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P. Daniel Knott, MD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentOtolaryngology
Address2233 Post Street
San Francisco CA 94115
Phone415-353-9500
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    University of California San DiegoM.D.2000School of Medicine
    Collapse Awards and Honors
    American Head and Neck Society2006  - 2007Robert Maxwell Byers Award
    American Academy of Facial Plastic and Reconstructive Surgery2007  - 2008Ben Shuster Memorial Award
    American Academy of Facial Plastic and Reconstructive Surgery2008  - 2009Ira Tresley Research Award
    UCSF Department of Otolaryngology/Head and Neck Surgery2011  - 2012Roger Boles Teaching Award
    UCSF Medical Center2012  - 2013Kaiser Teacher of the Year Award-Inpatient Care

    Collapse Overview 
    Collapse Overview
    P. Daniel Knott, MD, is a Professor in the Facial Plastic, Aesthetic and Reconstructive Surgery Division, and he is the Director of Facial Plastic and Aesthetic Surgery in Department of Otolaryngology – Head and Neck Surgery (OHNS) at the University of California, San Francisco. Dr. Knott received his medical degree from the University of California, San Diego in La Jolla. He completed a one-year General Surgery internship from the Cleveland Clinic in Ohio, and a five-year OHNS residency from the same institution, followed by a Facial Plastic and Reconstructive Surgery fellowship from the University of California, Los Angeles Medical Center.

    Dr. Knott particularly specializes in artificial tissue and tissue engineering applications. He has extensive experience on the full spectrum of facial anesthetic operations and treatments, with great focus of the reconstruction of traumatic, malignant, and congenital defects of the head and neck. He also has experience in creating solutions for the two common issues that affect the face over time - treating the descent of the soft tissues and facial soft tissue atrophy.

    Dr. Knott’s clinical research has focused on the novel applications, morbidities, and recipient potential of the antero-lateral thigh free flap. He has been using free flap in many innovative ways including, pharyngeal, nasal, scalp, and mid-facial reconstruction. Dr. Knott continues his research efforts in the basic science sphere, which focuses on the broad concept of cartilage bioengineering. Along with cross-sectional colleagues, Dr. Knott has patented a technique of cross-linking collagen and hyaluronic acid using a tyramine-based chemical process. The cross-linking can be performed across a wide spectrum of concentrations, yielding a variety of biomaterials of differing strengths, shear resistances, and biomechanical properties.

    Dr. Knott has authored over 30 peer-reviewed papers and serves as a peer reviewer on topics related to facial plastic and reconstructive surgery for multiple national journals including, Head and Neck Surgery, JAMA Facial Plastic Surgery, Laryngoscope, the International Journal of Dermatology, and Otolaryngology-Head and Neck Surgery. Dr. Knott has authored six book chapters on facial aesthetic surgery and published a book on the aesthetic use of botox.

    Specialty:
    Facial Plastic, Aesthetic and Reconstructive Surgery

    Expertise:
    Rhinoplasty, treatment of facial aging, treatment of facial paralysis, reconstruction of facial cutaneous malignancies, and free tissue transfer

    Professional Interests:
    Facial paralysis, microvascular facial reconstruction, free tissue transfer, maxillary reconstruction

    Education and Training:
    • Medical School: University of California, San Diego, La Jolla
    • Internship: Cleveland Clinic, OH – General Surgery
    • Residency: Cleveland Clinic, OH – Otolaryngology – Head and Neck Surgery
    • Fellowship: University of California, Los Angeles Medical Center– Facial Plastic and Reconstructive Surgery
    • Medical Licensure, California
    • Medical Licensure, Ohio
    • Board Certification, Otolaryngology - Head and Neck Surgery
    • Board Certification, Facial Plastic and Reconstructive Surgery


    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Likhterov I, Fritz MA, El-Sayed IH, Rayess HM, Knott PD. Locoregional recurrence following maxillectomy: implications for microvascular reconstruction. Laryngoscope. 2017 May 09. PMID: 28485495.
      View in: PubMed
    2. Alemi AS, Seth R, Heaton C, Wang SJ, Knott PD. Comparison of Video and In-person Free Flap Assessment following Head and Neck Free Tissue Transfer. Otolaryngol Head Neck Surg. 2017 Jun; 156(6):1035-1040. PMID: 28140835.
      View in: PubMed
    3. Tamplen ML, Tamplen J, Torrecillas V, Seth R, Ricceri S, Hemmat S, Heaton C, Ryan WR, Knott PD. Does a Standalone Cancer Center Improve Head and Neck Microsurgical Outcomes? J Reconstr Microsurg. 2017 May; 33(4):252-256. PMID: 28061519.
      View in: PubMed
    4. Jáuregui EJ, Tummala N, Seth R, Arron S, Neuhaus I, Yu S, Grekin R, Knott PD. Comparison of W-Plasty vs Traditional Straight-Line Techniques for Primary Paramedian Forehead Flap Donor Site Closure. JAMA Facial Plast Surg. 2016 Jul 01; 18(4):258-62. PMID: 27031499.
      View in: PubMed
    5. Tamplen M, Knott PD, Fritz MA, Seth R. Controversies in Parotid Defect Reconstruction. Facial Plast Surg Clin North Am. 2016 Aug; 24(3):235-43. PMID: 27400838.
      View in: PubMed
    6. Tamplen ML, Ricceri S, Hemmat S, Seth R, Ryan WR, Knott PD. Benefits of Immediate Extubation Following Free Tissue Transfer for Head and Neck Reconstruction. J Reconstr Microsurg. 2016 Sep; 32(7):533-9. PMID: 27110906.
      View in: PubMed
    7. Knott PD. A Facial Nerve Anniversary--Twelve Months of Treatment Time Saved. JAMA Facial Plast Surg. 2016 Jan-Feb; 18(1):60-1. PMID: 26583947.
      View in: PubMed
    8. Naunheim M, Seth R, Knott PD. Sternocleidomastoid contour restoration: an added benefit of the anterolateral thigh free flap during facial reconstruction. Am J Otolaryngol. 2016 Mar-Apr; 37(2):139-43. PMID: 26954870.
      View in: PubMed
    9. Xu X, Wilschut KJ, Kouklis G, Tian H, Hesse R, Garland C, Sbitany H, Hansen S, Seth R, Knott PD, Hoffman WY, Pomerantz JH. Human Satellite Cell Transplantation and Regeneration from Diverse Skeletal Muscles. Stem Cell Reports. 2015 Sep 08; 5(3):419-34. PMID: 26352798; PMCID: PMC4618654.
    10. Markey JD, Seth R, Wang SJ, Ryan WR, El-Sayed IH, Knott PD. Anterolateral Thigh Adipofascial Flap: A New Option for Scalp Reconstruction. J Reconstr Microsurg. 2016 Feb; 32(2):160-3. PMID: 26340759.
      View in: PubMed
    11. Markey J, Knott PD, Fritz MA, Seth R. Recent advances in head and neck free tissue transfer. Curr Opin Otolaryngol Head Neck Surg. 2015 Aug; 23(4):297-301. PMID: 26164856.
      View in: PubMed
    12. Knott PD, Seth R, Waters HH, Revenaugh PC, Alam D, Scharpf J, Meltzer NE, Fritz MA. Short-term donor site morbidity: A comparison of the anterolateral thigh and radial forearm fasciocutaneous free flaps. Head Neck. 2016 Apr; 38 Suppl 1:E945-8. PMID: 25994936.
      View in: PubMed
    13. Markey J, Seth R, Knott PD. Safety of cyanoacrylate-based adhesives in creating layered septal cartilage grafts during open structure septorhinoplasty. Am J Otolaryngol. 2015 Jul-Aug; 36(4):499-502. PMID: 25936774.
      View in: PubMed
    14. Revenaugh PC, Fritz MA, Haffey TM, Seth R, Markey J, Knott PD. Minimizing morbidity in microvascular surgery: small-caliber anastomotic vessels and minimal access approaches. JAMA Facial Plast Surg. 2015 Jan-Feb; 17(1):44-8. PMID: 25393515.
      View in: PubMed
    15. Kram YA, Russell MS, Russell MD, Knott P. Single-stage, double-conduit microvascular pharyngotracheal reconstruction. J Reconstr Microsurg. 2015 Mar; 31(3):233-5. PMID: 25290532.
      View in: PubMed
    16. Cannady SB, Rosenthal EL, Knott PD, Fritz M, Wax MK. Free tissue transfer for head and neck reconstruction: a contemporary review. JAMA Facial Plast Surg. 2014 Sep-Oct; 16(5):367-73. PMID: 24994489.
      View in: PubMed
    17. Revenaugh PC, Knott PD, Alam DS, Kmiecik J, Fritz MA. Voice outcomes following reconstruction of laryngopharyngectomy defects using the radial forearm free flap and the anterolateral thigh free flap. Laryngoscope. 2014 Feb; 124(2):397-400. PMID: 24130092.
      View in: PubMed
    18. Revenaugh PC, Waters HH, Scharpf J, Knott PD, Fritz MA. Suprastomal cutaneous monitoring paddle for free flap reconstruction of laryngopharyngectomy defects. JAMA Facial Plast Surg. 2013 Jul-Aug; 15(4):287-91. PMID: 23598743.
      View in: PubMed
    19. Punthakee X, Zaghi S, Nabili V, Knott PD, Blackwell KE. Effects of salivary bypass tubes on fistula and stricture formation. JAMA Facial Plast Surg. 2013 May; 15(3):219-25. PMID: 23519300.
      View in: PubMed
    20. Rayess HM, Revenaugh PC, Benninger MS, Knott PD. Predictive factors for patient outcomes following open bedside tracheotomy. Laryngoscope. 2013 Apr; 123(4):923-8. PMID: 23404808.
      View in: PubMed
    21. Revenaugh PC, Knott D, McBride JM, Fritz MA. Motor nerve to the vastus lateralis. Arch Facial Plast Surg. 2012 Sep-Oct; 14(5):365-8. PMID: 22508894.
      View in: PubMed
    22. Shipchandler TZ, Waters HH, Knott PD, Fritz MA. Orbitomaxillary reconstruction using the layered fibula osteocutaneous flap. Arch Facial Plast Surg. 2012 Mar-Apr; 14(2):110-5. PMID: 22431815.
      View in: PubMed
    23. Revenaugh PC, Knott PD, Scharpf J, Fritz MA. Simultaneous anterolateral thigh flap and temporalis tendon transfer to optimize facial form and function after radical parotidectomy. Arch Facial Plast Surg. 2012 Mar-Apr; 14(2):104-9. PMID: 22431814.
      View in: PubMed
    24. Knott PD, Hicks D, Braun W, Strome M. A 12-year perspective on the world's first total laryngeal transplant. Transplantation. 2011 Apr 15; 91(7):804-5. PMID: 21436654.
      View in: PubMed
    25. Seth R, Nabili V, Fritz MA, Alam DS, Knott PD. Volume-directed facial soft tissue deficit reconstruction. Facial Plast Surg. 2010 Dec; 26(6):494-503. PMID: 21086236.
      View in: PubMed
    26. Seth R, Futran ND, Alam DS, Knott PD. Outcomes of vascularized bone graft reconstruction of the mandible in bisphosphonate-related osteonecrosis of the jaws. Laryngoscope. 2010 Nov; 120(11):2165-71. PMID: 20824743.
      View in: PubMed
    27. Revenaugh PC, Seth R, Pavlovich JB, Knott PD, Batra PS. Minimally invasive endoscopic resection of sinonasal undifferentiated carcinoma. Am J Otolaryngol. 2011 Nov-Dec; 32(6):464-9. PMID: 21041001.
      View in: PubMed
    28. Makin V, Hatipoglu B, Hamrahian AH, Arrossi AV, Knott PD, Lee JH, Sade B. Spontaneous cerebrospinal fluid rhinorrhea as the initial presentation of growth hormone-secreting pituitary adenoma. Am J Otolaryngol. 2011 Sep-Oct; 32(5):433-7. PMID: 20888068.
      View in: PubMed
    29. Seth R, Waters HH, Knott PD. Vascularized bone graft reconstruction of the temporomandibular joint using the tunneled, anchored suture technique. Laryngoscope. 2010; 120 Suppl 4:S236. PMID: 21225834.
      View in: PubMed
    30. Knott PD, Newman J, Keller GS, Apfelberg DB. A novel bioabsorbable device for facial suspension and rejuvenation. Arch Facial Plast Surg. 2009 Mar-Apr; 11(2):129-35. PMID: 19289687.
      View in: PubMed
    31. Knott PD, Dan O, Strome M. Induction with T-cell receptor antibody leads to long-term laryngeal allograft function. Am J Otolaryngol. 2008 Nov-Dec; 29(6):398-402. PMID: 19144301.
      View in: PubMed
    32. Nabili V, Knott PD. Advanced lip reconstruction: functional and aesthetic considerations. Facial Plast Surg. 2008 Jan; 24(1):92-104. PMID: 18286438.
      View in: PubMed
    33. Knott PD, Suh JD, Nabili V, Sercarz JA, Head C, Abemayor E, Blackwell KE. Evaluation of hardware-related complications in vascularized bone grafts with locking mandibular reconstruction plate fixation. Arch Otolaryngol Head Neck Surg. 2007 Dec; 133(12):1302-6. PMID: 18086976.
      View in: PubMed
    34. Knott PD, Tamai H, Strome M, Van Lente F, Shu S. RAD inhibition of sarcoma growth: implications for laryngeal transplantation. Am J Otolaryngol. 2007 Nov-Dec; 28(6):375-8. PMID: 17980767.
      View in: PubMed
    35. Knott PD, Zins JE, Banbury J, Djohan R, Yetman RJ, Papay F. A comparison of dermabond tissue adhesive and sutures in the primary repair of the congenital cleft lip. Ann Plast Surg. 2007 Feb; 58(2):121-5. PMID: 17245135.
      View in: PubMed
    36. Knott PD, Milstein CF, Hicks DM, Abelson TI, Byrd MC, Strome M. Vocal outcomes after laser resection of early-stage glottic cancer with adjuvant cryotherapy. Arch Otolaryngol Head Neck Surg. 2006 Nov; 132(11):1226-30. PMID: 17116819.
      View in: PubMed
    37. Knott PD, Batra PS, Butler RS, Citardi MJ. Contour and paired-point registration in a model for image-guided surgery. Laryngoscope. 2006 Oct; 116(10):1877-81. PMID: 17003709.
      View in: PubMed
    38. Knott PD, Byrd MC, Hicks DG, Strome M. Vocal fold healing after laser cordectomy with adjuvant cryotherapy. Laryngoscope. 2006 Sep; 116(9):1580-4. PMID: 16954983.
      View in: PubMed
    39. Knott PD, Batra PS, Citardi MJ. Computer aided surgery: concepts and applications in rhinology. Otolaryngol Clin North Am. 2006 Jun; 39(3):503-22, ix. PMID: 16757228.
      View in: PubMed
    40. Khariwala SS, Knott PD, Dan O, Klimczak A, Siemionow M, Strome M. Pulsed immunosuppression with everolimus and anti-alphabeta T-cell receptor: laryngeal allograft preservation at six months. Ann Otol Rhinol Laryngol. 2006 Jan; 115(1):74-80. PMID: 16466103.
      View in: PubMed
    41. Knott PD, Khariwala SS, Minarchek J. Hemophilia B and free tissue transfer: medical and surgical management. Ann Plast Surg. 2005 Mar; 54(3):336-8. PMID: 15725848.
      View in: PubMed
    42. Knott PD, Hazony D, Karafa M, Koltai PJ. High-frequency ultrasound in the measurement of pediatric craniofacial integrity. Otolaryngol Head Neck Surg. 2004 Dec; 131(6):851-5. PMID: 15577779.
      View in: PubMed
    43. Knott PD, Maurer CR, Gallivan R, Roh HJ, Citardi MJ. The impact of fiducial distribution on headset-based registration in image-guided sinus surgery. Otolaryngol Head Neck Surg. 2004 Nov; 131(5):666-72. PMID: 15523446.
      View in: PubMed
    44. Akst LM, Lee W, Discolo C, Knott D, Younes A, Koltai PJ. Stepped-dose protocol of cidofovir therapy in recurrent respiratory papillomatosis in children. Arch Otolaryngol Head Neck Surg. 2003 Aug; 129(8):841-6. PMID: 12925342.
      View in: PubMed
    45. Knott PD, Gannon FH, Thompson LD. Mesenchymal chondrosarcoma of the sinonasal tract: a clinicopathological study of 13 cases with a review of the literature. Laryngoscope. 2003 May; 113(5):783-90. PMID: 12792311.
      View in: PubMed
    46. Knott PD, Orloff LA, Harris JP, Novak RE, Burns JC. Sensorineural hearing loss and Kawasaki disease: a prospective study. Am J Otolaryngol. 2001 Sep-Oct; 22(5):343-8. PMID: 11562886.
      View in: PubMed
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