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    Paul Schnier, PhD

    TitleAssociate Professor
    SchoolUCSF School of Medicine
    DepartmentInstitute for Neurodegenerative Diseases
    Address675 Nelson Rising Lane
    San Francisco CA 94158
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      Collapse Biography 
      Collapse Education and Training
      UC BerkeleyPh.D.Department of Chemistry1998
      SUNY BinghamtonB.S.Mathematics1993

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Noland CL, Gierke S, Schnier PD, Murray J, Sandoval WN, Sagolla M, Dey A, Hannoush RN, Fairbrother WJ, Cunningham CN. Palmitoylation of TEAD Transcription Factors Is Required for Their Stability and Function in Hippo Pathway Signaling. Structure. 2016 Jan 5; 24(1):179-86. PMID: 26724994.
        View in: PubMed
      2. Poppe L, Jordan JB, Rogers G, Schnier PD. Correction to On the Analytical Superiority of 1D NMR for Fingerprinting the Higher Order Structure of Protein Therapeutics Compared to Multidimensional NMR Methods. Anal Chem. 2015 Jul 21; 87(14):7493. PMID: 26125133.
        View in: PubMed
      3. Poppe L, Jordan JB, Rogers G, Schnier PD. On the Analytical Superiority of 1D NMR for Fingerprinting the Higher Order Structure of Protein Therapeutics Compared to Multidimensional NMR Methods. Anal Chem. 2015 Jun 2; 87(11):5539-45. PMID: 25929316.
        View in: PubMed
      4. Raina M, Moghal A, Kano A, Jerums M, Schnier PD, Luo S, Deshpande R, Bondarenko PV, Lin H, Ibba M. Reduced amino acid specificity of mammalian tyrosyl-tRNA synthetase is associated with elevated mistranslation of Tyr codons. J Biol Chem. 2014 Jun 20; 289(25):17780-90. PMID: 24828507; PMCID: PMC4067211.
      5. Liu L, Baergen A, Michelsen K, Kitova EN, Schnier PD, Klassen JS. Energetics of intermolecular hydrogen bonds in a hydrophobic protein cavity. J Am Soc Mass Spectrom. 2014 May; 25(5):742-50. PMID: 24658798.
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      6. Kevany BM, Tsybovsky Y, Campuzano ID, Schnier PD, Engel A, Palczewski K. Structural and functional analysis of the native peripherin-ROM1 complex isolated from photoreceptor cells. J Biol Chem. 2013 Dec 20; 288(51):36272-84. PMID: 24196967; PMCID: PMC3868743.
      7. Poppe L, Jordan JB, Lawson K, Jerums M, Apostol I, Schnier PD. Profiling formulated monoclonal antibodies by (1)H NMR spectroscopy. Anal Chem. 2013 Oct 15; 85(20):9623-9. PMID: 24006877.
        View in: PubMed
      8. Michelsen K, Jordan JB, Lewis J, Long AM, Yang E, Rew Y, Zhou J, Yakowec P, Schnier PD, Huang X, Poppe L. Ordering of the N-terminus of human MDM2 by small molecule inhibitors. J Am Chem Soc. 2012 Oct 17; 134(41):17059-67. PMID: 22991965.
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      9. Liu L, Michelsen K, Kitova EN, Schnier PD, Brown A, Klassen JS. Deuterium kinetic isotope effects on the dissociation of a protein-fatty acid complex in the gas phase. J Am Chem Soc. 2012 Apr 4; 134(13):5931-7. PMID: 22409493.
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      10. Liu L, Michelsen K, Kitova EN, Schnier PD, Klassen JS. Energetics of lipid binding in a hydrophobic protein cavity. J Am Chem Soc. 2012 Feb 15; 134(6):3054-60. PMID: 22280480.
        View in: PubMed
      11. Kitova EN, El-Hawiet A, Schnier PD, Klassen JS. Reliable determinations of protein-ligand interactions by direct ESI-MS measurements. Are we there yet? J Am Soc Mass Spectrom. 2012 Mar; 23(3):431-41. PMID: 22270873.
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      12. Jordan JB, Poppe L, Xia X, Cheng AC, Sun Y, Michelsen K, Eastwood H, Schnier PD, Nixey T, Zhong W. Fragment based drug discovery: practical implementation based on ยน?F NMR spectroscopy. J Med Chem. 2012 Jan 26; 55(2):678-87. PMID: 22165820.
        View in: PubMed
      13. Poppe L, Hui JO, Ligutti J, Murray JK, Schnier PD. PADLOC: a powerful tool to assign disulfide bond connectivities in peptides and proteins by NMR spectroscopy. Anal Chem. 2012 Jan 3; 84(1):262-6. PMID: 22126836.
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      14. Qu Y, Schnier P, Zanon R, Vargas HM. hERG potency estimates based upon dose solution analysis: What have we learned? J Pharmacol Toxicol Methods. 2011 Nov-Dec; 64(3):251-7. PMID: 21888984.
        View in: PubMed
      15. Liu L, Michelsen K, Kitova EN, Schnier PD, Klassen JS. Evidence that water can reduce the kinetic stability of protein-hydrophobic ligand interactions. J Am Chem Soc. 2010 Dec 22; 132(50):17658-60. PMID: 21121620.
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      16. Valliere-Douglass JF, Connell-Crowley L, Jensen R, Schnier PD, Trilisky E, Leith M, Follstad BD, Kerr J, Lewis N, Vunnum S, Treuheit MJ, Balland A, Wallace A. Photochemical degradation of citrate buffers leads to covalent acetonation of recombinant protein therapeutics. Protein Sci. 2010 Nov; 19(11):2152-63. PMID: 20836085; PMCID: PMC3005786.
      17. Bagal D, Valliere-Douglass JF, Balland A, Schnier PD. Resolving disulfide structural isoforms of IgG2 monoclonal antibodies by ion mobility mass spectrometry. Anal Chem. 2010 Aug 15; 82(16):6751-5. PMID: 20704363.
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      18. Beel AJ, Barrett P, Schnier PD, Hitchcock SA, Bagal D, Sanders CR, Jordan JB. Nonspecificity of binding of gamma-secretase modulators to the amyloid precursor protein. Biochemistry. 2009 Dec 22; 48(50):11837-9. PMID: 19928774; PMCID: PMC2794937.
      19. Liu L, Bagal D, Kitova EN, Schnier PD, Klassen JS. Hydrophobic protein-ligand interactions preserved in the gas phase. J Am Chem Soc. 2009 Nov 11; 131(44):15980-1. PMID: 19886690.
        View in: PubMed
      20. Bagal D, Kitova EN, Liu L, El-Hawiet A, Schnier PD, Klassen JS. Gas phase stabilization of noncovalent protein complexes formed by electrospray ionization. Anal Chem. 2009 Sep 15; 81(18):7801-6. PMID: 19746998.
        View in: PubMed
      21. Khera S, Grillo M, Schnier P, Hollis S. Application of diffusion-edited NMR spectroscopy for the structural characterization of drug metabolites in mixtures. J Pharm Biomed Anal. 2010 Jan 5; 51(1):164-9. PMID: 19656649.
        View in: PubMed
      22. Jordan JB, Poppe L, Haniu M, Arvedson T, Syed R, Li V, Kohno H, Kim H, Schnier PD, Harvey TS, Miranda LP, Cheetham J, Sasu BJ. Hepcidin revisited, disulfide connectivity, dynamics, and structure. J Biol Chem. 2009 Sep 4; 284(36):24155-67. PMID: 19553669; PMCID: PMC2782009.
      23. Bagal D, Zhang H, Schnier PD. Gas-phase proton-transfer chemistry coupled with TOF mass spectrometry and ion mobility-MS for the facile analysis of poly(ethylene glycols) and PEGylated polypeptide conjugates. Anal Chem. 2008 Apr 1; 80(7):2408-18. PMID: 18324791.
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      24. Kruppa G, Schnier PD, Tabei K, Van Orden S, Siegel MM. Multiple ion isolation applications in FT-ICR MS: exact-mass MSn internal calibration and purification/interrogation of protein-drug complexes. Anal Chem. 2002 Aug 1; 74(15):3877-86. PMID: 12175179.
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      25. Van Berkel GJ, Asano KG, Schnier PD. Electrochemical processes in a wire-in-a-capillary bulk-loaded, nano-electrospray emitter. J Am Soc Mass Spectrom. 2001 Jul; 12(7):853-62. PMID: 11444609.
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      26. Strittmatter EF, Schnier PD, Klassen JS, Williams ER. Dissociation energies of deoxyribose nucleotide dimer anions measured using blackbody infrared radiative dissociation. J Am Soc Mass Spectrom. 1999 Nov; 10(11):1095-104. PMID: 10536816; PMCID: PMC1409745.
      27. Schnier PD, Jurchen JC, Williams ER. The effective temperature of Peptide ions dissociated by sustained off-resonance irradiation collisional activation in fourier transform mass spectrometry. J Phys Chem B. 1999 Jan 28; 103(4):737-45. PMID: 16614752; PMCID: PMC1435862.
      28. Klassen JS, Schnier PD, Williams ER. Blackbody infrared radiative dissociation of oligonucleotide anions. J Am Soc Mass Spectrom. 1998 Nov; 9(11):1117-24. PMID: 9794082; PMCID: PMC1343443.
      29. Schnier PD, Klassen JS, Strittmatter EF, Williams ER. Activation energies for dissociation of double strand oligonucleotide anions: evidence for watson-crick base pairing in vacuo. J Am Chem Soc. 1998 Sep 23; 120(37):9605-13. PMID: 16498487; PMCID: PMC1380309.
      30. Schnier PD, Williams ER. Analysis of isomeric mixtures using blackbody infrared radiative dissociation: determining isomeric purity and obtaining individual tandem mass spectra simultaneously. Anal Chem. 1998 Jul 15; 70(14):3033-41. PMID: 9684551; PMCID: PMC1343442.
      31. Schnier PD, Price WD, Strittmatter EF, Williams ER. Dissociation energetics and mechanisms of leucine enkephalin (M + H)+ and (2M + X)+ ions (X = H, Li, Na, K, and Rb) measured by blackbody infrared radiative dissociation. J Am Soc Mass Spectrom. 1997 Aug; 8(8):771-80. PMID: 16554908; PMCID: PMC1409762.
      32. Jockusch RA, Schnier PD, Price WD, Strittmatter EF, Demirev PA, Williams ER. Effects of charge state on fragmentation pathways, dynamics, and activation energies of ubiquitin ions measured by blackbody infrared radiative dissociation. Anal Chem. 1997 Mar 15; 69(6):1119-26. PMID: 9075403; PMCID: PMC1434665.
      33. Price WD, Schnier PD, Williams ER. Binding energies of the proton-bound amino Acid dimers gly.gly, ala.ala, gly.ala, and lys.lys measured by blackbody infrared radiative dissociation. J Phys Chem B. 1997 Jan 23; 101(4):664-73. PMID: 17235378; PMCID: PMC1776505.
      34. Price WD, Schnier PD, Jockusch RA, Strittmatter EF, Williams ER. Unimolecular reaction kinetics in the high-pressure limit without collisions. J Am Chem Soc. 1996 Oct 30; 118(43):10640-4. PMID: 16467929; PMCID: PMC1357232.
      35. Schnier PD, Price WD, Williams ER. Modeling the maximum charge state of arginine-containing Peptide ions formed by electrospray ionization. J Am Soc Mass Spectrom. 1996 Sep; 7(9):972-6. PMID: 16467911; PMCID: PMC1350975.
      36. Schnier PD, Price WD, Jockusch RA, Williams ER. Blackbody infrared radiative dissociation of bradykinin and its analogues: energetics, dynamics, and evidence for salt-bridge structures in the gas phase. J Am Chem Soc. 1996 Jul 31; 118(30):7178-89. PMID: 16525512; PMCID: PMC1393282.
      37. Gross DS, Schnier PD, Rodriguez-Cruz SE, Fagerquist CK, Williams ER. Conformations and folding of lysozyme ions in vacuo. Proc Natl Acad Sci U S A. 1996 Apr 2; 93(7):3143-8. PMID: 8610183; PMCID: PMC39776.
      38. Price WD, Schnier PD, Williams ER. Tandem mass spectrometry of large biomolecule ions by blackbody infrared radiative dissociation. Anal Chem. 1996 Mar 1; 68(5):859-66. PMID: 21619182.
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      39. Schnier PD, Gross DS, Williams ER. On the maximum charge state and proton transfer reactivity of peptide and protein ions formed by electrospray ionization. J Am Soc Mass Spectrom. 1995 Nov; 6(11):1086-97. PMID: 24214055.
        View in: PubMed
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