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Phuoc Le graduated from Dartmouth in 2000 with a double major in Biochemistry and Molecular Biology and Asian and Middle Eastern Languages and Literatures. He then matriculated at Stanford Medical School where he earned his MD. During his time at Stanford, Phuoc also obtained a Master's of Public Health from UC Berkeley with a focus on global health. He completed a combined residency in Internal Medicine, Pediatrics, and Global Health Equity at Harvard's Brigham and Women's Hospital and Massachusetts General Hospital. During residency he has worked with the NGO Partners in Health (PIH) to provide equitable health care in Rwanda, Lesotho, Malawi, and most recently, post-earthquake Haiti. He has participated in both quantitative and qualitative public/community health, and anthropological research in Tibet, Shanghai, and Qinghai, PRC, and Geneva, Switzerland.

Currently, Phuoc is an Assistant Clinical Professor of Medicine and Pediatrics at UCSF, where he is a hospitalist splitting his time between both departments. He co-directs the Global Health-Hospital Medicine Fellowship at UCSF, directs the Global Health Pathway for the Pediatric Residency, and is director of international rotations for the Internal Medicine Residency. He is also a visiting Assistant Professor at the University of California, Berkeley School of Public Health, where he directs the Interdisciplinary Masters of Public Health Program. He continues to work with PIH for several months a year.