; 290(9):5725-38. PMID: 25586181; PMCID: PMC4342483 [Available on 02/27/16].
      5. Julien O, Kampmann M, Bassik MC, Zorn JA, Venditto VJ, Shimbo K, Agard NJ, Shimada K, Rheingold AL, Stockwell BR, Weissman JS, Wells JA. Unraveling the mechanism of cell death induced by chemical fibrils. Nat Chem Biol. 2014 Nov; 10(11):969-76. PMID: 25262416; PMCID: PMC4201873.
      6. Pineda-Sanabria SE, Julien O, Sykes BD. Versatile cardiac troponin chimera for muscle protein structural biology and drug discovery. ACS Chem Biol. 2014 Sep 19; 9(9):2121-30. PMID: 25010113.
        View in: PubMed
      7. Morgan CW, Julien O, Unger EK, Shah NM, Wells JA. Turning on caspases with genetics and small molecules. Methods Enzymol. 2014; 544:179-213. PMID: 24974291; PMCID: PMC4249682.
      8. Wiita AP, Ziv E, Wiita PJ, Urisman A, Julien O, Burlingame AL, Weissman JS, Wells JA. Global cellular response to chemotherapy-induced apoptosis. Elife. 2013; 2:e01236. PMID: 24171104; PMCID: PMC3808542.
      9. Crawford ED, Seaman JE, Agard N, Hsu GW, Julien O, Mahrus S, Nguyen H, Shimbo K, Yoshihara HA, Zhuang M, Chalkley RJ, Wells JA. The DegraBase: a database of proteolysis in healthy and apoptotic human cells. Mol Cell Proteomics. 2013 Mar; 12(3):813-24. PMID: 23264352; PMCID: PMC3591672.
      10. Julien O, Wang G, Jonckheer A, Engelborghs Y, Sykes BD. Tryptophan side chain conformers monitored by NMR and time-resolved fluorescence spectroscopies. Proteins. 2012 Jan; 80(1):239-45. PMID: 22072563.
        View in: PubMed
      11. Julien O, Chatterjee S, Bjorndahl TC, Sweeting B, Acharya S, Semenchenko V, Chakrabartty A, Pai EF, Wishart DS, Sykes BD, Cashman NR. Relative and regional stabilities of the hamster, mouse, rabbit, and bovine prion proteins toward urea unfolding assessed by nuclear magnetic resonance and circular dichroism spectroscopies. Biochemistry. 2011 Sep 6; 50(35):7536-45. PMID: 21800884.
        View in: PubMed
      12. Julien O, Mercier P, Allen CN, Fisette O, Ramos CH, Lagüe P, Blumenschein TM, Sykes BD. Is there nascent structure in the intrinsically disordered region of troponin I? Proteins. 2011 Apr; 79(4):1240-50. PMID: 21322033.
        View in: PubMed
      13. Julien O, Beadle JR, Magee WC, Chatterjee S, Hostetler KY, Evans DH, Sykes BD. Solution structure of a DNA duplex containing the potent anti-poxvirus agent cidofovir. J Am Chem Soc. 2011 Feb 23; 133(7):2264-74. PMID: 21280608; PMCID: PMC3051402.
      14. Julien O, Chatterjee S, Thiessen A, Graether SP, Sykes BD. Differential stability of the bovine prion protein upon urea unfolding. Protein Sci. 2009 Oct; 18(10):2172-82. PMID: 19693935; PMCID: PMC2786980.
      15. Julien O, Mercier P, Crane ML, Sykes BD. The effect of the cosolvent trifluoroethanol on a tryptophan side chain orientation in the hydrophobic core of troponin C. Protein Sci. 2009 Jun; 18(6):1165-74. PMID: 19472326; PMCID: PMC2774427.
      16. Julien O, Graether SP, Sykes BD. Monitoring prion protein stability by NMR. J Toxicol Environ Health A. 2009; 72(17-18):1069-74. PMID: 19697241.
        View in: PubMed
      17. Julien O, Mercier P, Spyracopoulos L, Corrie JE, Sykes BD. NMR studies of the dynamics of a bifunctional rhodamine probe attached to troponin C. J Am Chem Soc. 2008 Feb 27; 130(8):2602-9. PMID: 18251471.
        View in: PubMed
      18. Julien O, Sun YB, Wang X, Lindhout DA, Thiessen A, Irving M, Sykes BD. Tryptophan mutants of cardiac troponin C: 3D structure, troponin I affinity, and in situ activity. Biochemistry. 2008 Jan 15; 47(2):597-606. PMID: 18092822.
        View in: PubMed
      19. Julien O, Sun YB, Knowles AC, Brandmeier BD, Dale RE, Trentham DR, Corrie JE, Sykes BD, Irving M. Toward protein structure in situ: comparison of two bifunctional rhodamine adducts of troponin C. Biophys J. 2007 Aug 1; 93(3):1008-20. PMID: 17483167; PMCID: PMC1913146.
      20. Julien O, Gignac I, Hutton A, Yee A, Arrowsmith CH, Gagné SM. MTH187 from Methanobacterium thermoautotrophicum has three HEAT-like repeats. J Biomol NMR. 2006 Jun; 35(2):149-54. PMID: 16819590.
        View in: PubMed
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