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    Piotr Hadaczek, PhD

    TitleRES-FY
    SchoolUCSF School of Medicine
    DepartmentNeurological Surgery
    Address1855 Folsom Street
    San Francisco CA 94103
    Phone415-476-1125
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      Collapse Biography 
      Collapse Education and Training
      University of California San FranciscoPostdoctoral FellowDept. of Neurosurgery2001
      Thomas Jefferson UniversityPostdoctoral FellowKimmel Cancer Center1996
      Pomeranian Medical University, Szczecin, PolandPh.D. (cum laude)Dept. of Genetics and Pathology1995
      University of Szczecin, PolandM.Sc.Dept. of Biology1992

      Collapse ORNG Applications 
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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Dreisig K, Degn M, Sund L, Hadaczek P, Samaranch L, San Sebastian W, Bankiewicz K, Rahbek Kornum B. Validation of antibodies for neuroanatomical localization of the P2Y11 receptor in macaque brain. J Chem Neuroanat. 2016 Aug 8; 78:25-33. PMID: 27515691.
        View in: PubMed
      2. Hadaczek P, Stanek L, Ciesielska A, Sudhakar V, Samaranch L, Pivirotto P, Bringas J, O'Riordan C, Mastis B, San Sebastian W, Forsayeth J, Cheng SH, Bankiewicz KS, Shihabuddin LS. Widespread AAV1- and AAV2-mediated transgene expression in the nonhuman primate brain: implications for Huntington's disease. Mol Ther Methods Clin Dev. 2016; 3:16037. PMID: 27408903.
        View in: PubMed
      3. Samaranch L, Hadaczek P, Kells AP, Bringas JR, Stockinger D, San Sebastian W, Macayan M, Samineni S, Pivirotto P, Forsayeth J, Bankiewicz KS. Slow AAV2 clearance from the brain of nonhuman primates and anti-capsid immune response. Gene Ther. 2016 Apr; 23(4):393-8. PMID: 26510688.
        View in: PubMed
      4. Soroceanu L, Matlaf L, Khan S, Akhavan A, Singer E, Bezrookove V, Decker S, Ghanny S, Hadaczek P, Bengtsson H, Ohlfest J, Luciani-Torres MG, Harkins L, Perry A, Guo H, Soteropoulos P, Cobbs CS. Cytomegalovirus Immediate-Early Proteins Promote Stemness Properties in Glioblastoma. Cancer Res. 2015 Aug 1; 75(15):3065-76. PMID: 26239477; PMCID: PMC4526117 [Available on 08/01/16].
      5. Hadaczek P, Wu G, Sharma N, Ciesielska A, Bankiewicz K, Davidow AL, Lu ZH, Forsayeth J, Ledeen RW. GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model. Exp Neurol. 2015 Jan; 263:177-89. PMID: 25448159.
        View in: PubMed
      6. San Sebastian W, Kells AP, Bringas J, Samaranch L, Hadaczek P, Ciesielska A, Macayan M, Pivirotto PJ, Forsayeth J, Osborne S, Wright JF, Green F, Heller G, Bankiewicz KS. SAFETY AND TOLERABILITY OF MRI-GUIDED INFUSION OF AAV2-hAADC INTO THE MID-BRAIN OF NON-HUMAN PRIMATE. Mol Ther Methods Clin Dev. 2014 Oct 15; 3. PMID: 25541617.
        View in: PubMed
      7. Joniec-Maciejak I, Ciesielska A, Wawer A, Sznejder-Pacholek A, Schwenkgrub J, Cudna A, Hadaczek P, Bankiewicz KS, Czlonkowska A, Czlonkowski A. The influence of AAV2-mediated gene transfer of human IL-10 on neurodegeneration and immune response in a murine model of Parkinson's disease. Pharmacol Rep. 2014 Aug; 66(4):660-9. PMID: 24948069.
        View in: PubMed
      8. Salegio EA, Streeter H, Dube N, Hadaczek P, Samaranch L, Kells AP, San Sebastian W, Zhai Y, Bringas J, Xu T, Forsayeth J, Bankiewicz KS. Distribution of nanoparticles throughout the cerebral cortex of rodents and non-human primates: Implications for gene and drug therapy. Front Neuroanat. 2014; 8:9. PMID: 24672434; PMCID: PMC3956368.
      9. Noble CO, Krauze MT, Drummond DC, Forsayeth J, Hayes ME, Beyer J, Hadaczek P, Berger MS, Kirpotin DB, Bankiewicz KS, Park JW. Pharmacokinetics, tumor accumulation and antitumor activity of nanoliposomal irinotecan following systemic treatment of intracranial tumors. Nanomedicine (Lond). 2014 Jul; 9(14):2099-108. PMID: 24494810.
        View in: PubMed
      10. Hadaczek P, Ozawa T, Soroceanu L, Yoshida Y, Matlaf L, Singer E, Fiallos E, James CD, Cobbs CS. Cidofovir: a novel antitumor agent for glioblastoma. Clin Cancer Res. 2013 Dec 1; 19(23):6473-83. PMID: 24170543; PMCID: PMC3919795.
      11. Ciesielska A, Hadaczek P, Mittermeyer G, Zhou S, Wright JF, Bankiewicz KS, Forsayeth J. Cerebral infusion of AAV9 vector-encoding non-self proteins can elicit cell-mediated immune responses. Mol Ther. 2013 Jan; 21(1):158-66. PMID: 22929660; PMCID: PMC3538301.
      12. Mendiburu-Eliçabe M, Yin D, Hadaczek P, Zhai Y, Forsayeth J, Bankiewicz KS. Systemic rapamycin alone may not be a treatment option for malignant glioma: evidence from an in vivo study. J Neurooncol. 2012 May; 108(1):53-8. PMID: 22350373.
        View in: PubMed
      13. Hadaczek P, Beyer J, Kells A, Narrow W, Bowers W, Federoff HJ, Forsayeth J, Bankiewicz KS. Evaluation of an AAV2-based rapamycin-regulated glial cell line-derived neurotrophic factor (GDNF) expression vector system. PLoS One. 2011; 6(11):e27728. PMID: 22132130; PMCID: PMC3221672.
      14. Ziegler RJ, Salegio EA, Dodge JC, Bringas J, Treleaven CM, Bercury SD, Tamsett TJ, Shihabuddin L, Hadaczek P, Fiandaca M, Bankiewicz K, Scheule RK. Distribution of acid sphingomyelinase in rodent and non-human primate brain after intracerebroventricular infusion. Exp Neurol. 2011 Oct; 231(2):261-71. PMID: 21777586.
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      15. Ciesielska A, Mittermeyer G, Hadaczek P, Kells AP, Forsayeth J, Bankiewicz KS. Anterograde axonal transport of AAV2-GDNF in rat basal ganglia. Mol Ther. 2011 May; 19(5):922-7. PMID: 21102559; PMCID: PMC3098627.
      16. Salegio EA, Kells AP, Richardson RM, Hadaczek P, Forsayeth J, Bringas J, Sardi SP, Passini MA, Shihabuddin LS, Cheng SH, Fiandaca MS, Bankiewicz KS. Magnetic resonance imaging-guided delivery of adeno-associated virus type 2 to the primate brain for the treatment of lysosomal storage disorders. Hum Gene Ther. 2010 Sep; 21(9):1093-103. PMID: 20408734; PMCID: PMC2936496.
      17. Kells AP, Eberling J, Su X, Pivirotto P, Bringas J, Hadaczek P, Narrow WC, Bowers WJ, Federoff HJ, Forsayeth J, Bankiewicz KS. Regeneration of the MPTP-lesioned dopaminergic system after convection-enhanced delivery of AAV2-GDNF. J Neurosci. 2010 Jul 14; 30(28):9567-77. PMID: 20631185; PMCID: PMC2914692.
      18. Su X, Kells AP, Salegio EA, Salegio EA, Richardson RM, Hadaczek P, Beyer J, Bringas J, Pivirotto P, Forsayeth J, Bankiewicz KS. Real-time MR imaging with Gadoteridol predicts distribution of transgenes after convection-enhanced delivery of AAV2 vectors. Mol Ther. 2010 Aug; 18(8):1490-5. PMID: 20551915; PMCID: PMC2927064.
      19. Hadaczek P, Eberling JL, Pivirotto P, Bringas J, Forsayeth J, Bankiewicz KS. Eight years of clinical improvement in MPTP-lesioned primates after gene therapy with AAV2-hAADC. Mol Ther. 2010 Aug; 18(8):1458-61. PMID: 20531394; PMCID: PMC2927057.
      20. Hadaczek P, Johnston L, Forsayeth J, Bankiewicz KS. Pharmacokinetics and bioactivity of glial cell line-derived factor (GDNF) and neurturin (NTN) infused into the rat brain. Neuropharmacology. 2010 Jun; 58(7):1114-21. PMID: 20153340; PMCID: PMC2849906.
      21. Gimenez F, Krauze MT, Valles F, Hadaczek P, Bringas J, Sharma N, Forsayeth J, Bankiewicz KS. Image-guided convection-enhanced delivery of GDNF protein into monkey putamen. Neuroimage. 2011 Jan; 54 Suppl 1:S189-95. PMID: 20080195.
        View in: PubMed
      22. Su X, Kells AP, Huang EJ, Lee HS, Hadaczek P, Beyer J, Bringas J, Pivirotto P, Penticuff J, Eberling J, Federoff HJ, Forsayeth J, Bankiewicz KS. Safety evaluation of AAV2-GDNF gene transfer into the dopaminergic nigrostriatal pathway in aged and parkinsonian rhesus monkeys. Hum Gene Ther. 2009 Dec; 20(12):1627-40. PMID: 19671001; PMCID: PMC2861959.
      23. Grahn AY, Bankiewicz KS, Dugich-Djordjevic M, Bringas JR, Hadaczek P, Johnson GA, Eastman S, Luz M. Non-PEGylated liposomes for convection-enhanced delivery of topotecan and gadodiamide in malignant glioma: initial experience. J Neurooncol. 2009 Nov; 95(2):185-97. PMID: 19466380; PMCID: PMC2759007.
      24. Johnston LC, Eberling J, Pivirotto P, Hadaczek P, Federoff HJ, Forsayeth J, Bankiewicz KS. Clinically relevant effects of convection-enhanced delivery of AAV2-GDNF on the dopaminergic nigrostriatal pathway in aged rhesus monkeys. Hum Gene Ther. 2009 May; 20(5):497-510. PMID: 19203243; PMCID: PMC2767387.
      25. Hadaczek P, Forsayeth J, Mirek H, Munson K, Bringas J, Pivirotto P, McBride JL, Davidson BL, Bankiewicz KS. Transduction of nonhuman primate brain with adeno-associated virus serotype 1: vector trafficking and immune response. Hum Gene Ther. 2009 Mar; 20(3):225-37. PMID: 19292604; PMCID: PMC2730589.
      26. Kells AP, Hadaczek P, Yin D, Bringas J, Varenika V, Forsayeth J, Bankiewicz KS. Efficient gene therapy-based method for the delivery of therapeutics to primate cortex. Proc Natl Acad Sci U S A. 2009 Feb 17; 106(7):2407-11. PMID: 19193857; PMCID: PMC2650169.
      27. Varenika V, Kells AP, Valles F, Hadaczek P, Forsayeth J, Bankiewicz KS. Controlled dissemination of AAV vectors in the primate brain. Prog Brain Res. 2009; 175:163-72. PMID: 19660655.
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      28. Fiandaca MS, Varenika V, Eberling J, McKnight T, Bringas J, Pivirotto P, Beyer J, Hadaczek P, Bowers W, Park J, Federoff H, Forsayeth J, Bankiewicz KS. Real-time MR imaging of adeno-associated viral vector delivery to the primate brain. Neuroimage. 2009 Aug; 47 Suppl 2:T27-35. PMID: 19095069; PMCID: PMC2730220.
      29. Johnston LC, Su X, Maguire-Zeiss K, Horovitz K, Ankoudinova I, Guschin D, Hadaczek P, Federoff HJ, Bankiewicz K, Forsayeth J. Human interleukin-10 gene transfer is protective in a rat model of Parkinson's disease. Mol Ther. 2008 Aug; 16(8):1392-9. PMID: 18545225; PMCID: PMC2725180.
      30. Hadaczek P, Yamashita Y, Mirek H, Tamas L, Bohn MC, Noble C, Park JW, Bankiewicz K. The "perivascular pump" driven by arterial pulsation is a powerful mechanism for the distribution of therapeutic molecules within the brain. Mol Ther. 2006 Jul; 14(1):69-78. PMID: 16650807; PMCID: PMC2730223.
      31. Hadaczek P, Kohutnicka M, Krauze MT, Bringas J, Pivirotto P, Cunningham J, Bankiewicz K. Convection-enhanced delivery of adeno-associated virus type 2 (AAV2) into the striatum and transport of AAV2 within monkey brain. Hum Gene Ther. 2006 Mar; 17(3):291-302. PMID: 16544978.
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      32. Kardas I, Mrózek K, Babinska M, Krajka K, Hadaczek P, Lubinski J, Roszkiewicz A, Kuziemska E, Limon J. Cytogenetic and molecular findings in 75 clear cell renal cell carcinomas. Oncol Rep. 2005 May; 13(5):949-56. PMID: 15809763.
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      33. Hadaczek P, Mirek H, Berger MS, Bankiewicz K. Limited efficacy of gene transfer in herpes simplex virus-thymidine kinase/ganciclovir gene therapy for brain tumors. J Neurosurg. 2005 Feb; 102(2):328-35. PMID: 15739562.
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      34. Hadaczek P, Mirek H, Bringas J, Cunningham J, Bankiewicz K. Basic fibroblast growth factor enhances transduction, distribution, and axonal transport of adeno-associated virus type 2 vector in rat brain. Hum Gene Ther. 2004 May; 15(5):469-79. PMID: 15144577.
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      35. Mamot C, Nguyen JB, Pourdehnad M, Hadaczek P, Saito R, Bringas JR, Drummond DC, Hong K, Kirpotin DB, McKnight T, Berger MS, Park JW, Bankiewicz KS. Extensive distribution of liposomes in rodent brains and brain tumors following convection-enhanced delivery. J Neurooncol. 2004 May; 68(1):1-9. PMID: 15174514.
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      36. Jakubowska A, Górski B, Byrski T, Huzarski T, Gronwald J, Menkiszak J, Cybulski C, Debniak T, Hadaczek P, Scott RJ, Lubinski J. Detection of germline mutations in the BRCA1 gene by RNA-based sequencing. Hum Mutat. 2001 Aug; 18(2):149-56. PMID: 11462239.
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      37. Jakubowska A, Górski B, Kurzawski G, Debniak T, Hadaczek P, Cybulski C, Kladny J, Oszurek O, Scott RJ, Lubinski J. Optimization of experimental conditions for RNA-based sequencing of MLH1 and MSH2 genes. Hum Mutat. 2001; 17(1):52-60. PMID: 11139242.
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      38. Hadaczek P, Gronwald J, Chosia M, Huebner K, Lubinski J. Fhit protein expression in endometrial cancers: no correlation with histological grade. Pol J Pathol. 2001; 52(4):199-203. PMID: 11915181.
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      39. Hadaczek P, Debniak T, Kurzawski G, Jakubowska A, Huzarski T, Huebner K, Lubinski J. Fhit protein expression in hereditary and sporadic colorectal cancers. Pol J Pathol. 2001; 52(3):125-32. PMID: 11769399.
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      40. Götte K, Hadaczek P, Coy JF, Wirtz HW, Riedel F, Neubauer J, Hörmann K. Fhit expression is absent or reduced in a subset of primary head and neck cancer. Anticancer Res. 2000 Mar-Apr; 20(2A):1057-60. PMID: 10810397.
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      41. Hadaczek P, Kovatich A, Gronwald J, Lubinski J, Huebner K, McCue PA. Loss or reduction of Fhit expression in renal neoplasias: correlation with histogenic class. Hum Pathol. 1999 Nov; 30(11):1276-83. PMID: 10571505.
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      42. Gronwald J, Hadaczek P, Störkel S, Holtgreve-Grez H, Rabbitts P, Cremer T, Lubinski J. Molecular evidence for derivation of metastatic cells from minor subclones of primary clear renal cell carcinomas. Cancer Detect Prev. 1999; 23(6):479-84. PMID: 10571658.
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      43. Kovatich A, Friedland DM, Druck T, Hadaczek P, Huebner K, Comis RL, Hauck W, McCue PA. Molecular alterations to human chromosome 3p loci in neuroendocrine lung tumors. Cancer. 1998 Sep 15; 83(6):1109-17. PMID: 9740075.
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      44. Hadaczek P, Siprashvili Z, Markiewski M, Domagala W, Druck T, McCue PA, Pekarsky Y, Ohta M, Huebner K, Lubinski J. Absence or reduction of Fhit expression in most clear cell renal carcinomas. Cancer Res. 1998 Jul 15; 58(14):2946-51. PMID: 9679951.
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      45. Huebner K, Hadaczek P, Siprashvili Z, Druck T, Croce CM. The FHIT gene, a multiple tumor suppressor gene encompassing the carcinogen sensitive chromosome fragile site, FRA3B. Biochim Biophys Acta. 1997 Jun 7; 1332(3):M65-70. PMID: 9196019.
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      46. Gronwald J, Störkel S, Holtgreve-Grez H, Hadaczek P, Brinkschmidt C, Jauch A, Lubinski J, Cremer T. Comparison of DNA gains and losses in primary renal clear cell carcinomas and metastatic sites: importance of 1q and 3p copy number changes in metastatic events. Cancer Res. 1997 Feb 1; 57(3):481-7. PMID: 9012478.
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      47. Druck T, Hadaczek P, Fu TB, Ohta M, Siprashvili Z, Baffa R, Negrini M, Kastury K, Veronese ML, Rosen D, Rothstein J, McCue P, Cotticelli MG, Inoue H, Croce CM, Huebner K. Structure and expression of the human FHIT gene in normal and tumor cells. Cancer Res. 1997 Feb 1; 57(3):504-12. PMID: 9012482.
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      48. Hadaczek P, Podolski J, Toloczko A, Kurzawski G, Sikorski A, Rabbitts P, Huebner K, Lubinski J. Losses at 3p common deletion sites in subtypes of kidney tumours: histopathological correlations. Virchows Arch. 1996 Sep; 429(1):37-42. PMID: 8865851.
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      49. Druck T, Kastury K, Hadaczek P, Podolski J, Toloczko A, Sikorski A, Ohta M, LaForgia S, Lasota J, McCue P. Loss of heterozygosity at the familial RCC t(3;8) locus in most clear cell renal carcinomas. Cancer Res. 1995 Nov 15; 55(22):5348-53. PMID: 7585599.
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      50. Podolski J, Hadaczek P, Gibas Z, Gibas L, Grossman HB, Limon J, Huebner K, Lubinski J. Non-isotopic procedure with silver staining of polyacrylamide gels in detection of genomic abnormalities in tumors using microsatellites. Folia Histochem Cytobiol. 1995; 33(2):117-23. PMID: 8617377.
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      51. Lubinski J, Podolski J, Hadaczek P, Mioduszewska O, Rylski M, Huebner K. Environmental factors may regulate BCL2 associated lymphomagenesis: a very low incidence of BCL2-MBR translocation in Poland. Pol J Pathol. 1995; 46(4):219-24. PMID: 8713288.
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      52. Lubinski J, Hadaczek P, Podolski J, Toloczko A, Sikorski A, McCue P, Druck T, Huebner K. Common regions of deletion in chromosome regions 3p12 and 3p14.2 in primary clear cell renal carcinomas. Cancer Res. 1994 Jul 15; 54(14):3710-3. PMID: 8033088.
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      53. Podolski J, Hadaczek P, Cpbulski C, Rylski M, Sumera K, Sowinska E, Uznanski B, Rzepka-Górska I, Lubinski J. [Detection of tumor virus infections with HPV 16, 18, and 33 from cytologic material in the uterine neck using the PCR method]. Ginekol Pol. 1993 Jul; 64(7):326-31. PMID: 8397151.
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      54. Rzepka-Górska I, Blogowska A, Zielinska D, Lubinski J, Podolski J, Hadaczek P, Górski B, Debniak T. [HPV virus infections and other promotion factors of the carcinogenic process in girls]. Ginekol Pol. 1993 Jul; 64(7):322-5. PMID: 8397150.
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