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    Randall Kramer, PhD

    TitleProfessor
    SchoolUCSF School of Dentistry
    DepartmentCell and Tissue Biology
    Address513 Parnassus Ave
    San Francisco CA 94143
    Phone415-476-3275
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      Collapse Biography 
      Collapse Education and Training
      University of California, BerkeleyBABiochemistry1971
      Yale University School of MedicineMS, PhDPharmacology1977
      University of California, IrvinePostdoctoral FellowTumor Biology1980

      Collapse ORNG Applications 
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      Collapse Global Health

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Ozeki N, Mogi M, Yamaguchi H, Hiyama T, Kawai R, Hase N, Nakata K, Nakamura H, Kramer RH. Differentiation of human skeletal muscle stem cells into odontoblasts is dependent on induction of a1 integrin expression. J Biol Chem. 2014 May 16; 289(20):14380-91. PMID: 24692545; PMCID: PMC4022904.
      2. Yang F, Liu R, Kramer R, Xiao W, Jordan R, Lam KS. Discovery of specific ligands for oral squamous carcinoma to develop anti-cancer drug loaded precise targeting nanotherapeutics. J Calif Dent Assoc. 2012 Dec; 40(12):939-43. PMID: 23362666; PMCID: PMC4562383.
      3. Humtsoe JO, Koya E, Pham E, Aramoto T, Zuo J, Ishikawa T, Kramer RH. Transcriptional profiling identifies upregulated genes following induction of epithelial-mesenchymal transition in squamous carcinoma cells. Exp Cell Res. 2012 Feb 15; 318(4):379-90. PMID: 22154512.
        View in: PubMed
      4. Zuo J, Ishikawa T, Boutros S, Xiao Z, Humtsoe JO, Kramer RH. Bcl-2 overexpression induces a partial epithelial to mesenchymal transition and promotes squamous carcinoma cell invasion and metastasis. Mol Cancer Res. 2010 Feb; 8(2):170-82. PMID: 20145039.
        View in: PubMed
      5. Ishikawa T, Kramer RH. Sdc1 negatively modulates carcinoma cell motility and invasion. Exp Cell Res. 2010 Apr 1; 316(6):951-65. PMID: 20036233; PMCID: PMC2834805.
      6. Humtsoe JO, Kramer RH. Differential epidermal growth factor receptor signaling regulates anchorage-independent growth by modulation of the PI3K/AKT pathway. Oncogene. 2010 Feb 25; 29(8):1214-26. PMID: 19935697; PMCID: PMC2829113.
      7. Pawlikowski B, Lee L, Zuo J, Kramer RH. Analysis of human muscle stem cells reveals a differentiation-resistant progenitor cell population expressing Pax7 capable of self-renewal. Dev Dyn. 2009 Jan; 238(1):138-49. PMID: 19097049; PMCID: PMC2799339.
      8. Gorfu G, Virtanen I, Hukkanen M, Lehto VP, Rousselle P, Kenne E, Lindbom L, Kramer R, Tryggvason K, Patarroyo M. Laminin isoforms of lymph nodes and predominant role of alpha5-laminin(s) in adhesion and migration of blood lymphocytes. J Leukoc Biol. 2008 Sep; 84(3):701-12. PMID: 18523231.
        View in: PubMed
      9. El-Sayed I, Huang X, Macheret F, Humstoe JO, Kramer R, El-Sayed M. Effect of plasmonic gold nanoparticles on benign and malignant cellular autofluorescence: a novel probe for fluorescence based detection of cancer. Technol Cancer Res Treat. 2007 Oct; 6(5):403-12. PMID: 17877428.
        View in: PubMed
      10. Onishi A, Chen Q, Humtsoe JO, Kramer RH. STAT3 signaling is induced by intercellular adhesion in squamous cell carcinoma cells. Exp Cell Res. 2008 Jan 15; 314(2):377-86. PMID: 17961551; PMCID: PMC2766263.
      11. Ozeki N, Jethanandani P, Nakamura H, Ziober BL, Kramer RH. Modulation of satellite cell adhesion and motility following BMP2-induced differentiation to osteoblast lineage. Biochem Biophys Res Commun. 2007 Feb 2; 353(1):54-9. PMID: 17166482; PMCID: PMC1868413.
      12. Ozeki N, Lim M, Yao CC, Tolar M, Kramer RH. alpha7 integrin expressing human fetal myogenic progenitors have stem cell-like properties and are capable of osteogenic differentiation. Exp Cell Res. 2006 Dec 10; 312(20):4162-80. PMID: 17054947; PMCID: PMC2766282.
      13. Jethanandani P, Kramer RH. Alpha7 integrin expression is negatively regulated by deltaEF1 during skeletal myogenesis. J Biol Chem. 2005 Oct 28; 280(43):36037-46. PMID: 16129691.
        View in: PubMed
      14. Kramer RH, Shen X, Zhou H. Tumor cell invasion and survival in head and neck cancer. Cancer Metastasis Rev. 2005 Jan; 24(1):35-45. PMID: 15785871.
        View in: PubMed
      15. Zhou H, Kramer RH. Integrin engagement differentially modulates epithelial cell motility by RhoA/ROCK and PAK1. J Biol Chem. 2005 Mar 18; 280(11):10624-35. PMID: 15611088.
        View in: PubMed
      16. Murai M, Shen X, Huang L, Carpenter WM, Lin CS, Silverman S, Regezi J, Kramer RH. Overexpression of c-met in oral SCC promotes hepatocyte growth factor-induced disruption of cadherin junctions and invasion. Int J Oncol. 2004 Oct; 25(4):831-40. PMID: 15375530.
        View in: PubMed
      17. Shen X, Kramer RH. Adhesion-mediated squamous cell carcinoma survival through ligand-independent activation of epidermal growth factor receptor. Am J Pathol. 2004 Oct; 165(4):1315-29. PMID: 15466396; PMCID: PMC1618631.
      18. Chen Q, Lipkina G, Song Q, Kramer RH. Promoter methylation regulates cadherin switching in squamous cell carcinoma. Biochem Biophys Res Commun. 2004 Mar 19; 315(4):850-6. PMID: 14985090.
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      19. Xiao J, Jethanandani P, Ziober BL, Kramer RH. Regulation of alpha7 integrin expression during muscle differentiation. J Biol Chem. 2003 Dec 12; 278(50):49780-8. PMID: 14525975.
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      20. Ferguson JW, Thoma BS, Mikesh MF, Kramer RH, Bennett KL, Purchio A, Bellard BJ, LeBaron RG. The extracellular matrix protein betaIG-H3 is expressed at myotendinous junctions and supports muscle cell adhesion. Cell Tissue Res. 2003 Jul; 313(1):93-105. PMID: 12838408.
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      21. Yeh MG, Ziober BL, Liu B, Lipkina G, Vizirianakis IS, Kramer RH. The beta1 cytoplasmic domain regulates the laminin-binding specificity of the alpha7X1 integrin. Mol Biol Cell. 2003 Sep; 14(9):3507-18. PMID: 12972542; PMCID: PMC196545.
      22. Kim TW, Chen Q, Shen X, Regezi JA, Ramos DM, Tanaka H, Jordan RC, Kramer RH. Oral mucosal carcinogenesis in SENCAR mice. Anticancer Res. 2002 Sep-Oct; 22(5):2733-40. PMID: 12529989.
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      23. Vizirianakis IS, Chen YQ, Kantak SS, Tsiftsoglou AS, Kramer RH. Dominant-negative E-cadherin alters adhesion and reverses contact inhibition of growth in breast carcinoma cells. Int J Oncol. 2002 Jul; 21(1):135-44. PMID: 12063560.
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      24. Blanco-Bose WE, Yao CC, Kramer RH, Blau HM. Purification of mouse primary myoblasts based on alpha 7 integrin expression. Exp Cell Res. 2001 May 1; 265(2):212-20. PMID: 11302686.
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      25. Kawano K, Kantak SS, Murai M, Yao CC, Kramer RH. Integrin alpha3beta1 engagement disrupts intercellular adhesion. Exp Cell Res. 2001 Jan 15; 262(2):180-96. PMID: 11139342.
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      26. Ziober BL, Silverman SS, Kramer RH. Adhesive mechanisms regulating invasion and metastasis in oral cancer. Crit Rev Oral Biol Med. 2001; 12(6):499-510. PMID: 11806519.
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      27. Vizirianakis IS, Yao CC, Chen Y, Ziober BL, Tsiftsoglou AS, Kramer RH. Transfection of MCF-7 carcinoma cells with human integrin alpha7 cDNA promotes adhesion to laminin. Arch Biochem Biophys. 2001 Jan 1; 385(1):108-16. PMID: 11361006.
        View in: PubMed
      28. Ziober BL, Turner MA, Palefsky JM, Banda MJ, Kramer RH. Type I collagen degradation by invasive oral squamous cell carcinoma. Oral Oncol. 2000 Jul; 36(4):365-72. PMID: 10899676.
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      29. Beviglia L, Kramer RH. HGF induces FAK activation and integrin-mediated adhesion in MTLn3 breast carcinoma cells. Int J Cancer. 1999 Nov 26; 83(5):640-9. PMID: 10521801.
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      30. Ziober BL, Chen YQ, Ramos DM, Waleh N, Kramer RH. Expression of the alpha7beta1 laminin receptor suppresses melanoma growth and metastatic potential. Cell Growth Differ. 1999 Jul; 10(7):479-90. PMID: 10437916.
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      31. Kantak SS, Kramer RH. E-cadherin regulates anchorage-independent growth and survival in oral squamous cell carcinoma cells. J Biol Chem. 1998 Jul 3; 273(27):16953-61. PMID: 9642258.
        View in: PubMed
      32. Hayashi YK, Chou FL, Engvall E, Ogawa M, Matsuda C, Hirabayashi S, Yokochi K, Ziober BL, Kramer RH, Kaufman SJ, Ozawa E, Goto Y, Nonaka I, Tsukahara T, Wang JZ, Hoffman EP, Arahata K. Mutations in the integrin alpha7 gene cause congenital myopathy. Nat Genet. 1998 May; 19(1):94-7. PMID: 9590299.
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      33. Lenferink AE, Kramer RH, van Vugt MJ, Königswieser M, Di Fiore PP, van Zoelen EJ, van de Poll ML. Superagonistic behaviour of epidermal growth factor/transforming growth factor-alpha chimaeras: correlation with receptor routing after ligand-induced internalization. Biochem J. 1997 Nov 1; 327 ( Pt 3):859-65. PMID: 9581567; PMCID: PMC1218868.
      34. Ziober BL, Chen Y, Kramer RH. The laminin-binding activity of the alpha 7 integrin receptor is defined by developmentally regulated splicing in the extracellular domain. Mol Biol Cell. 1997 Sep; 8(9):1723-34. PMID: 9307969; PMCID: PMC305732.
      35. Ramos DM, Chen BL, Boylen K, Stern M, Kramer RH, Sheppard D, Nishimura SL, Greenspan D, Zardi L, Pytela R. Stromal fibroblasts influence oral squamous-cell carcinoma cell interactions with tenascin-C. Int J Cancer. 1997 Jul 17; 72(2):369-76. PMID: 9219848.
        View in: PubMed
      36. Yao CC, Breuss J, Pytela R, Kramer RH. Functional expression of the alpha 7 integrin receptor in differentiated smooth muscle cells. J Cell Sci. 1997 Jul; 110 ( Pt 13):1477-87. PMID: 9224765.
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      37. Beviglia L, Matsumoto K, Lin CS, Ziober BL, Kramer RH. Expression of the c-Met/HGF receptor in human breast carcinoma: correlation with tumor progression. Int J Cancer. 1997 Jun 20; 74(3):301-9. PMID: 9221809.
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      38. Yao CC, Ziober BL, Sutherland AE, Mendrick DL, Kramer RH. Laminins promote the locomotion of skeletal myoblasts via the alpha 7 integrin receptor. J Cell Sci. 1996 Dec; 109 ( Pt 13):3139-50. PMID: 9004048.
        View in: PubMed
      39. Yao CC, Ziober BL, Squillace RM, Kramer RH. Alpha7 integrin mediates cell adhesion and migration on specific laminin isoforms. J Biol Chem. 1996 Oct 11; 271(41):25598-603. PMID: 8810334.
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      40. Zhang K, Kramer RH. Laminin 5 deposition promotes keratinocyte motility. Exp Cell Res. 1996 Sep 15; 227(2):309-22. PMID: 8831569.
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      41. Ziober BL, Kramer RH. Identification and characterization of the cell type-specific and developmentally regulated alpha7 integrin gene promoter. J Biol Chem. 1996 Sep 13; 271(37):22915-22. PMID: 8798472.
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      42. Zhang K, Kim JP, Woodley DT, Waleh NS, Chen YQ, Kramer RH. Restricted expression and function of laminin 1-binding integrins in normal and malignant oral mucosal keratinocytes. Cell Adhes Commun. 1996 Sep; 4(3):159-74. PMID: 8969862.
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      43. Clyman RI, Goetzman BW, Chen YQ, Mauray F, Kramer RH, Pytela R, Schnapp LM. Changes in endothelial cell and smooth muscle cell integrin expression during closure of the ductus arteriosus: an immunohistochemical comparison of the fetal, preterm newborn, and full-term newborn rhesus monkey ductus. Pediatr Res. 1996 Aug; 40(2):198-208. PMID: 8827767.
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      44. Ziober BL, Lin CS, Kramer RH. Laminin-binding integrins in tumor progression and metastasis. Semin Cancer Biol. 1996 Jun; 7(3):119-28. PMID: 8773297.
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      45. Martin PT, Kaufman SJ, Kramer RH, Sanes JR. Synaptic integrins in developing, adult, and mutant muscle: selective association of alpha1, alpha7A, and alpha7B integrins with the neuromuscular junction. Dev Biol. 1996 Feb 25; 174(1):125-39. PMID: 8626012.
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      46. Matsumoto K, Ziober BL, Yao CC, Kramer RH. Growth factor regulation of integrin-mediated cell motility. Cancer Metastasis Rev. 1995 Sep; 14(3):205-17. PMID: 8548869.
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      47. Tannenbaum JE, Waleh NS, Mauray F, Breuss J, Pytela R, Kramer RH, Clyman RI. Transforming growth factor beta 1 inhibits fetal lamb ductus arteriosus smooth muscle cell migration. Pediatr Res. 1995 May; 37(5):561-70. PMID: 7603772.
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      48. Matsumoto K, Matsumoto K, Nakamura T, Kramer RH. Hepatocyte growth factor/scatter factor induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and promotes migration and invasion by oral squamous cell carcinoma cells. J Biol Chem. 1994 Dec 16; 269(50):31807-13. PMID: 7527397.
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      49. Berston ED, Ramos DM, Kramer RH. Metastatic melanoma cells interact with the reticular fibres of the lymph node. Melanoma Res. 1994 Apr; 4(2):115-25. PMID: 8069097.
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      50. Clyman RI, Tannenbaum J, Chen YQ, Cooper D, Yurchenco PD, Kramer RH, Waleh NS. Ductus arteriosus smooth muscle cell migration on collagen: dependence on laminin and its receptors. J Cell Sci. 1994 Apr; 107 ( Pt 4):1007-18. PMID: 8056826.
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      51. Waleh NS, Gallo J, Grant TD, Murphy BJ, Kramer RH, Sutherland RM. Selective down-regulation of integrin receptors in spheroids of squamous cell carcinoma. Cancer Res. 1994 Feb 1; 54(3):838-43. PMID: 8306347.
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      52. Kramer RH. Characterization of laminin-binding integrins. Methods Enzymol. 1994; 245:129-47. PMID: 7760732.
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      53. Ziober BL, Vu MP, Waleh N, Crawford J, Lin CS, Kramer RH. Alternative extracellular and cytoplasmic domains of the integrin alpha 7 subunit are differentially expressed during development. J Biol Chem. 1993 Dec 15; 268(35):26773-83. PMID: 8253814.
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      54. Chen JD, Kim JP, Zhang K, Sarret Y, Wynn KC, Kramer RH, Woodley DT. Epidermal growth factor (EGF) promotes human keratinocyte locomotion on collagen by increasing the alpha 2 integrin subunit. Exp Cell Res. 1993 Dec; 209(2):216-23. PMID: 8262138.
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      55. Enenstein J, Waleh NS, Kramer RH. Basic FGF and TGF-beta differentially modulate integrin expression of human microvascular endothelial cells. Exp Cell Res. 1992 Dec; 203(2):499-503. PMID: 1459210.
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      56. Douglass GD, Zhang K, Kramer RH. The role of integrin adhesion receptors in gingival wound healing. J Calif Dent Assoc. 1992 Dec; 20(12):37-40. PMID: 1283879.
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      57. Clyman RI, Mauray F, Kramer RH. Beta 1 and beta 3 integrins have different roles in the adhesion and migration of vascular smooth muscle cells on extracellular matrix. Exp Cell Res. 1992 Jun; 200(2):272-84. PMID: 1374036.
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      58. Kramer RH, Vu MP, Cheng YF, Ramos DM, Timpl R, Waleh N. Laminin-binding integrin alpha 7 beta 1: functional characterization and expression in normal and malignant melanocytes. Cell Regul. 1991 Oct; 2(10):805-17. PMID: 1839357; PMCID: PMC361876.
      59. Cheng YF, Clyman RI, Enenstein J, Waleh N, Pytela R, Kramer RH. The integrin complex alpha v beta 3 participates in the adhesion of microvascular endothelial cells to fibronectin. Exp Cell Res. 1991 May; 194(1):69-77. PMID: 1707824.
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      60. Kramer RH, Vu M, Cheng YF, Ramos DM. Integrin expression in malignant melanoma. Cancer Metastasis Rev. 1991 May; 10(1):49-59. PMID: 1833083.
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      61. Ramos DM, Cheng YF, Kramer RH. Role of laminin-binding integrin in the invasion of basement membrane matrices by fibrosarcoma cells. Invasion Metastasis. 1991; 11(3):125-38. PMID: 1938274.
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      62. Kramer RH, Cheng YF, Clyman R. Human microvascular endothelial cells use beta 1 and beta 3 integrin receptor complexes to attach to laminin. J Cell Biol. 1990 Sep; 111(3):1233-43. PMID: 1697296; PMCID: PMC2116258.
      63. Clyman RI, McDonald KA, Kramer RH. Integrin receptors on aortic smooth muscle cells mediate adhesion to fibronectin, laminin, and collagen. Circ Res. 1990 Jul; 67(1):175-86. PMID: 1694736.
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      64. Clyman RI, Turner DC, Kramer RH. An alpha 1/beta 1-like integrin receptor on rat aortic smooth muscle cells mediates adhesion to laminin and collagen types I and IV. Arteriosclerosis. 1990 May-Jun; 10(3):402-9. PMID: 2160805.
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      65. Ramos DM, Berston ED, Kramer RH. Analysis of integrin receptors for laminin and type IV collagen on metastatic B16 melanoma cells. Cancer Res. 1990 Feb 1; 50(3):728-34. PMID: 2153445.
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      66. Kramer RH, McDonald KA, Vu MP. Human melanoma cells express a novel integrin receptor for laminin. J Biol Chem. 1989 Sep 15; 264(26):15642-9. PMID: 2527855.
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      67. Cheng YF, Kramer RH. Human microvascular endothelial cells express integrin-related complexes that mediate adhesion to the extracellular matrix. J Cell Physiol. 1989 May; 139(2):275-86. PMID: 2469686.
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      68. Kramer RH, Marks N. Identification of integrin collagen receptors on human melanoma cells. J Biol Chem. 1989 Mar 15; 264(8):4684-8. PMID: 2538453.
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      69. Kramer RH, McDonald KA, Crowley E, Ramos DM, Damsky CH. Melanoma cell adhesion to basement membrane mediated by integrin-related complexes. Cancer Res. 1989 Jan 15; 49(2):393-402. PMID: 2535959.
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      70. Chen L, Rezaee M, Kramer RH. Solubilization of immobilized protein substrates by metastatic tumor cells. Invasion Metastasis. 1989; 9(1):27-45. PMID: 2649447.
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      71. Green TL, Meyer JR, Daniels TE, Greenspan JS, de Souza Y, Kramer RH. Kaposi's sarcoma in AIDS: basement membrane and endothelial cell markers in late-stage lesions. J Oral Pathol. 1988 Jul; 17(6):266-72. PMID: 3144589.
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      72. Kramer RH, Rosen SD, McDonald KA. Basement-membrane components associated with the extracellular matrix of the lymph node. Cell Tissue Res. 1988 May; 252(2):367-75. PMID: 3383216.
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      73. Winkler JR, Matarese V, Hoover CI, Kramer RH, Murray PA. An in vitro model to study bacterial invasion of periodontal tissues. J Periodontol. 1988 Jan; 59(1):40-5. PMID: 3422291.
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      74. Rezaee M, Chen L, Kramer RH. Measurement of plasminogen activator activity from human fibrosarcoma cells by a new microassay. Int J Cancer. 1987 Dec 15; 40(6):823-9. PMID: 3692627.
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      75. Winkler JR, John SR, Kramer RH, Hoover CI, Murray PA. Attachment of oral bacteria to a basement-membrane-like matrix and to purified matrix proteins. Infect Immun. 1987 Nov; 55(11):2721-6. PMID: 3666961; PMCID: PMC259967.
      76. Kramer RH, Bensch KG, Wong J. Invasion of reconstituted basement membrane matrix by metastatic human tumor cells. Cancer Res. 1986 Apr; 46(4 Pt 2):1980-9. PMID: 3948175.
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      77. Kramer RH, Gonzalez R, Nicolson GL. Metastatic tumor cells adhere preferentially to the extracellular matrix underlying vascular endothelial cells. Int J Cancer. 1980 Nov 15; 26(5):639-45. PMID: 7239720.
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