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    Pei-Ken Hsu, PhD

    TitlePostdoc Employee
    SchoolUCSF School of Medicine
    DepartmentHoward Hughes Medical Instit
    Address1550 4th Street, Bldg 19B
    San Francisco CA 94158
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      Collapse Biography 
      Collapse Education and Training
      Columbia UniversityPhDPhysiology2012
      National Taiwan UniversityMSMolecular and Cellular Biology2005
      National Taiwan UniversityBSZoology2003

      Collapse Overview 
      Collapse Overview
      I am interested in the fundamental processes underlying cognitive and behavioral control and how the imbalance of these processes contributes to behavioral abnormality and psychiatric disorders. Currently I focus on dissecting the mechanism of sleep regulation, including sleep onset/offset and sleep homeostasis. By incorporating diverse tools and innovative approaches, such as CRISPR genome-editting, whole-brain imaging and in vivo recording and manipulation tools, I aim to construct a comprehensive view of the spatial and temporal dynamic in the sleep-regulating neural circuits and understand how this dynamic controls the behavioral outcomes.

      The lab also takes a complementary genetic approach to study sleep. Our past endeavors uncovered a wealth of genetic variants associated with genuine human sleep phenotypes, such as familial natural short sleep (FNSS) and familial advanced sleep phase (FASP). I have generated several etiologically valid mouse models accordingly. These new mouse models offer golden opportunities to elucidate the processes of sleep regulation. Careful examination at molecular, cellular, and systems levels will provide significant knowledge that will be particularly precious in designing pharmaceutical agents that improves sleep quality.

      My past training and works were focusing on molecular genetics of developmental processes of C. elegans and pathophysiology of schizophrenia. Besides specific research topics, I also have strong interests and knowledge of human genetics, psychiatric disorders, cognitive neuroscience, regulatory RNA and synthetic biology.

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      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Zhang L, Hirano A, Hsu PK, Jones CR, Sakai N, Okuro M, McMahon T, Yamazaki M, Xu Y, Saigoh N, Saigoh K, Lin ST, Kaasik K, Nishino S, Ptácek LJ, Fu YH. A PERIOD3 variant causes a circadian phenotype and is associated with a seasonal mood trait. Proc Natl Acad Sci U S A. 2016 Mar 15; 113(11):E1536-44. PMID: 26903630.
        View in: PubMed
      2. Ian Barr, Sara H. Weitz, Talia Atkin, PeiKen Hsu, Maria Karayiorgou, Joseph A. Gogos, Shimon Weiss, Feng Guo. . Cobalt(III) Protoporphyrin Activates the DGCR8 Protein and Can Compensate microRNA Processing Deficiency. Chemistry & Biology. 2015; 22(6):793–802.
      3. Hsu PK, Xu B, Mukai J, Karayiorgou M, Gogos JA. The BDNF Val66Met variant affects gene expression through miR-146b. Neurobiol Dis. 2015 May; 77:228-37. PMID: 25771167.
        View in: PubMed
      4. Hsu PK, Ptácek LJ, Fu YH. Genetics of human sleep behavioral phenotypes. Methods Enzymol. 2015; 552:309-24. PMID: 25707283.
        View in: PubMed
      5. Fénelon K, Xu B, Lai CS, Mukai J, Markx S, Stark KL, Hsu PK, Gan WB, Fischbach GD, MacDermott AB, Karayiorgou M, Gogos JA. The pattern of cortical dysfunction in a mouse model of a schizophrenia-related microdeletion. J Neurosci. 2013 Sep 11; 33(37):14825-39. PMID: 24027283; PMCID: PMC3771024.
      6. Xu B, Hsu PK, Stark KL, Karayiorgou M, Gogos JA. Derepression of a neuronal inhibitor due to miRNA dysregulation in a schizophrenia-related microdeletion. Cell. 2013 Jan 17; 152(1-2):262-75. PMID: 23332760; PMCID: PMC3556818.
      7. Xu B, Hsu PK, Karayiorgou M, Gogos JA. MicroRNA dysregulation in neuropsychiatric disorders and cognitive dysfunction. Neurobiol Dis. 2012 May; 46(2):291-301. PMID: 22406400; PMCID: PMC3329786.
      8. Fénelon K, Mukai J, Xu B, Hsu PK, Drew LJ, Karayiorgou M, Fischbach GD, Macdermott AB, Gogos JA. Deficiency of Dgcr8, a gene disrupted by the 22q11.2 microdeletion, results in altered short-term plasticity in the prefrontal cortex. Proc Natl Acad Sci U S A. 2011 Mar 15; 108(11):4447-52. PMID: 21368174; PMCID: PMC3060227.
      9. Drew LJ, Crabtree GW, Markx S, Stark KL, Chaverneff F, Xu B, Mukai J, Fenelon K, Hsu PK, Gogos JA, Karayiorgou M. The 22q11.2 microdeletion: fifteen years of insights into the genetic and neural complexity of psychiatric disorders. Int J Dev Neurosci. 2011 May; 29(3):259-81. PMID: 20920576; PMCID: PMC3074020.
      10. deBakker CD, Haney LB, Kinchen JM, Grimsley C, Lu M, Klingele D, Hsu PK, Chou BK, Cheng LC, Blangy A, Sondek J, Hengartner MO, Wu YC, Ravichandran KS. Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIO-MIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMO. Curr Biol. 2004 Dec 29; 14(24):2208-16. PMID: 15620647.
        View in: PubMed
      11. Wang X, Wu YC, Fadok VA, Lee MC, Gengyo-Ando K, Cheng LC, Ledwich D, Hsu PK, Chen JY, Chou BK, Henson P, Mitani S, Xue D. Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12. Science. 2003 Nov 28; 302(5650):1563-6. PMID: 14645848.
        View in: PubMed
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