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    Rajalingam Raja, PhD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentSurgery
    Address45 Castro Street
    San Francisco CA 94114
    Phone415-476-0647
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Heaney AP, Sumerel B, Rajalingam R, Bergsneider M, Yong WH, Liau LM. HLA Markers DQ8 and DR53 Are Associated With Lymphocytic Hypophysitis and May Aid in Differential Diagnosis. J Clin Endocrinol Metab. 2015 Nov; 100(11):4092-7. PMID: 26317559.
        View in: PubMed
      2. Lin L, Ma C, Wei B, Aziz N, Rajalingam R, Yusung S, Erlich HA, Trachtenberg EA, Targan SR, McGovern DP, Heath JR, Braun J. Human NK cells licensed by killer Ig receptor genes have an altered cytokine program that modifies CD4+ T cell function. J Immunol. 2014 Jul 15; 193(2):940-9. PMID: 24935928; PMCID: PMC4096688.
      3. Osman AE, Mubasher M, ElSheikh NE, AlHarthi H, Al Yami AS, Rajalingam R, Al-Dehaimi A, Middleton D, ElGhazali G. Characterization of human killer immunoglobulin-like receptors (KIRs) among healthy Saudis. Hum Immunol. 2014 Jun; 75(6):536-40. PMID: 24613458.
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      4. Rajalingam R, Ashouri E. Gene-specific PCR typing of killer cell immunoglobulin-like receptors. Methods Mol Biol. 2013; 1034:239-55. PMID: 23775740.
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      5. Vierra-Green C, Roe D, Hou L, Hurley CK, Rajalingam R, Reed E, Lebedeva T, Yu N, Stewart M, Noreen H, Hollenbach JA, Guethlein LA, Wang T, Spellman S, Maiers M. Allele-level haplotype frequencies and pairwise linkage disequilibrium for 14 KIR loci in 506 European-American individuals. PLoS One. 2012; 7(11):e47491. PMID: 23139747; PMCID: PMC3489906.
      6. Sauna ZE, Ameri A, Kim B, Yanover C, Viel KR, Rajalingam R, Cole SA, Howard TE. Observations regarding the immunogenicity of BDD-rFVIII derived from a mechanistic personalized medicine perspective. J Thromb Haemost. 2012 Sep; 10(9):1961-5. PMID: 22734827.
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      7. Rajalingam R. Overview of the killer cell immunoglobulin-like receptor system. Methods Mol Biol. 2012; 882:391-414. PMID: 22665247.
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      8. Rajalingam R. Human diversity of killer cell immunoglobulin-like receptors and disease. Korean J Hematol. 2011 Dec; 46(4):216-28. PMID: 22259627; PMCID: PMC3259513.
      9. Abi-Rached L, Jobin MJ, Kulkarni S, McWhinnie A, Dalva K, Gragert L, Babrzadeh F, Gharizadeh B, Luo M, Plummer FA, Kimani J, Carrington M, Middleton D, Rajalingam R, Beksac M, Marsh SG, Maiers M, Guethlein LA, Tavoularis S, Little AM, Green RE, Norman PJ, Parham P. The shaping of modern human immune systems by multiregional admixture with archaic humans. Science. 2011 Oct 7; 334(6052):89-94. PMID: 21868630; PMCID: PMC3677943.
      10. Solgi G, Ghafari H, Ashouri E, Alimoghdam K, Rajalingam R, Amirzargar A. Comparison of KIR gene content profiles revealed a difference between northern and southern Persians in the distribution of KIR2DS5 and its linked loci. Hum Immunol. 2011 Nov; 72(11):1079-83. PMID: 21867738.
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      11. Rajalingam R, Gebel HM. KIR-HLA mismatching in human renal allograft transplantation: emergence of a new concept. Am J Transplant. 2011 Sep; 11(9):1771-2. PMID: 21714847.
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      12. Sanchez-Mazas A, Fernandez-ViƱa M, Middleton D, Hollenbach JA, Buhler S, Di D, Rajalingam R, Dugoujon JM, Mack SJ, Thorsby E. Immunogenetics as a tool in anthropological studies. Immunology. 2011 Jun; 133(2):143-64. PMID: 21480890; PMCID: PMC3088978.
      13. Mackensen F, David F, Schwenger V, Smith LK, Rajalingam R, Levinson RD, Austin CR, Houghton D, Martin TM, Rosenbaum JT. HLA-DRB1*0102 is associated with TINU syndrome and bilateral, sudden-onset anterior uveitis but not with interstitial nephritis alone. Br J Ophthalmol. 2011 Jul; 95(7):971-5. PMID: 21059595.
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      14. Abi-Rached L, Moesta AK, Rajalingam R, Guethlein LA, Parham P. Human-specific evolution and adaptation led to major qualitative differences in the variable receptors of human and chimpanzee natural killer cells. PLoS Genet. 2010 Nov; 6(11):e1001192. PMID: 21079681; PMCID: PMC2973822.
      15. Levinson RD, Okada AA, Ashouri E, Keino H, Rajalingam R. Killer cell immunoglobulin-like receptor gene-cluster 3DS1-2DL5-2DS1-2DS5 predisposes susceptibility to Vogt-Koyanagi-Harada syndrome in Japanese individuals. Hum Immunol. 2010 Feb; 71(2):192-4. PMID: 19897003.
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      16. Bonagura VR, Du Z, Ashouri E, Luo L, Hatam LJ, DeVoti JA, Rosenthal DW, Steinberg BM, Abramson AL, Gjertson DW, Reed EF, Rajalingam R. Activating killer cell immunoglobulin-like receptors 3DS1 and 2DS1 protect against developing the severe form of recurrent respiratory papillomatosis. Hum Immunol. 2010 Feb; 71(2):212-9. PMID: 19861144; PMCID: PMC2815039.
      17. Levinson RD, Martin TM, Luo L, Ashouri E, Rosenbaum JT, Smith JR, Austin CR, Lutt JR, Rajalingam R. Killer cell immunoglobulin-like receptors in HLA-B27-associated acute anterior uveitis, with and without axial spondyloarthropathy. Invest Ophthalmol Vis Sci. 2010 Mar; 51(3):1505-10. PMID: 19850842; PMCID: PMC2868435.
      18. Ashouri E, Farjadian S, Reed EF, Ghaderi A, Rajalingam R. KIR gene content diversity in four Iranian populations. Immunogenetics. 2009 Jul; 61(7):483-92. PMID: 19521696; PMCID: PMC2706385.
      19. Ashouri E, Ghaderi A, Reed EF, Rajalingam R. A novel duplex SSP-PCR typing method for KIR gene profiling. Tissue Antigens. 2009 Jul; 74(1):62-7. PMID: 19392793.
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      20. Alves LG, Rajalingam R, Canavez F. A novel real-time PCR method for KIR genotyping. Tissue Antigens. 2009 Feb; 73(2):188-91. PMID: 19140829.
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      21. Shastry A, Sedimbi SK, Rajalingam R, Rumba I, Kanungo A, Sanjeevi CB. Different KIRs confer susceptibility and protection to adults with latent autoimmune diabetes in Latvian and Asian Indian populations. Ann N Y Acad Sci. 2008 Dec; 1150:133-8. PMID: 19120281.
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      22. Shastry A, Sedimbi SK, Rajalingam R, Nikitina-Zake L, Rumba I, Wigzell H, Sanjeevi CB. Combination of KIR 2DL2 and HLA-C1 (Asn 80) confers susceptibility to type 1 diabetes in Latvians. Int J Immunogenet. 2008 Dec; 35(6):439-46. PMID: 19046302.
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      23. Rajalingam R. Variable interactions of recipient killer cell immunoglobulin-like receptors with self and allogenic human leukocyte antigen class I ligands may influence the outcome of solid organ transplants. Curr Opin Organ Transplant. 2008 Aug; 13(4):430-7. PMID: 18685341.
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      24. Du Z, Sharma SK, Spellman S, Reed EF, Rajalingam R. KIR2DL5 alleles mark certain combination of activating KIR genes. Genes Immun. 2008 Jul; 9(5):470-80. PMID: 18509341.
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      25. Levinson RD, Du Z, Luo L, Holland GN, Rao NA, Reed EF, Rajalingam R. KIR and HLA gene combinations in Vogt-Koyanagi-Harada disease. Hum Immunol. 2008 Jun; 69(6):349-53. PMID: 18571006.
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      26. Rajalingam R, Du Z, Meenagh A, Luo L, Kavitha VJ, Pavithra-Arulvani R, Vidhyalakshmi A, Sharma SK, Balazs I, Reed EF, Pitchappan RM, Middleton D. Distinct diversity of KIR genes in three southern Indian populations: comparison with world populations revealed a link between KIR gene content and pre-historic human migrations. Immunogenetics. 2008 May; 60(5):207-17. PMID: 18369612.
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      27. Kulkarni S, Single RM, Martin MP, Rajalingam R, Badwe R, Joshi N, Carrington M. Comparison of the rapidly evolving KIR locus in Parsis and natives of India. Immunogenetics. 2008 Apr; 60(3-4):121-9. PMID: 18351333.
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      28. Levinson RD, Du Z, Luo L, Monnet D, Tabary T, Brezin AP, Zhao L, Gjertson DW, Holland GN, Reed EF, Cohen JH, Rajalingam R. Combination of KIR and HLA gene variants augments the risk of developing birdshot chorioretinopathy in HLA-A*29-positive individuals. Genes Immun. 2008 Apr; 9(3):249-58. PMID: 18340360.
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      29. Luo L, Du Z, Sharma SK, Cullen R, Spellman S, Reed EF, Rajalingam R. Chain-terminating natural mutations affect the function of activating KIR receptors 3DS1 and 2DS3. Immunogenetics. 2007 Oct; 59(10):779-92. PMID: 17646980.
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      30. Rajalingam R. Killer cell immunoglobulin-like receptors influence the innate and adaptive immune responses. Iran J Immunol. 2007 Jun; 4(2):61-78. PMID: 17652846.
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      31. Du Z, Gjertson DW, Reed EF, Rajalingam R. Receptor-ligand analyses define minimal killer cell Ig-like receptor (KIR) in humans. Immunogenetics. 2007 Jan; 59(1):1-15. PMID: 17103212.
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      32. Levinson RD, See RF, Rajalingam R, Reed EF, Park MS, Rao NA, Holland GN. HLA-DRB1 and -DQB1 alleles in mestizo patients with Vogt-Koyanagi-Harada's disease in Southern California. Hum Immunol. 2004 Dec; 65(12):1477-82. PMID: 15603876.
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      33. Levinson RD, Rajalingam R, Park MS, Reed EF, Gjertson DW, Kappel PJ, See RF, Rao NA, Holland GN. Human leukocyte antigen A29 subtypes associated with birdshot retinochoroidopathy. Am J Ophthalmol. 2004 Oct; 138(4):631-4. PMID: 15488792.
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      34. Rajalingam R, Ge P, Reed EF. A sequencing-based typing method for HLA-DQA1 alleles. Hum Immunol. 2004 Apr; 65(4):373-9. PMID: 15120193.
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      35. Jin YP, Fishbein MC, Said JW, Jindra PT, Rajalingam R, Rozengurt E, Reed EF. Anti-HLA class I antibody-mediated activation of the PI3K/Akt signaling pathway and induction of Bcl-2 and Bcl-xL expression in endothelial cells. Hum Immunol. 2004 Apr; 65(4):291-302. PMID: 15120184.
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      36. Rajalingam R, Parham P, Abi-Rached L. Domain shuffling has been the main mechanism forming new hominoid killer cell Ig-like receptors. J Immunol. 2004 Jan 1; 172(1):356-69. PMID: 14688344.
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      37. Yawata M, Yawata N, McQueen KL, Cheng NW, Guethlein LA, Rajalingam R, Shilling HG, Parham P. Predominance of group A KIR haplotypes in Japanese associated with diverse NK cell repertoires of KIR expression. Immunogenetics. 2002 Nov; 54(8):543-50. PMID: 12439616.
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      38. Rajalingam R, Krausa P, Shilling HG, Stein JB, Balamurugan A, McGinnis MD, Cheng NW, Mehra NK, Parham P. Distinctive KIR and HLA diversity in a panel of north Indian Hindus. Immunogenetics. 2002 Mar; 53(12):1009-19. PMID: 11904677.
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      39. Shum BP, Flodin LR, Muir DG, Rajalingam R, Khakoo SI, Cleland S, Guethlein LA, Uhrberg M, Parham P. Conservation and variation in human and common chimpanzee CD94 and NKG2 genes. J Immunol. 2002 Jan 1; 168(1):240-52. PMID: 11751968.
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      40. Canavez F, Young NT, Guethlein LA, Rajalingam R, Khakoo SI, Shum BP, Parham P. Comparison of chimpanzee and human leukocyte Ig-like receptor genes reveals framework and rapidly evolving genes. J Immunol. 2001 Nov 15; 167(10):5786-94. PMID: 11698452.
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      41. Mehra NK, Jaini R, Rajalingam R, Balamurugan A, Kaur G. Molecular diversity of HLA-A*02 in Asian Indians: predominance of A*0211. Tissue Antigens. 2001 Jun; 57(6):502-7. PMID: 11556980.
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      42. Gardiner CM, Guethlein LA, Shilling HG, Pando M, Carr WH, Rajalingam R, Vilches C, Parham P. Different NK cell surface phenotypes defined by the DX9 antibody are due to KIR3DL1 gene polymorphism. J Immunol. 2001 Mar 1; 166(5):2992-3001. PMID: 11207248.
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      43. Rajalingam R, Gardiner CM, Canavez F, Vilches C, Parham P. Identification of seventeen novel KIR variants: fourteen of them from two non-Caucasian donors. Tissue Antigens. 2001 Jan; 57(1):22-31. PMID: 11169255.
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      44. Rajalingam R, Hong M, Adams EJ, Shum BP, Guethlein LA, Parham P. Short KIR haplotypes in pygmy chimpanzee (Bonobo) resemble the conserved framework of diverse human KIR haplotypes. J Exp Med. 2001 Jan 1; 193(1):135-46. PMID: 11136827; PMCID: PMC2195888.
      45. Vilches C, Pando MJ, Rajalingam R, Gardiner CM, Parham P. Discovery of two novel variants of KIR2DS5 reveals this gene to be a common component of human KIR 'B' haplotypes. Tissue Antigens. 2000 Nov; 56(5):453-6. PMID: 11144295.
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      46. Rajalingam R, Mehra NK, Singal DP. Polymorphism in heat-shock protein 70-1 (HSP70-1) gene promoter region and susceptibility to tuberculoid leprosy and pulmonary tuberculosis in Asian Indians. Indian J Exp Biol. 2000 Jul; 38(7):658-62. PMID: 11215307.
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      47. Rajalingam R, Mehra NK, Jain RC. Cold reactive lymphocytotoxic antibodies in pulmonary tuberculosis: correlation with disease activity and HLA. Indian J Exp Biol. 2000 Jul; 38(7):643-50. PMID: 11215305.
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      48. Khakoo SI, Rajalingam R, Shum BP, Weidenbach K, Flodin L, Muir DG, Canavez F, Cooper SL, Valiante NM, Lanier LL, Parham P. Rapid evolution of NK cell receptor systems demonstrated by comparison of chimpanzees and humans. Immunity. 2000 Jun; 12(6):687-98. PMID: 10894168.
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      49. Vilches C, Rajalingam R, Uhrberg M, Gardiner CM, Young NT, Parham P. KIR2DL5, a novel killer-cell receptor with a D0-D2 configuration of Ig-like domains. J Immunol. 2000 Jun 1; 164(11):5797-804. PMID: 10820258.
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      50. Shum BP, Rajalingam R, Magor KE, Azumi K, Carr WH, Dixon B, Stet RJ, Adkison MA, Hedrick RP, Parham P. A divergent non-classical class I gene conserved in salmonids. Immunogenetics. 1999 Jun; 49(6):479-90. PMID: 10380691.
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      51. Mehra NK, Mitra DK, Rajalingam R. Polymorphic MHC molecules dictate cytokine profile and clinical disease in mycobacterial diseases. Indian J Clin Biochem. 1997 Dec; 12(Suppl 1):100. PMID: 23100914; PMCID: PMC3454303.
      52. Rajalingam R, Mehra NK, Mehra RD, Neolia S, Jain RC, Pande JN. HLA class I profile in Asian Indian patients with pulmonary tuberculosis. Indian J Exp Biol. 1997 Oct; 35(10):1055-9. PMID: 9475039.
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      53. Habeeb MA, Rajalingam R, Dhar A, Kumar A, Sharma MP, Mehra NK. HLA association and occurrence of autoantibodies in Asian-Indian patients with ulcerative colitis. Am J Gastroenterol. 1997 May; 92(5):772-6. PMID: 9149183.
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      54. Rajalingam R, Singal DP, Mehra NK. Transporter associated with antigen-processing (TAP) genes and susceptibility to tuberculoid leprosy and pulmonary tuberculosis. Tissue Antigens. 1997 Feb; 49(2):168-72. PMID: 9062973.
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      55. Mitra DK, Rajalingam R, Taneja V, Bhattacharyya BC, Mehra NK. HLA-DR polymorphism modulates the cytokine profile of Mycobacterium leprae HSP-reactive CD4+ T cells. Clin Immunol Immunopathol. 1997 Jan; 82(1):60-7. PMID: 9000043.
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      56. Rajalingam R, Mehra NK, Chopra GS, Puri MM, Jain RC. Anti-IgG autoantibodies and possible immune regulatory mechanisms in patients with pulmonary tuberculosis. Tuber Lung Dis. 1996 Dec; 77(6):502-9. PMID: 9039442.
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      57. Rajalingam R, Mehra NK, Pande JN, Jain RC, Singla R. Correlation of serum interleukin-2 receptor-alpha levels with clinical manifestations in pulmonary tuberculosis. Tuber Lung Dis. 1996 Aug; 77(4):374-9. PMID: 8796256.
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      58. Mehra NK, Rajalingam R, Sagar S, Jain S, Sharma BK. Direct role of HLA-B5 in influencing susceptibility to Takayasu aortoarteritis. Int J Cardiol. 1996 Aug; 54 Suppl:S71-9. PMID: 9119529.
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      59. Rajalingam R, Mehra NK, Jain RC, Myneedu VP, Pande JN. Polymerase chain reaction--based sequence-specific oligonucleotide hybridization analysis of HLA class II antigens in pulmonary tuberculosis: relevance to chemotherapy and disease severity. J Infect Dis. 1996 Mar; 173(3):669-76. PMID: 8627031.
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      60. Mehra NK, Rajalingam R, Giphart MJ. Generation of DR51-associated DQA1, DQB1 haplotypes in Asian Indians. Tissue Antigens. 1996 Jan; 47(1):85-9. PMID: 8929717.
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      61. Mitra DK, Mehra NK, Maiti TK, Banerjee A, Taneja V, Rajalingam R, Ahuja RK, Bhattacharya BC. CD4+ T-cell responses to recombinant hsp65 and hsp18 of M. leprae and their trypsin-digested fragments in leprosy: diversity in HLA-DR restriction. Int J Lepr Other Mycobact Dis. 1995 Dec; 63(4):518-28. PMID: 8642214.
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      62. Mehra NK, Rajalingam R, Mitra DK, Taneja V, Giphart MJ. Variants of HLA-DR2/DR51 group haplotypes and susceptibility to tuberculoid leprosy and pulmonary tuberculosis in Asian Indians. Int J Lepr Other Mycobact Dis. 1995 Jun; 63(2):241-8. PMID: 7602219.
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      63. Sidharthan V, Rose PJ, Rajalingam R, Udhayakumar RC, Aruldhas MM, Govindarajulu P. Dorsolateral prostatic phosphomonoesterases and adenosine triphosphatases in hypo- and hyperthyroid rats. Indian J Exp Biol. 1994 Sep; 32(9):616-8. PMID: 7814039.
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      64. Mehra NK, Bouwens AG, Naipal A, Rajalingam R, Grubic Z, Taneja V, Tilanus MG, Giphart MJ. Asian Indian HLA-DR2-, DR4-, and DR52-related DR-DQ genotypes analyzed by polymerase chain reaction based nonradioactive oligonucleotide typing. Unique haplotypes and a novel DR4 subtype. Hum Immunol. 1994 Mar; 39(3):202-10. PMID: 8026988.
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      65. Rajalingam R, Srinivasan N, Govindarajulu P. Effects of alloxan induced diabetes on lipid profiles in renal cortex and medulla of mature albino rats. Indian J Exp Biol. 1993 Jun; 31(6):577-9. PMID: 8406610.
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      66. Sidharthan V, Rajalingam R, Aruldhas MM, Govindarajulu P. Ventral prostatic phosphomonoesterases and adenosine triphosphatases in hypo- and hyperthyroid albino rats. Indian J Exp Biol. 1993 May; 31(5):414-6. PMID: 8395467.
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      67. Mehra NK, Rajalingam R, Bovornkitti S. Human leukocyte antigen (HLA) in respiratory allergy. Asian Pac J Allergy Immunol. 1992 Dec; 10(2):151-8. PMID: 1305817.
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