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    Prescott Woodruff, MD, MPH

    TitleAssociate Professor in Residence
    SchoolUCSF School of Medicine
    DepartmentMedicine
    Address513 Parnassus Ave
    San Francisco CA 94143
    Phone415-514-2061

       Biography 
       Awards and Honors
      2012Elected to the American Society for Clinical Investigation
      1993AOA

       Overview 
       Overview
      Research Interests

      I. The identification of molecular sub-phenotypes of asthma and COPD:

      These studies are funded by:
      1) An R01 from the NIH/NHLBI, entitled “Molecular Phenotyping of Asthma” (R01 HL-095372) which has applied genomic analyses to airway samples from patients with asthma to distinguish Th2-driven and non-Th2-driven sub-phenotypes of asthma that have distinct clinical, pathological and treatment-related characteristics.

      2) A seven-year NIH contract to apply similar methods to study COPD as part of the NHLBI Spiromics Project (N01 HR-08-08). The goal of the Spiromics project is to identify molecular phenotypes of COPD and to develop intermediate outcome measures for clinical trials.

      II. Mechanisms of airway inflammation and remodeling in lung diseases:
      These studies apply innovative methods for quantitative morphometry and gene expression analyses to human tissue samples obtained at fiberoptic bronchoscopy. In work to date, we have applied these methods to study mechanisms of disease in asthma, COPD and sarcoidosis. Ongoing work in this area is supported by the NIH (R01 HL-095372). Our approaches combine the application of gene expression profiling methods (microarrays, qPCR, laser capture microdissection) and design–based stereology (for quantitative measurement of tissue remodeling in human samples).

      III. Development of blood-based diagnostic tests for lung disease using genomic approaches:
      These studies apply gene expression profiling and miRNA profiling in blood cells and plasma/serum to develop diagnostic tests in asthma, COPD and sarcoidosis.

      IV. Sample analysis and support for Clinical Trials:
      Finally, the Woodruff Laboratory supports sample analyses for clinical trials in asthma and COPD in both NIH and industry-supported studies. These sample analyses include measurement of changes in airway remodeling in response to specific therapeutic interventions, assessment of inflammation and the application of biomarkers to enhance the interpretation of clinical trials.


       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Levänen B, Bhakta NR, Torregrosa Paredes P, Barbeau R, Hiltbrunner S, Pollack JL, Sköld CM, Svartengren M, Grunewald J, Gabrielsson S, Eklund A, Larsson BM, Woodruff PG, Erle DJ, Wheelock AM. Altered microRNA profiles in bronchoalveolar lavage fluid exosomes in asthmatic patients. J Allergy Clin Immunol. 2013 Mar; 131(3):894-903.e8.
        View in: PubMed
      2. Kudo M, Khalifeh Soltani SM, Sakuma SA, McKleroy W, Lee TH, Woodruff PG, Lee JW, Huang K, Chen C, Arjomandi M, Huang X, Atabai K. Mfge8 suppresses airway hyperresponsiveness in asthma by regulating smooth muscle contraction. Proc Natl Acad Sci U S A. 2013 Jan 8; 110(2):660-5.
        View in: PubMed
      3. Albert RK, Connett J, Curtis JL, Martinez FJ, Han MK, Lazarus SC, Woodruff PG. Mannose-binding lectin deficiency and acute exacerbations of chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2012; 7:767-77.
        View in: PubMed
      4. Huang F, Zhang H, Wu M, Yang H, Kudo M, Peters CJ, Woodruff PG, Solberg OD, Donne ML, Huang X, Sheppard D, Fahy JV, Wolters PJ, Hogan BL, Finkbeiner WE, Li M, Jan YN, Jan LY, Rock JR. Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. Proc Natl Acad Sci U S A. 2012 Oct 2; 109(40):16354-9.
        View in: PubMed
      5. Solberg OD, Ostrin EJ, Love MI, Peng JC, Bhakta NR, Hou L, Nguyen C, Solon M, Nguyen C, Barczak AJ, Zlock LT, Blagev DP, Finkbeiner WE, Ansel KM, Arron JR, Erle DJ, Woodruff PG. Airway Epithelial miRNA Expression Is Altered in Asthma. Am J Respir Crit Care Med. 2012 Nov 15; 186(10):965-74.
        View in: PubMed
      6. Albert RK, Connett J, Woodruff PG. Azithromycin and the risk of cardiovascular death. N Engl J Med. 2012 Aug 23; 367(8):773-4; author reply 775.
        View in: PubMed
      7. Jia G, Erickson RW, Choy DF, Mosesova S, Wu LC, Solberg OD, Shikotra A, Carter R, Audusseau S, Hamid Q, Bradding P, Fahy JV, Woodruff PG, Harris JM, Arron JR. Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients. J Allergy Clin Immunol. 2012 Sep; 130(3):647-654.e10.
        View in: PubMed
      8. Diez D, Goto S, Fahy JV, Erle DJ, Woodruff PG, Wheelock ÅM, Wheelock CE. Network analysis identifies a putative role for the PPAR and type 1 interferon pathways in glucocorticoid actions in asthmatics. BMC Med Genomics. 2012; 5:27.
        View in: PubMed
      9. Dransfield MT, Harnden S, Burton RL, Albert RK, Bailey WC, Casaburi R, Connett J, Cooper JA, Criner GJ, Curtis JL, Han MK, Make B, Marchetti N, Martinez FJ, McEvoy C, Nahm MH, Niewoehner DE, Porszasz J, Reilly J, Scanlon PD, Scharf SM, Sciurba FC, Washko GR, Woodruff PG, Lazarus SC. Long-term comparative immunogenicity of protein conjugate and free polysaccharide pneumococcal vaccines in chronic obstructive pulmonary disease. Clin Infect Dis. 2012 Sep; 55(5):e35-44.
        View in: PubMed
      10. Thomas MF, Abdul-Wajid S, Panduro M, Babiarz JE, Rajaram M, Woodruff P, Lanier LL, Heissmeyer V, Ansel KM. Eri1 regulates microRNA homeostasis and mouse lymphocyte development and antiviral function. Blood. 2012 Jul 5; 120(1):130-42.
        View in: PubMed
      11. Hallstrand TS, Woodruff PG, Holgate ST, Knight DA. Function of the airway epithelium in asthma. J Allergy (Cairo). 2012; 2012:160586.
        View in: PubMed
      12. A combined pulmonary-radiology workshop for visual evaluation of COPD: study design, chest CT findings and concordance with quantitative evaluation. COPD. 2012 Apr; 9(2):151-9.
        View in: PubMed
      13. Casaburi R, Porszasz J, Hecht A, Tiep B, Albert RK, Anthonisen NR, Bailey WC, Connett JE, Cooper JA, Criner GJ, Curtis J, Dransfield M, Lazarus SC, Make B, Martinez FJ, McEvoy C, Niewoehner DE, Reilly JJ, Scanlon P, Scharf SM, Sciurba FC, Woodruff P. Influence of lightweight ambulatory oxygen on oxygen use and activity patterns of COPD patients receiving long-term oxygen therapy. COPD. 2012 Feb; 9(1):3-11.
        View in: PubMed
      14. Albert RK, Connett J, Bailey WC, Casaburi R, Cooper JA, Criner GJ, Curtis JL, Dransfield MT, Han MK, Lazarus SC, Make B, Marchetti N, Martinez FJ, Madinger NE, McEvoy C, Niewoehner DE, Porsasz J, Price CS, Reilly J, Scanlon PD, Sciurba FC, Scharf SM, Washko GR, Woodruff PG, Anthonisen NR. Azithromycin for prevention of exacerbations of COPD. N Engl J Med. 2011 Aug 25; 365(8):689-98.
        View in: PubMed
      15. Gordon ED, Sidhu SS, Wang ZE, Woodruff PG, Yuan S, Solon MC, Conway SJ, Huang X, Locksley RM, Fahy JV. A protective role for periostin and TGF-ß in IgE-mediated allergy and airway hyperresponsiveness. Clin Exp Allergy. 2012 Jan; 42(1):144-55.
        View in: PubMed
      16. Koth LL, Solberg OD, Peng JC, Bhakta NR, Nguyen CP, Woodruff PG. Sarcoidosis blood transcriptome reflects lung inflammation and overlaps with tuberculosis. Am J Respir Crit Care Med. 2011 Nov 15; 184(10):1153-63.
        View in: PubMed
      17. Woodruff PG. Novel outcomes and end points: biomarkers in chronic obstructive pulmonary disease clinical trials. Proc Am Thorac Soc. 2011 Aug; 8(4):350-5.
        View in: PubMed
      18. Bhakta NR, Woodruff PG. Human asthma phenotypes: from the clinic, to cytokines, and back again. Immunol Rev. 2011 Jul; 242(1):220-32.
        View in: PubMed
      19. Woodruff PG, Albert RK, Bailey WC, Casaburi R, Connett JE, Cooper JA, Criner GJ, Curtis JL, Dransfield MT, Han MK, Harnden SM, Kim V, Marchetti N, Martinez FJ, McEvoy CE, Niewoehner DE, Reilly JJ, Rice K, Scanlon PD, Scharf SM, Sciurba FC, Washko GR, Lazarus SC. Randomized trial of zileuton for treatment of COPD exacerbations requiring hospitalization. COPD. 2011 Feb; 8(1):21-9.
        View in: PubMed
      20. Choy DF, Modrek B, Abbas AR, Kummerfeld S, Clark HF, Wu LC, Fedorowicz G, Modrusan Z, Fahy JV, Woodruff PG, Arron JR. Gene expression patterns of Th2 inflammation and intercellular communication in asthmatic airways. J Immunol. 2011 Feb 1; 186(3):1861-9.
        View in: PubMed
      21. Innes AL, McGrath KW, Dougherty RH, McCulloch CE, Woodruff PG, Seibold MA, Okamoto KS, Ingmundson KJ, Solon MC, Carrington SD, Fahy JV. The H antigen at epithelial surfaces is associated with susceptibility to asthma exacerbation. Am J Respir Crit Care Med. 2011 Jan 15; 183(2):189-94.
        View in: PubMed
      22. Sidhu SS, Yuan S, Innes AL, Kerr S, Woodruff PG, Hou L, Muller SJ, Fahy JV. Roles of epithelial cell-derived periostin in TGF-beta activation, collagen production, and collagen gel elasticity in asthma. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14170-5.
        View in: PubMed
      23. Dougherty RH, Sidhu SS, Raman K, Solon M, Solberg OD, Caughey GH, Woodruff PG, Fahy JV. Accumulation of intraepithelial mast cells with a unique protease phenotype in T(H)2-high asthma. J Allergy Clin Immunol. 2010 May; 125(5):1046-1053.e8.
        View in: PubMed
      24. Koth LL, Cambier CJ, Ellwanger A, Solon M, Hou L, Lanier LL, Abram CL, Hamerman JA, Woodruff PG. DAP12 is required for macrophage recruitment to the lung in response to cigarette smoke and chemotaxis toward CCL2. J Immunol. 2010 Jun 1; 184(11):6522-8.
        View in: PubMed
      25. Woodruff PG, Wolff M, Hohlfeld JM, Krug N, Dransfield MT, Sutherland ER, Criner GJ, Kim V, Prasse A, Nivens MC, Tetzlaff K, Heilker R, Fahy JV. Safety and efficacy of an inhaled epidermal growth factor receptor inhibitor (BIBW 2948 BS) in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2010 Mar 1; 181(5):438-45.
        View in: PubMed
      26. Park SW, Verhaeghe C, Nguyenvu LT, Barbeau R, Eisley CJ, Nakagami Y, Huang X, Woodruff PG, Fahy JV, Erle DJ. Distinct roles of FOXA2 and FOXA3 in allergic airway disease and asthma. Am J Respir Crit Care Med. 2009 Oct 1; 180(7):603-10.
        View in: PubMed
      27. Dransfield MT, Nahm MH, Han MK, Harnden S, Criner GJ, Martinez FJ, Scanlon PD, Woodruff PG, Washko GR, Connett JE, Anthonisen NR, Bailey WC. Superior immune response to protein-conjugate versus free pneumococcal polysaccharide vaccine in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2009 Sep 15; 180(6):499-505.
        View in: PubMed
      28. Woodruff PG, Modrek B, Choy DF, Jia G, Abbas AR, Ellwanger A, Koth LL, Arron JR, Fahy JV. T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am J Respir Crit Care Med. 2009 Sep 1; 180(5):388-95.
        View in: PubMed
      29. Woodruff PG, Ellwanger A, Solon M, Cambier CJ, Pinkerton KE, Koth LL. Alveolar macrophage recruitment and activation by chronic second hand smoke exposure in mice. COPD. 2009 Apr; 6(2):86-94.
        View in: PubMed
      30. Goswami S, Angkasekwinai P, Shan M, Greenlee KJ, Barranco WT, Polikepahad S, Seryshev A, Song LZ, Redding D, Singh B, Sur S, Woodruff P, Dong C, Corry DB, Kheradmand F. Divergent functions for airway epithelial matrix metalloproteinase 7 and retinoic acid in experimental asthma. Nat Immunol. 2009 May; 10(5):496-503.
        View in: PubMed
      31. Seibold MA, Donnelly S, Solon M, Innes A, Woodruff PG, Boot RG, Burchard EG, Fahy JV. Chitotriosidase is the primary active chitinase in the human lung and is modulated by genotype and smoking habit. J Allergy Clin Immunol. 2008 Nov; 122(5):944-950.e3.
        View in: PubMed
      32. Schane RE, Walter LC, Dinno A, Covinsky KE, Woodruff PG. Prevalence and risk factors for depressive symptoms in persons with chronic obstructive pulmonary disease. J Gen Intern Med. 2008 Nov; 23(11):1757-62.
        View in: PubMed
      33. Woodruff PG. Gene expression in asthmatic airway smooth muscle. Proc Am Thorac Soc. 2008 Jan 1; 5(1):113-8.
        View in: PubMed
      34. Panettieri RA, Kotlikoff MI, Gerthoffer WT, Hershenson MB, Woodruff PG, Hall IP, Banks-Schlegel S. Airway smooth muscle in bronchial tone, inflammation, and remodeling: basic knowledge to clinical relevance. Am J Respir Crit Care Med. 2008 Feb 1; 177(3):248-52.
        View in: PubMed
      35. Woodruff PG, Boushey HA, Dolganov GM, Barker CS, Yang YH, Donnelly S, Ellwanger A, Sidhu SS, Dao-Pick TP, Pantoja C, Erle DJ, Yamamoto KR, Fahy JV. Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids. Proc Natl Acad Sci U S A. 2007 Oct 2; 104(40):15858-63.
        View in: PubMed
      36. Innes AL, Woodruff PG, Ferrando RE, Donnelly S, Dolganov GM, Lazarus SC, Fahy JV. Epithelial mucin stores are increased in the large airways of smokers with airflow obstruction. Chest. 2006 Oct; 130(4):1102-8.
        View in: PubMed
      37. Woodruff PG, Koth LL, Yang YH, Rodriguez MW, Favoreto S, Dolganov GM, Paquet AC, Erle DJ. A distinctive alveolar macrophage activation state induced by cigarette smoking. Am J Respir Crit Care Med. 2005 Dec 1; 172(11):1383-92.
        View in: PubMed
      38. Kuperman DA, Lewis CC, Woodruff PG, Rodriguez MW, Yang YH, Dolganov GM, Fahy JV, Erle DJ. Dissecting asthma using focused transgenic modeling and functional genomics. J Allergy Clin Immunol. 2005 Aug; 116(2):305-11.
        View in: PubMed
      39. Hays SR, Ferrando RE, Carter R, Wong HH, Woodruff PG. Structural changes to airway smooth muscle in cystic fibrosis. Thorax. 2005 Mar; 60(3):226-8.
        View in: PubMed
      40. Kotlikoff MI, Kannan MS, Solway J, Deng KY, Deshpande DA, Dowell M, Feldman M, Green KS, Ji G, Johnston R, Lakser O, Lee J, Lund FE, Milla C, Mitchell RW, Nakai J, Rishniw M, Walseth TF, White TA, Wilson J, Xin HB, Woodruff PG. Methodologic advancements in the study of airway smooth muscle. J Allergy Clin Immunol. 2004 Aug; 114(2 Suppl):S18-31.
        View in: PubMed
      41. Kalayci O, Sonna LA, Woodruff PG, Camargo CA, Luster AD, Lilly CM. Monocyte chemotactic protein-4 (MCP-4; CCL-13): a biomarker of asthma. J Asthma. 2004 Feb; 41(1):27-33.
        View in: PubMed
      42. Woodruff PG, Dolganov GM, Ferrando RE, Donnelly S, Hays SR, Solberg OD, Carter R, Wong HH, Cadbury PS, Fahy JV. Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression. Am J Respir Crit Care Med. 2004 May 1; 169(9):1001-6.
        View in: PubMed
      43. Ferrando RE, Nyengaard JR, Hays SR, Fahy JV, Woodruff PG. Applying stereology to measure thickness of the basement membrane zone in bronchial biopsy specimens. J Allergy Clin Immunol. 2003 Dec; 112(6):1243-5.
        View in: PubMed
      44. Silverman RA, Boudreaux ED, Woodruff PG, Clark S, Camargo CA. Cigarette smoking among asthmatic adults presenting to 64 emergency departments. Chest. 2003 May; 123(5):1472-9.
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      45. Ferris TG, Blumenthal D, Woodruff PG, Clark S, Camargo CA. Insurance and quality of care for adults with acute asthma. J Gen Intern Med. 2002 Dec; 17(12):905-13.
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      46. Weber EJ, Silverman RA, Callaham ML, Pollack CV, Woodruff PG, Clark S, Camargo CA. A prospective multicenter study of factors associated with hospital admission among adults with acute asthma. Am J Med. 2002 Oct 1; 113(5):371-8.
        View in: PubMed
      47. Pollack CV, Pollack ES, Baren JM, Smith SR, Woodruff PG, Clark S, Camargo CA. A prospective multicenter study of patient factors associated with hospital admission from the emergency department among children with acute asthma. Arch Pediatr Adolesc Med. 2002 Sep; 156(9):934-40.
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      48. Woodruff PG, Fahy JV. Airway remodeling in asthma. Semin Respir Crit Care Med. 2002 Aug; 23(4):361-7.
        View in: PubMed
      49. Woodruff PG, Fahy JV. A role for neutrophils in asthma? Am J Med. 2002 Apr 15; 112(6):498-500.
        View in: PubMed
      50. Hays SR, Woodruff PG, Khashayar R, Ferrando RE, Liu J, Fung P, Zhao CQ, Wong HH, Fahy JV. Allergen challenge causes inflammation but not goblet cell degranulation in asthmatic subjects. J Allergy Clin Immunol. 2001 Nov; 108(5):784-90.
        View in: PubMed
      51. Woodruff PG, Khashayar R, Lazarus SC, Janson S, Avila P, Boushey HA, Segal M, Fahy JV. Relationship between airway inflammation, hyperresponsiveness, and obstruction in asthma. J Allergy Clin Immunol. 2001 Nov; 108(5):753-8.
        View in: PubMed
      52. Dolganov GM, Woodruff PG, Novikov AA, Zhang Y, Ferrando RE, Szubin R, Fahy JV. A novel method of gene transcript profiling in airway biopsy homogenates reveals increased expression of a Na+-K+-Cl- cotransporter (NKCC1) in asthmatic subjects. Genome Res. 2001 Sep; 11(9):1473-83.
        View in: PubMed
      53. Cydulka RK, Emerman CL, Rowe BH, Clark S, Woodruff PG, Singh AK, Camargo CA. Differences between men and women in reporting of symptoms during an asthma exacerbation. Ann Emerg Med. 2001 Aug; 38(2):123-8.
        View in: PubMed
      54. Woodruff PG, Fahy JV. Asthma: prevalence, pathogenesis, and prospects for novel therapies. JAMA. 2001 Jul 25; 286(4):395-8.
        View in: PubMed
      55. Zimmerman JL, Woodruff PG, Clark S, Camargo CA. Relation between phase of menstrual cycle and emergency department visits for acute asthma. Am J Respir Crit Care Med. 2000 Aug; 162(2 Pt 1):512-5.
        View in: PubMed
      56. Barr RG, Woodruff PG, Clark S, Camargo CA. Sudden-onset asthma exacerbations: clinical features, response to therapy, and 2-week follow-up. Multicenter Airway Research Collaboration (MARC) investigators. Eur Respir J. 2000 Feb; 15(2):266-73.
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      57. Lilly CM, Woodruff PG, Camargo CA, Nakamura H, Drazen JM, Nadel ES, Hanrahan JP. Elevated plasma eotaxin levels in patients with acute asthma. J Allergy Clin Immunol. 1999 Oct; 104(4 Pt 1):786-90.
        View in: PubMed
      58. Emond SD, Woodruff PG, Lee EY, Singh AK, Camargo CA. Effect of an emergency department asthma program on acute asthma care. Ann Emerg Med. 1999 Sep; 34(3):321-5.
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      59. Cydulka RK, Emerman CL, Schreiber D, Molander KH, Woodruff PG, Camargo CA. Acute asthma among pregnant women presenting to the emergency department. Am J Respir Crit Care Med. 1999 Sep; 160(3):887-92.
        View in: PubMed
      60. Singh AK, Cydulka RK, Stahmer SA, Woodruff PG, Camargo CA. Sex differences among adults presenting to the emergency department with acute asthma. Multicenter Asthma Research Collaboration Investigators. Arch Intern Med. 1999 Jun 14; 159(11):1237-43.
        View in: PubMed
      61. Emerman CL, Woodruff PG, Cydulka RK, Gibbs MA, Pollack CV, Camargo CA. Prospective multicenter study of relapse following treatment for acute asthma among adults presenting to the emergency department. MARC investigators. Multicenter Asthma Research Collaboration. Chest. 1999 Apr; 115(4):919-27.
        View in: PubMed
      62. Singh AK, Woodruff PG, Ritz RH, Mitchell D, Camargo CA. Inhaled corticosteroids for asthma: are ED visits a missed opportunity for prevention? Am J Emerg Med. 1999 Mar; 17(2):144-7.
        View in: PubMed
      63. Woodruff PG, Emond SD, Singh AK, Camargo CA. Sudden-onset severe acute asthma: clinical features and response to therapy. Acad Emerg Med. 1998 Jul; 5(7):695-701.
        View in: PubMed
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