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    Rahul Desikan, MD, PhD

    TitleClinical Instructor
    SchoolUCSF School of Medicine
    DepartmentRadiology
    Address550 16th. Street
    San Francisco CA 94158
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      Collapse Biography 
      Collapse Education and Training
      Boston UniversityBA Classics, Neuroscience and Biology1999
      Boston UniversityM.D.School of Medicine2009
      Boston UniversityPhDAnatomy and Neurobiology2009
      University of California, San DiegoResidency (Research Track)Radiology2015
      Collapse Awards and Honors
      American Society of Neuroradiology (ASNR)2012Cornelius G. Dyke Award
      NeuroImage2011Top Cited Article from 2006-2010
      National Alzheimer's Coordinating Center2016 - 2017Junior Investigator Award
      RSNA2016 - 2017Resident/Fellow Research Award
      ASNR Foundation2017 - 2019Alzheimer's Neuroimaging Award

      Collapse ORNG Applications 
      Collapse Featured Publications

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Bonham LW, Geier EG, Fan CC, Leong JK, Besser L, Kukull WA, Kornak J, Andreassen OA, Schellenberg GD, Rosen HJ, Dillon WP, Hess CP, Miller BL, Dale AM, Desikan RS, Yokoyama JS. Age-dependent effects of APOE e4 in preclinical Alzheimer's disease. Ann Clin Transl Neurol. 2016 Sep; 3(9):668-77. PMID: 27648456.
        View in: PubMed
      2. Yokoyama JS, Desikan RS, et al. Association of Alzheimer Disease Susceptibility Variants and Gene Expression in the Human Brain-Reply. JAMA Neurol. 2016 Aug 8. PMID: 27532297.
        View in: PubMed
      3. Bonham LW, Desikan RS, Yokoyama JS. The relationship between complement factor C3, APOE e4, amyloid and tau in Alzheimer's disease. Acta Neuropathol Commun. 2016; 4(1):65. PMID: 27357286.
        View in: PubMed
      4. Le Hellard S, Wang Y, Witoelar A, Zuber V, Bettella F, Hugdahl K, Espeseth T, Steen VM, Melle I, Desikan R, Schork AJ, Thompson WK, Dale AM, Djurovic S, Andreassen OA, et al. Identification of Gene Loci That Overlap Between Schizophrenia and Educational Attainment. Schizophr Bull. 2016 Jun 23. PMID: 27338279.
        View in: PubMed
      5. Yokoyama JS, Wang Y, Schork AJ, Thompson WK, Karch CM, Cruchaga C, McEvoy LK, Witoelar A, Chen CH, Holland D, Brewer JB, Franke A, Dillon WP, Wilson DM, Mukherjee P, Hess CP, Miller Z, Bonham LW, Shen J, Rabinovici GD, Rosen HJ, Miller BL, Hyman BT, Schellenberg GD, Karlsen TH, Andreassen OA, Dale AM, Desikan RS. Association Between Genetic Traits for Immune-Mediated Diseases and Alzheimer Disease. JAMA Neurol. 2016 Jun 1; 73(6):691-7. PMID: 27088644.
        View in: PubMed
      6. McCammack KC, Schenker-Ahmed NM, White NS, Best SR, Marks RM, Heimbigner J, Kane CJ, Parsons JK, Kuperman JM, Bartsch H, Desikan RS, Rakow-Penner RA, Liss MA, Margolis DJ, Raman SS, Shabaik A, Dale AM, Karow DS. Restriction spectrum imaging improves MRI-based prostate cancer detection. Abdom Radiol (NY). 2016 May; 41(5):946-53. PMID: 26910114.
        View in: PubMed
      7. Wang Y, Bos SD, Harbo HF, Thompson WK, Schork AJ, Bettella F, Witoelar A, Lie BA, Li W, McEvoy LK, Djurovic S, Desikan RS, Dale AM, Andreassen OA. Genetic overlap between multiple sclerosis and several cardiovascular disease risk factors. Mult Scler. 2016 Feb 26. PMID: 26920376.
        View in: PubMed
      8. Wang Y, Thompson WK, Schork AJ, Holland D, Chen CH, Bettella F, Desikan RS, Li W, Witoelar A, Zuber V, Devor A, Nöthen MM, Rietschel M, Chen Q, Werge T, Cichon S, Weinberger DR, Djurovic S, O'Donovan M, Visscher PM, Andreassen OA, Dale AM. Leveraging Genomic Annotations and Pleiotropic Enrichment for Improved Replication Rates in Schizophrenia GWAS. PLoS Genet. 2016 Jan; 12(1):e1005803. PMID: 26808560.
        View in: PubMed
      9. McCammack KC, Kane CJ, Parsons JK, White NS, Schenker-Ahmed NM, Kuperman JM, Bartsch H, Desikan RS, Rakow-Penner RA, Adams D, Liss MA, Mattrey RF, Bradley WG, Margolis DJ, Raman SS, Shabaik A, Dale AM, Karow DS. In vivo prostate cancer detection and grading using restriction spectrum imaging-MRI. Prostate Cancer Prostatic Dis. 2016 Jun; 19(2):168-73. PMID: 26754261.
        View in: PubMed
      10. Reppe S, Wang Y, Thompson WK, McEvoy LK, Schork AJ, Zuber V, LeBlanc M, Bettella F, Mills IG, Desikan RS, Djurovic S, Gautvik KM, Dale AM, Andreassen OA. Genetic Sharing with Cardiovascular Disease Risk Factors and Diabetes Reveals Novel Bone Mineral Density Loci. PLoS One. 2015; 10(12):e0144531. PMID: 26695485.
        View in: PubMed
      11. Andreassen OA, Thompson WK, Schork AJ, Ripke S, Mattingsdal M, Kelsoe JR, Kendler KS, O'Donovan MC, Rujescu D, Werge T, Sklar P, Roddey JC, Chen CH, McEvoy L, Desikan RS, Djurovic S, Dale AM. Correction: Improved Detection of Common Variants Associated with Schizophrenia and Bipolar Disorder Using Pleiotropy-Informed Conditional False Discovery Rate. PLoS Genet. 2015 Nov; 11(11):e1005544. PMID: 26540268.
        View in: PubMed
      12. Srinivasan S, Bettella F, Mattingsdal M, Wang Y, Witoelar A, Schork AJ, Thompson WK, Zuber V, Winsvold BS, Zwart JA, Collier DA, Desikan RS, Melle I, Werge T, Dale AM, Djurovic S, Andreassen OA. Genetic Markers of Human Evolution Are Enriched in Schizophrenia. Biol Psychiatry. 2015 Oct 21. PMID: 26681495.
        View in: PubMed
      13. LeBlanc M, Zuber V, Andreassen BK, Witoelar A, Zeng L, Bettella F, Wang Y, McEvoy LK, Thompson WK, Schork AJ, Reppe S, Barrett-Connor E, Ligthart S, Dehghan A, Gautvik KM, Nelson CP, Schunkert H, Samani NJ, Ridker PM, Chasman DI, Aukrust P, Djurovic S, Frigessi A, Desikan RS, Dale A, Andreassen OA. Identifying Novel Gene Variants in Coronary Artery Disease and Shared Genes With Several Cardiovascular Risk Factors. Circ Res. 2016 Jan 8; 118(1):83-94. PMID: 26487741.
        View in: PubMed
      14. Chen CH, Peng Q, Schork AJ, Lo MT, Fan CC, Wang Y, Desikan RS, Bettella F, Hagler DJ, Westlye LT, Kremen WS, Jernigan TL, Hellard SL, Steen VM, Espeseth T, Huentelman M, Håberg AK, Agartz I, Djurovic S, Andreassen OA, Schork N, Dale AM. Large-scale genomics unveil polygenic architecture of human cortical surface area. Nat Commun. 2015; 6:7549. PMID: 26189703; PMCID: PMC4518289.
      15. Jack CR, Barnes J, Bernstein MA, Borowski BJ, Brewer J, Clegg S, Dale AM, Carmichael O, Ching C, DeCarli C, Desikan RS, Fennema-Notestine C, Fjell AM, Fletcher E, Fox NC, Gunter J, Gutman BA, Holland D, Hua X, Insel P, Kantarci K, Killiany RJ, Krueger G, Leung KK, Mackin S, Maillard P, Malone IB, Mattsson N, McEvoy L, Modat M, Mueller S, Nosheny R, Ourselin S, Schuff N, Senjem ML, Simonson A, Thompson PM, Rettmann D, Vemuri P, Walhovd K, Zhao Y, Zuk S, Weiner M. Magnetic resonance imaging in Alzheimer's Disease Neuroimaging Initiative 2. Alzheimers Dement. 2015 Jul; 11(7):740-56. PMID: 26194310; PMCID: PMC4523217 [Available on 07/01/16].
      16. Andreassen OA, Desikan RS, Wang Y, Thompson WK, Schork AJ, Zuber V, Doncheva NT, Ellinghaus E, Albrecht M, Mattingsdal M, Franke A, Lie BA, Mills IG, Aukrust P, McEvoy LK, Djurovic S, Karlsen TH, Dale AM. Correction: Abundant Genetic Overlap between Blood Lipids and Immune-Mediated Diseases Indicates Shared Molecular Genetic Mechanisms. PLoS One. 2015; 10(5):e0128048. PMID: 25978331; PMCID: PMC4433198.
      17. Desikan RS, Schork AJ, Wang Y, Thompson WK, Dehghan A, Ridker PM, Chasman DI, McEvoy LK, Holland D, Chen CH, Karow DS, Brewer JB, Hess CP, Williams J, Sims R, O'Donovan MC, Choi SH, Bis JC, Ikram MA, Gudnason V, DeStefano AL, van der Lee SJ, Psaty BM, van Duijn CM, Launer L, Seshadri S, Pericak-Vance MA, Mayeux R, Haines JL, Farrer LA, Hardy J, Ulstein ID, Aarsland D, Fladby T, White LR, Sando SB, Rongve A, Witoelar A, Djurovic S, Hyman BT, Snaedal J, Steinberg S, Stefansson H, Stefansson K, Schellenberg GD, Andreassen OA, Dale AM. Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease. Circulation. 2015 Jun 9; 131(23):2061-9. PMID: 25862742.
        View in: PubMed
      18. Andreassen OA, Desikan RS, Wang Y, Thompson WK, Schork AJ, Zuber V, Doncheva NT, Ellinghaus E, Albrecht M, Mattingsdal M, Franke A, Lie BA, Mills I, Aukrust P, McEvoy LK, Djurovic S, Karlsen TH, Dale AM. Abundant genetic overlap between blood lipids and immune-mediated diseases indicates shared molecular genetic mechanisms. PLoS One. 2015; 10(4):e0123057. PMID: 25853426; PMCID: PMC4390360.
      19. Desikan RS, Schork AJ, Wang Y, Witoelar A, Sharma M, McEvoy LK, Holland D, Brewer JB, Chen CH, Thompson WK, Harold D, Williams J, Owen MJ, O'Donovan MC, Pericak-Vance MA, Mayeux R, Haines JL, Farrer LA, Schellenberg GD, Heutink P, Singleton AB, Brice A, Wood NW, Hardy J, Martinez M, Choi SH, DeStefano A, Ikram MA, Bis JC, Smith A, Fitzpatrick AL, Launer L, van Duijn C, Seshadri S, Ulstein ID, Aarsland D, Fladby T, Djurovic S, Hyman BT, Snaedal J, Stefansson H, Stefansson K, Gasser T, Andreassen OA, Dale AM. Genetic overlap between Alzheimer's disease and Parkinson's disease at the MAPT locus. Mol Psychiatry. 2015 Dec; 20(12):1588-95. PMID: 25687773; PMCID: PMC4539304 [Available on 06/01/16].
      20. Andreassen OA, Zuber V, Thompson WK, Schork AJ, Bettella F, Djurovic S, Desikan RS, Mills IG, Dale AM. Shared common variants in prostate cancer and blood lipids. Int J Epidemiol. 2014 Aug; 43(4):1205-14. PMID: 24786909; PMCID: PMC4121563.
      21. Biffi A, Sabuncu MR, Desikan RS, Schmansky N, Salat DH, Rosand J, Anderson CD. Genetic variation of oxidative phosphorylation genes in stroke and Alzheimer's disease. Neurobiol Aging. 2014 Aug; 35(8):1956.e1-8. PMID: 24650791; PMCID: PMC4329419.
      22. Desikan RS, Thompson WK, Holland D, Hess CP, Brewer JB, Zetterberg H, Blennow K, Andreassen OA, McEvoy LK, Hyman BT, Dale AM. The role of clusterin in amyloid-ß-associated neurodegeneration. JAMA Neurol. 2014 Feb; 71(2):180-7. PMID: 24378367; PMCID: PMC4118752.
      23. Andreassen OA, Harbo HF, Wang Y, Thompson WK, Schork AJ, Mattingsdal M, Zuber V, Bettella F, Ripke S, Kelsoe JR, Kendler KS, O'Donovan MC, Sklar P, McEvoy LK, Desikan RS, Lie BA, Djurovic S, Dale AM. Genetic pleiotropy between multiple sclerosis and schizophrenia but not bipolar disorder: differential involvement of immune-related gene loci. Mol Psychiatry. 2015 Feb; 20(2):207-14. PMID: 24468824; PMCID: PMC4356743.
      24. Andreassen OA, McEvoy LK, Thompson WK, Wang Y, Reppe S, Schork AJ, Zuber V, Barrett-Connor E, Gautvik K, Aukrust P, Karlsen TH, Djurovic S, Desikan RS, Dale AM. Identifying common genetic variants in blood pressure due to polygenic pleiotropy with associated phenotypes. Hypertension. 2014 Apr; 63(4):819-26. PMID: 24396023; PMCID: PMC3984909.
      25. Rafii MS, Taylor CS, Kim HT, Desikan RS, Fleisher AS, Katibian D, Brewer JB, Dale AM, Aisen PS. Neuropsychiatric symptoms and regional neocortical atrophy in mild cognitive impairment and Alzheimer's disease. Am J Alzheimers Dis Other Demen. 2014 Mar; 29(2):159-65. PMID: 24164929.
        View in: PubMed
      26. Desikan RS, Thompson WK, Holland D, Hess CP, Brewer JB, Zetterberg H, Blennow K, Andreassen OA, McEvoy LK, Hyman BT, Dale AM. Heart fatty acid binding protein and Aß-associated Alzheimer's neurodegeneration. Mol Neurodegener. 2013; 8:39. PMID: 24088526; PMCID: PMC3850652.
      27. Holland D, Desikan RS, Dale AM, McEvoy LK. Higher rates of decline for women and apolipoprotein E epsilon4 carriers. AJNR Am J Neuroradiol. 2013 Dec; 34(12):2287-93. PMID: 23828104; PMCID: PMC3894062.
      28. Desikan RS, Rafii MS, Brewer JB, Hess CP. An expanded role for neuroimaging in the evaluation of memory impairment. AJNR Am J Neuroradiol. 2013 Nov-Dec; 34(11):2075-82. PMID: 23764728; PMCID: PMC4077712.
      29. Andreassen OA, Thompson WK, Schork AJ, Ripke S, Mattingsdal M, Kelsoe JR, Kendler KS, O'Donovan MC, Rujescu D, Werge T, Sklar P, Roddey JC, Chen CH, McEvoy L, Desikan RS, Djurovic S, Dale AM. Improved detection of common variants associated with schizophrenia and bipolar disorder using pleiotropy-informed conditional false discovery rate. PLoS Genet. 2013 Apr; 9(4):e1003455. PMID: 23637625; PMCID: PMC3636100.
      30. Andreassen OA, Djurovic S, Thompson WK, Schork AJ, Kendler KS, O'Donovan MC, Rujescu D, Werge T, van de Bunt M, Morris AP, McCarthy MI, Roddey JC, McEvoy LK, Desikan RS, Dale AM. Improved detection of common variants associated with schizophrenia by leveraging pleiotropy with cardiovascular-disease risk factors. Am J Hum Genet. 2013 Feb 7; 92(2):197-209. PMID: 23375658; PMCID: PMC3567279.
      31. Holland D, McEvoy LK, Desikan RS, Dale AM. Enrichment and stratification for predementia Alzheimer disease clinical trials. PLoS One. 2012; 7(10):e47739. PMID: 23082203; PMCID: PMC3474753.
      32. Desikan RS, McEvoy LK, Holland D, Thompson WK, Brewer JB, Aisen PS, Andreassen OA, Hyman BT, Sperling RA, Dale AM. Apolipoprotein E epsilon4 does not modulate amyloid-ß-associated neurodegeneration in preclinical Alzheimer disease. AJNR Am J Neuroradiol. 2013 Mar; 34(3):505-10. PMID: 22976236; PMCID: PMC4041629.
      33. Holland D, Desikan RS, Dale AM, McEvoy LK. Rates of decline in Alzheimer disease decrease with age. PLoS One. 2012; 7(8):e42325. PMID: 22876315; PMCID: PMC3410919.
      34. Desikan RS, McEvoy LK, Thompson WK, Holland D, Brewer JB, Aisen PS, Sperling RA, Dale AM. Amyloid-ß--associated clinical decline occurs only in the presence of elevated P-tau. Arch Neurol. 2012 Jun; 69(6):709-13. PMID: 22529247; PMCID: PMC3423526.
      35. Desikan RS, McEvoy LK, Thompson WK, Holland D, Roddey JC, Blennow K, Aisen PS, Brewer JB, Hyman BT, Dale AM. Amyloid-ß associated volume loss occurs only in the presence of phospho-tau. Ann Neurol. 2011 Oct; 70(4):657-61. PMID: 22002658; PMCID: PMC3368003.
      36. Sabuncu MR, Desikan RS, Sepulcre J, Yeo BT, Liu H, Schmansky NJ, Reuter M, Weiner MW, Buckner RL, Sperling RA, Fischl B. The dynamics of cortical and hippocampal atrophy in Alzheimer disease. Arch Neurol. 2011 Aug; 68(8):1040-8. PMID: 21825241; PMCID: PMC3248949.
      37. Desikan RS, Sabuncu MR, Schmansky NJ, Reuter M, Cabral HJ, Hess CP, Weiner MW, Biffi A, Anderson CD, Rosand J, Salat DH, Kemper TL, Dale AM, Sperling RA, Fischl B. Selective disruption of the cerebral neocortex in Alzheimer's disease. PLoS One. 2010; 5(9):e12853. PMID: 20886094; PMCID: PMC2944799.
      38. Desikan RS, Cabral HJ, Settecase F, Hess CP, Dillon WP, Glastonbury CM, Weiner MW, Schmansky NJ, Salat DH, Fischl B. Automated MRI measures predict progression to Alzheimer's disease. Neurobiol Aging. 2010 Aug; 31(8):1364-74. PMID: 20570399; PMCID: PMC2902697.
      39. Biffi A, Anderson CD, Desikan RS, Sabuncu M, Cortellini L, Schmansky N, Salat D, Rosand J. Genetic variation and neuroimaging measures in Alzheimer disease. Arch Neurol. 2010 Jun; 67(6):677-85. PMID: 20558387; PMCID: PMC2956757.
      40. Desikan RS, Cabral HJ, Hess CP, Dillon WP, Glastonbury CM, Weiner MW, Schmansky NJ, Greve DN, Salat DH, Buckner RL, Fischl B. Automated MRI measures identify individuals with mild cognitive impairment and Alzheimer's disease. Brain. 2009 Aug; 132(Pt 8):2048-57. PMID: 19460794; PMCID: PMC2714061.
      41. Desikan RS, Cabral HJ, Fischl B, Guttmann CR, Blacker D, Hyman BT, Albert MS, Killiany RJ. Temporoparietal MR imaging measures of atrophy in subjects with mild cognitive impairment that predict subsequent diagnosis of Alzheimer disease. AJNR Am J Neuroradiol. 2009 Mar; 30(3):532-8. PMID: 19112067; PMCID: PMC2656417.
      42. Desikan RS, Fischl B, Cabral HJ, Kemper TL, Guttmann CR, Blacker D, Hyman BT, Albert MS, Killiany RJ. MRI measures of temporoparietal regions show differential rates of atrophy during prodromal AD. Neurology. 2008 Sep 9; 71(11):819-25. PMID: 18672473; PMCID: PMC2577003.
      43. Yeo BT, Sabuncu MR, Desikan R, Fischl B, Golland P. Effects of registration regularization and atlas sharpness on segmentation accuracy. Med Image Anal. 2008 Oct; 12(5):603-15. PMID: 18667352; PMCID: PMC2615799.
      44. Dickerson BC, Fenstermacher E, Salat DH, Wolk DA, Maguire RP, Desikan R, Pacheco J, Quinn BT, Van der Kouwe A, Greve DN, Blacker D, Albert MS, Killiany RJ, Fischl B. Detection of cortical thickness correlates of cognitive performance: Reliability across MRI scan sessions, scanners, and field strengths. Neuroimage. 2008 Jan 1; 39(1):10-8. PMID: 17942325; PMCID: PMC2141650.
      45. Yeo BT, Sabuncu MR, Desikan R, Fischl B, Golland P. Effects of registration regularization and atlas sharpness on segmentation accuracy. Med Image Comput Comput Assist Interv. 2007; 10(Pt 1):683-91. PMID: 18051118; PMCID: PMC2858002.
      46. Postelnicu G, Zollei L, Desikan R, Fischl B. Geometry driven volumetric registration. Inf Process Med Imaging. 2007; 20:675-86. PMID: 17633739.
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      47. Desikan RS, Ségonne F, Fischl B, Quinn BT, Dickerson BC, Blacker D, Buckner RL, Dale AM, Maguire RP, Hyman BT, Albert MS, Killiany RJ. An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. Neuroimage. 2006 Jul 1; 31(3):968-80. PMID: 16530430.
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      48. Salat DH, Buckner RL, Snyder AZ, Greve DN, Desikan RS, Busa E, Morris JC, Dale AM, Fischl B. Thinning of the cerebral cortex in aging. Cereb Cortex. 2004 Jul; 14(7):721-30. PMID: 15054051.
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      49. Budson AE, Desikan R, Daffner KR, Schacter DL. Perceptual false recognition in Alzheimer's disease. Neuropsychology. 2001 Apr; 15(2):230-43. PMID: 11324866.
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      50. Budson AE, Daffner KR, Desikan R, Schacter DL. When false recognition is unopposed by true recognition: gist-based memory distortion in Alzheimer's disease. Neuropsychology. 2000 Apr; 14(2):277-87. PMID: 10791867.
        View in: PubMed
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