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    Rich Sievers

    TitleSpecialist
    SchoolUCSF School of Medicine
    DepartmentMedicine
    Address513 Parnassus Avenue
    San Francisco CA 94117
    Phone415-476-2600
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      Collapse Biography 
      Collapse Awards and Honors
      UCSF2010Great People Award

      Collapse Overview 
      Collapse Overview
      Research Techniques:

      Developed the ischemia-reflow model in the rat which characterized the snare loop occlusion of the left coronary artery. By using the rat, this technique resulted in lowered costs and higher throughput with pharmaceutical interventions. (see articles below)

      Pioneered a technique for in vivo gene therapy transfer directly into the AV node. We have extended this knowledge to include the feasibility for a therapeutic role for cell transplantation and gene transfer in myocardial repair.

      Developed a chronic model in the rat to assess the effects of pharmaceuticals on left ventricular remodeling.

      Developed a closed-chest cell injection technique into mouse myocardium guided by high-resolution echocardiography. The use of this technique will allow more precise cellular implantation into the mouse/rat myocardium by accurately guiding injections to desired locations, confirming successful implantation of stem cells, in a clinically relevant time frame.

      Developed the first integrative physiologic model to reproducibly study Flow-mediated dilation in living rats. This approach demonstrates that the physiology of rodent vascular reactivity is concordant with that of humans, validating its use for the study of therapeutic modulators of vascular function.

      Collapse Interests
      Extensive consulting background at Universities and Biotech/Pharmaceutical companies.,

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      Collapse Featured Publications

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Nazer B, Salgaonkar V, Diederich CJ, Jones PD, Duggirala S, Tanaka Y, Ng B, Sievers R, Gerstenfeld EP. Epicardial Catheter Ablation Using High-Intensity Ultrasound: Validation in a Swine Model. Circ Arrhythm Electrophysiol. 2015 Dec; 8(6):1491-7. PMID: 26546345.
        View in: PubMed
      2. Tanaka Y, Rahmutula D, Duggirala S, Nazer B, Fang Q, Olgin J, Sievers R, Gerstenfeld EP. Diffuse fibrosis leads to a decrease in unipolar voltage: Validation in a swine model of premature ventricular contraction-induced cardiomyopathy. Heart Rhythm. 2016 Feb; 13(2):547-54. PMID: 26416621.
        View in: PubMed
      3. Ye J, Gaur M, Zhang Y, Sievers RE, Woods BJ, Aurigui J, Bernstein HS, Yeghiazarians Y. Treatment with hESC-Derived Myocardial Precursors Improves Cardiac Function after a Myocardial Infarction. PLoS One. 2015; 10(7):e0131123. PMID: 26230835; PMCID: PMC4521814.
      4. Nguyen J, Sievers R, Motion JP, Kivimäe S, Fang Q, Lee RJ. Delivery of lipid micelles into infarcted myocardium using a lipid-linked matrix metalloproteinase targeting peptide. Mol Pharm. 2015 Apr 6; 12(4):1150-7. PMID: 25642730.
        View in: PubMed
      5. Tanaka Y, Genet M, Chuan Lee L, Martin AJ, Sievers R, Gerstenfeld EP. Utility of high-resolution electroanatomic mapping of the left ventricle using a multispline basket catheter in a swine model of chronic myocardial infarction. Heart Rhythm. 2015 Jan; 12(1):144-54. PMID: 25173890.
        View in: PubMed
      6. Pinney JR, Du KT, Ayala P, Fang Q, Sievers RE, Chew P, Delrosario L, Lee RJ, Desai TA. Discrete microstructural cues for the attenuation of fibrosis following myocardial infarction. Biomaterials. 2014 Oct; 35(31):8820-8. PMID: 25047625; PMCID: PMC4144416.
      7. Pinnamaneni K, Sievers RE, Sharma R, Selchau AM, Gutierrez G, Nordsieck EJ, Su R, An S, Chen Q, Wang X, Derakhshandeh R, Aschbacher K, Heiss C, Glantz SA, Schick SF, Springer ML. Brief exposure to secondhand smoke reversibly impairs endothelial vasodilatory function. Nicotine Tob Res. 2014 May; 16(5):584-90. PMID: 24302638; PMCID: PMC3977486.
      8. Boyle AJ, Hwang J, Ye J, Shih H, Jun K, Zhang Y, Fang Q, Sievers R, Yeghiazarians Y, Lee RJ. The effects of aging on apoptosis following myocardial infarction. Cardiovasc Ther. 2013 Dec; 31(6):e102-10. PMID: 24279384; PMCID: PMC3895658.
      9. Mihardja SS, Gonzales JA, Gao D, Sievers RE, Fang Q, Stillson CA, Yu J, Peng M, Lee RJ. The effect of a peptide-modified thermo-reversible methylcellulose on wound healing and LV function in a chronic myocardial infarction rodent model. Biomaterials. 2013 Nov; 34(35):8869-77. PMID: 23895998.
        View in: PubMed
      10. Fang Q, Mok PY, Thomas AE, Haddad DJ, Saini SA, Clifford BT, Kapasi NK, Danforth OM, Usui M, Ye W, Luu E, Sharma R, Bartel MJ, Pathmanabhan JA, Ang AA, Sievers RE, Lee RJ, Springer ML. Pleiotrophin gene therapy for peripheral ischemia: evaluation of full-length and truncated gene variants. PLoS One. 2013; 8(4):e61413. PMID: 23630585; PMCID: PMC3632611.
      11. Chen Q, Sievers RE, Varga M, Kharait S, Haddad DJ, Patton AK, Delany CS, Mutka SC, Blonder JP, Dubé GP, Rosenthal GJ, Springer ML. Pharmacological inhibition of S-nitrosoglutathione reductase improves endothelial vasodilatory function in rats in vivo. J Appl Physiol (1985). 2013 Mar 15; 114(6):752-60. PMID: 23349456; PMCID: PMC3615603.
      12. Ye J, Boyle AJ, Shih H, Sievers RE, Wang ZE, Gormley M, Yeghiazarians Y. CD45-positive cells are not an essential component in cardiosphere formation. Cell Tissue Res. 2013 Jan; 351(1):201-5. PMID: 23064904.
        View in: PubMed
      13. Angeli FS, Zhang Y, Sievers R, Jun K, Yim S, Boyle A, Yeghiazarians Y. Injection of human bone marrow and mononuclear cell extract into infarcted mouse hearts results in functional improvement. Open Cardiovasc Med J. 2012; 6:38-43. PMID: 22550548; PMCID: PMC3339429.
      14. Koskenvuo JW, Sievers RE, Zhang Y, Angeli FS, Lee B, Shih H, Ye J, Boyle AJ, Yeghiazarians Y. Fractionation of mouse bone-marrow cells limits functional efficacy in non-reperfused mouse model of acute myocardial infarction. Ann Med. 2012 Dec; 44(8):829-35. PMID: 22494088.
        View in: PubMed
      15. Ye J, Boyle A, Shih H, Sievers RE, Zhang Y, Prasad M, Su H, Zhou Y, Grossman W, Bernstein HS, Yeghiazarians Y. Sca-1+ cardiosphere-derived cells are enriched for Isl1-expressing cardiac precursors and improve cardiac function after myocardial injury. PLoS One. 2012; 7(1):e30329. PMID: 22272337; PMCID: PMC3260268.
      16. Wang X, Takagawa J, Haddad DJ, Pinnamaneni K, Zhang Y, Sievers RE, Grossman W, Yeghiazarians Y, Springer ML. Advanced Donor Age Impairs Bone Marrow Cell Therapeutic Efficacy for Cardiac Disease. J Tissue Sci Eng. 2011 Nov 18; S3. PMID: 22675670.
        View in: PubMed
      17. Yeghiazarians Y, Gaur M, Zhang Y, Sievers RE, Ritner C, Prasad M, Boyle A, Bernstein HS. Myocardial improvement with human embryonic stem cell-derived cardiomyocytes enriched by p38MAPK inhibition. Cytotherapy. 2012 Feb; 14(2):223-31. PMID: 22040108; PMCID: PMC3270940.
      18. Wang X, Takagawa J, Lam VC, Haddad DJ, Tobler DL, Mok PY, Zhang Y, Clifford BT, Pinnamaneni K, Saini SA, Su R, Bartel MJ, Sievers RE, Carbone L, Kogan S, Yeghiazarians Y, Hermiston M, Springer ML. Donor myocardial infarction impairs the therapeutic potential of bone marrow cells by an interleukin-1-mediated inflammatory response. Sci Transl Med. 2011 Sep 14; 3(100):100ra90. PMID: 21918107; PMCID: PMC3350804.
      19. Boyle AJ, Yeghiazarians Y, Shih H, Hwang J, Ye J, Sievers R, Zheng D, Palasubramaniam J, Palasubramaniam D, Karschimkus C, Whitbourn R, Jenkins A, Wilson AM. Myocardial production and release of MCP-1 and SDF-1 following myocardial infarction: differences between mice and man. J Transl Med. 2011; 9:150. PMID: 21910857; PMCID: PMC3180393.
      20. Mirsky R, Jahn S, Koskenvuo JW, Sievers RE, Yim SM, Ritner C, Bernstein HS, Angeli FS, Boyle AJ, De Marco T, Yeghiazarians Y. Treatment of pulmonary arterial hypertension with circulating angiogenic cells. Am J Physiol Lung Cell Mol Physiol. 2011 Jul; 301(1):L12-9. PMID: 21398496.
        View in: PubMed
      21. Boyle AJ, Shih H, Hwang J, Ye J, Lee B, Zhang Y, Kwon D, Jun K, Zheng D, Sievers R, Angeli F, Yeghiazarians Y, Lee R. Cardiomyopathy of aging in the mammalian heart is characterized by myocardial hypertrophy, fibrosis and a predisposition towards cardiomyocyte apoptosis and autophagy. Exp Gerontol. 2011 Jul; 46(7):549-59. PMID: 21377520; PMCID: PMC3104129.
      22. Gaur M, Ritner C, Sievers R, Pedersen A, Prasad M, Bernstein HS, Yeghiazarians Y. Timed inhibition of p38MAPK directs accelerated differentiation of human embryonic stem cells into cardiomyocytes. Cytotherapy. 2010 Oct; 12(6):807-17. PMID: 20586669; PMCID: PMC2946443.
      23. Zhang Y, Sievers RE, Prasad M, Mirsky R, Shih H, Wong ML, Angeli FS, Ye J, Takagawa J, Koskenvuo JW, Springer ML, Grossman W, Boyle AJ, Yeghiazarians Y. Timing of bone marrow cell therapy is more important than repeated injections after myocardial infarction. Cardiovasc Pathol. 2011 Jul-Aug; 20(4):204-12. PMID: 20667749.
        View in: PubMed
      24. Yu J, Du KT, Fang Q, Gu Y, Mihardja SS, Sievers RE, Wu JC, Lee RJ. The use of human mesenchymal stem cells encapsulated in RGD modified alginate microspheres in the repair of myocardial infarction in the rat. Biomaterials. 2010 Sep; 31(27):7012-20. PMID: 20566215.
        View in: PubMed
      25. Mihardja SS, Gao D, Sievers RE, Fang Q, Feng J, Wang J, Vanbrocklin HF, Larrick JW, Huang M, Dae M, Lee RJ. Targeted in vivo extracellular matrix formation promotes neovascularization in a rodent model of myocardial infarction. PLoS One. 2010; 5(4):e10384. PMID: 20442783; PMCID: PMC2860995.
      26. Huang NF, Lam A, Fang Q, Sievers RE, Li S, Lee RJ. Bone marrow-derived mesenchymal stem cells in fibrin augment angiogenesis in the chronically infarcted myocardium. Regen Med. 2009 Jul; 4(4):527-38. PMID: 19580402; PMCID: PMC2778008.
      27. Yeghiazarians Y, Zhang Y, Prasad M, Shih H, Saini SA, Takagawa J, Sievers RE, Wong ML, Kapasi NK, Mirsky R, Koskenvuo J, Minasi P, Ye J, Viswanathan MN, Angeli FS, Boyle AJ, Springer ML, Grossman W. Injection of bone marrow cell extract into infarcted hearts results in functional improvement comparable to intact cell therapy. Mol Ther. 2009 Jul; 17(7):1250-6. PMID: 19384293; PMCID: PMC2835212.
      28. Yu J, Christman KL, Chin E, Sievers RE, Saeed M, Lee RJ. Restoration of left ventricular geometry and improvement of left ventricular function in a rodent model of chronic ischemic cardiomyopathy. J Thorac Cardiovasc Surg. 2009 Jan; 137(1):180-7. PMID: 19154923.
        View in: PubMed
      29. Yu J, Gu Y, Du KT, Mihardja S, Sievers RE, Lee RJ. The effect of injected RGD modified alginate on angiogenesis and left ventricular function in a chronic rat infarct model. Biomaterials. 2009 Feb; 30(5):751-6. PMID: 19010528.
        View in: PubMed
      30. Mihardja SS, Sievers RE, Lee RJ. The effect of polypyrrole on arteriogenesis in an acute rat infarct model. Biomaterials. 2008 Nov; 29(31):4205-10. PMID: 18678406; PMCID: PMC2572870.
      31. Li X, Tjwa M, Van Hove I, Enholm B, Neven E, Paavonen K, Jeltsch M, Juan TD, Sievers RE, Chorianopoulos E, Wada H, Vanwildemeersch M, Noel A, Foidart JM, Springer ML, von Degenfeld G, Dewerchin M, Blau HM, Alitalo K, Eriksson U, Carmeliet P, Moons L. Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium. Arterioscler Thromb Vasc Biol. 2008 Sep; 28(9):1614-20. PMID: 18511699; PMCID: PMC2753879.
      32. Heiss C, Sievers RE, Amabile N, Momma TY, Chen Q, Natarajan S, Yeghiazarians Y, Springer ML. In vivo measurement of flow-mediated vasodilation in living rats using high-resolution ultrasound. Am J Physiol Heart Circ Physiol. 2008 Feb; 294(2):H1086-93. PMID: 18055528.
        View in: PubMed
      33. Takagawa J, Zhang Y, Wong ML, Sievers RE, Kapasi NK, Wang Y, Yeghiazarians Y, Lee RJ, Grossman W, Springer ML. Myocardial infarct size measurement in the mouse chronic infarction model: comparison of area- and length-based approaches. J Appl Physiol (1985). 2007 Jun; 102(6):2104-11. PMID: 17347379; PMCID: PMC2675697.
      34. Lee RJ, Fang Q, Davol PA, Gu Y, Sievers RE, Grabert RC, Gall JM, Tsang E, Yee MS, Fok H, Huang NF, Padbury JF, Larrick JW, Lum LG. Antibody targeting of stem cells to infarcted myocardium. Stem Cells. 2007 Mar; 25(3):712-7. PMID: 17138964.
        View in: PubMed
      35. Zhang Y, Takagawa J, Sievers RE, Khan MF, Viswanathan MN, Springer ML, Foster E, Yeghiazarians Y. Validation of the wall motion score and myocardial performance indexes as novel techniques to assess cardiac function in mice after myocardial infarction. Am J Physiol Heart Circ Physiol. 2007 Feb; 292(2):H1187-92. PMID: 17028161.
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      36. Joho S, Ishizaka S, Sievers R, Foster E, Simpson PC, Grossman W. Left ventricular pressure-volume relationship in conscious mice. Am J Physiol Heart Circ Physiol. 2007 Jan; 292(1):H369-77. PMID: 16905597.
        View in: PubMed
      37. Huang NF, Sievers RE, Park JS, Fang Q, Li S, Lee RJ. A rodent model of myocardial infarction for testing the efficacy of cells and polymers for myocardial reconstruction. Nat Protoc. 2006; 1(3):1596-609. PMID: 17406452.
        View in: PubMed
      38. Huang NF, Yu J, Sievers R, Li S, Lee RJ. Injectable biopolymers enhance angiogenesis after myocardial infarction. Tissue Eng. 2005 Nov-Dec; 11(11-12):1860-6. PMID: 16411832.
        View in: PubMed
      39. Christman KL, Fang Q, Kim AJ, Sievers RE, Fok HH, Candia AF, Colley KJ, Herradon G, Ezquerra L, Deuel TF, Lee RJ. Pleiotrophin induces formation of functional neovasculature in vivo. Biochem Biophys Res Commun. 2005 Jul 15; 332(4):1146-52. PMID: 15949466.
        View in: PubMed
      40. Springer ML, Sievers RE, Viswanathan MN, Yee MS, Foster E, Grossman W, Yeghiazarians Y. Closed-chest cell injections into mouse myocardium guided by high-resolution echocardiography. Am J Physiol Heart Circ Physiol. 2005 Sep; 289(3):H1307-14. PMID: 15908468.
        View in: PubMed
      41. Christman KL, Fang Q, Yee MS, Johnson KR, Sievers RE, Lee RJ. Enhanced neovasculature formation in ischemic myocardium following delivery of pleiotrophin plasmid in a biopolymer. Biomaterials. 2005 Apr; 26(10):1139-44. PMID: 15451633.
        View in: PubMed
      42. Christman KL, Vardanian AJ, Fang Q, Sievers RE, Fok HH, Lee RJ. Injectable fibrin scaffold improves cell transplant survival, reduces infarct expansion, and induces neovasculature formation in ischemic myocardium. J Am Coll Cardiol. 2004 Aug 4; 44(3):654-60. PMID: 15358036.
        View in: PubMed
      43. Christman KL, Fok HH, Sievers RE, Fang Q, Lee RJ. Fibrin glue alone and skeletal myoblasts in a fibrin scaffold preserve cardiac function after myocardial infarction. Tissue Eng. 2004 Mar-Apr; 10(3-4):403-9. PMID: 15165457.
        View in: PubMed
      44. Lum LG, Fok H, Sievers R, Abedi M, Quesenberry PJ, Lee RJ. Targeting of Lin-Sca+ hematopoietic stem cells with bispecific antibodies to injured myocardium. Blood Cells Mol Dis. 2004 Jan-Feb; 32(1):82-7. PMID: 14757418.
        View in: PubMed
      45. Ishizaka S, Sievers RE, Zhu BQ, Rodrigo MC, Joho S, Foster E, Simpson PC, Grossman W. New technique for measurement of left ventricular pressure in conscious mice. Am J Physiol Heart Circ Physiol. 2004 Mar; 286(3):H1208-15. PMID: 14563661.
        View in: PubMed
      46. Zhu BQ, Heeschen C, Sievers RE, Karliner JS, Parmley WW, Glantz SA, Cooke JP. Second hand smoke stimulates tumor angiogenesis and growth. Cancer Cell. 2003 Sep; 4(3):191-6. PMID: 14522253.
        View in: PubMed
      47. Wu MC, Gao DW, Sievers RE, Lee RJ, Hasegawa BH, Dae MW. Pinhole single-photon emission computed tomography for myocardial perfusion imaging of mice. J Am Coll Cardiol. 2003 Aug 6; 42(3):576-82. PMID: 12906991.
        View in: PubMed
      48. Zhu BQ, Sievers RE, Browne AE, Lee RJ, Chatterjee K, Grossman W, Karliner JS, Parmley WW. Comparative effects of aspirin with ACE inhibitor or angiotensin receptor blocker on myocardial infarction and vascular function. J Renin Angiotensin Aldosterone Syst. 2003 Mar; 4(1):31-7. PMID: 12692751.
        View in: PubMed
      49. Altman PA, Sievers R, Lee R. Exploring heart lymphatics in local drug delivery. Lymphat Res Biol. 2003; 1(1):47-53; discussion 54. PMID: 15624321.
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      50. Zhu BQ, Sievers RE, Browne AE, Hillman RT, Chair K, Lee RJ, Chatterjee K, Glantz SA, Parmley WW. The renin-angiotensin system does not contribute to the endothelial dysfunction and increased infarct size in rats exposed to second hand smoke. J Renin Angiotensin Aldosterone Syst. 2002 Mar; 3(1):54-60. PMID: 11984749.
        View in: PubMed
      51. Hutchison SJ, Sievers RE, Zhu BQ, Sun YP, Stewart DJ, Parmley WW, Chatterjee K. Secondhand tobacco smoke impairs rabbit pulmonary artery endothelium-dependent relaxation. Chest. 2001 Dec; 120(6):2004-12. PMID: 11742935.
        View in: PubMed
      52. Sun YP, Zhu BQ, Browne AE, Sievers RE, Bekker JM, Chatterjee K, Parmley WW, Glantz SA. Nicotine does not influence arterial lipid deposits in rabbits exposed to second-hand smoke. Circulation. 2001 Aug 14; 104(7):810-4. PMID: 11502707.
        View in: PubMed
      53. Zhu B, Sun Y, Sievers RE, Browne AE, Lee RJ, Chatterjee K, Parmley WW. Effects of different durations of pretreatment with losartan on myocardial infarct size, endothelial function, and vascular endothelial growth factor. J Renin Angiotensin Aldosterone Syst. 2001 Jun; 2(2):129-33. PMID: 11881112.
        View in: PubMed
      54. Engler MB, Engler MM, Browne A, Sun YP, Sievers R. Mechanisms of vasorelaxation induced by eicosapentaenoic acid (20:5n-3) in WKY rat aorta. Br J Pharmacol. 2000 Dec; 131(8):1793-9. PMID: 11139460; PMCID: PMC1572512.
      55. Zhu B, Sun Y, Sievers RE, Browne AE, Pulukurthy S, Sudhir K, Lee RJ, Chou TM, Chatterjee K, Parmley WW. Comparative effects of pretreatment with captopril and losartan on cardiovascular protection in a rat model of ischemia-reperfusion. J Am Coll Cardiol. 2000 Mar 1; 35(3):787-95. PMID: 10716484.
        View in: PubMed
      56. Sievers RF, Tang AT, Haw MP. Complete surgical resection of intrapericardial teratoma in a neonate with compression of the central airways. Cardiol Young. 2000 Jan; 10(1):64-6. PMID: 10695546.
        View in: PubMed
      57. Hutchison SJ, Sudhir K, Sievers RE, Zhu BQ, Sun YP, Chou TM, Chatterjee K, Deedwania PC, Cooke JP, Glantz SA, Parmley WW. Effects of L-arginine on atherogenesis and endothelial dysfunction due to secondhand smoke. Hypertension. 1999 Jul; 34(1):44-50. PMID: 10406822.
        View in: PubMed
      58. Lee RJ, Sievers RE, Gallinghouse GJ, Ursell PC. Development of a model of complete heart block in rats. J Appl Physiol (1985). 1998 Aug; 85(2):758-63. PMID: 9688757.
        View in: PubMed
      59. Sun YP, Zhu BQ, Sievers RE, Norkus EP, Parmley WW, Deedwania PC. Effects of antioxidant vitamins C and E on atherosclerosis in lipid-fed rabbits. Cardiology. 1998 Mar; 89(3):189-94. PMID: 9570433.
        View in: PubMed
      60. Zhu BQ, Sun YP, Sudhir K, Sievers RE, Browne AE, Gao L, Hutchison SJ, Chou TM, Deedwania PC, Chatterjee K, Glantz SA, Parmley WW. Effects of second-hand smoke and gender on infarct size of young rats exposed in utero and in the neonatal to adolescent period. J Am Coll Cardiol. 1997 Dec; 30(7):1878-85. PMID: 9385922.
        View in: PubMed
      61. Piot CA, Padmanaban D, Ursell PC, Sievers RE, Wolfe CL. Ischemic preconditioning decreases apoptosis in rat hearts in vivo. Circulation. 1997 Sep 2; 96(5):1598-604. PMID: 9315553.
        View in: PubMed
      62. Hutchison SJ, Reitz MS, Sudhir K, Sievers RE, Zhu BQ, Sun YP, Chou TM, Deedwania PC, Chatterjee K, Glantz SA, Parmley WW. Chronic dietary L-arginine prevents endothelial dysfunction secondary to environmental tobacco smoke in normocholesterolemic rabbits. Hypertension. 1997 May; 29(5):1186-91. PMID: 9149685.
        View in: PubMed
      63. Hutchison SJ, Sudhir K, Chou TM, Sievers RE, Zhu BQ, Sun YP, Deedwania PC, Glantz SA, Parmley WW, Chatterjee K. Testosterone worsens endothelial dysfunction associated with hypercholesterolemia and environmental tobacco smoke exposure in male rabbit aorta. J Am Coll Cardiol. 1997 Mar 15; 29(4):800-7. PMID: 9091527.
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      64. Hutter JJ, Mestril R, Tam EK, Sievers RE, Dillmann WH, Wolfe CL. Overexpression of heat shock protein 72 in transgenic mice decreases infarct size in vivo. Circulation. 1996 Sep 15; 94(6):1408-11. PMID: 8823000.
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      65. Zhu B, Sun Y, Sievers RE, Shuman JL, Glantz SA, Chatterjee K, Parmley WW, Wolfe CL. L-arginine decreases infarct size in rats exposed to environmental tobacco smoke. Am Heart J. 1996 Jul; 132(1 Pt 1):91-100. PMID: 8701882.
        View in: PubMed
      66. Barbosa V, Sievers RE, Zaugg CE, Wolfe CL. Preconditioning ischemia time determines the degree of glycogen depletion and infarct size reduction in rat hearts. Am Heart J. 1996 Feb; 131(2):224-30. PMID: 8579012.
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      67. Auyeung Y, Sievers RE, Weng D, Barbosa V, Wolfe CL. Catalase inhibition with 3-amino-1,2,4-triazole does not abolish infarct size reduction in heat-shocked rats. Circulation. 1995 Dec 1; 92(11):3318-22. PMID: 7586320.
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      68. Sun YP, Zhu BQ, Sievers RE, Glantz SA, Parmley WW. Metoprolol does not attenuate atherosclerosis in lipid-fed rabbits exposed to environmental tobacco smoke. Circulation. 1994 May; 89(5):2260-5. PMID: 8181151.
        View in: PubMed
      69. Zhu BQ, Sievers RE, Sun YP, Morse-Fisher N, Parmley WW, Wolfe CL. Is the reduction of myocardial infarct size by dietary fish oil the result of altered platelet function? Am Heart J. 1994 Apr; 127(4 Pt 1):744-55. PMID: 8154411.
        View in: PubMed
      70. Zhu BQ, Sun YP, Sievers RE, Glantz SA, Parmley WW, Wolfe CL. Exposure to environmental tobacco smoke increases myocardial infarct size in rats. Circulation. 1994 Mar; 89(3):1282-90. PMID: 8124817.
        View in: PubMed
      71. Hutter MM, Sievers RE, Barbosa V, Wolfe CL. Heat-shock protein induction in rat hearts. A direct correlation between the amount of heat-shock protein induced and the degree of myocardial protection. Circulation. 1994 Jan; 89(1):355-60. PMID: 8281669.
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      72. Zhu BQ, Sun YP, Sievers RE, Isenberg WM, Moorehead TJ, Parmley WW. Effects of etidronate and lovastatin on the regression of atherosclerosis in cholesterol-fed rabbits. Cardiology. 1994; 85(6):370-7. PMID: 7697672.
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      73. Levitt MA, Sievers RE, Wolfe CL. Reduction of infarct size during myocardial ischemia and reperfusion by lazaroid U-74500A, a nonglucocorticoid 21-aminosteroid. J Cardiovasc Pharmacol. 1994 Jan; 23(1):136-40. PMID: 7511726.
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      74. Wolfe CL, O'Connell JW, Sievers RE, Cobb C, Dae MW, Botvinick E. Assessment of perfused left ventricular mass in normal, ischemic, and reperfused myocardium by means of single-photon emission computed tomography of technetium-99m isonitrile. Am Heart J. 1993 Dec; 126(6):1275-86. PMID: 8249782.
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      75. Wolfe CL, Sievers RE, Visseren FL, Donnelly TJ. Loss of myocardial protection after preconditioning correlates with the time course of glycogen recovery within the preconditioned segment. Circulation. 1993 Mar; 87(3):881-92. PMID: 8443909.
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      76. Sun YP, Zhu BQ, Sievers RE, Isenberg WM, Parmley WW. Aspirin inhibits platelet activity but does not attenuate experimental atherosclerosis. Am Heart J. 1993 Jan; 125(1):79-86. PMID: 8417546.
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      77. Zhu BQ, Sun YP, Sievers RE, Isenberg WM, Glantz SA, Parmley WW. Passive smoking increases experimental atherosclerosis in cholesterol-fed rabbits. J Am Coll Cardiol. 1993 Jan; 21(1):225-32. PMID: 8417066.
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      78. Gould R, Brasch RC, Sievers R, Baxter A, Aicher K. Comparison of vascular opacification after bolus injection of iodixanol-320 iohexol-350. Invest Radiol. 1992 Dec; 27(12):1031-4. PMID: 1473920.
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      79. Vexler VS, Berthezène Y, Wolfe CL, Sievers R, Dupon JW, Aicher K, Moseley ME, Brasch RC. Magnetic resonance imaging demonstration of pharmacologic-induced myocardial vasodilatation using a macromolecular gadolinium contrast agent. Invest Radiol. 1992 Nov; 27(11):935-41. PMID: 1464513.
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      80. Donnelly TJ, Sievers RE, Vissern FL, Welch WJ, Wolfe CL. Heat shock protein induction in rat hearts. A role for improved myocardial salvage after ischemia and reperfusion? Circulation. 1992 Feb; 85(2):769-78. PMID: 1735169.
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      81. Zhu BQ, Sievers RE, Sun YP, Isenberg WM, Parmley WW. Effect of lovastatin on suppression and regression of atherosclerosis in lipid-fed rabbits. J Cardiovasc Pharmacol. 1992 Feb; 19(2):246-55. PMID: 1376794.
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      82. Berthezene Y, Vexler V, Jerome H, Sievers R, Moseley ME, Brasch RC. Differentiation of capillary leak and hydrostatic pulmonary edema with a macromolecular MR imaging contrast agent. Radiology. 1991 Dec; 181(3):773-7. PMID: 1947095.
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      83. Wolfe CL, Donnelly TJ, Sievers R, Parmley WW. Myocardial protection with verapamil during ischaemia and reperfusion: dissociation between myocardial salvage and the degree of ATP depletion during ischaemia. Cardiovasc Res. 1991 Feb; 25(2):101-9. PMID: 1742760.
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      84. Jaschke W, Sievers RS, Lipton MJ, Cogan MG. Cine-computed tomographic assessment of regional renal blood flow. Acta Radiol. 1990 Jan; 31(1):77-81. PMID: 2340226.
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      85. Zhu BQ, Sievers RE, Isenberg WM, Smith DL, Parmley WW. Regression of atherosclerosis in cholesterol-fed rabbits: effects of fish oil and verapamil. J Am Coll Cardiol. 1990 Jan; 15(1):231-7. PMID: 2136876.
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      86. Wolfe CL, Moseley ME, Wikstrom MG, Sievers RE, Wendland MF, Dupon JW, Finkbeiner WE, Lipton MJ, Parmley WW, Brasch RC. Assessment of myocardial salvage after ischemia and reperfusion using magnetic resonance imaging and spectroscopy. Circulation. 1989 Oct; 80(4):969-82. PMID: 2791255.
        View in: PubMed
      87. Sievers RE, Schmiedl U, Wolfe CL, Moseley ME, Parmley WW, Brasch RC, Lipton MJ. A model of acute regional myocardial ischemia and reperfusion in the rat. Magn Reson Med. 1989 May; 10(2):172-81. PMID: 2761378.
        View in: PubMed
      88. Watters T, Wikman-Coffelt J, Wu S, James TL, Sievers R, Parmley WW. Effects of perfusion pressure on energy and work of isolated rat hearts. Hypertension. 1989 May; 13(5):480-8. PMID: 2722227.
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      89. Schmiedl U, Sievers RE, Brasch RC, Wolfe CL, Chew WM, Ogan MD, Engeseth H, Lipton MJ, Moseley ME. Acute myocardial ischemia and reperfusion: MR imaging with albumin-Gd-DTPA. Radiology. 1989 Feb; 170(2):351-6. PMID: 2911657.
        View in: PubMed
      90. Zhu BQ, Smith DL, Sievers RE, Isenberg WM, Parmley WW. Inhibition of atherosclerosis by fish oil in cholesterol-fed rabbits. J Am Coll Cardiol. 1988 Oct; 12(4):1073-8. PMID: 3417980.
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      91. Gould RG, Lipton MJ, McNamara MT, Sievers RE, Koshold S, Higgins CB. Measurement of regional myocardial blood flow in dogs by ultrafast CT. Invest Radiol. 1988 May; 23(5):348-53. PMID: 3384614.
        View in: PubMed
      92. Camacho SA, Parmley WW, James TL, Abe H, Wu ST, Botvinick EH, Watters TA, Schiller N, Sievers R, Wikman-Coffelt J. Substrate regulation of the nucleotide pool during regional ischaemia and reperfusion in an isolated rat heart preparation: a phosphorus-31 magnetic resonance spectroscopy analysis. Cardiovasc Res. 1988 Mar; 22(3):193-203. PMID: 3167943.
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      93. Camacho SA, Wikman-Coffelt J, Wu ST, Watters TA, Botvinick EH, Sievers R, James TL, Jasmin G, Parmley WW. Improvement in myocardial performance without a decrease in high-energy phosphate metabolites after isoproterenol in Syrian cardiomyopathic hamsters. Circulation. 1988 Mar; 77(3):712-9. PMID: 3342496.
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      94. Auffermann W, Wu S, Parmley WW, Higgins CB, Sievers R, Wikman-Coffelt J. Reversibility of acute alcohol cardiac depression: 31P NMR in hamsters. FASEB J. 1988 Mar 1; 2(3):256-63. PMID: 3350237.
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      95. Markiewicz W, Wu SS, Sievers R, Parmley WW, Watters TA, James TL, Higgins CB, Wikman-Coffelt J. Beneficial effects of verapamil during metabolic acidosis in isolated perfused rat hearts. Cardiovasc Drugs Ther. 1988 Jan; 1(5):493-502. PMID: 3154678.
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      96. Ringertz HG, Jaschke W, Sievers R, Lipton MJ. Relative carotid blood flow measurements in dogs by high-speed CT. A preliminary study. Invest Radiol. 1987 Dec; 22(12):960-4. PMID: 3440730.
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      97. Watters TA, Wendland MF, Parmley WW, James TL, Botvinick EH, Wu ST, Sievers R, Wikman-Coffelt J. Factors influencing myocardial response to metabolic acidosis in isolated rat hearts. Am J Physiol. 1987 Nov; 253(5 Pt 2):H1261-70. PMID: 3688265.
        View in: PubMed
      98. Bouchard A, Watters TA, Wu S, Parmley WW, Stone RD, Botvinick E, Sievers R, Jasmin G, Wikman-Coffelt J. Effects of altered coronary perfusion pressure on function and metabolism of normal and cardiomyopathic hamster hearts. J Mol Cell Cardiol. 1987 Oct; 19(10):1011-23. PMID: 3437452.
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      99. Tubau JF, Wikman-Coffelt J, Massie BM, Sievers R, Parmley WW. Improved myocardial efficiency in the working perfused heart of the spontaneously hypertensive rat. Hypertension. 1987 Oct; 10(4):396-403. PMID: 3653968.
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      100. Jaschke WR, Gould RG, Cogan MG, Sievers R, Lipton MJ. Cine-CT measurement of cortical renal blood flow. J Comput Assist Tomogr. 1987 Sep-Oct; 11(5):779-84. PMID: 3308987.
        View in: PubMed
      101. Schmiedl U, Moseley ME, Sievers R, Ogan MD, Chew WM, Engeseth H, Finkbeiner WE, Lipton MJ, Brasch RC. Magnetic resonance imaging of myocardial infarction using albumin-(Gd-DTPA), a macromolecular blood-volume contrast agent in a rat model. Invest Radiol. 1987 Sep; 22(9):713-21. PMID: 3679762.
        View in: PubMed
      102. Markiewicz W, Wu S, Sievers R, Parmley WW, Higgins CB, James TL, Jasmin G, Wikman-Coffelt J. Influence of heart rate on metabolic and hemodynamic parameters in the Syrian hamster cardiomyopathy. Am Heart J. 1987 Aug; 114(2):362-8. PMID: 3604893.
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      103. Tubau JF, Wikman-Coffelt J, Massie BM, Szlachcic J, Parmley WW, Sievers R, Henderson S. Diltiazem prevents hypertrophy progression, preserves systolic function, and normalises myocardial oxygen utilisation in the spontaneously hypertensive rat. Cardiovasc Res. 1987 Aug; 21(8):606-14. PMID: 2965615.
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      104. Richards TL, Terrier F, Sievers RE, Lipton MJ, Moseley ME, Higgins CB. Lactate accumulation in ischemic- and anoxic-isolated rat hearts assessed by H-1 spectroscopy. Invest Radiol. 1987 Aug; 22(8):638-41. PMID: 3667170.
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      105. Garrett JS, Wikman-Coffelt J, Sievers R, Finkbeiner WE, Parmley WW. Verapamil prevents the development of alcoholic dysfunction in hamster myocardium. J Am Coll Cardiol. 1987 Jun; 9(6):1326-31. PMID: 3584721.
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      106. Wu S, White R, Wikman-Coffelt J, Sievers R, Wendland M, Garrett J, Higgins CB, James T, Parmley WW. The preventive effect of verapamil on ethanol-induced cardiac depression: phosphorus-31 nuclear magnetic resonance and high-pressure liquid chromatographic studies of hamsters. Circulation. 1987 May; 75(5):1058-64. PMID: 3568306.
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      107. Jünemann M, Smiseth OA, Refsum H, Sievers R, Lipton MJ, Carlsson E, Tyberg JV. Quantification of effect of pericardium on LV diastolic PV relation in dogs. Am J Physiol. 1987 May; 252(5 Pt 2):H963-8. PMID: 2437808.
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      108. Jaschke W, Cogan MG, Sievers R, Gould R, Lipton MJ. Measurement of renal blood flow by cine computed tomography. Kidney Int. 1987 Apr; 31(4):1038-42. PMID: 3586494.
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      109. Sievers RE, Rashid T, Garrett J, Blumlein S, Parmley WW. Verapamil and diet halt progression of atherosclerosis in cholesterol fed rabbits. Cardiovasc Drugs Ther. 1987; 1(1):65-9. PMID: 3154310.
        View in: PubMed
      110. Markiewicz W, Wu SS, Parmley WW, Higgins CB, Sievers R, James TL, Wikman-Coffelt J, Jasmin G. Evaluation of the hereditary Syrian hamster cardiomyopathy by 31P nuclear magnetic resonance spectroscopy: improvement after acute verapamil therapy. Circ Res. 1986 Dec; 59(6):597-604. PMID: 3815756.
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      111. Lanzer P, Garrett J, Lipton MJ, Gould R, Sievers R, O'Connell W, Botvinick E, Higgins CB. Quantitation of regional myocardial function by cine computed tomography: pharmacologic changes in wall thickness. J Am Coll Cardiol. 1986 Sep; 8(3):682-92. PMID: 3745717.
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      112. Wikman-Coffelt J, Sievers R, Parmley WW, Jasmin G. Cardiomyopathic and healthy acidotic hamster hearts: mitochondrial activity may regulate cardiac performance. Cardiovasc Res. 1986 Jul; 20(7):471-81. PMID: 3779743.
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      113. Wikman-Coffelt J, Sievers R, Parmley WW, Jasmin G. Verapamil preserves adenine nucleotide pool in cardiomyopathic Syrian hamster. Am J Physiol. 1986 Jan; 250(1 Pt 2):H22-8. PMID: 3942235.
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      114. Jaschke W, Lipton MJ, Boyd D, Moss AA, Cann C, Goldberg HI, Margulis AR, Sievers R. Dynamic CT scanning of the normal canine liver: interpretation of time density curves resulting from an intravenous bolus injection of contrast material. Eur J Radiol. 1985 Nov; 5(4):256-60. PMID: 2935396.
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      115. Lanzer P, Dean PB, Lipton MJ, Sievers R, Botvinick E, Higgins CB. Effects of intravenous administration of a new nonionic dimeric contrast medium on the coronary circulation. Comparison with monomeric ionic and nonionic media. Invest Radiol. 1985 Oct; 20(7):746-50. PMID: 4066245.
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      116. Garrett JS, Lanzer P, Jaschke W, Botvinick E, Sievers R, Higgins CB, Lipton MJ. Measurement of cardiac output by cine computed tomography. Am J Cardiol. 1985 Oct 1; 56(10):657-61. PMID: 3901722.
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      117. McNamara MT, Wesbey GE, Brasch RC, Sievers R, Lipton MJ, Higgins CB. Magnetic resonance imaging of acute myocardial infarction using a nitroxyl spin label (PCA). Invest Radiol. 1985 Sep; 20(6):591-5. PMID: 4066230.
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      118. Wikman-Coffelt J, Sievers R, Parmley WW. Influence of myocardial isomyosins on cardiac performance and oxygen consumption. Biochem Biophys Res Commun. 1985 Aug 15; 130(3):1314-23. PMID: 4026865.
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      119. Blumlein SL, Sievers R, Wikman-Coffelt J, Parmley WW, Rouleau JL. Effects of ryanodine on cat papillary muscle and isolated rat heart. Am Heart J. 1985 Aug; 110(2):386-94. PMID: 2992260.
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      120. Farmer D, Lipton MJ, Higgins CB, Ringertz H, Dean PB, Sievers R, Boyd DP. In vivo assessment of left ventricular wall and chamber dynamics during transient myocardial ischemia using cine computed tomography. Am J Cardiol. 1985 Feb 15; 55(5):560-5. PMID: 3969899.
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      121. Parmley WW, Blumlein S, Sievers R. Modification of experimental atherosclerosis by calcium-channel blockers. Am J Cardiol. 1985 Jan 25; 55(3):165B-171B. PMID: 3881909.
        View in: PubMed
      122. Blumlein SL, Sievers R, Kidd P, Parmley WW. Mechanism of protection from atherosclerosis by verapamil in the cholesterol-fed rabbit. Am J Cardiol. 1984 Oct 1; 54(7):884-9. PMID: 6486041.
        View in: PubMed
      123. Wesbey GE, Higgins CB, McNamara MT, Engelstad BL, Lipton MJ, Sievers R, Ehman RL, Lovin J, Brasch RC. Effect of gadolinium-DTPA on the magnetic relaxation times of normal and infarcted myocardium. Radiology. 1984 Oct; 153(1):165-9. PMID: 6473778.
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      124. McNamara MT, Higgins CB, Ehman RL, Revel D, Sievers R, Brasch RC. Acute myocardial ischemia: magnetic resonance contrast enhancement with gadolinium-DTPA. Radiology. 1984 Oct; 153(1):157-63. PMID: 6473777.
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      125. Chuck LH, Refsum H, Rouleau JL, Mathey D, Sievers RE, Parmley WW. Direct pharmacologic and osmolal effects of contrast media on the mechanics of heart muscle isolated from cats. Am Heart J. 1984 Jul; 108(1):97-104. PMID: 6428210.
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      126. Jaschke W, Lipton M, Cann C, Sievers R. [Imaging of blood flow-dependent curve parameters in the course of sequential computed tomography of the kidneys following intravenous injection of a contrast bolus]. Rofo. 1984 Jul; 141(1):1-7. PMID: 6431504.
        View in: PubMed
      127. Smiseth OA, Refsum H, Junemann M, Sievers RE, Lipton MJ, Carlsson E, Tyberg JV. Ventricular diastolic pressure-volume shifts during acute ischemic left ventricular failure in dogs. J Am Coll Cardiol. 1984 Apr; 3(4):966-77. PMID: 6707361.
        View in: PubMed
      128. Sievers R, Parmley WW, James T, Wikman-Coffelt J. Energy levels at systole vs. diastole in normal hamster hearts vs. myopathic hamster hearts. Circ Res. 1983 Dec; 53(6):759-66. PMID: 6640862.
        View in: PubMed
      129. Wikman-Coffelt J, Coffelt RJ, Rapcsak M, Sievers R, Rouleau JL, Parmley WW. A new apex-ejecting perfused rat heart preparation: relation between coronary flow and loading conditions. Cardiovasc Res. 1983 Dec; 17(12):747-55. PMID: 6661747.
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      130. Blumlein S, Sievers R, Wikman-Coffelt J, Parmley WW. Lack of decreased contractility in hearts from atherosclerotic rabbits. Am Heart J. 1983 Dec; 106(6):1383-8. PMID: 6650360.
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      131. Wikman-Coffelt J, Sievers R, Coffelt RJ, Parmley WW. The cardiac cycle: regulation and energy oscillations. Am J Physiol. 1983 Aug; 245(2):H354-62. PMID: 6881368.
        View in: PubMed
      132. Higgins CB, Herfkens R, Lipton MJ, Sievers R, Sheldon P, Kaufman L, Crooks LE. Nuclear magnetic resonance imaging of acute myocardial infarction in dogs: alterations in magnetic relaxation times. Am J Cardiol. 1983 Jul; 52(1):184-8. PMID: 6858909.
        View in: PubMed
      133. Rouleau JL, Parmley WW, Stevens J, Wikman-Coffelt J, Sievers R, Mahley RW, Havel RJ. Verapamil suppresses atherosclerosis in cholesterol-fed rabbits. J Am Coll Cardiol. 1983 Jun; 1(6):1453-60. PMID: 6304174.
        View in: PubMed
      134. Herfkens RJ, Sievers R, Kaufman L, Sheldon PE, Ortendahl DA, Lipton MJ, Crooks LE, Higgins CB. Nuclear magnetic resonance imaging of the infarcted muscle: a rat model. Radiology. 1983 Jun; 147(3):761-4. PMID: 6844611.
        View in: PubMed
      135. Linderer T, Chatterjee K, Parmley WW, Sievers RE, Glantz SA, Tyberg JV. Influence of atrial systole on the Frank-Starling relation and the end-diastolic pressure-diameter relation of the left ventricle. Circulation. 1983 May; 67(5):1045-53. PMID: 6831669.
        View in: PubMed
      136. Wikman-Coffelt J, Sievers R, Coffelt RJ, Parmley WW. Oscillations of cAMP with the cardiac cycle. Biochem Biophys Res Commun. 1983 Mar 16; 111(2):450-5. PMID: 6301471.
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      137. Wikman-Coffelt J, Rapcsak M, Sievers R, Rouleau JL, Parmley WW. Verapamil, propranolol, and hydralazine protect against the acute cardiac depression induced by adriamycin. Cardiovasc Res. 1983 Jan; 17(1):43-9. PMID: 6850716.
        View in: PubMed
      138. Rouleau JL, Chuck LH, Hollosi G, Kidd P, Sievers RE, Wikman-Coffelt J, Parmley WW. Verapamil preserves myocardial contractility in the hereditary cardiomyopathy of the Syrian hamster. Circ Res. 1982 Mar; 50(3):405-12. PMID: 6460569.
        View in: PubMed
      139. Thomas HA, Sievers RE. The cuatico aspiration cannula as a depth guide during myelography. Radiology. 1979 Dec; 133(3 Pt 1):796-7. PMID: 583075.
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