Olivier Julien, PhD

SchoolUCSF School of Pharmacy
DepartmentPharmaceutical Chemistry
Address1700 4th St
San Francisco CA 94158
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    1. Julien O, Wells JA. Caspases and their substrates. Cell Death Differ. 2017 Aug; 24(8):1380-1389. PMID: 28498362.
      View in: PubMed
    2. Tran HL, Lexa KW, Julien O, Young TS, Walsh CT, Jacobson MP, Wells JA. Structure-Activity Relationship and Molecular Mechanics Reveal the Importance of Ring Entropy in the Biosynthesis and Activity of a Natural Product. J Am Chem Soc. 2017 Feb 22; 139(7):2541-2544. PMID: 28170244.
      View in: PubMed
    3. Calvo SE, Julien O, Clauser KR, Shen H, Kamer KJ, Wells JA, Mootha VK. Comparative Analysis of Mitochondrial N-Termini from Mouse, Human, and Yeast. Mol Cell Proteomics. 2017 Apr; 16(4):512-523. PMID: 28122942.
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    4. Seaman JE, Julien O, Lee PS, Rettenmaier TJ, Thomsen ND, Wells JA. Cacidases: caspases can cleave after aspartate, glutamate and phosphoserine residues. Cell Death Differ. 2016 Oct; 23(10):1717-26. PMID: 27367566.
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    5. Hill ME, MacPherson DJ, Wu P, Julien O, Wells JA, Hardy JA. Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition. ACS Chem Biol. 2016 06 17; 11(6):1603-12. PMID: 27032039; PMCID: PMC4912419.
    6. Julien O, Zhuang M, Wiita AP, O'Donoghue AJ, Knudsen GM, Craik CS, Wells JA. Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles. Proc Natl Acad Sci U S A. 2016 Apr 05; 113(14):E2001-10. PMID: 27006500; PMCID: PMC4833263 [Available on 10/05/16].
    7. Lee D, Kraus A, Prins D, Groenendyk J, Aubry I, Liu WX, Li HD, Julien O, Touret N, Sykes BD, Tremblay ML, Michalak M. UBC9-dependent association between calnexin and protein tyrosine phosphatase 1B (PTP1B) at the endoplasmic reticulum. J Biol Chem. 2015 Feb 27; 290(9):5725-38. PMID: 25586181; PMCID: PMC4342483.
    8. Julien O, Kampmann M, Bassik MC, Zorn JA, Venditto VJ, Shimbo K, Agard NJ, Shimada K, Rheingold AL, Stockwell BR, Weissman JS, Wells JA. Unraveling the mechanism of cell death induced by chemical fibrils. Nat Chem Biol. 2014 Nov; 10(11):969-76. PMID: 25262416; PMCID: PMC4201873.
    9. Pineda-Sanabria SE, Julien O, Sykes BD. Versatile cardiac troponin chimera for muscle protein structural biology and drug discovery. ACS Chem Biol. 2014 Sep 19; 9(9):2121-30. PMID: 25010113.
      View in: PubMed
    10. Morgan CW, Julien O, Unger EK, Shah NM, Wells JA. Turning on caspases with genetics and small molecules. Methods Enzymol. 2014; 544:179-213. PMID: 24974291; PMCID: PMC4249682.
    11. Wiita AP, Ziv E, Wiita PJ, Urisman A, Julien O, Burlingame AL, Weissman JS, Wells JA. Global cellular response to chemotherapy-induced apoptosis. Elife. 2013 Oct 29; 2:e01236. PMID: 24171104; PMCID: PMC3808542.
    12. Crawford ED, Seaman JE, Agard N, Hsu GW, Julien O, Mahrus S, Nguyen H, Shimbo K, Yoshihara HA, Zhuang M, Chalkley RJ, Wells JA. The DegraBase: a database of proteolysis in healthy and apoptotic human cells. Mol Cell Proteomics. 2013 Mar; 12(3):813-24. PMID: 23264352; PMCID: PMC3591672.
    13. Julien O, Wang G, Jonckheer A, Engelborghs Y, Sykes BD. Tryptophan side chain conformers monitored by NMR and time-resolved fluorescence spectroscopies. Proteins. 2012 Jan; 80(1):239-45. PMID: 22072563.
      View in: PubMed
    14. Julien O, Chatterjee S, Bjorndahl TC, Sweeting B, Acharya S, Semenchenko V, Chakrabartty A, Pai EF, Wishart DS, Sykes BD, Cashman NR. Relative and regional stabilities of the hamster, mouse, rabbit, and bovine prion proteins toward urea unfolding assessed by nuclear magnetic resonance and circular dichroism spectroscopies. Biochemistry. 2011 Sep 06; 50(35):7536-45. PMID: 21800884.
      View in: PubMed
    15. Julien O, Mercier P, Allen CN, Fisette O, Ramos CH, Lagüe P, Blumenschein TM, Sykes BD. Is there nascent structure in the intrinsically disordered region of troponin I? Proteins. 2011 Apr; 79(4):1240-50. PMID: 21322033.
      View in: PubMed
    16. Julien O, Beadle JR, Magee WC, Chatterjee S, Hostetler KY, Evans DH, Sykes BD. Solution structure of a DNA duplex containing the potent anti-poxvirus agent cidofovir. J Am Chem Soc. 2011 Feb 23; 133(7):2264-74. PMID: 21280608; PMCID: PMC3051402.
    17. Julien O, Chatterjee S, Thiessen A, Graether SP, Sykes BD. Differential stability of the bovine prion protein upon urea unfolding. Protein Sci. 2009 Oct; 18(10):2172-82. PMID: 19693935; PMCID: PMC2786980.
    18. Julien O, Mercier P, Crane ML, Sykes BD. The effect of the cosolvent trifluoroethanol on a tryptophan side chain orientation in the hydrophobic core of troponin C. Protein Sci. 2009 Jun; 18(6):1165-74. PMID: 19472326; PMCID: PMC2774427.
    19. Julien O, Graether SP, Sykes BD. Monitoring prion protein stability by NMR. J Toxicol Environ Health A. 2009; 72(17-18):1069-74. PMID: 19697241.
      View in: PubMed
    20. Julien O, Mercier P, Spyracopoulos L, Corrie JE, Sykes BD. NMR studies of the dynamics of a bifunctional rhodamine probe attached to troponin C. J Am Chem Soc. 2008 Feb 27; 130(8):2602-9. PMID: 18251471.
      View in: PubMed
    21. Julien O, Sun YB, Wang X, Lindhout DA, Thiessen A, Irving M, Sykes BD. Tryptophan mutants of cardiac troponin C: 3D structure, troponin I affinity, and in situ activity. Biochemistry. 2008 Jan 15; 47(2):597-606. PMID: 18092822.
      View in: PubMed
    22. Julien O, Sun YB, Knowles AC, Brandmeier BD, Dale RE, Trentham DR, Corrie JE, Sykes BD, Irving M. Toward protein structure in situ: comparison of two bifunctional rhodamine adducts of troponin C. Biophys J. 2007 Aug 01; 93(3):1008-20. PMID: 17483167; PMCID: PMC1913146.
    23. Julien O, Gignac I, Hutton A, Yee A, Arrowsmith CH, Gagné SM. MTH187 from Methanobacterium thermoautotrophicum has three HEAT-like repeats. J Biomol NMR. 2006 Jun; 35(2):149-54. PMID: 16819590.
      View in: PubMed
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