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    Peter Walter, PhD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentBiochemistry and Biophysics
    Address600 16th St
    San Francisco CA 94158
    Phone415-476-5017
    vCardDownload vCard
      Other Positions
      TitleHoward Hughes Investigator


      Collapse Biography 
      Collapse Awards and Honors
      Vilcek Foundation2015Vilcek Prize in Biomedical Science
      Lasker Foundation2014Lasker Basic Medical Research Award
      UCSF2014Shaw Prize in Life Science and Medicine
      UCSF2012Paul Ehrlich and Ludwig Darmstaedter Prize

      Collapse ORNG Applications 
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      Collapse Featured Publications

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Sabnis AJ, Guerriero CJ, Olivas V, Sayana A, Shue J, Flanagan J, Asthana S, Paton AW, Paton JC, Gestwicki JE, Walter P, Weissman JS, Wipf P, Brodsky JL, Bivona TG. Combined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma. Proc Natl Acad Sci U S A. 2016 Aug 9; 113(32):9015-20. PMID: 27450084.
        View in: PubMed
      2. Plate L, Cooley CB, Chen JJ, Paxman RJ, Gallagher CM, Madoux F, Genereux JC, Dobbs W, Garza D, Spicer TP, Scampavia L, Brown SJ, Rosen H, Powers ET, Walter P, Hodder P, Wiseman RL, Kelly JW. Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation. Elife. 2016; 5. PMID: 27435961.
        View in: PubMed
      3. Gallagher CM, Garri C, Cain EL, Ang KK, Wilson CG, Chen S, Hearn BR, Jaishankar P, Aranda-Diaz A, Arkin MR, Renslo AR, Walter P. Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6a branch. Elife. 2016; 5. PMID: 27435960.
        View in: PubMed
      4. Gallagher CM, Walter P. Ceapins inhibit ATF6a signaling by selectively preventing transport of ATF6a to the Golgi apparatus during ER stress. Elife. 2016; 5. PMID: 27435962.
        View in: PubMed
      5. Huang W, Placzek AN, Viana Di Prisco G, Khatiwada S, Sidrauski C, Krnjevic K, Walter P, Dani JA, Costa-Mattioli M. Translational control by eIF2a phosphorylation regulates vulnerability to the synaptic and behavioral effects of cocaine. Elife. 2016; 5. PMID: 26928234.
        View in: PubMed
      6. Placzek AN, Molfese DL, Khatiwada S, Viana Di Prisco G, Huang W, Sidrauski C, Krnjevic K, Amos CL, Ray R, Dani JA, Walter P, Salas R, Costa-Mattioli M. Translational control of nicotine-evoked synaptic potentiation in mice and neuronal responses in human smokers by eIF2a. Elife. 2016; 5. PMID: 26928076.
        View in: PubMed
      7. Starck SR, Tsai JC, Chen K, Shodiya M, Wang L, Yahiro K, Martins-Green M, Shastri N, Walter P. Translation from the 5' untranslated region shapes the integrated stress response. Science. 2016 Jan 29; 351(6272):aad3867. PMID: 26823435.
        View in: PubMed
      8. Hearn BR, Jaishankar P, Sidrauski C, Tsai JC, Vedantham P, Fontaine SD, Walter P, Renslo AR. Structure-Activity Studies of Bis-O-Arylglycolamides: Inhibitors of the Integrated Stress Response. ChemMedChem. 2016 Apr 19; 11(8):870-80. PMID: 26789650.
        View in: PubMed
      9. Elvekrog MM, Walter P. Dynamics of co-translational protein targeting. Curr Opin Chem Biol. 2015 Dec; 29:79-86. PMID: 26517565.
        View in: PubMed
      10. Peschek J, Acosta-Alvear D, Mendez AS, Walter P. A conformational RNA zipper promotes intron ejection during non-conventional XBP1 mRNA splicing. EMBO Rep. 2015 Dec; 16(12):1688-98. PMID: 26483401.
        View in: PubMed
      11. Lang AB, Peter AT, Walter P, Kornmann B. ER-mitochondrial junctions can be bypassed by dominant mutations in the endosomal protein Vps13. J Cell Biol. 2015 Sep 14; 210(6):883-90. PMID: 26370498; PMCID: PMC4576869 [Available on 03/14/16].
      12. Acosta-Alvear D, Cho MY, Wild T, Buchholz TJ, Lerner AG, Simakova O, Hahn J, Korde N, Landgren O, Maric I, Choudhary C, Walter P, Weissman JS, Kampmann M. Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits. Elife. 2015; 4. PMID: 26327694; PMCID: PMC4602331.
      13. Mendez AS, Alfaro J, Morales-Soto MA, Dar AC, McCullagh E, Gotthardt K, Li H, Acosta-Alvear D, Sidrauski C, Korennykh AV, Bernales S, Shokat KM, Walter P. Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic. Elife. 2015; 4. PMID: 25986605; PMCID: PMC4436593.
      14. Sidrauski C, Tsai JC, Kampmann M, Hearn BR, Vedantham P, Jaishankar P, Sokabe M, Mendez AS, Newton BW, Tang EL, Verschueren E, Johnson JR, Krogan NJ, Fraser CS, Weissman JS, Renslo AR, Walter P. Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response. Elife. 2015; 4:e07314. PMID: 25875391; PMCID: PMC4426669.
      15. Sidrauski C, McGeachy AM, Ingolia NT, Walter P. The small molecule ISRIB reverses the effects of eIF2a phosphorylation on translation and stress granule assembly. Elife. 2015; 4. PMID: 25719440; PMCID: PMC4341466.
      16. Osman C, Noriega TR, Okreglak V, Fung JC, Walter P. Integrity of the yeast mitochondrial genome, but not its distribution and inheritance, relies on mitochondrial fission and fusion. Proc Natl Acad Sci U S A. 2015 Mar 3; 112(9):E947-56. PMID: 25730886; PMCID: PMC4352819.
      17. Li X, Colvin T, Rauch JN, Acosta-Alvear D, Kampmann M, Dunyak B, Hann B, Aftab BT, Murnane M, Cho M, Walter P, Weissman JS, Sherman MY, Gestwicki JE. Validation of the Hsp70-Bag3 protein-protein interaction as a potential therapeutic target in cancer. Mol Cancer Ther. 2015 Mar; 14(3):642-8. PMID: 25564440; PMCID: PMC4456214 [Available on 03/01/16].
      18. van Anken E, Pincus D, Coyle S, Aragón T, Osman C, Lari F, Gómez Puerta S, Korennykh AV, Walter P. Specificity in endoplasmic reticulum-stress signaling in yeast entails a step-wise engagement of HAC1 mRNA to clusters of the stress sensor Ire1. Elife. 2014; 3:e05031. PMID: 25549299; PMCID: PMC4279078.
      19. Noriega TR, Chen J, Walter P, Puglisi JD. Real-time observation of signal recognition particle binding to actively translating ribosomes. Elife. 2014; 3. PMID: 25358118; PMCID: PMC4213662.
      20. Pincus D, Aranda-Díaz A, Zuleta IA, Walter P, El-Samad H. Delayed Ras/PKA signaling augments the unfolded protein response. Proc Natl Acad Sci U S A. 2014 Oct 14; 111(41):14800-5. PMID: 25275008; PMCID: PMC4205644.
      21. Walter P. Lasker Award winner Peter Walter. Nat Med. 2014 Oct; 20(10):1112-4. PMID: 25295946.
        View in: PubMed
      22. Schuck S, Gallagher CM, Walter P. ER-phagy mediates selective degradation of endoplasmic reticulum independently of the core autophagy machinery. J Cell Sci. 2014 Sep 15; 127(Pt 18):4078-88. PMID: 25052096; PMCID: PMC4163648.
      23. Lu M, Lawrence DA, Marsters S, Acosta-Alvear D, Kimmig P, Mendez AS, Paton AW, Paton JC, Walter P, Ashkenazi A. Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis. Science. 2014 Jul 4; 345(6192):98-101. PMID: 24994655; PMCID: PMC4284148.
      24. Di Prisco GV, Huang W, Buffington SA, Hsu CC, Bonnen PE, Placzek AN, Sidrauski C, Krnjevic K, Kaufman RJ, Walter P, Costa-Mattioli M. Translational control of mGluR-dependent long-term depression and object-place learning by eIF2a. Nat Neurosci. 2014 Aug; 17(8):1073-82. PMID: 24974795; PMCID: PMC4340591.
      25. Okreglak V, Walter P. The conserved AAA-ATPase Msp1 confers organelle specificity to tail-anchored proteins. Proc Natl Acad Sci U S A. 2014 Jun 3; 111(22):8019-24. PMID: 24821790; PMCID: PMC4050615.
      26. Noriega TR, Tsai A, Elvekrog MM, Petrov A, Neher SB, Chen J, Bradshaw N, Puglisi JD, Walter P. Signal recognition particle-ribosome binding is sensitive to nascent chain length. J Biol Chem. 2014 Jul 11; 289(28):19294-305. PMID: 24808175; PMCID: PMC4094042.
      27. Chang YC, Khanal Lamichhane A, Garraffo HM, Walter PJ, Leerkes M, Kwon-Chung KJ. Molecular mechanisms of hypoxic responses via unique roles of Ras1, Cdc24 and Ptp3 in a human fungal pathogen Cryptococcus neoformans. PLoS Genet. 2014 Apr; 10(4):e1004292. PMID: 24762475; PMCID: PMC3998916.
      28. Lim B, Miyazaki R, Neher S, Siegele DA, Ito K, Walter P, Akiyama Y, Yura T, Gross CA. Heat shock transcription factor s32 co-opts the signal recognition particle to regulate protein homeostasis in E. coli. PLoS Biol. 2013 Dec; 11(12):e1001735. PMID: 24358019; PMCID: PMC3866087.
      29. Sidrauski C, Acosta-Alvear D, Khoutorsky A, Vedantham P, Hearn BR, Li H, Gamache K, Gallagher CM, Ang KK, Wilson C, Okreglak V, Ashkenazi A, Hann B, Nader K, Arkin MR, Renslo AR, Sonenberg N, Walter P. Pharmacological brake-release of mRNA translation enhances cognitive memory. Elife. 2013; 2:e00498. PMID: 23741617; PMCID: PMC3667625.
      30. Cho JA, Lee AH, Platzer B, Cross BC, Gardner BM, De Luca H, Luong P, Harding HP, Glimcher LH, Walter P, Fiebiger E, Ron D, Kagan JC, Lencer WI. The unfolded protein response element IRE1a senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling. Cell Host Microbe. 2013 May 15; 13(5):558-69. PMID: 23684307; PMCID: PMC3766372.
      31. Murley A, Lackner LL, Osman C, West M, Voeltz GK, Walter P, Nunnari J. ER-associated mitochondrial division links the distribution of mitochondria and mitochondrial DNA in yeast. Elife. 2013; 2:e00422. PMID: 23682313; PMCID: PMC3654481.
      32. Walter P. Two structure papers, a call from Frankfurt airport, and how to escape from reviewer delays: an interview with Peter Walter by Miranda Robertson. BMC Biol. 2013; 11:34. PMID: 23587131; PMCID: PMC3626913.
      33. Gardner BM, Pincus D, Gotthardt K, Gallagher CM, Walter P. Endoplasmic reticulum stress sensing in the unfolded protein response. Cold Spring Harb Perspect Biol. 2013 Mar; 5(3):a013169. PMID: 23388626; PMCID: PMC3578356.
      34. Kimmig P, Diaz M, Zheng J, Williams CC, Lang A, Aragón T, Li H, Walter P. The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis. Elife. 2012; 1:e00048. PMID: 23066505; PMCID: PMC3470409.
      35. Fordyce PM, Pincus D, Kimmig P, Nelson CS, El-Samad H, Walter P, DeRisi JL. Basic leucine zipper transcription factor Hac1 binds DNA in two distinct modes as revealed by microfluidic analyses. Proc Natl Acad Sci U S A. 2012 Nov 6; 109(45):E3084-93. PMID: 23054834; PMCID: PMC3494901.
      36. Pincus D, Walter P. A first line of defense against ER stress. J Cell Biol. 2012 Aug 6; 198(3):277-9. PMID: 22869593; PMCID: PMC3413362.
      37. Moreira KE, Schuck S, Schrul B, Fröhlich F, Moseley JB, Walther TC, Walter P. Seg1 controls eisosome assembly and shape. J Cell Biol. 2012 Aug 6; 198(3):405-20. PMID: 22869600; PMCID: PMC3413353.
      38. Korennykh A, Walter P. Structural basis of the unfolded protein response. Annu Rev Cell Dev Biol. 2012; 28:251-77. PMID: 23057742.
        View in: PubMed
      39. Walter P, Ron D. The unfolded protein response: from stress pathway to homeostatic regulation. Science. 2011 Nov 25; 334(6059):1081-6. PMID: 22116877.
        View in: PubMed
      40. Braunstein MJ, Scott SS, Scott CM, Behrman S, Walter P, Wipf P, Coplan JD, Chrico W, Joseph D, Brodsky JL, Batuman O. Antimyeloma Effects of the Heat Shock Protein 70 Molecular Chaperone Inhibitor MAL3-101. J Oncol. 2011; 2011:232037. PMID: 21977030; PMCID: PMC3184436.
      41. Castillo K, Rojas-Rivera D, Lisbona F, Caballero B, Nassif M, Court FA, Schuck S, Ibar C, Walter P, Sierralta J, Glavic A, Hetz C. BAX inhibitor-1 regulates autophagy by controlling the IRE1a branch of the unfolded protein response. EMBO J. 2011 Nov 2; 30(21):4465-78. PMID: 21926971; PMCID: PMC3230375.
      42. Gardner BM, Walter P. Unfolded proteins are Ire1-activating ligands that directly induce the unfolded protein response. Science. 2011 Sep 30; 333(6051):1891-4. PMID: 21852455; PMCID: PMC3202989.
      43. Kornmann B, Osman C, Walter P. The conserved GTPase Gem1 regulates endoplasmic reticulum-mitochondria connections. Proc Natl Acad Sci U S A. 2011 Aug 23; 108(34):14151-6. PMID: 21825164; PMCID: PMC3161550.
      44. Nguyen TX, Chandrasekar S, Neher S, Walter P, Shan SO. Concerted complex assembly and GTPase activation in the chloroplast signal recognition particle. Biochemistry. 2011 Aug 23; 50(33):7208-17. PMID: 21780778.
        View in: PubMed
      45. Korennykh AV, Egea PF, Korostelev AA, Finer-Moore J, Stroud RM, Zhang C, Shokat KM, Walter P. Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1. BMC Biol. 2011; 9:48. PMID: 21729334; PMCID: PMC3158555.
      46. Korennykh AV, Korostelev AA, Egea PF, Finer-Moore J, Stroud RM, Zhang C, Shokat KM, Walter P. Structural and functional basis for RNA cleavage by Ire1. BMC Biol. 2011; 9:47. PMID: 21729333; PMCID: PMC3149027.
      47. Walter P. Peter Walter: investigating how the ER handles secretory proteins. Interview by Sedwick Caitlin. J Cell Biol. 2011 Apr 4; 193(1):4-5. PMID: 21464225; PMCID: PMC3082191.
      48. Rubio C, Pincus D, Korennykh A, Schuck S, El-Samad H, Walter P. Homeostatic adaptation to endoplasmic reticulum stress depends on Ire1 kinase activity. J Cell Biol. 2011 Apr 4; 193(1):171-84. PMID: 21444684; PMCID: PMC3082176.
      49. Behrman S, Acosta-Alvear D, Walter P. A CHOP-regulated microRNA controls rhodopsin expression. J Cell Biol. 2011 Mar 21; 192(6):919-27. PMID: 21402790; PMCID: PMC3063143.
      50. Hayat S, Walter P, Park Y, Helms V. Prediction of the exposure status of transmembrane beta barrel residues from protein sequence. J Bioinform Comput Biol. 2011 Feb; 9(1):43-65. PMID: 21328706.
        View in: PubMed
      51. Li H, Korennykh AV, Behrman SL, Walter P. Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering. Proc Natl Acad Sci U S A. 2010 Sep 14; 107(37):16113-8. PMID: 20798350; PMCID: PMC2941319.
      52. Pincus D, Chevalier MW, Aragón T, van Anken E, Vidal SE, El-Samad H, Walter P. BiP binding to the ER-stress sensor Ire1 tunes the homeostatic behavior of the unfolded protein response. PLoS Biol. 2010; 8(7):e1000415. PMID: 20625545; PMCID: PMC2897766.
      53. Battle A, Jonikas MC, Walter P, Weissman JS, Koller D. Automated identification of pathways from quantitative genetic interaction data. Mol Syst Biol. 2010 Jun 8; 6:379. PMID: 20531408; PMCID: PMC2913392.
      54. Aguilar PS, Fröhlich F, Rehman M, Shales M, Ulitsky I, Olivera-Couto A, Braberg H, Shamir R, Walter P, Mann M, Ejsing CS, Krogan NJ, Walther TC. A plasma-membrane E-MAP reveals links of the eisosome with sphingolipid metabolism and endosomal trafficking. Nat Struct Mol Biol. 2010 Jul; 17(7):901-8. PMID: 20526336; PMCID: PMC3073498.
      55. Engel A, Aguilar PS, Walter P. The yeast cell fusion protein Prm1p requires covalent dimerization to promote membrane fusion. PLoS One. 2010; 5(5):e10593. PMID: 20485669; PMCID: PMC2868043.
      56. Kornmann B, Walter P. ERMES-mediated ER-mitochondria contacts: molecular hubs for the regulation of mitochondrial biology. J Cell Sci. 2010 May 1; 123(Pt 9):1389-93. PMID: 20410371; PMCID: PMC2858017.
      57. Aguilar PS, Heiman MG, Walther TC, Engel A, Schwudke D, Gushwa N, Kurzchalia T, Walter P. Structure of sterol aliphatic chains affects yeast cell shape and cell fusion during mating. Proc Natl Acad Sci U S A. 2010 Mar 2; 107(9):4170-5. PMID: 20150508; PMCID: PMC2840153.
      58. Walter P. Walking along the serendipitous path of discovery. Mol Biol Cell. 2010 Jan 1; 21(1):15-7. PMID: 20048259; PMCID: PMC2801708.
      59. Schuck S, Prinz WA, Thorn KS, Voss C, Walter P. Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response. J Cell Biol. 2009 Nov 16; 187(4):525-36. PMID: 19948500; PMCID: PMC2779237.
      60. Doolittle MH, Neher SB, Ben-Zeev O, Ling-Liao J, Gallagher CM, Hosseini M, Yin F, Wong H, Walter P, Péterfy M. Lipase maturation factor LMF1, membrane topology and interaction with lipase proteins in the endoplasmic reticulum. J Biol Chem. 2009 Nov 27; 284(48):33623-33. PMID: 19783858; PMCID: PMC2785204.
      61. Hollien J, Lin JH, Li H, Stevens N, Walter P, Weissman JS. Regulated Ire1-dependent decay of messenger RNAs in mammalian cells. J Cell Biol. 2009 Aug 10; 186(3):323-31. PMID: 19651891; PMCID: PMC2728407.
      62. Fröhlich F, Moreira K, Aguilar PS, Hubner NC, Mann M, Walter P, Walther TC. A genome-wide screen for genes affecting eisosomes reveals Nce102 function in sphingolipid signaling. J Cell Biol. 2009 Jun 29; 185(7):1227-42. PMID: 19564405; PMCID: PMC2712959.
      63. Kornmann B, Currie E, Collins SR, Schuldiner M, Nunnari J, Weissman JS, Walter P. An ER-mitochondria tethering complex revealed by a synthetic biology screen. Science. 2009 Jul 24; 325(5939):477-81. PMID: 19556461; PMCID: PMC2933203.
      64. So AY, de la Fuente E, Walter P, Shuman M, Bernales S. The unfolded protein response during prostate cancer development. Cancer Metastasis Rev. 2009 Jun; 28(1-2):219-23. PMID: 19172382.
        View in: PubMed
      65. Lisbona F, Rojas-Rivera D, Thielen P, Zamorano S, Todd D, Martinon F, Glavic A, Kress C, Lin JH, Walter P, Reed JC, Glimcher LH, Hetz C. BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha. Mol Cell. 2009 Mar 27; 33(6):679-91. PMID: 19328063; PMCID: PMC2818874.
      66. Jonikas MC, Collins SR, Denic V, Oh E, Quan EM, Schmid V, Weibezahn J, Schwappach B, Walter P, Weissman JS, Schuldiner M. Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum. Science. 2009 Mar 27; 323(5922):1693-7. PMID: 19325107; PMCID: PMC2877488.
      67. Lin JH, Li H, Zhang Y, Ron D, Walter P. Divergent effects of PERK and IRE1 signaling on cell viability. PLoS One. 2009; 4(1):e4170. PMID: 19137072; PMCID: PMC2614882.
      68. Bradshaw N, Neher SB, Booth DS, Walter P. Signal sequences activate the catalytic switch of SRP RNA. Science. 2009 Jan 2; 323(5910):127-30. PMID: 19119234; PMCID: PMC2767340.
      69. Korennykh AV, Egea PF, Korostelev AA, Finer-Moore J, Zhang C, Shokat KM, Stroud RM, Walter P. The unfolded protein response signals through high-order assembly of Ire1. Nature. 2009 Feb 5; 457(7230):687-93. PMID: 19079236; PMCID: PMC2846394.
      70. Aragón T, van Anken E, Pincus D, Serafimova IM, Korennykh AV, Rubio CA, Walter P. Messenger RNA targeting to endoplasmic reticulum stress signalling sites. Nature. 2009 Feb 5; 457(7230):736-40. PMID: 19079237; PMCID: PMC2768538.
      71. Moreira KE, Walther TC, Aguilar PS, Walter P. Pil1 controls eisosome biogenesis. Mol Biol Cell. 2009 Feb; 20(3):809-18. PMID: 19037108; PMCID: PMC2633383.
      72. Egea PF, Tsuruta H, de Leon GP, Napetschnig J, Walter P, Stroud RM. Structures of the signal recognition particle receptor from the archaeon Pyrococcus furiosus: implications for the targeting step at the membrane. PLoS One. 2008; 3(11):e3619. PMID: 18978942; PMCID: PMC2572998.
      73. Egea PF, Napetschnig J, Walter P, Stroud RM. Structures of SRP54 and SRP19, the two proteins that organize the ribonucleic core of the signal recognition particle from Pyrococcus furiosus. PLoS One. 2008; 3(10):e3528. PMID: 18953414; PMCID: PMC2568955.
      74. Engel A, Walter P. Membrane lysis during biological membrane fusion: collateral damage by misregulated fusion machines. J Cell Biol. 2008 Oct 20; 183(2):181-6. PMID: 18852300; PMCID: PMC2568015.
      75. Neher SB, Bradshaw N, Floor SN, Gross JD, Walter P. SRP RNA controls a conformational switch regulating the SRP-SRP receptor interaction. Nat Struct Mol Biol. 2008 Sep; 15(9):916-23. PMID: 19172744; PMCID: PMC2767265.
      76. Raff M, Johnson A, Walter P. Painful publishing. Science. 2008 Jul 4; 321(5885):36. PMID: 18599755.
        View in: PubMed
      77. Guo Y, Walther TC, Rao M, Stuurman N, Goshima G, Terayama K, Wong JS, Vale RD, Walter P, Farese RV. Functional genomic screen reveals genes involved in lipid-droplet formation and utilization. Nature. 2008 May 29; 453(7195):657-61. PMID: 18408709; PMCID: PMC2734507.
      78. Lin JH, Walter P, Yen TS. Endoplasmic reticulum stress in disease pathogenesis. Annu Rev Pathol. 2008; 3:399-425. PMID: 18039139; PMCID: PMC3653419.
      79. Walther TC, Aguilar PS, Fröhlich F, Chu F, Moreira K, Burlingame AL, Walter P. Pkh-kinases control eisosome assembly and organization. EMBO J. 2007 Dec 12; 26(24):4946-55. PMID: 18034155; PMCID: PMC2094096.
      80. Lin JH, Li H, Yasumura D, Cohen HR, Zhang C, Panning B, Shokat KM, Lavail MM, Walter P. IRE1 signaling affects cell fate during the unfolded protein response. Science. 2007 Nov 9; 318(5852):944-9. PMID: 17991856; PMCID: PMC3670588.
      81. Haass FA, Jonikas M, Walter P, Weissman JS, Jan YN, Jan LY, Schuldiner M. Identification of yeast proteins necessary for cell-surface function of a potassium channel. Proc Natl Acad Sci U S A. 2007 Nov 13; 104(46):18079-84. PMID: 17989219; PMCID: PMC2084299.
      82. Shan SO, Chandrasekar S, Walter P. Conformational changes in the GTPase modules of the signal reception particle and its receptor drive initiation of protein translocation. J Cell Biol. 2007 Aug 13; 178(4):611-20. PMID: 17682051; PMCID: PMC2064468.
      83. Reyes CL, Rutenber E, Walter P, Stroud RM. X-ray structures of the signal recognition particle receptor reveal targeting cycle intermediates. PLoS One. 2007; 2(7):e607. PMID: 17622352; PMCID: PMC1904258.
      84. Ron D, Walter P. Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol. 2007 Jul; 8(7):519-29. PMID: 17565364.
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      85. Bradshaw N, Walter P. The signal recognition particle (SRP) RNA links conformational changes in the SRP to protein targeting. Mol Biol Cell. 2007 Jul; 18(7):2728-34. PMID: 17507650; PMCID: PMC1924838.
      86. Bernales S, Schuck S, Walter P. ER-phagy: selective autophagy of the endoplasmic reticulum. Autophagy. 2007 May-Jun; 3(3):285-7. PMID: 17351330.
        View in: PubMed
      87. Heiman MG, Engel A, Walter P. The Golgi-resident protease Kex2 acts in conjunction with Prm1 to facilitate cell fusion during yeast mating. J Cell Biol. 2007 Jan 15; 176(2):209-22. PMID: 17210951; PMCID: PMC2063940.
      88. Aguilar PS, Engel A, Walter P. The plasma membrane proteins Prm1 and Fig1 ascertain fidelity of membrane fusion during yeast mating. Mol Biol Cell. 2007 Feb; 18(2):547-56. PMID: 17151357; PMCID: PMC1783792.
      89. Bernales S, McDonald KL, Walter P. Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response. PLoS Biol. 2006 Nov; 4(12):e423. PMID: 17132049; PMCID: PMC1661684.
      90. Walther TC, Brickner JH, Aguilar PS, Bernales S, Pantoja C, Walter P. Eisosomes mark static sites of endocytosis. Nature. 2006 Feb 23; 439(7079):998-1003. PMID: 16496001.
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      91. Bernales S, Papa FR, Walter P. Intracellular signaling by the unfolded protein response. Annu Rev Cell Dev Biol. 2006; 22:487-508. PMID: 16822172.
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      92. Credle JJ, Finer-Moore JS, Papa FR, Stroud RM, Walter P. On the mechanism of sensing unfolded protein in the endoplasmic reticulum. Proc Natl Acad Sci U S A. 2005 Dec 27; 102(52):18773-84. PMID: 16365312; PMCID: PMC1316886.
      93. Kaiser SE, Brickner JH, Reilein AR, Fenn TD, Walter P, Brunger AT. Structural basis of FFAT motif-mediated ER targeting. Structure. 2005 Jul; 13(7):1035-45. PMID: 16004875.
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      94. Shan SO, Walter P. Molecular crosstalk between the nucleotide specificity determinant of the SRP GTPase and the SRP receptor. Biochemistry. 2005 Apr 26; 44(16):6214-22. PMID: 15835909.
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      95. Egea PF, Stroud RM, Walter P. Targeting proteins to membranes: structure of the signal recognition particle. Curr Opin Struct Biol. 2005 Apr; 15(2):213-20. PMID: 15837181.
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      96. Shan SO, Walter P. Co-translational protein targeting by the signal recognition particle. FEBS Lett. 2005 Feb 7; 579(4):921-6. PMID: 15680975.
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      129. Powers T, Walter P. A ribosome at the end of the tunnel. Science. 1997 Dec 19; 278(5346):2072-3. PMID: 9432719.
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      131. Sidrauski C, Walter P. The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response. Cell. 1997 Sep 19; 90(6):1031-9. PMID: 9323131.
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      137. Sidrauski C, Cox JS, Walter P. tRNA ligase is required for regulated mRNA splicing in the unfolded protein response. Cell. 1996 Nov 1; 87(3):405-13. PMID: 8898194.
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      138. Cox JS, Walter P. A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response. Cell. 1996 Nov 1; 87(3):391-404. PMID: 8898193.
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      140. Shamu CE, Walter P. Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus. EMBO J. 1996 Jun 17; 15(12):3028-39. PMID: 8670804; PMCID: PMC450244.
      141. Powers T, Walter P. The nascent polypeptide-associated complex modulates interactions between the signal recognition particle and the ribosome. Curr Biol. 1996 Mar 1; 6(3):331-8. PMID: 8805251.
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      142. Nunnari J, Walter P. Regulation of organelle biogenesis. Cell. 1996 Feb 9; 84(3):389-94. PMID: 8608592.
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      143. Ng DT, Walter P. ER membrane protein complex required for nuclear fusion. J Cell Biol. 1996 Feb; 132(4):499-509. PMID: 8647883; PMCID: PMC2199862.
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      145. Ogg SC, Walter P. SRP samples nascent chains for the presence of signal sequences by interacting with ribosomes at a discrete step during translation elongation. Cell. 1995 Jun 30; 81(7):1075-84. PMID: 7600575.
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      146. Matlack KE, Walter P. The 70 carboxyl-terminal amino acids of nascent secretory proteins are protected from proteolysis by the ribosome and the protein translocation apparatus of the endoplasmic reticulum membrane. J Biol Chem. 1995 Mar 17; 270(11):6170-80. PMID: 7890751.
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      147. Miller JD, Tajima S, Lauffer L, Walter P. The beta subunit of the signal recognition particle receptor is a transmembrane GTPase that anchors the alpha subunit, a peripheral membrane GTPase, to the endoplasmic reticulum membrane. J Cell Biol. 1995 Feb; 128(3):273-82. PMID: 7844142; PMCID: PMC2120348.
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      152. Miller JD, Bernstein HD, Walter P. Interaction of E. coli Ffh/4.5S ribonucleoprotein and FtsY mimics that of mammalian signal recognition particle and its receptor. Nature. 1994 Feb 17; 367(6464):657-9. PMID: 8107852.
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      153. Shamu CE, Cox JS, Walter P. The unfolded-protein-response pathway in yeast. Trends Cell Biol. 1994 Feb; 4(2):56-60. PMID: 14731868.
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      155. Nunnari J, Fox TD, Walter P. A mitochondrial protease with two catalytic subunits of nonoverlapping specificities. Science. 1993 Dec 24; 262(5142):1997-2004. PMID: 8266095.
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      157. Matlack KE, Walter P. Shedding light on the translocation pore. Curr Biol. 1993 Oct 1; 3(10):677-9. PMID: 15335859.
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      158. Cox JS, Shamu CE, Walter P. Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase. Cell. 1993 Jun 18; 73(6):1197-206. PMID: 8513503.
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      159. Wolin SL, Walter P. Discrete nascent chain lengths are required for the insertion of presecretory proteins into microsomal membranes. J Cell Biol. 1993 Jun; 121(6):1211-9. PMID: 8389768; PMCID: PMC2119713.
      160. Bernstein HD, Zopf D, Freymann DM, Walter P. Functional substitution of the signal recognition particle 54-kDa subunit by its Escherichia coli homolog. Proc Natl Acad Sci U S A. 1993 Jun 1; 90(11):5229-33. PMID: 8389475; PMCID: PMC46689.
      161. Zopf D, Bernstein HD, Walter P. GTPase domain of the 54-kD subunit of the mammalian signal recognition particle is required for protein translocation but not for signal sequence binding. J Cell Biol. 1993 Mar; 120(5):1113-21. PMID: 8382204; PMCID: PMC2119734.
      162. Miller JD, Walter P. A GTPase cycle in initiation of protein translocation across the endoplasmic reticulum membrane. Ciba Found Symp. 1993; 176:147-59; discussion 159-63. PMID: 8299417.
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      163. Nunnari J, Walter P. Protein targeting to and translocation across the membrane of the endoplasmic reticulum. Curr Opin Cell Biol. 1992 Aug; 4(4):573-80. PMID: 1419037.
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      164. Ogg SC, Poritz MA, Walter P. Signal recognition particle receptor is important for cell growth and protein secretion in Saccharomyces cerevisiae. Mol Biol Cell. 1992 Aug; 3(8):895-911. PMID: 1327299; PMCID: PMC275647.
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      166. Hann BC, Stirling CJ, Walter P. SEC65 gene product is a subunit of the yeast signal recognition particle required for its integrity. Nature. 1992 Apr 9; 356(6369):532-3. PMID: 1313947.
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      167. Green N, Fang H, Walter P. Mutants in three novel complementation groups inhibit membrane protein insertion into and soluble protein translocation across the endoplasmic reticulum membrane of Saccharomyces cerevisiae. J Cell Biol. 1992 Feb; 116(3):597-604. PMID: 1730771; PMCID: PMC2289319.
      168. Green N, Walter P. C-terminal sequences can inhibit the insertion of membrane proteins into the endoplasmic reticulum of Saccharomyces cerevisiae. Mol Cell Biol. 1992 Jan; 12(1):276-82. PMID: 1729604; PMCID: PMC364098.
      169. Hann BC, Walter P. The signal recognition particle in S. cerevisiae. Cell. 1991 Oct 4; 67(1):131-44. PMID: 1655273.
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      170. Zimmerman DL, Walter P. An ATP-binding membrane protein is required for protein translocation across the endoplasmic reticulum membrane. Cell Regul. 1991 Oct; 2(10):851-9. PMID: 1801920; PMCID: PMC361880.
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      172. Strub K, Moss J, Walter P. Binding sites of the 9- and 14-kilodalton heterodimeric protein subunit of the signal recognition particle (SRP) are contained exclusively in the Alu domain of SRP RNA and contain a sequence motif that is conserved in evolution. Mol Cell Biol. 1991 Aug; 11(8):3949-59. PMID: 1712900; PMCID: PMC361190.
      173. Zopf D, Bernstein HD, Johnson AE, Walter P. The methionine-rich domain of the 54 kd protein subunit of the signal recognition particle contains an RNA binding site and can be crosslinked to a signal sequence. EMBO J. 1990 Dec; 9(13):4511-7. PMID: 1702385; PMCID: PMC552245.
      174. Poritz MA, Bernstein HD, Strub K, Zopf D, Wilhelm H, Walter P. An E. coli ribonucleoprotein containing 4.5S RNA resembles mammalian signal recognition particle. Science. 1990 Nov 23; 250(4984):1111-7. PMID: 1701272.
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      175. Zimmerman DL, Walter P. Reconstitution of protein translocation activity from partially solubilized microsomal vesicles. J Biol Chem. 1990 Mar 5; 265(7):4048-53. PMID: 2105958.
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      176. Strub K, Walter P. Assembly of the Alu domain of the signal recognition particle (SRP): dimerization of the two protein components is required for efficient binding to SRP RNA. Mol Cell Biol. 1990 Feb; 10(2):777-84. PMID: 2153922; PMCID: PMC360878.
      177. Wolin SL, Walter P. Signal recognition particle mediates a transient elongation arrest of preprolactin in reticulocyte lysate. J Cell Biol. 1989 Dec; 109(6 Pt 1):2617-22. PMID: 2556403; PMCID: PMC2115964.
      178. Strub K, Walter P. Isolation of a cDNA clone of the 14-kDa subunit of the signal recognition particle by cross-hybridization of differently primed polymerase chain reactions. Proc Natl Acad Sci U S A. 1989 Dec; 86(24):9747-51. PMID: 2557625; PMCID: PMC298578.
      179. Hann BC, Poritz MA, Walter P. Saccharomyces cerevisiae and Schizosaccharomyces pombe contain a homologue to the 54-kD subunit of the signal recognition particle that in S. cerevisiae is essential for growth. J Cell Biol. 1989 Dec; 109(6 Pt 2):3223-30. PMID: 2557350; PMCID: PMC2115968.
      180. Bernstein HD, Rapoport TA, Walter P. Cytosolic protein translocation factors. Is SRP still unique? Cell. 1989 Sep 22; 58(6):1017-9. PMID: 2550141.
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      181. Bernstein HD, Poritz MA, Strub K, Hoben PJ, Brenner S, Walter P. Model for signal sequence recognition from amino-acid sequence of 54K subunit of signal recognition particle. Nature. 1989 Aug 10; 340(6233):482-6. PMID: 2502718.
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      182. Andrews DW, Lauffer L, Walter P, Lingappa VR. Evidence for a two-step mechanism involved in assembly of functional signal recognition particle receptor. J Cell Biol. 1989 Mar; 108(3):797-810. PMID: 2537835; PMCID: PMC2115407.
      183. Green GN, Hansen W, Walter P. The use of gene-fusions to determine membrane protein topology in Saccharomyces cerevisiae. J Cell Sci Suppl. 1989; 11:109-13. PMID: 2693456.
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      184. Wolin SL, Walter P. Ribosome pausing and stacking during translation of a eukaryotic mRNA. EMBO J. 1988 Nov; 7(11):3559-69. PMID: 2850168; PMCID: PMC454858.
      185. Poritz MA, Strub K, Walter P. Human SRP RNA and E. coli 4.5S RNA contain a highly homologous structural domain. Cell. 1988 Oct 7; 55(1):4-6. PMID: 2458843.
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      186. Siegel V, Walter P. The affinity of signal recognition particle for presecretory proteins is dependent on nascent chain length. EMBO J. 1988 Jun; 7(6):1769-75. PMID: 3169004; PMCID: PMC457167.
      187. Poritz MA, Siegel V, Hansen W, Walter P. Small ribonucleoproteins in Schizosaccharomyces pombe and Yarrowia lipolytica homologous to signal recognition particle. Proc Natl Acad Sci U S A. 1988 Jun; 85(12):4315-9. PMID: 2837764; PMCID: PMC280419.
      188. Kassenbrock CK, Garcia PD, Walter P, Kelly RB. Heavy-chain binding protein recognizes aberrant polypeptides translocated in vitro. Nature. 1988 May 5; 333(6168):90-3. PMID: 3129663.
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      189. Garcia PD, Walter P. Full-length prepro-alpha-factor can be translocated across the mammalian microsomal membrane only if translation has not terminated. J Cell Biol. 1988 Apr; 106(4):1043-8. PMID: 2834400; PMCID: PMC2115022.
      190. Hansen W, Walter P. Prepro-carboxypeptidase Y and a truncated form of pre-invertase, but not full-length pre-invertase, can be posttranslationally translocated across microsomal vesicle membranes from Saccharomyces cerevisiae. J Cell Biol. 1988 Apr; 106(4):1075-81. PMID: 3283144; PMCID: PMC2115026.
      191. Garcia PD, Ou JH, Rutter WJ, Walter P. Targeting of the hepatitis B virus precore protein to the endoplasmic reticulum membrane: after signal peptide cleavage translocation can be aborted and the product released into the cytoplasm. J Cell Biol. 1988 Apr; 106(4):1093-104. PMID: 3283145; PMCID: PMC2114996.
      192. Siegel V, Walter P. Binding sites of the 19-kDa and 68/72-kDa signal recognition particle (SRP) proteins on SRP RNA as determined in protein-RNA "footprinting". Proc Natl Acad Sci U S A. 1988 Mar; 85(6):1801-5. PMID: 2450348; PMCID: PMC279867.
      193. Siegel V, Walter P. Each of the activities of signal recognition particle (SRP) is contained within a distinct domain: analysis of biochemical mutants of SRP. Cell. 1988 Jan 15; 52(1):39-49. PMID: 2830980.
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