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    Osamu Tetsu, MD, PhD

    TitleAssociate Professor
    SchoolUCSF School of Medicine
    DepartmentOtolaryngology
    Address1450 Third St
    San Francisco CA 94158
    Phone415-514-0870
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      Collapse Biography 
      Collapse Education and Training
      Chiba UniversityM.D.School of Medicine1989
      Chiba UniversityPh.D.Graduate School of Medicine1997
      Chiba UniversityResidencyDepartment of Surgery1997
      University of California, San FranciscoPost-docCancer Research Institute2002

      Collapse Overview 
      Collapse Overview
      Osamu Tetsu, MD, PhD, is an Associate Professor and Director of the Head and Neck Cancer Research Laboratory in the Department of Otolaryngology – Head and Neck Surgery (OHNS) at the University of California, San Francisco. He received his MD from Chiba University, Japan and he completed his residency program from the Chiba University Hospital in Japan. Dr. Tetsu obtained his PhD in molecular immunology at Chiba University, and this was following by a postdoctoral in cancer biology at UCSF.

      Dr. Tetsu’s research focus is to understand the molecular mechanism of head and neck cancer, especially salivary gland tumors, and to identify novel therapeutic approaches to the treatment of various types of neoplasm in the head and neck. His laboratory is interested in molecular mechanism underlying initiation and progression of head and neck cancers and other malignancies. They have exploited the cell signaling pathways that make cancers different from normal tissues.

      Specialty:
      Cancer Biology

      Expertise:
      Tumor Initiation and Progression, Growth Control, Cell-Signaling, Targeted Therapy, and Molecular Biomarkers

      Professional Interests:
      Cancer Biology, Salivary gland and Head and Neck cancers, Targeted Therapy, Receptor Tyrosine Kinases (RTKs), cyclin D1, Cell-cycle Regulation, Signal Transduction, the Wnt/ß-Catenin Pathway, the Ras/MAPK Pathway, the Proteasome-Ubiquitin Pathway, Apoptotic Cell Death, Cellular Senescence, Developmental Therapeutics, Drug Discovery, Small-Molecule Inhibitors, and Molecular Biomarkers

      Education and Training:
      • Medical School: Chiba University, Japan
      • Residency: Chiba University Hospital, Japan – General and GI Surgery
      • PhD: Chiba University, Japan – Molecular Immunology
      • Postdoctoral: University of California, San Francisco – Cancer Biology

      Awards and Honors:
      • 1990 Chiba University Department of Surgery - Dr. Kaichi Isono, M.D. Award
      • 2000 Uehara Memorial Foundation – Uehara Scholar Award
      • 2003 American Cancer Society – Institutional Individual Award
      • 2004 Concern Foundation – Young Investigator Award
      • 2004 Chiba University School of Medicine Alumni Association - Outstanding Academic Achievement Award
      • 2005 V Foundation – V Scholar Award
      • 2010 American Head and Neck Society – Dr. Alando J Ballantyne, M.D. Research Award


      Collapse ORNG Applications 
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      Collapse In The News

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Tetsu O, Hangauer MJ, Phuchareon J, Eisele DW, McCormick F. Drug Resistance to EGFR Inhibitors in Lung Cancer. Chemotherapy. 2016; 61(5):223-35. PMID: 26910730.
        View in: PubMed
      2. Phuchareon J, McCormick F, Eisele DW, Tetsu O. . EGFR inhibition generates drug-tolerant persister cells by blocking AKT activity. Cancer Cell Microenviron. 2015; 2(3):e1045.
      3. Tetsu O, Phuchareon J, Eisele DW, Hangauer MJ, McCormick F. AKT inactivation causes persistent drug tolerance to EGFR inhibitors. Pharmacol Res. 2015 Dec; 102:132-7. PMID: 26453958.
        View in: PubMed
      4. Tetsu O, Eisele DW, McCormick F. Resistance to EGFR-targeted therapy by Ets-1 inactivation. Cell Cycle. 2015 Oct 18; 14(20):3211-2. PMID: 26313421.
        View in: PubMed
      5. Tetsu O, Phuchareon J, Eisele DW, McCormick F. ETS1 inactivation causes innate drug resistance to EGFR inhibitors. Mol Cell Oncol. 2016 Mar; 3(2):e1078924. PMID: 27308601.
        View in: PubMed
      6. Phuchareon J, McCormick F, Eisele DW, Tetsu O. EGFR inhibition evokes innate drug resistance in lung cancer cells by preventing Akt activity and thus inactivating Ets-1 function. Proc Natl Acad Sci U S A. 2015 Jul 21; 112(29):E3855-63. PMID: 26150526; PMCID: PMC4517222 [Available on 01/21/16].
      7. You B, Yang YL, Xu Z, Dai Y, Liu S, Mao JH, Tetsu O, Li H, Jablons DM, You L. Inhibition of ERK1/2 down-regulates the Hippo/YAP signaling pathway in human NSCLC cells. Oncotarget. 2015 Feb 28; 6(6):4357-68. PMID: 25738359; PMCID: PMC4414195.
      8. Phuchareon J, Overdevest JB, McCormick F, Eisele DW, van Zante A, Tetsu O. Fatty Acid binding protein 7 is a molecular marker in adenoid cystic carcinoma of the salivary glands: implications for clinical significance. Transl Oncol. 2014 Dec; 7(6):780-7. PMID: 25500088; PMCID: PMC4311037.
      9. Phuchareon J, van Zante A, Overdevest JB, McCormick F, Eisele DW, Tetsu O. c-Kit Expression is Rate-Limiting for Stem Cell Factor-Mediated Disease Progression in Adenoid Cystic Carcinoma of the Salivary Glands. Transl Oncol. 2014 Oct; 7(5):537-45. PMID: 25389449; PMCID: PMC4225653.
      10. Heaton CM, Durr ML, Tetsu O, van Zante A, Wang SJ. TP53 and CDKN2a mutations in never-smoker oral tongue squamous cell carcinoma. Laryngoscope. 2014 Jul; 124(7):E267-73. PMID: 24431303.
        View in: PubMed
      11. Ikeda Y, Oda K, Hiraike-Wada O, Koso T, Miyasaka A, Kashiyama T, Tanikawa M, Sone K, Nagasaka K, Maeda D, Kawana K, Nakagawa S, Fukayama M, Tetsu O, Fujii T, Yano T, Kozuma S. Cyclin D1 harboring the T286I mutation promotes oncogenic activation in endometrial cancer. Oncol Rep. 2013 Aug; 30(2):584-8. PMID: 23733133.
        View in: PubMed
      12. Tetsu O, Phuchareon J, Chou A, Cox DP, Eisele DW, Jordan RC. Mutations in the c-Kit gene disrupt mitogen-activated protein kinase signaling during tumor development in adenoid cystic carcinoma of the salivary glands. Neoplasia. 2010 Sep; 12(9):708-17. PMID: 20824047; PMCID: PMC2933691.
      13. Phuchareon J, Ohta Y, Woo JM, Eisele DW, Tetsu O. Genetic profiling reveals cross-contamination and misidentification of 6 adenoid cystic carcinoma cell lines: ACC2, ACC3, ACCM, ACCNS, ACCS and CAC2. PLoS One. 2009; 4(6):e6040. PMID: 19557180; PMCID: PMC2698276.
      14. Senawong T, Phuchareon J, Ohara O, McCormick F, Rauen KA, Tetsu O. Germline mutations of MEK in cardio-facio-cutaneous syndrome are sensitive to MEK and RAF inhibition: implications for therapeutic options. Hum Mol Genet. 2008 Feb 1; 17(3):419-30. PMID: 17981815.
        View in: PubMed
      15. Okabe H, McCormick F, Tetsu O. . Modulation of MAPK-mediated phosphorylation and/or FBXW8-mediated ubiquitinylation of cyclin D1 in modulation of cellular proliferation. 2007.
      16. Okabe H, Lee SH, Phuchareon J, Albertson DG, McCormick F, Tetsu O. A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation. PLoS One. 2006; 1:e128. PMID: 17205132; PMCID: PMC1762433.
      17. Rodriguez-Viciana P, Tetsu O, Tidyman WE, Estep AL, Conger BA, Cruz MS, McCormick F, Rauen KA. Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome. Science. 2006 Mar 3; 311(5765):1287-90. PMID: 16439621.
        View in: PubMed
      18. Rodriguez-Viciana P, Tetsu O, Oda K, Okada J, Rauen K, McCormick F. Cancer targets in the Ras pathway. Cold Spring Harb Symp Quant Biol. 2005; 70:461-7. PMID: 16869784.
        View in: PubMed
      19. Tetsu O, Wakita K, McCormick F. . Mammalian two-hybrid system for screening for modulators of the accumulation of metabolic products. 2004.
      20. Tetsu O, McCormick F. Proliferation of cancer cells despite CDK2 inhibition. Cancer Cell. 2003 Mar; 3(3):233-45. PMID: 12676582.
        View in: PubMed
      21. Wakita K, McCormick F, Tetsu O. Method for screening ecdysone-inducible stable cell lines. Biotechniques. 2001 Aug; 31(2):414-8. PMID: 11515378.
        View in: PubMed
      22. Wakita K, Tetsu O, McCormick F. A mammalian two-hybrid system for adenomatous polyposis coli-mutated colon cancer therapeutics. Cancer Res. 2001 Feb 1; 61(3):854-8. PMID: 11221869.
        View in: PubMed
      23. Tetsu O, McCormick F. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature. 1999 Apr 1; 398(6726):422-6. PMID: 10201372.
        View in: PubMed
      24. Tetsu O, Ishihara H, Kanno R, Kamiyasu M, Inoue H, Tokuhisa T, Taniguchi M, Kanno M. mel-18 negatively regulates cell cycle progression upon B cell antigen receptor stimulation through a cascade leading to c-myc/cdc25. Immunity. 1998 Oct; 9(4):439-48. PMID: 9806630.
        View in: PubMed
      25. Hasegawa M, Tetsu O, Kanno R, Inoue H, Ishihara H, Kamiyasu M, Taniguchi M, Kanno M. Mammalian Polycomb group genes are categorized as a new type of early response gene induced by B-cell receptor cross-linking. Mol Immunol. 1998 Jun; 35(9):559-63. PMID: 9809583.
        View in: PubMed
      26. Kenmochi T, Asano T, Nakagori T, Kaneko K, Nakajima K, Tetsu O, Jingu K, Iwashita C, Kainuma O, Tokoro Y, Sugamoto Y, Sakamoto K, Hatakeyama E, Yamada K, Isono K. Successful gene transfer into murine pancreatic islets using polyamine transfection reagents. Transplant Proc. 1998 Mar; 30(2):470-2. PMID: 9532132.
        View in: PubMed
      27. Akasaka T, Tsuji K, Kawahira H, Kanno M, Harigaya K, Hu L, Ebihara Y, Nakahata T, Tetsu O, Taniguchi M, Koseki H. The role of mel-18, a mammalian Polycomb group gene, during IL-7-dependent proliferation of lymphocyte precursors. Immunity. 1997 Jul; 7(1):135-46. PMID: 9252126.
        View in: PubMed
      28. Tetsu O, Kanno R, Isono K, Taniguchi M, Kanno M. Cloning and characterization of two transcripts generated from the mel-13 gene positioned adjacent to the mammalian Polycomb group-related gene mel-18. Biochim Biophys Acta. 1996 Mar 1; 1305(3):109-12. PMID: 8597592.
        View in: PubMed
      29. Tetsu O, Sakamoto K, Uematsu T, Hachisu T, Tanaka H, Hishikawa E, Kashiwabara H, Yokoyama T. . A case of liosarcoma on anterior chest wall. Japanese Journal of National Medical Services (IRYO). 1995; 49(7):568-571.
      30. Tetsu O, Furukawa H, Taniguchi T, Takahashi T, Hara T . . A case of primary omental leiomyosarcoma. The Journal of the Japanese Practical Surgeon Society. 1993; 54(6):1648-1652.
      31. Furukawa H, Hara T, Taniguchi T, Tetsu O. A case of spontaneous intramural hematoma of the esophagus. Gastroenterol Jpn. 1993 Feb; 28(1):81-7. PMID: 8440426.
        View in: PubMed
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