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    Pedro Gambus Cerrillo, MD

    TitleAssociate Professor
    SchoolUCSF School of Medicine
    DepartmentAnesthesia
    Address513 Parnassus Ave, Med Sci
    San Francisco CA 94143
    Phone415-476-6783
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      MD School of Medicine of the Universidad de Barcelona (Spain). Specialty training in Anesthesiology in Hospital General de Granollers (Barcelona).

      Postdoctoral fellowship in "Clinical Pharmacology in Anesthesia: PKPD Modelling of i.v. Anesthetics" (Prof S.L. Shafer, D.R. Stanski) Department of Anesthesia, Stanford University School of Medicine. Jan 1993-June 1995.

      PhD degree School of Medicine of the Universidad de Barcelona (Spain); "Applications of EEG as a measure of depth of anesthetic drug effects"

      Currently work at the Department of Anesthesia, Hospital CLINIC de Barcelona (Spain)

      Principal investigator: Research group on Modeling and Control of Anesthetic Drug Effects (Hospital CLINIC):

      1) Applications of PKPD modelling in sedation-analgesia for diagnostic or therapeutic procedures: TCI systems
      2) Optimal control of sedation analgesia drug effects: EEG, AEP, Respiratory function, signal analysis
      3) Mathematical modeling: nonlinear mixed effects modeling, fuzzy logic modeling methods (ANFIS)

      Public funding from the Clinical Research Agency (Fondo de Investigaciones Sanitarias [FIS]), Government of Spain.
      Private funding from Fundacion Mutua Madrilena (Spain)


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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Rocha C, Mendonça T, Silva ME, Gambús P. Erratum to: Individualizing propofol dosage: a multivariate linear model approach. J Clin Monit Comput. 2016 Feb 10. PMID: 26861640.
        View in: PubMed
      2. Hannam JA, Borrat X, Trocóniz IF, Valencia JF, Jensen EW, Pedroso A, Muñoz J, Castellví-Bel S, Castells A, Gambús PL. Modeling Respiratory Depression Induced by Remifentanil and Propofol during Sedation and Analgesia Using a Continuous Noninvasive Measurement of pCO2. J Pharmacol Exp Ther. 2016 Mar; 356(3):563-73. PMID: 26660440.
        View in: PubMed
      3. Gambús PL, Trocóniz IF, Feng X, Gimenez-Milá M, Mellado R, Degos V, Vacas S, Maze M. Relation between acute and long-term cognitive decline after surgery: Influence of metabolic syndrome. Brain Behav Immun. 2015 Nov; 50:203-8. PMID: 26164200; PMCID: PMC4631699 [Available on 11/01/16].
      4. Borrat X, Valencia JF, Magrans R, Gimenez-Mila M, Mellado R, Sendino O, Perez M, Nunez M, Jospin M, Jensen EW, Troconiz I, Gambus PL. Sedation-analgesia with propofol and remifentanil: concentrations required to avoid gag reflex in upper gastrointestinal endoscopy. Anesth Analg. 2015 Jul; 121(1):90-6. PMID: 25902320.
        View in: PubMed
      5. Melia U, Vallverdú M, Borrat X, Valencia JF, Jospin M, Jensen EW, Gambus P, Caminal P. Prediction of Nociceptive Responses during Sedation by Linear and Non-Linear Measures of EEG Signals in High Frequencies. PLoS One. 2015; 10(4):e0123464. PMID: 25901571; PMCID: PMC4406496.
      6. Gambús PL, Trocóniz IF. Pharmacokinetic-pharmacodynamic modelling in anaesthesia. Br J Clin Pharmacol. 2015 Jan; 79(1):72-84. PMID: 24251846; PMCID: PMC4294078 [Available on 01/01/16].
      7. Jensen EW, Valencia JF, López A, Anglada T, Agustí M, Ramos Y, Serra R, Jospin M, Pineda P, Gambus P. Monitoring hypnotic effect and nociception with two EEG-derived indices, qCON and qNOX, during general anaesthesia. Acta Anaesthesiol Scand. 2014 Sep; 58(8):933-41. PMID: 24995461.
        View in: PubMed
      8. Melia U, Vallverdu M, Jospin M, Valencia JF, Jensen EW, Gambus PL, Perera Lluna A, Caminal P. Interaction between EEG and drug concentration to predict response to noxious stimulation during sedation-analgesia: effect of the A118G genetic polymorphism. Conf Proc IEEE Eng Med Biol Soc. 2014; 2014:4298-301. PMID: 25570943.
        View in: PubMed
      9. Borrat X, Trocóniz IF, Valencia JF, Rivadulla S, Sendino O, Llach J, Muñoz J, Castellví-Bel S, Jospin M, Jensen EW, Castells A, Gambús PL. Modeling the influence of the A118G polymorphism in the OPRM1 gene and of noxious stimulation on the synergistic relation between propofol and remifentanil: sedation and analgesia in endoscopic procedures. Anesthesiology. 2013 Jun; 118(6):1395-407. PMID: 23503369.
        View in: PubMed
      10. Melia U, Vallverdú M, Jospin M, Jensen EW, Valencia JF, Clariá F, Gambus PL, Caminal P. Prediction of nociceptive responses during sedation by time-frequency representation. Conf Proc IEEE Eng Med Biol Soc. 2013; 2013:2547-50. PMID: 24110246.
        View in: PubMed
      11. Faulí A, Anglada MT, Gomar C, Sala X, López A, Pons M, Gambús P, Fábregas N. [Comparison of 3 combinations of 0.5% levobupivacaine and 1% mepivacaine in popliteal sciatic block in hallux valgus outpatient surgery]. Rev Esp Anestesiol Reanim. 2012 Dec; 59(10):549-55. PMID: 23040652.
        View in: PubMed
      12. Jospin M, Aguilar JP, Gambus PL, Jensen EW, Vallverdu M, Caminal P. Validation of the qCO cardiac output monitor during Valsalva maneuver. Conf Proc IEEE Eng Med Biol Soc. 2012; 2012:240-3. PMID: 23365875.
        View in: PubMed
      13. Cortínez LI, Gambús P, Trocóniz IF, Echevarría G, Muñoz HR. Obesity does not influence the onset and offset of sevoflurane effect as measured by the hysteresis between sevoflurane concentration and bispectral index. Anesth Analg. 2011 Jul; 113(1):70-6. PMID: 21596877.
        View in: PubMed
      14. López AM, Valero R, Hurtado P, Gambús P, Pons M, Anglada T. Comparison of the LMA Supreme™ with the LMA Proseal™ for airway management in patients anaesthetized in prone position. Br J Anaesth. 2011 Aug; 107(2):265-71. PMID: 21576096.
        View in: PubMed
      15. Gambús PL, Jensen EW, Jospin M, Borrat X, Martínez Pallí G, Fernández-Candil J, Valencia JF, Barba X, Caminal P, Trocóniz IF. Modeling the effect of propofol and remifentanil combinations for sedation-analgesia in endoscopic procedures using an Adaptive Neuro Fuzzy Inference System (ANFIS). Anesth Analg. 2011 Feb; 112(2):331-9. PMID: 21131550.
        View in: PubMed
      16. Fernández-Candil J, Gambús PL, Trocóniz IF, Valero R, Carrero E, Fábregas N. Feasibility of microdialysis to determine interstitial rocuronium concentration in the muscle tissue of anesthetized neurosurgical patients. J Neurosurg Anesthesiol. 2010 Apr; 22(2):163-9. PMID: 20308820.
        View in: PubMed
      17. Cortínez LI, Trocóniz IF, Fuentes R, Gambús P, Hsu YW, Altermatt F, Muñoz HR. The influence of age on the dynamic relationship between end-tidal sevoflurane concentrations and bispectral index. Anesth Analg. 2008 Nov; 107(5):1566-72. PMID: 18931213.
        View in: PubMed
      18. Fernández-Candil J, Gambús PL, Trocóniz IF, Valero R, Carrero E, Bueno L, Fábregas N. Pharmacokinetic-pharmacodynamic modeling of the influence of chronic phenytoin therapy on the rocuronium bromide response in patients undergoing brain surgery. Eur J Clin Pharmacol. 2008 Aug; 64(8):795-806. PMID: 18521585.
        View in: PubMed
      19. Jensen EW, Jospin M, Gambus PL, Vallverdu M, Caminal P. Validation of the Index of Consciousness (IoC) during sedation/analgesia for ultrasonographic endoscopy. Conf Proc IEEE Eng Med Biol Soc. 2008; 2008:5552-5. PMID: 19163975.
        View in: PubMed
      20. Gambús PL, Stanski DR. Lessons learned in drug development from anesthesia. Rev Esp Anestesiol Reanim. 2005 Jun-Jul; 52(6):311-4. PMID: 16038169.
        View in: PubMed
      21. Fàbregas N, Gambús PL, Valero R, Carrero EJ, Salvador L, Zavala E, Ferrer E. Can bispectral index monitoring predict recovery of consciousness in patients with severe brain injury? Anesthesiology. 2004 Jul; 101(1):43-51. PMID: 15220770.
        View in: PubMed
      22. Parramon F, García Ch, Gambús P, Vilaplana J, Aragonés N, Villalonga A. [Postoperative patient-controlled analgesia is more effective with epidural methadone than with intravenous methadone in thoracic surgery]. Rev Esp Anestesiol Reanim. 2003 Aug-Sep; 50(7):326-31. PMID: 14552104.
        View in: PubMed
      23. Fábregas N, Rapado J, Gambús PL, Valero R, Carrero E, Salvador L, Nalda-Felipe MA, Trocóniz IF. Modeling of the sedative and airway obstruction effects of propofol in patients with Parkinson disease undergoing stereotactic surgery. Anesthesiology. 2002 Dec; 97(6):1378-86. PMID: 12459662.
        View in: PubMed
      24. Barbanoj MJ, Valle M, Kulisevsky J, Pérez V, Gambús P. Uses of pharmaco-EEG and pharmacokinetic-pharmacodynamic modeling in the clinical scenario. Methods Find Exp Clin Pharmacol. 2002; 24 Suppl D:139-44. PMID: 12575481.
        View in: PubMed
      25. Barr J, Egan TD, Sandoval NF, Zomorodi K, Cohane C, Gambus PL, Shafer SL. Propofol dosing regimens for ICU sedation based upon an integrated pharmacokinetic-pharmacodynamic model. Anesthesiology. 2001 Aug; 95(2):324-33. PMID: 11506101.
        View in: PubMed
      26. Fàbregas N, Gambús P, Trocóniz I, Valero R, Guix E, Zavala E. [Use of the electroencephalographic spectral edge frequency 90 to monitor sedation of chronically ill patients]. Rev Esp Anestesiol Reanim. 2001 Aug-Sep; 48(7):314-20. PMID: 11591279.
        View in: PubMed
      27. Gambús P. [Anesthetic status monitoring: reality or pending matter?]. Rev Esp Anestesiol Reanim. 1999 Dec; 46(10):425-6. PMID: 10670262.
        View in: PubMed
      28. Schnider TW, Minto CF, Shafer SL, Gambus PL, Andresen C, Goodale DB, Youngs EJ. The influence of age on propofol pharmacodynamics. Anesthesiology. 1999 Jun; 90(6):1502-16. PMID: 10360845.
        View in: PubMed
      29. Gambús PL, Schnider TW, Minto CF. [Characterization of dose profile of remifentanil with computer simulation: comparative study with fentanyl and alfentanyl]. Rev Esp Anestesiol Reanim. 1998 Oct; 45(8):317-25. PMID: 9847642.
        View in: PubMed
      30. Gambús PL, Schnider TW, Minto CF, Youngs EJ, Billard V, Brose WG, Hochhaus G, Shafer SL. Pharmacokinetics of intravenous dynorphin A(1-13) in opioid-naive and opioid-treated human volunteers. Clin Pharmacol Ther. 1998 Jul; 64(1):27-38. PMID: 9695716.
        View in: PubMed
      31. Schnider TW, Minto CF, Gambus PL, Andresen C, Goodale DB, Shafer SL, Youngs EJ. The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers. Anesthesiology. 1998 May; 88(5):1170-82. PMID: 9605675.
        View in: PubMed
      32. Müller S, Ho B, Gambus P, Millard W, Hochhaus G. An HPLC/RIA method for dynorphin A1-13 and its main metabolites in human blood. J Pharm Biomed Anal. 1997 Sep; 16(1):101-9. PMID: 9447557.
        View in: PubMed
      33. Minto CF, Schnider TW, Egan TD, Youngs E, Lemmens HJ, Gambus PL, Billard V, Hoke JF, Moore KH, Hermann DJ, Muir KT, Mandema JW, Shafer SL. Influence of age and gender on the pharmacokinetics and pharmacodynamics of remifentanil. I. Model development. Anesthesiology. 1997 Jan; 86(1):10-23. PMID: 9009935.
        View in: PubMed
      34. Billard V, Gambus PL, Chamoun N, Stanski DR, Shafer SL. A comparison of spectral edge, delta power, and bispectral index as EEG measures of alfentanil, propofol, and midazolam drug effect. Clin Pharmacol Ther. 1997 Jan; 61(1):45-58. PMID: 9024173.
        View in: PubMed
      35. Shafer SL, Gambús PL. Inhalation versus intravenous anesthesia: a fictitious debate between E.I. Eger II and P.F. White. J Clin Anesth. 1996 May; 8(3 Suppl):38S-41S. PMID: 8695113.
        View in: PubMed
      36. Gambús PL. Structural modeling: simultaneous pharmacokinetic-pharmacodynamic modeling. Methods Find Exp Clin Pharmacol. 1996; 18 Suppl C:47-8. PMID: 9003578.
        View in: PubMed
      37. Billard V, Gambus PL, Barr J, Minto CF, Corash L, Tessman JW, Stickney JL, Shafer SL. The pharmacokinetics of 8-methoxypsoralen following i.v. administration in humans. Br J Clin Pharmacol. 1995 Oct; 40(4):347-60. PMID: 8554937; PMCID: PMC1365154.
      38. Gambús PL, Gregg KM, Shafer SL. Validation of the alfentanil canonical univariate parameter as a measure of opioid effect on the electroencephalogram. Anesthesiology. 1995 Oct; 83(4):747-56. PMID: 7574054.
        View in: PubMed
      39. Salvador L, Fita G, Gomar C, Gambús P, Nalda MA. [Effects of premedication in children with congenital cardiopathy]. Rev Esp Anestesiol Reanim. 1993 Nov-Dec; 40(6):340-3. PMID: 8134673.
        View in: PubMed
      40. Gambús PL, Fita G, Jiménez MJ, Gomar C, Lapena CL, Nalda MA. [Cryoanalgesia in post-thoracotomy pain]. Rev Esp Anestesiol Reanim. 1992 Nov-Dec; 39(6):390. PMID: 1293665.
        View in: PubMed
      41. Vila M, Gaitán ME, Gambús P, Sentís M, Arén JJ. [Transient pneumothorax caused by carbon dioxide following laparoscopy]. Rev Esp Anestesiol Reanim. 1992 May-Jun; 39(3):192. PMID: 1410740.
        View in: PubMed
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