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    Prasanna Jagannathan, MD

    TitleAssistant Professor
    SchoolUCSF School of Medicine
    Address1001 Potrero Ave
    San Francisco CA 94110
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      Collapse Biography 
      Collapse Education and Training
      University of California, San FranciscoResidency School of Medicine - Primary Care
      Collapse Awards and Honors
      Makerere University-UCSF-LSHTM-IDRC Young Investigator Conference2015Distinguished Scholar Award
      University of California, San Francisco2014Hellman Fellow
      Burroughs Wellcome Fund/American Society of Tropical Medicine and Hygiene2011 - 2015Burroughs Wellcome Fund/ASTMH Fellowship in Tropical Infectious Diseases
      University of California, San Francisco2009T.E.A.C.H. Graduation Teaching Award
      San Francisco General Hospital, UCSF2006Julius Krevans Award for Clinical Excellence
      HHMI/National Institutes of Health2004 - 2005HHMI/NIH Research Scholar

      Collapse Overview 
      Collapse Overview
      Prasanna Jagannathan, M.D. is an assistant professor of medicine and infectious diseases in the HIV/AIDS Division at San Francisco General Hospital, UCSF. The goals of his research are to further our understanding of the correlates and mechanisms of protective immunity to malaria through field-based studies, and perform research dedicated to the design of immunogenic interventions and vaccines. He is currently investigating the impact of highly effective antimalarial chemoprevention on the development of malaria-specific T cell responses in children in the laboratory of Dr. Margaret Feeney.

      Dr. Jagannathan earned his undergraduate degree in Religious Studies from the University of California at Berkeley, followed by his M.D. from Harvard Medical School. He completed residency, chief residency, and infectious disease fellowship at UCSF. Dr. Jagannathan serves as an outpatient HIV physician in the Positive Health Practice Clinic at San Francisco General Hospital, and an attending physician on the Joint HIV/Infectious Disease inpatient consultation service.

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      Collapse Global Health

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Prahl M, Jagannathan P, McIntyre TI, Auma A, Farrington L, Wamala S, Nalubega M, Musinguzi K, Naluwu K, Sikyoma E, Budker R, Vance H, Odorizzi P, Nayebare P, Ategeka J, Kakuru A, Havlir DV, Kamya MR, Dorsey G, Feeney ME. Timing of in utero malaria exposure influences fetal CD4 T cell regulatory versus effector differentiation. Malar J. 2016 Oct 7; 15(1):497. PMID: 27717402.
        View in: PubMed
      2. Rek J, Katrak S, Obasi H, Nayebare P, Katureebe A, Kakande E, Arinaitwe E, Nankabirwa JI, Jagannathan P, Drakeley C, Staedke SG, Smith DL, Bousema T, Kamya M, Rosenthal PJ, Dorsey G, Greenhouse B. Characterizing microscopic and submicroscopic malaria parasitaemia at three sites with varied transmission intensity in Uganda. Malar J. 2016; 15:470. PMID: 27628178.
        View in: PubMed
      3. Muhindo MK, Kakuru A, Natureeba P, Awori P, Olwoch P, Ategeka J, Nayebare P, Clark TD, Muehlenbachs A, Roh M, Mpeka B, Greenhouse B, Havlir DV, Kamya MR, Dorsey G, Jagannathan P. Reductions in malaria in pregnancy and adverse birth outcomes following indoor residual spraying of insecticide in Uganda. Malar J. 2016; 15(1):437. PMID: 27566109; PMCID: PMC5002129.
      4. Rodriguez-Barraquer I, Arinaitwe E, Jagannathan P, Boyle MJ, Tappero J, Muhindo M, Kamya MR, Dorsey G, Drakeley C, Ssewanyana I, Smith DL, Greenhouse B, et al. Quantifying heterogeneous malaria exposure and clinical protection in a cohort of Ugandan children. J Infect Dis. 2016 Aug 1. PMID: 27481862.
        View in: PubMed
      5. Jagannathan P, Bowen K, Nankya F, McIntyre T, Auma A, Wamala S, Sikyomu E, Naluwu K, Nalubega M, Boyle MJ, Farrington L, Bigira V, Kapisi J, Aweeka F, Greenhouse B, Kamya M, Dorsey G, Feeney ME. Effective Antimalarial Chemoprevention in Childhood Enhances the Quality of CD4+ T Cells and Limits Their Production of Immunoregulatory Interleukin 10. J Infect Dis. 2016 Jul 15; 214(2):329-38. PMID: 27067196.
        View in: PubMed
      6. Kakuru A, Jagannathan P, Muhindo MK, Natureeba P, Awori P, Nakalembe M, Opira B, Olwoch P, Ategeka J, Nayebare P, Clark TD, Feeney ME, Charlebois ED, Rizzuto G, Muehlenbachs A, Havlir DV, Kamya MR, Dorsey G. Dihydroartemisinin-Piperaquine for the Prevention of Malaria in Pregnancy. N Engl J Med. 2016 Mar 10; 374(10):928-39. PMID: 26962728.
        View in: PubMed
      7. Sullivan RT, Ssewanyana I, Wamala S, Nankya F, Jagannathan P, Tappero JW, Mayanja-Kizza H, Muhindo MK, Arinaitwe E, Kamya M, Dorsey G, Feeney ME, Riley EM, Drakeley CJ, Greenhouse B, Sullivan R. B cell sub-types following acute malaria and associations with clinical immunity. Malar J. 2016; 15(1):139. PMID: 26939776.
        View in: PubMed
      8. Farrington LA, Jagannathan P, McIntyre TI, Vance HM, Bowen K, Boyle MJ, Nankya F, Wamala S, Auma A, Nalubega M, Sikyomu E, Naluwu K, Bigira V, Kapisi J, Dorsey G, Kamya MR, Feeney ME. Frequent Malaria Drives Progressive Vd2 T-Cell Loss, Dysfunction, and CD16 Up-regulation During Early Childhood. J Infect Dis. 2016 May 1; 213(9):1483-90. PMID: 26667315.
        View in: PubMed
      9. Sundell K, Jagannathan P, Huang L, Bigira V, Kapisi J, Kakuru MM, Savic R, Kamya MR, Dorsey G, Aweeka F. Variable piperaquine exposure significantly impacts protective efficacy of monthly dihydroartemisinin-piperaquine for the prevention of malaria in Ugandan children. Malar J. 2015; 14(1):368. PMID: 26403465; PMCID: PMC4582734.
      10. Boyle MJ, Jagannathan P, Farrington LA, Eccles-James I, Wamala S, McIntyre TI, Vance HM, Bowen K, Nankya F, Auma A, Nalubega M, Sikyomu E, Naluwu K, Rek J, Katureebe A, Bigira V, Kapisi J, Tappero J, Muhindo MK, Greenhouse B, Arinaitwe E, Dorsey G, Kamya MR, Feeney ME. Decline of FoxP3+ Regulatory CD4 T Cells in Peripheral Blood of Children Heavily Exposed to Malaria. PLoS Pathog. 2015 Jul; 11(7):e1005041. PMID: 26182204; PMCID: PMC4504515.
      11. Sullivan RT, Kim CC, Fontana MF, Feeney ME, Jagannathan P, Boyle MJ, Drakeley CJ, Ssewanyana I, Nankya F, Mayanja-Kizza H, Dorsey G, Greenhouse B. FCRL5 Delineates Functionally Impaired Memory B Cells Associated with Plasmodium falciparum Exposure. PLoS Pathog. 2015 May; 11(5):e1004894. PMID: 25993340; PMCID: PMC4438005.
      12. Boyle MJ, Jagannathan P, Bowen K, McIntyre TI, Vance HM, Farrington LA, Greenhouse B, Nankya F, Rek J, Katureebe A, Arinaitwe E, Dorsey G, Kamya MR, Feeney ME. Effector Phenotype of Plasmodium falciparum-Specific CD4+ T Cells Is Influenced by Both Age and Transmission Intensity in Naturally Exposed Populations. J Infect Dis. 2015 Aug 1; 212(3):416-25. PMID: 25646355; PMCID: PMC4539911 [Available on 08/01/16].
      13. Jagannathan P, Nankya F, Stoyanov C, Eccles-James I, Sikyomu E, Naluwu K, Wamala S, Nalubega M, Briggs J, Bowen K, Bigira V, Kapisi J, Kamya MR, Dorsey G, Feeney ME. IFN? Responses to Pre-erythrocytic and Blood-stage Malaria Antigens Exhibit Differential Associations With Past Exposure and Subsequent Protection. J Infect Dis. 2015 Jun 15; 211(12):1987-96. PMID: 25520427.
        View in: PubMed
      14. Kamya MR, Kapisi J, Bigira V, Clark TD, Kinara S, Mwangwa F, Muhindo MK, Kakuru A, Aweeka FT, Huang L, Jagannathan P, Achan J, Havlir DV, Rosenthal PJ, Dorsey G. Efficacy and safety of three regimens for the prevention of malaria in young HIV-exposed Ugandan children: a randomized controlled trial. AIDS. 2014 Nov 28; 28(18):2701-9. PMID: 25493596; PMCID: PMC4487368 [Available on 11/28/15].
      15. Jagannathan P, Kim CC, Greenhouse B, Nankya F, Bowen K, Eccles-James I, Muhindo MK, Arinaitwe E, Tappero JW, Kamya MR, Dorsey G, Feeney ME. Loss and dysfunction of Vd2? ?d T cells are associated with clinical tolerance to malaria. Sci Transl Med. 2014 Aug 27; 6(251):251ra117. PMID: 25163477; PMCID: PMC4198150.
      16. Muhindo MK, Kakuru A, Jagannathan P, Talisuna A, Osilo E, Orukan F, Arinaitwe E, Tappero JW, Kaharuza F, Kamya MR, Dorsey G. Early parasite clearance following artemisinin-based combination therapy among Ugandan children with uncomplicated Plasmodium falciparum malaria. Malar J. 2014; 13:32. PMID: 24468007; PMCID: PMC3909240.
      17. Jagannathan P, Eccles-James I, Bowen K, Nankya F, Auma A, Wamala S, Ebusu C, Muhindo MK, Arinaitwe E, Briggs J, Greenhouse B, Tappero JW, Kamya MR, Dorsey G, Feeney ME. IFN?/IL-10 co-producing cells dominate the CD4 response to malaria in highly exposed children. PLoS Pathog. 2014 Jan; 10(1):e1003864. PMID: 24415936; PMCID: PMC3887092.
      18. Kakuru A, Jagannathan P, Arinaitwe E, Wanzira H, Muhindo M, Bigira V, Osilo E, Homsy J, Kamya MR, Tappero JW, Dorsey G. The effects of ACT treatment and TS prophylaxis on Plasmodium falciparum gametocytemia in a cohort of young Ugandan children. Am J Trop Med Hyg. 2013 Apr; 88(4):736-43. PMID: 23382157; PMCID: PMC3617862.
      19. Jagannathan P, Muhindo MK, Kakuru A, Arinaitwe E, Greenhouse B, Tappero J, Rosenthal PJ, Kaharuza F, Kamya MR, Dorsey G. Increasing incidence of malaria in children despite insecticide-treated bed nets and prompt anti-malarial therapy in Tororo, Uganda. Malar J. 2012; 11:435. PMID: 23273022; PMCID: PMC3551700.
      20. Shubov A, Jagannathan P, Chin-Hong PV. Pantoea agglomerans pneumonia in a heart-lung transplant recipient: case report and a review of an emerging pathogen in immunocompromised hosts. Transpl Infect Dis. 2011 Oct; 13(5):536-9. PMID: 21504526.
        View in: PubMed
      21. Jagannathan P, Davis E, Jacobson M, Huang L. Life-threatening immune reconstitution inflammatory syndrome after Pneumocystis pneumonia: a cautionary case series. AIDS. 2009 Aug 24; 23(13):1794-6. PMID: 19684486.
        View in: PubMed
      22. Jagannathan P, Osborne CM, Royce C, Manion MM, Tilton JC, Li L, Fischer S, Hallahan CW, Metcalf JA, McLaughlin M, Pipeling M, McDyer JF, Manley TJ, Meier JL, Altman JD, Hertel L, Davey RT, Connors M, Migueles SA. Comparisons of CD8+ T cells specific for human immunodeficiency virus, hepatitis C virus, and cytomegalovirus reveal differences in frequency, immunodominance, phenotype, and interleukin-2 responsiveness. J Virol. 2009 Mar; 83(6):2728-42. PMID: 19129459; PMCID: PMC2648273.
      23. Staedke SG, Jagannathan P, Yeka A, Bukirwa H, Banek K, Maiteki-Sebuguzi C, Clark TD, Nzarubara B, Njama-Meya D, Mpimbaza A, Rosenthal PJ, Kamya MR, Wabwire-Mangen F, Dorsey G, Talisuna AO. Monitoring antimalarial safety and tolerability in clinical trials: a case study from Uganda. Malar J. 2008; 7:107. PMID: 18547416; PMCID: PMC2464601.
      24. Maiteki-Sebuguzi C, Jagannathan P, Yau VM, Clark TD, Njama-Meya D, Nzarubara B, Talisuna AO, Kamya MR, Rosenthal PJ, Dorsey G, Staedke SG. Safety and tolerability of combination antimalarial therapies for uncomplicated falciparum malaria in Ugandan children. Malar J. 2008; 7:106. PMID: 18547415; PMCID: PMC2441629.
      25. Jaganathan P, Landovitz RJ, Roland, M. . Future HIV Therapy. Post-Exposure Prophylaxis after Sexual Exposure to Human Immunodeficiency Virus. 2007; 1(1):35-47.
      26. Smith Fawzi MC, Jagannathan P, Cabral J, Banares R, Salazar J, Farmer P, Behforouz H. Limitations in knowledge of HIV transmission among HIV-positive patients accessing case management services in a resource-poor setting. AIDS Care. 2006 Oct; 18(7):764-71. PMID: 16971286.
        View in: PubMed
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