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    P. Daniel Knott, MD

    TitleAssociate Professor
    SchoolUCSF School of Medicine
    DepartmentOtolaryngology
    Address2233 Post Street
    San Francisco CA 94115
    Phone415-353-9500
    vCardDownload vCard

      Collapse Biography 
      Collapse Education and Training
      University of California San DiegoM.D.School of Medicine2000
      Collapse Awards and Honors
      American Head and Neck Society2006 - 2007Robert Maxwell Byers Award
      American Academy of Facial Plastic and Reconstructive Surgery2007 - 2008Ben Shuster Memorial Award
      American Academy of Facial Plastic and Reconstructive Surgery2008 - 2009Ira Tresley Research Award
      UCSF Department of Otolaryngology/Head and Neck Surgery2011 - 2012Roger Boles Teaching Award
      UCSF Medical Center2012 - 2013Kaiser Teacher of the Year Award-Inpatient Care

      Collapse Overview 
      Collapse Overview
      P. Daniel Knott, MD, is an Associate Professor in the Facial Plastic, Aesthetic and Reconstructive Surgery Division, and he is the Director of Facial Plastic and Aesthetic Surgery in Department of Otolaryngology – Head and Neck Surgery (OHNS) at the University of California, San Francisco. Dr. Knott received his medical degree from the University of California, San Diego in La Jolla. He completed a one-year General Surgery internship from the Cleveland Clinic in Ohio, and a five-year OHNS residency from the same institution, followed by a Facial Plastic and Reconstructive Surgery fellowship from the University of California, Los Angeles Medical Center.

      Dr. Knott particularly specializes in artificial tissue and tissue engineering applications. He has extensive experience on the full spectrum of facial anesthetic operations and treatments, with great focus of the reconstruction of traumatic, malignant, and congenital defects of the head and neck. He also has experience in creating solutions for the two common issues that affect the face over time - treating the descent of the soft tissues and facial soft tissue atrophy.

      Dr. Knott’s clinical research has focused on the novel applications, morbidities, and recipient potential of the antero-lateral thigh free flap. He has been using free flap in many innovative ways including, pharyngeal, nasal, scalp, and mid-facial reconstruction. Dr. Knott continues his research efforts in the basic science sphere, which focuses on the broad concept of cartilage bioengineering. Along with cross-sectional colleagues, Dr. Knott has patented a technique of cross-linking collagen and hyaluronic acid using a tyramine-based chemical process. The cross-linking can be performed across a wide spectrum of concentrations, yielding a variety of biomaterials of differing strengths, shear resistances, and biomechanical properties.

      Dr. Knott has authored over 30 peer-reviewed papers and serves as a peer reviewer on topics related to facial plastic and reconstructive surgery for multiple national journals including, Head and Neck Surgery, JAMA Facial Plastic Surgery, Laryngoscope, the International Journal of Dermatology, and Otolaryngology-Head and Neck Surgery. Dr. Knott has authored six book chapters on facial aesthetic surgery and published a book on the aesthetic use of botox.

      Specialty:
      Facial Plastic, Aesthetic and Reconstructive Surgery

      Expertise:
      Rhinoplasty, treatment of facial aging, treatment of facial paralysis, reconstruction of facial cutaneous malignancies, and free tissue transfer

      Professional Interests:
      Facial paralysis, microvascular facial reconstruction, free tissue transfer, maxillary reconstruction

      Education and Training:
      • Medical School: University of California, San Diego, La Jolla
      • Internship: Cleveland Clinic, OH – General Surgery
      • Residency: Cleveland Clinic, OH – Otolaryngology – Head and Neck Surgery
      • Fellowship: University of California, Los Angeles Medical Center– Facial Plastic and Reconstructive Surgery
      • Medical Licensure, California
      • Medical Licensure, Ohio
      • Board Certification, Otolaryngology - Head and Neck Surgery
      • Board Certification, Facial Plastic and Reconstructive Surgery


      Collapse ORNG Applications 
      Collapse Websites

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Jáuregui EJ, Tummala N, Seth R, Arron S, Neuhaus I, Yu S, Grekin R, Knott PD. Comparison of W-Plasty vs Traditional Straight-Line Techniques for Primary Paramedian Forehead Flap Donor Site Closure. JAMA Facial Plast Surg. 2016 Jul 1; 18(4):258-62. PMID: 27031499.
        View in: PubMed
      2. Tamplen M, Knott PD, Fritz MA, Seth R. Controversies in Parotid Defect Reconstruction. Facial Plast Surg Clin North Am. 2016 Aug; 24(3):235-43. PMID: 27400838.
        View in: PubMed
      3. Tamplen ML, Ricceri S, Hemmat S, Seth R, Ryan WR, Knott PD. Benefits of Immediate Extubation Following Free Tissue Transfer for Head and Neck Reconstruction. J Reconstr Microsurg. 2016 Sep; 32(7):533-9. PMID: 27110906.
        View in: PubMed
      4. Knott PD. A Facial Nerve Anniversary-Twelve Months of Treatment Time Saved. JAMA Facial Plast Surg. 2016 Jan 1; 18(1):60-1. PMID: 26583947.
        View in: PubMed
      5. Naunheim M, Seth R, Knott PD. Sternocleidomastoid contour restoration: an added benefit of the anterolateral thigh free flap during facial reconstruction. Am J Otolaryngol. 2016 Mar-Apr; 37(2):139-43. PMID: 26954870.
        View in: PubMed
      6. Xu X, Wilschut KJ, Kouklis G, Tian H, Hesse R, Garland C, Sbitany H, Hansen S, Seth R, Knott PD, Hoffman WY, Pomerantz JH. Human Satellite Cell Transplantation and Regeneration from Diverse Skeletal Muscles. Stem Cell Reports. 2015 Sep 8; 5(3):419-34. PMID: 26352798; PMCID: PMC4618654.
      7. Markey JD, Seth R, Wang SJ, Ryan WR, El-Sayed IH, Knott PD. Anterolateral Thigh Adipofascial Flap: A New Option for Scalp Reconstruction. J Reconstr Microsurg. 2016 Feb; 32(2):160-3. PMID: 26340759.
        View in: PubMed
      8. Markey J, Knott PD, Fritz MA, Seth R. Recent advances in head and neck free tissue transfer. Curr Opin Otolaryngol Head Neck Surg. 2015 Aug; 23(4):297-301. PMID: 26164856.
        View in: PubMed
      9. Knott PD, Seth R, Waters HH, Revenaugh PC, Alam D, Scharpf J, Meltzer NE, Fritz MA. Short-term donor site morbidity: A comparison of the anterolateral thigh and radial forearm fasciocutaneous free flaps. Head Neck. 2016 Apr; 38 Suppl 1:E945-8. PMID: 25994936.
        View in: PubMed
      10. Markey J, Seth R, Knott PD. Safety of cyanoacrylate-based adhesives in creating layered septal cartilage grafts during open structure septorhinoplasty. Am J Otolaryngol. 2015 Jul-Aug; 36(4):499-502. PMID: 25936774.
        View in: PubMed
      11. Revenaugh PC, Fritz MA, Haffey TM, Seth R, Markey J, Knott PD. Minimizing morbidity in microvascular surgery: small-caliber anastomotic vessels and minimal access approaches. JAMA Facial Plast Surg. 2015 Jan-Feb; 17(1):44-8. PMID: 25393515.
        View in: PubMed
      12. Kram YA, Russell MS, Russell MD, Knott PD. Single-stage, double-conduit microvascular pharyngotracheal reconstruction. J Reconstr Microsurg. 2015 Mar; 31(3):233-5. PMID: 25290532.
        View in: PubMed
      13. Cannady SB, Rosenthal EL, Knott PD, Fritz M, Wax MK. Free tissue transfer for head and neck reconstruction: a contemporary review. JAMA Facial Plast Surg. 2014 Sep-Oct; 16(5):367-73. PMID: 24994489.
        View in: PubMed
      14. Revenaugh PC, Knott PD, Alam DS, Kmiecik J, Fritz MA. Voice outcomes following reconstruction of laryngopharyngectomy defects using the radial forearm free flap and the anterolateral thigh free flap. Laryngoscope. 2014 Feb; 124(2):397-400. PMID: 24130092.
        View in: PubMed
      15. Revenaugh PC, Waters HH, Scharpf J, Knott PD, Fritz MA. Suprastomal cutaneous monitoring paddle for free flap reconstruction of laryngopharyngectomy defects. JAMA Facial Plast Surg. 2013 Jul-Aug; 15(4):287-91. PMID: 23598743.
        View in: PubMed
      16. Punthakee X, Zaghi S, Nabili V, Knott PD, Blackwell KE. Effects of salivary bypass tubes on fistula and stricture formation. JAMA Facial Plast Surg. 2013 May; 15(3):219-25. PMID: 23519300.
        View in: PubMed
      17. Rayess HM, Revenaugh PC, Benninger MS, Knott PD. Predictive factors for patient outcomes following open bedside tracheotomy. Laryngoscope. 2013 Apr; 123(4):923-8. PMID: 23404808.
        View in: PubMed
      18. Revenaugh PC, Knott D, McBride JM, Fritz MA. Motor nerve to the vastus lateralis. Arch Facial Plast Surg. 2012 Sep-Oct; 14(5):365-8. PMID: 22508894.
        View in: PubMed
      19. Shipchandler TZ, Waters HH, Knott PD, Fritz MA. Orbitomaxillary reconstruction using the layered fibula osteocutaneous flap. Arch Facial Plast Surg. 2012 Mar-Apr; 14(2):110-5. PMID: 22431815.
        View in: PubMed
      20. Revenaugh PC, Knott PD, Scharpf J, Fritz MA. Simultaneous anterolateral thigh flap and temporalis tendon transfer to optimize facial form and function after radical parotidectomy. Arch Facial Plast Surg. 2012 Mar-Apr; 14(2):104-9. PMID: 22431814.
        View in: PubMed
      21. Knott PD, Hicks D, Braun W, Strome M. A 12-year perspective on the world's first total laryngeal transplant. Transplantation. 2011 Apr 15; 91(7):804-5. PMID: 21436654.
        View in: PubMed
      22. Seth R, Nabili V, Fritz MA, Alam DS, Knott PD. Volume-directed facial soft tissue deficit reconstruction. Facial Plast Surg. 2010 Dec; 26(6):494-503. PMID: 21086236.
        View in: PubMed
      23. Seth R, Futran ND, Alam DS, Knott PD. Outcomes of vascularized bone graft reconstruction of the mandible in bisphosphonate-related osteonecrosis of the jaws. Laryngoscope. 2010 Nov; 120(11):2165-71. PMID: 20824743.
        View in: PubMed
      24. Revenaugh PC, Seth R, Pavlovich JB, Knott PD, Batra PS. Minimally invasive endoscopic resection of sinonasal undifferentiated carcinoma. Am J Otolaryngol. 2011 Nov-Dec; 32(6):464-9. PMID: 21041001.
        View in: PubMed
      25. Makin V, Hatipoglu B, Hamrahian AH, Arrossi AV, Knott PD, Lee JH, Sade B. Spontaneous cerebrospinal fluid rhinorrhea as the initial presentation of growth hormone-secreting pituitary adenoma. Am J Otolaryngol. 2011 Sep-Oct; 32(5):433-7. PMID: 20888068.
        View in: PubMed
      26. Seth R, Waters HH, Knott PD. Vascularized bone graft reconstruction of the temporomandibular joint using the tunneled, anchored suture technique. Laryngoscope. 2010; 120 Suppl 4:S236. PMID: 21225834.
        View in: PubMed
      27. Knott PD, Newman J, Keller GS, Apfelberg DB. A novel bioabsorbable device for facial suspension and rejuvenation. Arch Facial Plast Surg. 2009 Mar-Apr; 11(2):129-35. PMID: 19289687.
        View in: PubMed
      28. Knott PD, Dan O, Strome M. Induction with T-cell receptor antibody leads to long-term laryngeal allograft function. Am J Otolaryngol. 2008 Nov-Dec; 29(6):398-402. PMID: 19144301.
        View in: PubMed
      29. Nabili V, Knott PD. Advanced lip reconstruction: functional and aesthetic considerations. Facial Plast Surg. 2008 Jan; 24(1):92-104. PMID: 18286438.
        View in: PubMed
      30. Knott PD, Suh JD, Nabili V, Sercarz JA, Head C, Abemayor E, Blackwell KE. Evaluation of hardware-related complications in vascularized bone grafts with locking mandibular reconstruction plate fixation. Arch Otolaryngol Head Neck Surg. 2007 Dec; 133(12):1302-6. PMID: 18086976.
        View in: PubMed
      31. Knott PD, Tamai H, Strome M, Van Lente F, Shu S. RAD inhibition of sarcoma growth: implications for laryngeal transplantation. Am J Otolaryngol. 2007 Nov-Dec; 28(6):375-8. PMID: 17980767.
        View in: PubMed
      32. Knott PD, Zins JE, Banbury J, Djohan R, Yetman RJ, Papay F. A comparison of dermabond tissue adhesive and sutures in the primary repair of the congenital cleft lip. Ann Plast Surg. 2007 Feb; 58(2):121-5. PMID: 17245135.
        View in: PubMed
      33. Knott PD, Milstein CF, Hicks DM, Abelson TI, Byrd MC, Strome M. Vocal outcomes after laser resection of early-stage glottic cancer with adjuvant cryotherapy. Arch Otolaryngol Head Neck Surg. 2006 Nov; 132(11):1226-30. PMID: 17116819.
        View in: PubMed
      34. Knott PD, Batra PS, Butler RS, Citardi MJ. Contour and paired-point registration in a model for image-guided surgery. Laryngoscope. 2006 Oct; 116(10):1877-81. PMID: 17003709.
        View in: PubMed
      35. Knott PD, Byrd MC, Hicks DG, Strome M. Vocal fold healing after laser cordectomy with adjuvant cryotherapy. Laryngoscope. 2006 Sep; 116(9):1580-4. PMID: 16954983.
        View in: PubMed
      36. Knott PD, Batra PS, Citardi MJ. Computer aided surgery: concepts and applications in rhinology. Otolaryngol Clin North Am. 2006 Jun; 39(3):503-22, ix. PMID: 16757228.
        View in: PubMed
      37. Khariwala SS, Knott PD, Dan O, Klimczak A, Siemionow M, Strome M. Pulsed immunosuppression with everolimus and anti-alphabeta T-cell receptor: laryngeal allograft preservation at six months. Ann Otol Rhinol Laryngol. 2006 Jan; 115(1):74-80. PMID: 16466103.
        View in: PubMed
      38. Knott PD, Khariwala SS, Minarchek J. Hemophilia B and free tissue transfer: medical and surgical management. Ann Plast Surg. 2005 Mar; 54(3):336-8. PMID: 15725848.
        View in: PubMed
      39. Knott PD, Hazony D, Karafa M, Koltai PJ. High-frequency ultrasound in the measurement of pediatric craniofacial integrity. Otolaryngol Head Neck Surg. 2004 Dec; 131(6):851-5. PMID: 15577779.
        View in: PubMed
      40. Knott PD, Maurer CR, Gallivan R, Roh HJ, Citardi MJ. The impact of fiducial distribution on headset-based registration in image-guided sinus surgery. Otolaryngol Head Neck Surg. 2004 Nov; 131(5):666-72. PMID: 15523446.
        View in: PubMed
      41. Akst LM, Lee W, Discolo C, Knott D, Younes A, Koltai PJ. Stepped-dose protocol of cidofovir therapy in recurrent respiratory papillomatosis in children. Arch Otolaryngol Head Neck Surg. 2003 Aug; 129(8):841-6. PMID: 12925342.
        View in: PubMed
      42. Knott PD, Gannon FH, Thompson LD. Mesenchymal chondrosarcoma of the sinonasal tract: a clinicopathological study of 13 cases with a review of the literature. Laryngoscope. 2003 May; 113(5):783-90. PMID: 12792311.
        View in: PubMed
      43. Knott PD, Orloff LA, Harris JP, Novak RE, Burns JC. Sensorineural hearing loss and Kawasaki disease: a prospective study. Am J Otolaryngol. 2001 Sep-Oct; 22(5):343-8. PMID: 11562886.
        View in: PubMed
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