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Peter Haggie, PhD

TitleAssociate Professor
SchoolUCSF School of Medicine
DepartmentMedicine
Address513 Parnassus Ave
San Francisco CA 94143
Phone415-476-8530
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPostdoctoral Studies Graduate Division

    Collapse Research 
    Collapse Research Activities and Funding
    Host-Targeted Homoserine Lactone Inhibitor as Adjunctive Antipseudomonal Therapy
    NIH/NIAID R21AI111634Mar 1, 2014 - Feb 29, 2016
    Role: Principal Investigator
    LIVE-CELL IMAGING OF CFTR OLIGOMERIZATION, TRAFFICKING AND INTERACTIONS
    NIH/NIDDK R01DK081355Aug 1, 2008 - May 31, 2014
    Role: Principal Investigator
    Novel Small-Molecule Therapies for CF
    NIH/NIDDK P30DK072517Sep 15, 2005 - May 31, 2020
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse Global Health

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Haggie PM, Phuan PW, Tan JA, Xu H, Avramescu RG, Perdomo D, Zlock L, Nielson DW, Finkbeiner WE, Lukacs GL, Verkman AS. Correctors and Potentiators Rescue Function of the Truncated W1282X-CFTR Translation Product. J Biol Chem. 2016 Nov 28. PMID: 27895116.
      View in: PubMed
    2. Valentine CD, Anderson MO, Papa FR, Haggie PM. Correction: X-Box Binding Protein 1 (XBP1s) Is a Critical Determinant of Pseudomonas aeruginosa Homoserine Lactone-Mediated Apoptosis. PLoS Pathog. 2016 May; 12(5):e1005628. PMID: 27191388.
      View in: PubMed
    3. Cil O, Haggie P, Phuan PW, Tan JA, Verkman AS, et al. Small-Molecule Inhibitors of Pendrin Potentiate the Diuretic Action of Furosemide. J Am Soc Nephrol. 2016 May 6. PMID: 27153921.
      View in: PubMed
    4. Haggie PM, Phuan PW, Tan JA, Zlock L, Finkbeiner WE, Verkman AS. Inhibitors of pendrin anion exchange identified in a small molecule screen increase airway surface liquid volume in cystic fibrosis. FASEB J. 2016 Jun; 30(6):2187-97. PMID: 26932931.
      View in: PubMed
    5. Cil O, Phuan PW, Lee S, Tan J, Haggie P, Levin MH, Sun L, Thiagarajah JR, Ma T, Verkman AS, et al. CFTR activator increases intestinal fluid secretion and normalizes stool output in a mouse model of constipation. Cell Mol Gastroenterol Hepatol. 2016 May; 2(3):317-327. PMID: 27127798.
      View in: PubMed
    6. Valentine CD, Anderson MO, Papa FR, Haggie PM. X-box binding protein 1 (XBP1s) is a critical determinant of Pseudomonas aeruginosa homoserine lactone-mediated apoptosis. PLoS Pathog. 2013; 9(8):e1003576. PMID: 23990788; PMCID: PMC3749957.
    7. Valentine CD, Zhang H, Phuan PW, Nguyen J, Verkman AS, Haggie PM. Small molecule screen yields inhibitors of Pseudomonas homoserine lactone-induced host responses. Cell Microbiol. 2014 Jan; 16(1):1-14. PMID: 23910799; PMCID: PMC3909729.
    8. Valentine CD, Lukacs GL, Verkman AS, Haggie PM. Reduced PDZ interactions of rescued ?F508CFTR increases its cell surface mobility. J Biol Chem. 2012 Dec 21; 287(52):43630-8. PMID: 23115232; PMCID: PMC3527949.
    9. Valentine CD, Verkman AS, Haggie PM. Protein trafficking rates assessed by quantum dot quenching with bromocresol green. Traffic. 2012 Jan; 13(1):25-9. PMID: 21951589; PMCID: PMC3237755.
    10. Valentine CD, Haggie PM. Confinement of ß(1)- and ß(2)-adrenergic receptors in the plasma membrane of cardiomyocyte-like H9c2 cells is mediated by selective interactions with PDZ domain and A-kinase anchoring proteins but not caveolae. Mol Biol Cell. 2011 Aug 15; 22(16):2970-82. PMID: 21680711; PMCID: PMC3154891.
    11. Haggie PM, Verkman AS. Defective organellar acidification as a cause of cystic fibrosis lung disease: reexamination of a recurring hypothesis. Am J Physiol Lung Cell Mol Physiol. 2009 Jun; 296(6):L859-67. PMID: 19329540; PMCID: PMC2692795.
    12. Crane JM, Haggie P, Verkman AS, et al. QUANTUM DOT SINGLE MOLECULE TRACKING REVEALS A WIDE RANGE OF DIFFUSIVE MOTIONS OF MEMBRANE TRANSPORT PROTEINS. Proc SPIE Int Soc Opt Eng. 2009 Mar 3; 7489. PMID: 24386532.
      View in: PubMed
    13. Haggie PM, Verkman AS. Unimpaired lysosomal acidification in respiratory epithelial cells in cystic fibrosis. J Biol Chem. 2009 Mar 20; 284(12):7681-6. PMID: 19136560; PMCID: PMC2658062.
    14. Haggie PM, Verkman AS. Monomeric CFTR in plasma membranes in live cells revealed by single molecule fluorescence imaging. J Biol Chem. 2008 Aug 29; 283(35):23510-3. PMID: 18617526; PMCID: PMC2527093.
    15. Haggie PM, Verkman AS. Cystic fibrosis transmembrane conductance regulator-independent phagosomal acidification in macrophages. J Biol Chem. 2007 Oct 26; 282(43):31422-8. PMID: 17724021.
      View in: PubMed
    16. Jin S, Haggie PM, Verkman AS. Single-particle tracking of membrane protein diffusion in a potential: simulation, detection, and application to confined diffusion of CFTR Cl- channels. Biophys J. 2007 Aug 1; 93(3):1079-88. PMID: 17483157; PMCID: PMC1913154.
    17. Haggie PM, Kim JK, Lukacs GL, Verkman AS. Tracking of quantum dot-labeled CFTR shows near immobilization by C-terminal PDZ interactions. Mol Biol Cell. 2006 Dec; 17(12):4937-45. PMID: 16987954; PMCID: PMC1679663.
    18. Botchway SW, Barba I, Jordan R, Harmston R, Haggie PM, Williams SP, Fulton AM, Parker AW, Brindle KM. A novel method for observing proteins in vivo using a small fluorescent label and multiphoton imaging. Biochem J. 2005 Sep 15; 390(Pt 3):787-90. PMID: 15946123; PMCID: PMC1199672.
    19. Salinas D, Haggie PM, Thiagarajah JR, Song Y, Rosbe K, Finkbeiner WE, Nielson DW, Verkman AS. Submucosal gland dysfunction as a primary defect in cystic fibrosis. FASEB J. 2005 Mar; 19(3):431-3. PMID: 15596485.
      View in: PubMed
    20. Binder DK, Papadopoulos MC, Haggie PM, Verkman AS. In vivo measurement of brain extracellular space diffusion by cortical surface photobleaching. J Neurosci. 2004 Sep 15; 24(37):8049-56. PMID: 15371505.
      View in: PubMed
    21. Thiagarajah JR, Song Y, Haggie PM, Verkman AS. A small molecule CFTR inhibitor produces cystic fibrosis-like submucosal gland fluid secretions in normal airways. FASEB J. 2004 May; 18(7):875-7. PMID: 15001557.
      View in: PubMed
    22. Haggie PM, Stanton BA, Verkman AS. Increased diffusional mobility of CFTR at the plasma membrane after deletion of its C-terminal PDZ binding motif. J Biol Chem. 2004 Feb 13; 279(7):5494-500. PMID: 14660592.
      View in: PubMed
    23. Haggie PM, Verkman AS. Diffusion of tricarboxylic acid cycle enzymes in the mitochondrial matrix in vivo. Evidence for restricted mobility of a multienzyme complex. J Biol Chem. 2002 Oct 25; 277(43):40782-8. PMID: 12198136.
      View in: PubMed
    24. Haggie PM, Stanton BA, Verkman AS. Diffusional mobility of the cystic fibrosis transmembrane conductance regulator mutant, delta F508-CFTR, in the endoplasmic reticulum measured by photobleaching of GFP-CFTR chimeras. J Biol Chem. 2002 May 10; 277(19):16419-25. PMID: 11877404.
      View in: PubMed
    25. Galietta LJ, Haggie PM, Verkman AS. Green fluorescent protein-based halide indicators with improved chloride and iodide affinities. FEBS Lett. 2001 Jun 22; 499(3):220-4. PMID: 11423120.
      View in: PubMed
    26. Levin MH, Haggie PM, Vetrivel L, Verkman AS. Diffusion in the endoplasmic reticulum of an aquaporin-2 mutant causing human nephrogenic diabetes insipidus. J Biol Chem. 2001 Jun 15; 276(24):21331-6. PMID: 11297561.
      View in: PubMed
    27. Jayaraman S, Haggie P, Wachter RM, Remington SJ, Verkman AS. Mechanism and cellular applications of a green fluorescent protein-based halide sensor. J Biol Chem. 2000 Mar 3; 275(9):6047-50. PMID: 10692389.
      View in: PubMed
    28. Lukacs GL, Haggie P, Seksek O, Lechardeur D, Freedman N, Verkman AS. Size-dependent DNA mobility in cytoplasm and nucleus. J Biol Chem. 2000 Jan 21; 275(3):1625-9. PMID: 10636854.
      View in: PubMed
    29. Haggie PM, Brindle KM. Mitochondrial citrate synthase is immobilized in vivo. J Biol Chem. 1999 Feb 12; 274(7):3941-5. PMID: 9933583.
      View in: PubMed
    30. Williams SP, Haggie PM, Brindle KM. 19F NMR measurements of the rotational mobility of proteins in vivo. Biophys J. 1997 Jan; 72(1):490-8. PMID: 8994636; PMCID: PMC1184340.
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