Sign in to see private stats on your profile page — or add photo, interests, videos, mentoring, etc.

    Richard Guy, PhD

    TitleProfessor
    SchoolUCSF School of Pharmacy
    DepartmentBioengineering
    Address401 Parnassus Ave, LangPorter
    San Francisco CA 94143
    Phone441-225-3849x01
    vCardDownload vCard

      Collapse Overview 
      Collapse Overview
      Richard Guy received an M.A. in Chemistry from Oxford University, and his Ph.D. in Pharmaceutical Chemistry from the University of London. He has held academic posts at the University of California, San Francisco (where he remains an Adjunct Professor) and the University of Geneva. In 2004, he joined the University of Bath as Professor of Pharmaceutical Sciences, and he currently serves as the Chair of the Research Committee of the Department of Pharmacy & Pharmacology. Dr. Guy is an elected fellow of the Academy of Pharmaceutical Scientists, Great Britain, the Royal Society of Chemistry, the Controlled Release Society, the American Association of Pharmaceutical Scientists, and the American Association for the Advancement of Science.

      Dr. Guy's research focuses on skin barrier function characterization, transdermal drug delivery, enhancement of percutaneous absorption, iontophoresis, noninvasive biosensing, and the prediction and assessment of skin penetration and topical bioavailability. Dr. Guy has published 300+ peer-reviewed articles and over 70 book chapters. He has co-authored one book and co-edited 7 others. He is also co-inventor of 12 patents. Specific ongoing projects include: measurement of the skin's biomechanical properties at the nanoscale using atomic force microscopy; the detection and quantification of skin barrier disruption by surfactants found in commonly used cosmetic, personal care and pharmaceutical products; the potential of polymeric film-forming systems as sustained release platforms for topical drugs; determination of the disposition of drug and formulation excipients (including nanoparticles) post-application to the skin using coherent Raman scattering and confocal microscopy; identification of skin-penetrating constituents of traditional, topical Thai medicines and their re-formulation; development of an integrated iontophoretic delivery system for buprenorphine and naltrexone to treat polydrug abuse; examination of a graphene-based biosensor for noninvasive, transdermal glucose monitoring; and derivation and evaluation of predictive models of percutaneous penetration for pharmaceutical and cosmetic 'actives', and for potentially toxic chemicals, which come into contact with skin.


      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Celebi D, Guy RH, Edler KJ, Scott JL. Ibuprofen delivery into and through the skin from novel oxidized cellulose-based gels and conventional topical formulations. Int J Pharm. 2016 Nov 30; 514(1):238-243. PMID: 27863667.
        View in: PubMed
      2. Ridd MJ, Garfield K, Gaunt DM, Hollinghurst S, Redmond NM, Powell K, Wilson V, Guy RH, Ball N, Shaw L, Purdy S, Metcalfe C. Choice of Moisturiser for Eczema Treatment (COMET): feasibility study of a randomised controlled parallel group trial in children recruited from primary care. BMJ Open. 2016 Nov 16; 6(11):e012021. PMID: 27852708.
        View in: PubMed
      3. Rzhevskiy AS, Guy RH, Anissimov YG. Modelling drug flux through microporated skin. J Control Release. 2016 Nov 10; 241:194-199. PMID: 27686580.
        View in: PubMed
      4. Celebi D, Guy RH, Edler KJ, Scott JL. Ibuprofen delivery into and through the skin from novel oxidized cellulose-based gels and conventional topical formulations. Int J Pharm. 2016 Sep 20. PMID: 27863988.
        View in: PubMed
      5. Oakland K, Guy R, Uberoi R, Seeney F, Collins G, Grant-Casey J, Mortensen N, Murphy M, Jairath V. Study protocol: first nationwide comparative audit of acute lower gastrointestinal bleeding in the UK. BMJ Open. 2016; 6(8):e011752. PMID: 27491671; PMCID: PMC4985848.
      6. Guy R. Diagnostic devices: Managing diabetes through the skin. Nat Nanotechnol. 2016 Jun; 11(6):493-4. PMID: 26999480.
        View in: PubMed
      7. Smith KS, Kaldor JM, Hocking JS, Jamil MS, McNulty AM, Read P, Bradshaw CS, Chen MY, Fairley CK, Wand H, Worthington K, Blake S, Knight V, Rawlinson W, Saville M, Tabrizi SN, Garland SM, Donovan B, Guy R. The acceptability and cost of a home-based chlamydia retesting strategy: findings from the REACT randomised controlled trial. BMC Public Health. 2016; 16:83. PMID: 26822715; PMCID: PMC4730759.
      8. Williams FM, Rothe H, Barrett G, Chiodini A, Whyte J, Cronin MT, Monteiro-Riviere NA, Plautz J, Roper C, Westerhout J, Yang C, Guy RH. Assessing the safety of cosmetic chemicals: Consideration of a flux decision tree to predict dermally delivered systemic dose for comparison with oral TTC (Threshold of Toxicological Concern). Regul Toxicol Pharmacol. 2016 Apr; 76:174-86. PMID: 26825378.
        View in: PubMed
      9. Frederiksen K, Guy RH, Petersson K. The potential of polymeric film-forming systems as sustained delivery platforms for topical drugs. Expert Opin Drug Deliv. 2016 Mar; 13(3):349-60. PMID: 26609868.
        View in: PubMed
      10. González-Sánchez MI, Lee PT, Guy RH, Compton RG. In situ detection of salicylate in Ocimum basilicum plant leaves via reverse iontophoresis. Chem Commun (Camb). 2015 Nov 5; 51(92):16534-6. PMID: 26419728.
        View in: PubMed
      11. Chiu WS, Belsey NA, Garrett NL, Moger J, Price GJ, Delgado-Charro MB, Guy RH. Drug delivery into microneedle-porated nails from nanoparticle reservoirs. J Control Release. 2015 Dec 28; 220(Pt A):98-106. PMID: 26478016.
        View in: PubMed
      12. Garvie-Cook H, Stone JM, Yu F, Guy RH, Gordeev SN. Femtosecond pulsed laser ablation to enhance drug delivery across the skin. J Biophotonics. 2016 Jan; 9(1-2):144-54. PMID: 26449289.
        View in: PubMed
      13. Gelfuso GM, Barros MA, Delgado-Charro MB, Guy RH, Lopez RF. Iontophoresis of minoxidil sulphate loaded microparticles, a strategy for follicular drug targeting? Colloids Surf B Biointerfaces. 2015 Oct 1; 134:408-12. PMID: 26222406.
        View in: PubMed
      14. Garvie-Cook H, Frederiksen K, Petersson K, Guy RH, Gordeev SN. Biophysical elucidation of the mechanism of enhanced drug release and topical delivery from polymeric film-forming systems. J Control Release. 2015 Aug 28; 212:103-12. PMID: 26087467.
        View in: PubMed
      15. Chiu WS, Belsey NA, Garrett NL, Moger J, Delgado-Charro MB, Guy RH. Molecular diffusion in the human nail measured by stimulated Raman scattering microscopy. Proc Natl Acad Sci U S A. 2015 Jun 23; 112(25):7725-30. PMID: 26056283; PMCID: PMC4485099 [Available on 12/23/15].
      16. Gainza G, Chu WS, Guy RH, Pedraz JL, Hernandez RM, Delgado-Charro B, Igartua M. Development and in vitro evaluation of lipid nanoparticle-based dressings for topical treatment of chronic wounds. Int J Pharm. 2015 Jul 25; 490(1-2):404-11. PMID: 26043822.
        View in: PubMed
      17. Clarke JF, Cordery SF, Morgan NA, Knowles PK, Guy RH. In Vitro Method to Quantify Dermal Absorption of Pesticide Residues. Chem Res Toxicol. 2015 Feb 16; 28(2):166-8. PMID: 25647690.
        View in: PubMed
      18. Garvie-Cook H, Frederiksen K, Petersson K, Guy RH, Gordeev S. Characterization of topical film-forming systems using atomic force microscopy and Raman microspectroscopy. Mol Pharm. 2015 Mar 2; 12(3):751-7. PMID: 25586343.
        View in: PubMed
      19. Frederiksen K, Guy RH, Petersson K. Formulation considerations in the design of topical, polymeric film-forming systems for sustained drug delivery to the skin. Eur J Pharm Biopharm. 2015 Apr; 91:9-15. PMID: 25595740.
        View in: PubMed
      20. Abernethy JK, Johnson AP, Guy R, Hinton N, Sheridan EA, Hope RJ. Thirty day all-cause mortality in patients with Escherichia coli bacteraemia in England. Clin Microbiol Infect. 2015 Mar; 21(3):251.e1-8. PMID: 25698659.
        View in: PubMed
      21. Thitilertdecha P, Rowan MG, Guy RH. Topical formulation and dermal delivery of active phenolic compounds in the Thai medicinal plant - Clerodendrum petasites S. Moore. Int J Pharm. 2015 Jan 15; 478(1):39-45. PMID: 25445977.
        View in: PubMed
      22. Djabri A, Van't Hoff W, Brock P, Wong IC, Guy RH, Delgado-Charro MB. Iontophoretic transdermal sampling of iohexol as a non-invasive tool to assess glomerular filtration rate. Pharm Res. 2015 Feb; 32(2):590-603. PMID: 25190007.
        View in: PubMed
      23. Yang Q, Guy RH. Characterisation of skin barrier function using bioengineering and biophysical techniques. Pharm Res. 2015 Feb; 32(2):445-57. PMID: 25092069.
        View in: PubMed
      24. Wiedersberg S, Guy RH. Transdermal drug delivery: 30+ years of war and still fighting! J Control Release. 2014 Sep 28; 190:150-6. PMID: 24852092.
        View in: PubMed
      25. Guy RH, Kuma H, Nakanishi M. Serious photocontact dermatitis induced by topical ketoprofen depends on the formulation. Eur J Dermatol. 2014 May-Jun; 24(3):365-71. PMID: 24721981.
        View in: PubMed
      26. Thitilertdecha P, Guy RH, Rowan MG. Characterisation of polyphenolic compounds in Clerodendrum petasites S. Moore and their potential for topical delivery through the skin. J Ethnopharmacol. 2014 Jun 11; 154(2):400-7. PMID: 24747028.
        View in: PubMed
      27. Ris F, Hompes R, Cunningham C, Lindsey I, Guy R, Jones O, George B, Cahill RA, Mortensen NJ. Near-infrared (NIR) perfusion angiography in minimally invasive colorectal surgery. Surg Endosc. 2014 Jul; 28(7):2221-6. PMID: 24566744; PMCID: PMC4065377.
      28. Guy RH. Interview with Richard H Guy by Hannah Coaker. Ther Deliv. 2014 Feb; 5(2):123-8. PMID: 24483191.
        View in: PubMed
      29. Delgado-Charro MB, Guy RH. Effective use of transdermal drug delivery in children. Adv Drug Deliv Rev. 2014 Jun; 73:63-82. PMID: 24333231.
        View in: PubMed
      30. Belsey NA, Garrett NL, Contreras-Rojas LR, Pickup-Gerlaugh AJ, Price GJ, Moger J, Guy RH. Evaluation of drug delivery to intact and porated skin by coherent Raman scattering and fluorescence microscopies. J Control Release. 2014 Jan 28; 174:37-42. PMID: 24231405.
        View in: PubMed
      31. Güngör S, Delgado-Charro MB, Masini-Etévé V, Potts RO, Guy RH. Transdermal flux predictions for selected selective oestrogen receptor modulators (SERMs): comparison with experimental results. J Control Release. 2013 Dec 28; 172(3):601-6. PMID: 24076520.
        View in: PubMed
      32. Guy RH. Skin--'that unfakeable young surface'. Skin Pharmacol Physiol. 2013; 26(4-6):181-9. PMID: 23921104.
        View in: PubMed
      33. Ridd M, Guy R, Ball N, Roberts A, Williams H. Products in "Bounty bags" potentially harm newborn skin. BMJ. 2013; 346:f3895. PMID: 23778276.
        View in: PubMed
      34. Benzeval I, Bowen CR, Guy RH, Delgado-Charro MB. Effects of iontophoresis, hydration, and permeation enhancers on human nail plate: infrared and impedance spectroscopy assessment. Pharm Res. 2013 Jun; 30(6):1652-62. PMID: 23462934.
        View in: PubMed
      35. Gelfuso GM, Gratieri T, Delgado-Charro MB, Guy RH, Vianna Lopez RF. Iontophoresis-targeted, follicular delivery of minoxidil sulfate for the treatment of alopecia. J Pharm Sci. 2013 May; 102(5):1488-94. PMID: 23450524.
        View in: PubMed
      36. Cordery SF, Taverner A, Ridzwan IE, Guy RH, Delgado-Charro MB, Husbands SM, Bailey CP. A non-rewarding, non-aversive buprenorphine/naltrexone combination attenuates drug-primed reinstatement to cocaine and morphine in rats in a conditioned place preference paradigm. Addict Biol. 2014 Jul; 19(4):575-86. PMID: 23240906.
        View in: PubMed
      37. Beard JD, Guy RH, Gordeev SN. Mechanical tomography of human corneocytes with a nanoneedle. J Invest Dermatol. 2013 Jun; 133(6):1565-71. PMID: 23223139.
        View in: PubMed
      38. Russell LM, Guy RH. Novel imaging method to quantify stratum corneum in dermatopharmacokinetic studies: proof-of-concept with acyclovir formulations. Pharm Res. 2012 Dec; 29(12):3362-72. PMID: 22810836.
        View in: PubMed
      39. Campbell CS, Contreras-Rojas LR, Delgado-Charro MB, Guy RH. Objective assessment of nanoparticle disposition in mammalian skin after topical exposure. J Control Release. 2012 Aug 20; 162(1):201-7. PMID: 22732479.
        View in: PubMed
      40. Mohammed D, Yang Q, Guy RH, Matts PJ, Hadgraft J, Lane ME. Comparison of gravimetric and spectroscopic approaches to quantify stratum corneum removed by tape-stripping. Eur J Pharm Biopharm. 2012 Sep; 82(1):171-4. PMID: 22713518.
        View in: PubMed
      41. Russell LM, Guy RH. Novel imaging method to quantify stratum corneum in dermatopharmacokinetic studies. Pharm Res. 2012 Sep; 29(9):2389-97. PMID: 22562497.
        View in: PubMed
      42. Djabri A, Guy RH, Delgado-Charro MB. Transdermal iontophoresis of ranitidine: an opportunity in paediatric drug therapy. Int J Pharm. 2012 Oct 1; 435(1):27-32. PMID: 22429890.
        View in: PubMed
      43. Djabri A, Guy RH, Delgado-Charro MB. Passive and iontophoretic transdermal delivery of phenobarbital: Implications in paediatric therapy. Int J Pharm. 2012 Oct 1; 435(1):76-82. PMID: 22387370.
        View in: PubMed
      44. Saar BG, Contreras-Rojas LR, Xie XS, Guy RH. Imaging drug delivery to skin with stimulated Raman scattering microscopy. Mol Pharm. 2011 Jun 6; 8(3):969-75. PMID: 21548600; PMCID: PMC3109166.
      45. Belsey NA, Cordery SF, Bunge AL, Guy RH. Assessment of dermal exposure to pesticide residues during re-entry. Environ Sci Technol. 2011 May 15; 45(10):4609-15. PMID: 21510672.
        View in: PubMed
      46. Mitragotri S, Anissimov YG, Bunge AL, Frasch HF, Guy RH, Hadgraft J, Kasting GB, Lane ME, Roberts MS. Mathematical models of skin permeability: an overview. Int J Pharm. 2011 Oct 10; 418(1):115-29. PMID: 21356301.
        View in: PubMed
      47. Guy RH, Szoka FC. Perturbation of solute transport at a liquid-liquid interface by polyethylene glycol (PEG): implications for PEG-induced biomembrane fusion. Phys Chem Chem Phys. 2011 Mar 28; 13(12):5346-52. PMID: 21286598.
        View in: PubMed
      48. Tsang M, Guy RH. Effect of Aqueous Cream BP on human stratum corneum in vivo. Br J Dermatol. 2010 Nov; 163(5):954-8. PMID: 20649794.
        View in: PubMed
      49. Sylvestre JP, Bouissou CC, Guy RH, Delgado-Charro MB. Extraction and quantification of amino acids in human stratum corneum in vivo. Br J Dermatol. 2010 Sep; 163(3):458-65. PMID: 20394632.
        View in: PubMed
      50. Hathout RM, Mansour S, Mortada ND, Geneidi AS, Guy RH. Uptake of microemulsion components into the stratum corneum and their molecular effects on skin barrier function. Mol Pharm. 2010 Aug 2; 7(4):1266-73. PMID: 20545350.
        View in: PubMed
      51. Güngör S, Delgado-Charro MB, Ruiz-Perez B, Schubert W, Isom P, Moslemy P, Patane MA, Guy RH. Trans-scleral iontophoretic delivery of low molecular weight therapeutics. J Control Release. 2010 Oct 15; 147(2):225-31. PMID: 20655965.
        View in: PubMed
      52. Watkinson RM, Guy RH, Oliveira G, Hadgraft J, Lane ME. Optimisation of cosolvent concentration for topical drug delivery III--influence of lipophilic vehicles on ibuprofen permeation. Skin Pharmacol Physiol. 2011; 24(1):22-6. PMID: 20616625.
        View in: PubMed
      53. Guy RH. Predicting the rate and extent of fragrance chemical absorption into and through the skin. Chem Res Toxicol. 2010 May 17; 23(5):864-70. PMID: 20392076.
        View in: PubMed
      54. Hathout RM, Woodman TJ, Mansour S, Mortada ND, Geneidi AS, Guy RH. Microemulsion formulations for the transdermal delivery of testosterone. Eur J Pharm Sci. 2010 Jun 14; 40(3):188-96. PMID: 20304048.
        View in: PubMed
      55. Guy RH. Transdermal drug delivery. Handb Exp Pharmacol. 2010; (197):399-410. PMID: 20217537.
        View in: PubMed
      56. Wu X, Landfester K, Musyanovych A, Guy RH. Disposition of charged nanoparticles after their topical application to the skin. Skin Pharmacol Physiol. 2010; 23(3):117-23. PMID: 20051712.
        View in: PubMed
      57. Bouissou CC, Sylvestre JP, Guy RH, Delgado-Charro MB. Reverse iontophoresis of amino acids: identification and separation of stratum corneum and subdermal sources in vitro. Pharm Res. 2009 Dec; 26(12):2630-8. PMID: 19806434.
        View in: PubMed
      58. Wu X, Griffin P, Price GJ, Guy RH. Preparation and in vitro evaluation of topical formulations based on polystyrene-poly-2-hydroxyl methacrylate nanoparticles. Mol Pharm. 2009 Sep-Oct; 6(5):1449-56. PMID: 19630401.
        View in: PubMed
      59. Wu X, Price GJ, Guy RH. Disposition of nanoparticles and an associated lipophilic permeant following topical application to the skin. Mol Pharm. 2009 Sep-Oct; 6(5):1441-8. PMID: 19630400.
        View in: PubMed
      60. Watkinson RM, Guy RH, Hadgraft J, Lane ME. Optimisation of cosolvent concentration for topical drug delivery - II: influence of propylene glycol on ibuprofen permeation. Skin Pharmacol Physiol. 2009; 22(4):225-30. PMID: 19648784.
        View in: PubMed
      61. Wu X, Biatry B, Cazeneuve C, Guy RH. Drug delivery to the skin from sub-micron polymeric particle formulations: influence of particle size and polymer hydrophobicity. Pharm Res. 2009 Aug; 26(8):1995-2001. PMID: 19513818.
        View in: PubMed
      62. Cork MJ, Danby SG, Vasilopoulos Y, Hadgraft J, Lane ME, Moustafa M, Guy RH, Macgowan AL, Tazi-Ahnini R, Ward SJ. Epidermal barrier dysfunction in atopic dermatitis. J Invest Dermatol. 2009 Aug; 129(8):1892-908. PMID: 19494826.
        View in: PubMed
      63. Sieg A, Jeanneret F, Fathi M, Hochstrasser D, Rudaz S, Veuthey JL, Guy RH, Delgado-Charro MB. Extraction of amino acids by reverse iontophoresis in vivo. Eur J Pharm Biopharm. 2009 May; 72(1):226-31. PMID: 19347973.
        View in: PubMed
      64. Russell LM, Guy RH. Measurement and prediction of the rate and extent of drug delivery into and through the skin. Expert Opin Drug Deliv. 2009 Apr; 6(4):355-69. PMID: 19382880.
        View in: PubMed
      65. Mehier-Humbert S, Bettinger T, Yan F, Guy R. Influence of polymer adjuvants on the ultrasound-mediated transfection of cells in culture. Eur J Pharm Biopharm. 2009 Aug; 72(3):567-73. PMID: 19268531.
        View in: PubMed
      66. Wiedersberg S, Leopold CS, Guy RH. Effects of various vehicles on skin hydration in vivo. Skin Pharmacol Physiol. 2009; 22(3):128-30. PMID: 19136833.
        View in: PubMed
      67. Watkinson RM, Herkenne C, Guy RH, Hadgraft J, Oliveira G, Lane ME. Influence of ethanol on the solubility, ionization and permeation characteristics of ibuprofen in silicone and human skin. Skin Pharmacol Physiol. 2009; 22(1):15-21. PMID: 19088498.
        View in: PubMed
      68. Yow HN, Wu X, Routh AF, Guy RH. Dye diffusion from microcapsules with different shell thickness into mammalian skin. Eur J Pharm Biopharm. 2009 May; 72(1):62-8. PMID: 19084062.
        View in: PubMed
      69. Nicoli S, Bunge AL, Delgado-Charro MB, Guy RH. Dermatopharmacokinetics: factors influencing drug clearance from the stratum corneum. Pharm Res. 2009 Apr; 26(4):865-71. PMID: 19034629.
        View in: PubMed
      70. N'Dri-Stempfer B, Navidi WC, Guy RH, Bunge AL. Improved bioequivalence assessment of topical dermatological drug products using dermatopharmacokinetics. Pharm Res. 2009 Feb; 26(2):316-28. PMID: 18941872.
        View in: PubMed
      71. Wiedersberg S, Leopold CS, Guy RH. Dermatopharmacokinetics of betamethasone 17-valerate: influence of formulation viscosity and skin surface cleaning procedure. Eur J Pharm Biopharm. 2009 Feb; 71(2):362-6. PMID: 18940255.
        View in: PubMed
      72. Grégoire S, Ribaud C, Benech F, Meunier JR, Garrigues-Mazert A, Guy RH. Prediction of chemical absorption into and through the skin from cosmetic and dermatological formulations. Br J Dermatol. 2009 Jan; 160(1):80-91. PMID: 18811683.
        View in: PubMed
      73. Wiedersberg S, Naik A, Leopold CS, Guy RH. Pharmacodynamics and dermatopharmacokinetics of betamethasone 17-valerate: assessment of topical bioavailability. Br J Dermatol. 2009 Mar; 160(3):676-86. PMID: 18782322.
        View in: PubMed
      74. Sylvestre JP, Guy RH, Delgado-Charro MB. In vitro optimization of dexamethasone phosphate delivery by iontophoresis. Phys Ther. 2008 Oct; 88(10):1177-85. PMID: 18719003; PMCID: PMC2557054.
      75. Sieg A, Jeanneret F, Fathi M, Hochstrasser D, Rudaz S, Veuthey JL, Guy RH, Delgado-Charro MB. Extraction of amino acids by reverse iontophoresis: simulation of therapeutic monitoring in vitro. Eur J Pharm Biopharm. 2008 Nov; 70(3):908-13. PMID: 18675906.
        View in: PubMed
      76. Sylvestre JP, Díaz-Marín C, Delgado-Charro MB, Guy RH. Iontophoresis of dexamethasone phosphate: competition with chloride ions. J Control Release. 2008 Oct 6; 131(1):41-6. PMID: 18662729; PMCID: PMC2574231.
      77. N'Dri-Stempfer B, Navidi WC, Guy RH, Bunge AL. Optimizing metrics for the assessment of bioequivalence between topical drug products. Pharm Res. 2008 Jul; 25(7):1621-30. PMID: 18449629.
        View in: PubMed
      78. Wascotte V, Rozet E, Salvaterra A, Hubert P, Jadoul M, Guy RH, Préat V. Non-invasive diagnosis and monitoring of chronic kidney disease by reverse iontophoresis of urea in vivo. Eur J Pharm Biopharm. 2008 Aug; 69(3):1077-82. PMID: 18406585.
        View in: PubMed
      79. Dias M, Naik A, Guy RH, Hadgraft J, Lane ME. In vivo infrared spectroscopy studies of alkanol effects on human skin. Eur J Pharm Biopharm. 2008 Aug; 69(3):1171-5. PMID: 18406117.
        View in: PubMed
      80. Herkenne C, Naik A, Kalia YN, Hadgraft J, Guy RH. Effect of propylene glycol on ibuprofen absorption into human skin in vivo. J Pharm Sci. 2008 Jan; 97(1):185-97. PMID: 17497726.
        View in: PubMed
      81. Nixon S, Sieg A, Delgado-Charro MB, Guy RH. Reverse iontophoresis of L-lactate: in vitro and in vivo studies. J Pharm Sci. 2007 Dec; 96(12):3457-65. PMID: 17506512.
        View in: PubMed
      82. Herkenne C, Alberti I, Naik A, Kalia YN, Mathy FX, Préat V, Guy RH. In vivo methods for the assessment of topical drug bioavailability. Pharm Res. 2008 Jan; 25(1):87-103. PMID: 17985216; PMCID: PMC2217624.
      83. Wiedersberg S, Leopold CS, Guy RH. Bioavailability and bioequivalence of topical glucocorticoids. Eur J Pharm Biopharm. 2008 Mar; 68(3):453-66. PMID: 17826047.
        View in: PubMed
      84. Trichard L, Delgado-Charro MB, Guy RH, Fattal E, Bochot A. Novel beads made of alpha-cyclodextrin and oil for topical delivery of a lipophilic drug. Pharm Res. 2008 Feb; 25(2):435-40. PMID: 17671830.
        View in: PubMed
      85. Mudry B, Carrupt PA, Guy RH, Delgado-Charro MB. Quantitative structure-permeation relationship for iontophoretic transport across the skin. J Control Release. 2007 Sep 26; 122(2):165-72. PMID: 17707106; PMCID: PMC2082109.
      86. Kroes R, Renwick AG, Feron V, Galli CL, Gibney M, Greim H, Guy RH, Lhuguenot JC, van de Sandt JJ. Application of the threshold of toxicological concern (TTC) to the safety evaluation of cosmetic ingredients. Food Chem Toxicol. 2007 Dec; 45(12):2533-62. PMID: 17664037.
        View in: PubMed
      87. Diaz del Consuelo I, Falson F, Guy RH, Jacques Y. Ex vivo evaluation of bioadhesive films for buccal delivery of fentanyl. J Control Release. 2007 Sep 26; 122(2):135-40. PMID: 17688966.
        View in: PubMed
      88. Wascotte V, Caspers P, de Sterke J, Jadoul M, Guy RH, Préat V. Assessment of the "skin reservoir" of urea by confocal Raman microspectroscopy and reverse iontophoresis in vivo. Pharm Res. 2007 Oct; 24(10):1897-901. PMID: 17497081.
        View in: PubMed
      89. Mehier-Humbert S, Yan F, Frinking P, Schneider M, Guy RH, Bettinger T. Ultrasound-mediated gene delivery: influence of contrast agent on transfection. Bioconjug Chem. 2007 May-Jun; 18(3):652-62. PMID: 17419583.
        View in: PubMed
      90. Wascotte V, Delgado-Charro MB, Rozet E, Wallemacq P, Hubert P, Guy RH, Préat V. Monitoring of urea and potassium by reverse iontophoresis in vitro. Pharm Res. 2007 Jun; 24(6):1131-7. PMID: 17380270.
        View in: PubMed
      91. Leichtnam ML, Rolland H, Wüthrich P, Guy RH. Impact of antinucleants on transdermal delivery of testosterone from a spray. J Pharm Sci. 2007 Jan; 96(1):84-92. PMID: 16998787.
        View in: PubMed
      92. Herkenne C, Naik A, Kalia YN, Hadgraft J, Guy RH. Dermatopharmacokinetic prediction of topical drug bioavailability in vivo. J Invest Dermatol. 2007 Apr; 127(4):887-94. PMID: 17139266.
        View in: PubMed
      93. Leichtnam ML, Rolland H, Wüthrich P, Guy RH. Enhancement of transdermal testosterone delivery by supersaturation. J Pharm Sci. 2006 Nov; 95(11):2373-9. PMID: 16886189.
        View in: PubMed
      94. Leichtnam ML, Rolland H, Wüthrich P, Guy RH. Formulation and evaluation of a testosterone transdermal spray. J Pharm Sci. 2006 Aug; 95(8):1693-702. PMID: 16795012.
        View in: PubMed
      95. Herkenne C, Naik A, Kalia YN, Hadgraft J, Guy RH. Pig ear skin ex vivo as a model for in vivo dermatopharmacokinetic studies in man. Pharm Res. 2006 Aug; 23(8):1850-6. PMID: 16841197.
        View in: PubMed
      96. Abla N, Naik A, Guy RH, Kalia YN. Topical iontophoresis of valaciclovir hydrochloride improves cutaneous aciclovir delivery. Pharm Res. 2006 Aug; 23(8):1842-9. PMID: 16850271.
        View in: PubMed
      97. Herkenne C, Naik A, Kalia YN, Hadgraft J, Guy RH. Ibuprofen transport into and through skin from topical formulations: in vitro-in vivo comparison. J Invest Dermatol. 2007 Jan; 127(1):135-42. PMID: 16858418.
        View in: PubMed
      98. Leichtnam ML, Rolland H, Wüthrich P, Guy RH. Testosterone hormone replacement therapy: state-of-the-art and emerging technologies. Pharm Res. 2006 Jun; 23(6):1117-32. PMID: 16755346.
        View in: PubMed
      99. Schuetz YB, Carrupt PA, Naik A, Guy RH, Kalia YN. Structure-permeation relationships for the non-invasive transdermal delivery of cationic peptides by iontophoresis. Eur J Pharm Sci. 2006 Sep; 29(1):53-9. PMID: 16837178.
        View in: PubMed
      100. Leichtnam ML, Rolland H, Wüthrich P, Guy RH. Identification of penetration enhancers for testosterone transdermal delivery from spray formulations. J Control Release. 2006 Jun 12; 113(1):57-62. PMID: 16677734.
        View in: PubMed
      101. Mudry B, Guy RH, Delgado-Charro MB. Electromigration of ions across the skin: determination and prediction of transport numbers. J Pharm Sci. 2006 Mar; 95(3):561-9. PMID: 16419050.
        View in: PubMed
      102. Mudry B, Guy RH, Begoña Delgado-Charro M. Prediction of iontophoretic transport across the skin. J Control Release. 2006 Apr 10; 111(3):362-7. PMID: 16488047.
        View in: PubMed
      103. Mudry B, Guy RH, Delgado-Charro MB. Transport numbers in transdermal iontophoresis. Biophys J. 2006 Apr 15; 90(8):2822-30. PMID: 16443654; PMCID: PMC1414545.
      104. Diaz Del Consuelo I, Pizzolato GP, Falson F, Guy RH, Jacques Y. Evaluation of pig esophageal mucosa as a permeability barrier model for buccal tissue. J Pharm Sci. 2005 Dec; 94(12):2777-88. PMID: 16258996.
        View in: PubMed
      105. Abla N, Geiser L, Mirgaldi M, Naik A, Veuthey JL, Guy RH, Kalia YN. Capillary zone electrophoresis for the estimation of transdermal iontophoretic mobility. J Pharm Sci. 2005 Dec; 94(12):2667-75. PMID: 16258982.
        View in: PubMed
      106. Schuetz YB, Naik A, Guy RH, Vuaridel E, Kalia YN. Transdermal iontophoretic delivery of triptorelin in vitro. J Pharm Sci. 2005 Oct; 94(10):2175-82. PMID: 16136544.
        View in: PubMed
      107. Abla N, Naik A, Guy RH, Kalia YN. Effect of charge and molecular weight on transdermal peptide delivery by iontophoresis. Pharm Res. 2005 Dec; 22(12):2069-78. PMID: 16170597.
        View in: PubMed
      108. Abla N, Naik A, Guy RH, Kalia YN. Contributions of electromigration and electroosmosis to peptide iontophoresis across intact and impaired skin. J Control Release. 2005 Nov 28; 108(2-3):319-30. PMID: 16169627.
        View in: PubMed
      109. Schuetz YB, Naik A, Guy RH, Kalia YN. Effect of amino acid sequence on transdermal iontophoretic peptide delivery. Eur J Pharm Sci. 2005 Dec; 26(5):429-37. PMID: 16143501.
        View in: PubMed
      110. Diaz Del Consuelo I, Falson F, Guy RH, Jacques Y. Transport of fentanyl through pig buccal and esophageal epithelia in vitro: influence of concentration and vehicle pH. Pharm Res. 2005 Sep; 22(9):1525-9. PMID: 16132365.
        View in: PubMed
      111. Schuetz YB, Naik A, Guy RH, Vuaridel E, Kalia YN. Transdermal iontophoretic delivery of vapreotide acetate across porcine skin in vitro. Pharm Res. 2005 Aug; 22(8):1305-12. PMID: 16078140.
        View in: PubMed
      112. Diaz-Del Consuelo I, Jacques Y, Pizzolato GP, Guy RH, Falson F. Comparison of the lipid composition of porcine buccal and esophageal permeability barriers. Arch Oral Biol. 2005 Dec; 50(12):981-7. PMID: 15955526.
        View in: PubMed
      113. Touraille GD, McCarley KD, Bunge AL, Marty JP, Guy RH. Percutaneous absorption of 4-cyanophenol from freshly contaminated soil in vitro: effects of soil loading and contamination concentration. Environ Sci Technol. 2005 May 15; 39(10):3723-31. PMID: 15954226.
        View in: PubMed
      114. Schuetz YB, Naik A, Guy RH, Kalia YN. Emerging strategies for the transdermal delivery of peptide and protein drugs. Expert Opin Drug Deliv. 2005 May; 2(3):533-48. PMID: 16296773.
        View in: PubMed
      115. Mehier-Humbert S, Guy RH. Physical methods for gene transfer: improving the kinetics of gene delivery into cells. Adv Drug Deliv Rev. 2005 Apr 5; 57(5):733-53. PMID: 15757758.
        View in: PubMed
      116. Mehier-Humbert S, Bettinger T, Yan F, Guy RH. Plasma membrane poration induced by ultrasound exposure: implication for drug delivery. J Control Release. 2005 May 5; 104(1):213-22. PMID: 15866347.
        View in: PubMed
      117. Mehier-Humbert S, Bettinger T, Yan F, Guy RH. Ultrasound-mediated gene delivery: kinetics of plasmid internalization and gene expression. J Control Release. 2005 May 5; 104(1):203-11. PMID: 15866346.
        View in: PubMed
      118. Sieg A, Guy RH, Delgado-Charro MB. Noninvasive and minimally invasive methods for transdermal glucose monitoring. Diabetes Technol Ther. 2005 Feb; 7(1):174-97. PMID: 15738715.
        View in: PubMed
      119. Wascotte V, Leboulanger B, Guy RH, Begoña Delgado-Charro M. Reverse iontophoresis of lithium: electrode formulation using a thermoreversible polymer. Eur J Pharm Biopharm. 2005 Jan; 59(1):237-40. PMID: 15567322.
        View in: PubMed
      120. Sekkat N, Kalia YN, Guy RH. Development of an in vitro model for premature neonatal skin: biophysical characterization using transepidermal water loss. J Pharm Sci. 2004 Dec; 93(12):2936-40. PMID: 15459948.
        View in: PubMed
      121. Merclin N, Bender J, Sparr E, Guy RH, Ehrsson H, Engström S. Transdermal delivery from a lipid sponge phase--iontophoretic and passive transport in vitro of 5-aminolevulinic acid and its methyl ester. J Control Release. 2004 Nov 24; 100(2):191-8. PMID: 15544867.
        View in: PubMed
      122. Sieg A, Guy RH, Delgado-Charro MB. Simultaneous extraction of urea and glucose by reverse iontophoresis in vivo. Pharm Res. 2004 Oct; 21(10):1805-10. PMID: 15553226.
        View in: PubMed
      123. Alvarez-Román R, Naik A, Kalia YN, Guy RH, Fessi H. Enhancement of topical delivery from biodegradable nanoparticles. Pharm Res. 2004 Oct; 21(10):1818-25. PMID: 15553228.
        View in: PubMed
      124. Alvarez-Román R, Naik A, Kalia YN, Guy RH, Fessi H. Skin penetration and distribution of polymeric nanoparticles. J Control Release. 2004 Sep 14; 99(1):53-62. PMID: 15342180.
        View in: PubMed
      125. Alvarez-Román R, Naik A, Kalia YN, Fessi H, Guy RH. Visualization of skin penetration using confocal laser scanning microscopy. Eur J Pharm Biopharm. 2004 Sep; 58(2):301-16. PMID: 15296957.
        View in: PubMed
      126. Sieg A, Guy RH, Delgado-Charro MB. Electroosmosis in transdermal iontophoresis: implications for noninvasive and calibration-free glucose monitoring. Biophys J. 2004 Nov; 87(5):3344-50. PMID: 15339817; PMCID: PMC1304802.
      127. Leboulanger B, Guy RH, Delgado-Charro MB. Non-invasive monitoring of phenytoin by reverse iontophoresis. Eur J Pharm Sci. 2004 Aug; 22(5):427-33. PMID: 15265512.
        View in: PubMed
      128. Sekkat N, Kalia YN, Guy RH. Porcine ear skin as a model for the assessment of transdermal drug delivery to premature neonates. Pharm Res. 2004 Aug; 21(8):1390-7. PMID: 15359573.
        View in: PubMed
      129. Leboulanger B, Fathi M, Guy RH, Delgado-Charro MB. Reverse iontophoresis as a noninvasive tool for lithium monitoring and pharmacokinetic profiling. Pharm Res. 2004 Jul; 21(7):1214-22. PMID: 15290862.
        View in: PubMed
      130. Leboulanger B, Aubry JM, Bondolfi G, Guy RH, Delgado-Charro MB. Lithium monitoring by reverse iontophoresis in vivo. Clin Chem. 2004 Nov; 50(11):2091-100. PMID: 15192031.
        View in: PubMed
      131. Leboulanger B, Guy RH, Delgado-Charro MB. Reverse iontophoresis for non-invasive transdermal monitoring. Physiol Meas. 2004 Jun; 25(3):R35-50. PMID: 15253111.
        View in: PubMed
      132. Sieg A, Guy RH, Delgado-Charro MB. Noninvasive glucose monitoring by reverse iontophoresis in vivo: application of the internal standard concept. Clin Chem. 2004 Aug; 50(8):1383-90. PMID: 15155544.
        View in: PubMed
      133. Kalia YN, Naik A, Garrison J, Guy RH. Iontophoretic drug delivery. Adv Drug Deliv Rev. 2004 Mar 27; 56(5):619-58. PMID: 15019750.
        View in: PubMed
      134. Curdy C, Naik A, Kalia YN, Alberti I, Guy RH. Non-invasive assessment of the effect of formulation excipients on stratum corneum barrier function in vivo. Int J Pharm. 2004 Mar 1; 271(1-2):251-6. PMID: 15129992.
        View in: PubMed
      135. Lopez RF, Lange N, Guy R, Bentley MV. Photodynamic therapy of skin cancer: controlled drug delivery of 5-ALA and its esters. Adv Drug Deliv Rev. 2004 Jan 13; 56(1):77-94. PMID: 14706446.
        View in: PubMed
      136. Geinoz S, Guy RH, Testa B, Carrupt PA. Quantitative structure-permeation relationships (QSPeRs) to predict skin permeation: a critical evaluation. Pharm Res. 2004 Jan; 21(1):83-92. PMID: 14984261.
        View in: PubMed
      137. Hadgraft J, Guy R. Biotechnological aspects of transport across human skin. Biotechnol Genet Eng Rev. 2004; 21:183-93. PMID: 17017032.
        View in: PubMed
      138. Sieg A, Guy RH, Delgado-Charro MB. Reverse iontophoresis for noninvasive glucose monitoring: the internal standard concept. J Pharm Sci. 2003 Nov; 92(11):2295-302. PMID: 14603514.
        View in: PubMed
      139. Delgado-Charro MB, Guy RH. Transdermal reverse iontophoresis of valproate: a noninvasive method for therapeutic drug monitoring. Pharm Res. 2003 Sep; 20(9):1508-13. PMID: 14567648.
        View in: PubMed
      140. Merino G, Kalia YN, Guy RH. Ultrasound-enhanced transdermal transport. J Pharm Sci. 2003 Jun; 92(6):1125-37. PMID: 12761802.
        View in: PubMed
      141. Alvarez-Román R, Merino G, Kalia YN, Naik A, Guy RH. Skin permeability enhancement by low frequency sonophoresis: lipid extraction and transport pathways. J Pharm Sci. 2003 Jun; 92(6):1138-46. PMID: 12761803.
        View in: PubMed
      142. Lopez RF, Bentley MV, Delgado-Charro MB, Salomon D, van den Bergh H, Lange N, Guy RH. Enhanced delivery of 5-aminolevulinic acid esters by iontophoresis in vitro. Photochem Photobiol. 2003 Mar; 77(3):304-8. PMID: 12685659.
        View in: PubMed
      143. Lopez RF, Bentley MV, Begoña Delgado-Charro M, Guy RH. Optimization of aminolevulinic acid delivery by iontophoresis. J Control Release. 2003 Feb 14; 88(1):65-70. PMID: 12586504.
        View in: PubMed
      144. Merino G, Kalia YN, Delgado-Charro MB, Potts RO, Guy RH. Frequency and thermal effects on the enhancement of transdermal transport by sonophoresis. J Control Release. 2003 Feb 14; 88(1):85-94. PMID: 12586506.
        View in: PubMed
      145. Geinoz S, Rey S, Boss G, Bunge AL, Guy RH, Carrupt PA, Reist M, Testa B. Quantitative structure-permeation relationships for solute transport across silicone membranes. Pharm Res. 2002 Nov; 19(11):1622-9. PMID: 12458667.
        View in: PubMed
      146. Sekkat N, Kalia YN, Guy RH. Biophysical study of porcine ear skin in vitro and its comparison to human skin in vivo. J Pharm Sci. 2002 Nov; 91(11):2376-81. PMID: 12379922.
        View in: PubMed
      147. Sekkat N, Naik A, Kalia YN, Glikfeld P, Guy RH. Reverse iontophoretic monitoring in premature neonates: feasibility and potential. J Control Release. 2002 May 17; 81(1-2):83-9. PMID: 11992681.
        View in: PubMed
      148. Reddy MB, Stinchcomb AL, Guy RH, Bunge AL. Determining dermal absorption parameters in vivo from tape strip data. Pharm Res. 2002 Mar; 19(3):292-8. PMID: 11934236.
        View in: PubMed
      149. Dujardin N, Staes E, Kalia Y, Clarys P, Guy R, Préat V. In vivo assessment of skin electroporation using square wave pulses. J Control Release. 2002 Feb 19; 79(1-3):219-27. PMID: 11853933.
        View in: PubMed
      150. Veuillez F, Rieg FF, Guy RH, Deshusses J, Buri P. Permeation of a myristoylated dipeptide across the buccal mucosa: topological distribution and evaluation of tissue integrity. Int J Pharm. 2002 Jan 1; 231(1):1-9. PMID: 11719008.
        View in: PubMed
      151. Curdy C, Kalia YN, Guy RH. Post-iontophoresis recovery of human skin impedance in vivo. Eur J Pharm Biopharm. 2002 Jan; 53(1):15-21. PMID: 11777748.
        View in: PubMed
      152. Marro D, Kalia YN, Delgado-Charro MB, Guy RH. Optimizing iontophoretic drug delivery: identification and distribution of the charge-carrying species. Pharm Res. 2001 Dec; 18(12):1709-13. PMID: 11785690.
        View in: PubMed
      153. Marro D, Kalia YN, Delgado-Charro MB, Guy RH. Contributions of electromigration and electroosmosis to iontophoretic drug delivery. Pharm Res. 2001 Dec; 18(12):1701-8. PMID: 11785689.
        View in: PubMed
      154. Alberti I, Kalia YN, Naik A, Guy RH. Assessment and prediction of the cutaneous bioavailability of topical terbinafine, in vivo, in man. Pharm Res. 2001 Oct; 18(10):1472-5. PMID: 11697475.
        View in: PubMed
      155. Curdy C, Kalia YN, Naik A, Guy RH. Piroxicam delivery into human stratum corneum in vivo: iontophoresis versus passive diffusion. J Control Release. 2001 Sep 11; 76(1-2):73-9. PMID: 11532314.
        View in: PubMed
      156. Moser K, Kriwet K, Naik A, Kalia YN, Guy RH. Passive skin penetration enhancement and its quantification in vitro. Eur J Pharm Biopharm. 2001 Sep; 52(2):103-12. PMID: 11522474.
        View in: PubMed
      157. Alvarez-Román R, Barré G, Guy RH, Fessi H. Biodegradable polymer nanocapsules containing a sunscreen agent: preparation and photoprotection. Eur J Pharm Biopharm. 2001 Sep; 52(2):191-5. PMID: 11522485.
        View in: PubMed
      158. Moser K, Kriwet K, Kalia YN, Guy RH. Stabilization of supersaturated solutions of a lipophilic drug for dermal delivery. Int J Pharm. 2001 Aug 14; 224(1-2):169-76. PMID: 11472826.
        View in: PubMed
      159. Moser K, Kriwet K, Froehlich C, Kalia YN, Guy RH. Supersaturation: enhancement of skin penetration and permeation of a lipophilic drug. Pharm Res. 2001 Jul; 18(7):1006-11. PMID: 11496937.
        View in: PubMed
      160. Moser K, Kriwet K, Kalia YN, Guy RH. Enhanced skin permeation of a lipophilic drug using supersaturated formulations. J Control Release. 2001 Jun 15; 73(2-3):245-53. PMID: 11516502.
        View in: PubMed
      161. Kalia YN, Guy RH. Modeling transdermal drug release. Adv Drug Deliv Rev. 2001 Jun 11; 48(2-3):159-72. PMID: 11369080.
        View in: PubMed
      162. Curdy C, Kalia YN, Guy RH. Non-invasive assessment of the effects of iontophoresis on human skin in-vivo. J Pharm Pharmacol. 2001 Jun; 53(6):769-77. PMID: 11428652.
        View in: PubMed
      163. Alberti I, Kalia YN, Naik A, Bonny J, Guy RH. Effect of ethanol and isopropyl myristate on the availability of topical terbinafine in human stratum corneum, in vivo. Int J Pharm. 2001 May 21; 219(1-2):11-9. PMID: 11337162.
        View in: PubMed
      164. Moser K, Kriwet K, Froehlich C, Naik A, Kalia YN, Guy RH. Permeation enhancement of a highly lipophilic drug using supersaturated systems. J Pharm Sci. 2001 May; 90(5):607-16. PMID: 11288105.
        View in: PubMed
      165. Alberti I, Kalia YN, Naik A, Bonny JD, Guy RH. In vivo assessment of enhanced topical delivery of terbinafine to human stratum corneum. J Control Release. 2001 Apr 28; 71(3):319-27. PMID: 11295224.
        View in: PubMed
      166. Lopez RF, Bentley MV, Delgado-Charro MB, Guy RH. Iontophoretic delivery of 5-aminolevulinic acid (ALA): effect of pH. Pharm Res. 2001 Mar; 18(3):311-5. PMID: 11442270.
        View in: PubMed
      167. Marro D, Guy RH, Delgado-Charro MB. Characterization of the iontophoretic permselectivity properties of human and pig skin. J Control Release. 2001 Jan 29; 70(1-2):213-7. PMID: 11166421.
        View in: PubMed
      168. Guy RH, Delgado-Charro MB, Kalia YN. Iontophoretic transport across the skin. Skin Pharmacol Appl Skin Physiol. 2001; 14 Suppl 1:35-40. PMID: 11509905.
        View in: PubMed
      169. Kalia YN, Alberti I, Naik A, Guy RH. Assessment of topical bioavailability in vivo: the importance of stratum corneum thickness. Skin Pharmacol Appl Skin Physiol. 2001; 14 Suppl 1:82-6. PMID: 11509911.
        View in: PubMed
      170. Reddy MB, Guy RH, Bunge AL. Does epidermal turnover reduce percutaneous penetration? Pharm Res. 2000 Nov; 17(11):1414-9. PMID: 11205736.
        View in: PubMed
      171. Kalia YN, Alberti I, Sekkat N, Curdy C, Naik A, Guy RH. Normalization of stratum corneum barrier function and transepidermal water loss in vivo. Pharm Res. 2000 Sep; 17(9):1148-50. PMID: 11087050.
        View in: PubMed
      172. Nonato LB, Lund CH, Kalia YN, Guy RH. Transepidermal water loss in 24 and 25 weeks gestational age infants. Acta Paediatr. 2000 Jun; 89(6):747-8. PMID: 10914980.
        View in: PubMed
      173. Guy RH, Kalia YN, Delgado-Charro MB, Merino V, López A, Marro D. Iontophoresis: electrorepulsion and electroosmosis. J Control Release. 2000 Feb 14; 64(1-3):129-32. PMID: 10640651.
        View in: PubMed
      174. Curdy C, Kalia YN, Falson-Rieg F, Guy RH. Recovery of human skin impedance in vivo after iontophoresis: effect of metal ions. AAPS PharmSci. 2000; 2(3):E23. PMID: 11741239; PMCID: PMC2761134.
      175. Bunge AL, Guy RH, Hadgraft J. The determination of a diffusional pathlength through the stratum corneum. Int J Pharm. 1999 Oct 15; 188(1):121-4. PMID: 10528090.
        View in: PubMed
      176. Merino V, López A, Hochstrasser D, Guy RH. Noninvasive sampling of phenylalanine by reverse iontophoresis. J Control Release. 1999 Aug 27; 61(1-2):65-9. PMID: 10469903.
        View in: PubMed
      177. Stinchcomb AL, Pirot F, Touraille GD, Bunge AL, Guy RH. Chemical uptake into human stratum corneum in vivo from volatile and non-volatile solvents. Pharm Res. 1999 Aug; 16(8):1288-93. PMID: 10468033.
        View in: PubMed
      178. Merino V, López A, Kalia YN, Guy RH. Electrorepulsion versus electroosmosis: effect of pH on the iontophoretic flux of 5-fluorouracil. Pharm Res. 1999 May; 16(5):758-61. PMID: 10350021.
        View in: PubMed
      179. Lim KC, Sun E, Bahgat M, Bucks D, Guy R, Hinz RS, Cullander C, McKerrow JH. Blockage of skin invasion by schistosome cercariae by serine protease inhibitors. Am J Trop Med Hyg. 1999 Mar; 60(3):487-92. PMID: 10466982.
        View in: PubMed
      180. Kalia YN, Pirot F, Potts RO, Guy RH. Ion mobility across human stratum corneum in vivo. J Pharm Sci. 1998 Dec; 87(12):1508-11. PMID: 10189257.
        View in: PubMed
      181. Turner NG, Guy RH. Visualization and quantitation of iontophoretic pathways using confocal microscopy. J Investig Dermatol Symp Proc. 1998 Aug; 3(2):136-42. PMID: 9734828.
        View in: PubMed
      182. Kalia YN, Nonato LB, Lund CH, Guy RH. Development of skin barrier function in premature infants. J Invest Dermatol. 1998 Aug; 111(2):320-6. PMID: 9699737.
        View in: PubMed
      183. Turner NG, Cullander C, Guy RH. Determination of the pH gradient across the stratum corneum. J Investig Dermatol Symp Proc. 1998 Aug; 3(2):110-3. PMID: 9734823.
        View in: PubMed
      184. Luzardo-Alvarez A, Rodríguez-Fernández M, Blanco-Méndez J, Guy RH, Delgado-Charro MB. Iontophoretic permselectivity of mammalian skin: characterization of hairless mouse and porcine membrane models. Pharm Res. 1998 Jul; 15(7):984-7. PMID: 9688048.
        View in: PubMed
      185. Guy R, Kealey T. The effects of inflammatory cytokines on the isolated human sebaceous infundibulum. J Invest Dermatol. 1998 Apr; 110(4):410-5. PMID: 9540984.
        View in: PubMed
      186. Kalia YN, Merino V, Guy RH. Transdermal drug delivery. Clinical aspects. Dermatol Clin. 1998 Apr; 16(2):289-99. PMID: 9589202.
        View in: PubMed
      187. Guy RH. Iontophoresis--recent developments. J Pharm Pharmacol. 1998 Apr; 50(4):371-4. PMID: 9625480.
        View in: PubMed
      188. Pirot F, Berardesca E, Kalia YN, Singh M, Maibach HI, Guy RH. Stratum corneum thickness and apparent water diffusivity: facile and noninvasive quantitation in vivo. Pharm Res. 1998 Mar; 15(3):492-4. PMID: 9563083.
        View in: PubMed
      189. Langkjaer L, Brange J, Grodsky GM, Guy RH. Iontophoresis of monomeric insulin analogues in vitro: effects of insulin charge and skin pretreatment. J Control Release. 1998 Jan 23; 51(1):47-56. PMID: 9685903.
        View in: PubMed
      190. Hirvonen J, Guy RH. Transdermal iontophoresis: modulation of electroosmosis by polypeptide. J Control Release. 1998 Jan 2; 50(1-3):283-9. PMID: 9685895.
        View in: PubMed
      191. Turner NG, Guy RH. Iontophoretic transport pathways: dependence on penetrant physicochemical properties. J Pharm Sci. 1997 Dec; 86(12):1385-9. PMID: 9423151.
        View in: PubMed
      192. Turner NG, Ferry L, Price M, Cullander C, Guy RH. Iontophoresis of poly-L-lysines: the role of molecular weight? Pharm Res. 1997 Oct; 14(10):1322-31. PMID: 9358543.
        View in: PubMed
      193. Hirvonen J, Guy RH. Iontophoretic delivery across the skin: electroosmosis and its modulation by drug substances. Pharm Res. 1997 Sep; 14(9):1258-63. PMID: 9327458.
        View in: PubMed
      194. Turner NG, Kalia YN, Guy RH. The effect of current on skin barrier function in vivo: recovery kinetics post-iontophoresis. Pharm Res. 1997 Sep; 14(9):1252-7. PMID: 9327457.
        View in: PubMed
      195. Merino V, Kalia YN, Guy RH. Transdermal therapy and diagnosis by iontophoresis. Trends Biotechnol. 1997 Aug; 15(8):288-90. PMID: 9263476.
        View in: PubMed
      196. Pirot F, Kalia YN, Stinchcomb AL, Keating G, Bunge A, Guy RH. Characterization of the permeability barrier of human skin in vivo. Proc Natl Acad Sci U S A. 1997 Feb 18; 94(4):1562-7. PMID: 9037093; PMCID: PMC19831.
      197. Prausnitz MR, Gimm JA, Guy RH, Langer R, Weaver JC, Cullander C. Imaging regions of transport across human stratum corneum during high-voltage and low-voltage exposures. J Pharm Sci. 1996 Dec; 85(12):1363-70. PMID: 8961154.
        View in: PubMed
      198. Hirvonen J, Kalia YN, Guy RH. Transdermal delivery of peptides by iontophoresis. Nat Biotechnol. 1996 Dec; 14(13):1710-3. PMID: 9634857.
        View in: PubMed
      199. Guy RH. Current status and future prospects of transdermal drug delivery. Pharm Res. 1996 Dec; 13(12):1765-9. PMID: 8987069.
        View in: PubMed
      200. Kalia YN, Pirot F, Guy RH. Homogeneous transport in a heterogeneous membrane: water diffusion across human stratum corneum in vivo. Biophys J. 1996 Nov; 71(5):2692-700. PMID: 8913606; PMCID: PMC1233755.
      201. Kennedy AH, Golden GM, Gay CL, Guy RH, Francoeur ML, Mak VH. Stratum corneum lipids of human epidermal keratinocyte air-liquid cultures: implications for barrier function. Pharm Res. 1996 Aug; 13(8):1162-7. PMID: 8865305.
        View in: PubMed
      202. Tsai JC, Guy RH, Thornfeldt CR, Gao WN, Feingold KR, Elias PM. Metabolic approaches to enhance transdermal drug delivery. 1. Effect of lipid synthesis inhibitors. J Pharm Sci. 1996 Jun; 85(6):643-8. PMID: 8773963.
        View in: PubMed
      203. Kalia YN, Nonato LB, Guy RH. The effect of iontophoresis on skin barrier integrity: non-invasive evaluation by impedance spectroscopy and transepidermal water loss. Pharm Res. 1996 Jun; 13(6):957-60. PMID: 8792440.
        View in: PubMed
      204. Rodríguez Bayón AM, Guy RH. Iontophoresis of nafarelin across human skin in vitro. Pharm Res. 1996 May; 13(5):798-800. PMID: 8860440.
        View in: PubMed
      205. van der Geest R, Hueber F, Szoka FC, Guy RH. Iontophoresis of bases, nucleosides, and nucleotides. Pharm Res. 1996 Apr; 13(4):553-8. PMID: 8710745.
        View in: PubMed
      206. Rao G, Guy RH, Glikfeld P, LaCourse WR, Leung L, Tamada J, Potts RO, Azimi N. Reverse iontophoresis: noninvasive glucose monitoring in vivo in humans. Pharm Res. 1995 Dec; 12(12):1869-73. PMID: 8786958.
        View in: PubMed
      207. Kalia YN, Guy RH. The electrical characteristics of human skin in vivo. Pharm Res. 1995 Nov; 12(11):1605-13. PMID: 8592657.
        View in: PubMed
      208. Potts RO, Guy RH. A predictive algorithm for skin permeability: the effects of molecular size and hydrogen bond activity. Pharm Res. 1995 Nov; 12(11):1628-33. PMID: 8592661.
        View in: PubMed
      209. Guy RH. A sweeter life for diabetics? Nat Med. 1995 Nov; 1(11):1132-3. PMID: 7584978.
        View in: PubMed
      210. Aspe E, Guy RH, Lee WA, Kennedy JA, Visor GC, Ennis RD. Optimization of in vitro flux through hairless mouse skin of cidofovir, a potent nucleotide analog. J Pharm Sci. 1995 Jun; 84(6):750-4. PMID: 7562417.
        View in: PubMed
      211. Guy RH. Percutaneous absorption: physical chemistry meets the skin. Curr Probl Dermatol. 1995; 22:132-8. PMID: 7587314.
        View in: PubMed
      212. Gay CL, Guy RH, Golden GM, Mak VH, Francoeur ML. Characterization of low-temperature (i.e., < 65 degrees C) lipid transitions in human stratum corneum. J Invest Dermatol. 1994 Aug; 103(2):233-9. PMID: 8040615.
        View in: PubMed
      213. Delgado-Charro MB, Guy RH. Characterization of convective solvent flow during iontophoresis. Pharm Res. 1994 Jul; 11(7):929-35. PMID: 7937551.
        View in: PubMed
      214. Rao G, Glikfeld P, Guy RH. Reverse iontophoresis: development of a noninvasive approach for glucose monitoring. Pharm Res. 1993 Dec; 10(12):1751-5. PMID: 8302761.
        View in: PubMed
      215. Higo N, Naik A, Bommannan DB, Potts RO, Guy RH. Validation of reflectance infrared spectroscopy as a quantitative method to measure percutaneous absorption in vivo. Pharm Res. 1993 Oct; 10(10):1500-6. PMID: 8272414.
        View in: PubMed
      216. Kim A, Green PG, Rao G, Guy RH. Convective solvent flow across the skin during iontophoresis. Pharm Res. 1993 Sep; 10(9):1315-20. PMID: 8234169.
        View in: PubMed
      217. Bucks DA, Hostynek JJ, Hinz RS, Guy RH. Uptake of two zwitterionic surfactants into human skin in vivo. Toxicol Appl Pharmacol. 1993 Jun; 120(2):224-7. PMID: 8511791.
        View in: PubMed
      218. Guy RH, Potts RO. Penetration of industrial chemicals across the skin: a predictive model. Am J Ind Med. 1993 May; 23(5):711-9. PMID: 8506849.
        View in: PubMed
      219. Potts RO, Guy RH. The influence of molecular volume and hydrogen-bonding on peptide transport across epithelial membranes. Pharm Res. 1993 Apr; 10(4):635-7. PMID: 8483853.
        View in: PubMed
      220. Guy R, Ridden C, Barth J, Kealey T. Isolation and maintenance of the human pilosebaceous duct: 13-cis retinoic acid acts directly on the duct in vitro. Br J Dermatol. 1993 Mar; 128(3):242-8. PMID: 7682433.
        View in: PubMed
      221. Hostýnek JJ, Hinz RS, Lorence CR, Price M, Guy RH. Metals and the skin. Crit Rev Toxicol. 1993; 23(2):171-235. PMID: 8329115.
        View in: PubMed
      222. Tur E, Tamir A, Guy RH. Cutaneous blood flow in gestational hypertension and normal pregnancy. J Invest Dermatol. 1992 Sep; 99(3):310-4. PMID: 1512468.
        View in: PubMed
      223. Bommannan D, Menon GK, Okuyama H, Elias PM, Guy RH. Sonophoresis. II. Examination of the mechanism(s) of ultrasound-enhanced transdermal drug delivery. Pharm Res. 1992 Aug; 9(8):1043-7. PMID: 1409375.
        View in: PubMed
      224. Ridout G, Houk J, Guy RH, Santus GC, Hadgraft J, Hall LL. An evaluation of structure-penetration relationships in percutaneous absorption. Farmaco. 1992 Jun; 47(6):869-92. PMID: 1388606.
        View in: PubMed
      225. Hadgraft J, Walters KA, Guy RH. Epidermal lipids and topical drug delivery. Semin Dermatol. 1992 Jun; 11(2):139-44. PMID: 1498017.
        View in: PubMed
      226. Guy RH, Potts RO. Structure-permeability relationships in percutaneous penetration. J Pharm Sci. 1992 Jun; 81(6):603-4. PMID: 1522504.
        View in: PubMed
      227. Potts RO, Guy RH. Predicting skin permeability. Pharm Res. 1992 May; 9(5):663-9. PMID: 1608900.
        View in: PubMed
      228. Hori M, Maibach HI, Guy RH. Enhancement of propranolol hydrochloride and diazepam skin absorption in vitro. II: Drug, vehicle, and enhancer penetration kinetics. J Pharm Sci. 1992 Apr; 81(4):330-3. PMID: 1501066.
        View in: PubMed
      229. Bommannan D, Okuyama H, Stauffer P, Guy RH. Sonophoresis. I. The use of high-frequency ultrasound to enhance transdermal drug delivery. Pharm Res. 1992 Apr; 9(4):559-64. PMID: 1495903.
        View in: PubMed
      230. Higo N, Hinz RS, Lau DT, Benet LZ, Guy RH. Cutaneous metabolism of nitroglycerin in vitro. II. Effects of skin condition and penetration enhancement. Pharm Res. 1992 Mar; 9(3):303-6. PMID: 1614960.
        View in: PubMed
      231. Higo N, Hinz RS, Lau DT, Benet LZ, Guy RH. Cutaneous metabolism of nitroglycerin in vitro. I. Homogenized versus intact skin. Pharm Res. 1992 Feb; 9(2):187-90. PMID: 1553339.
        View in: PubMed
      232. Guy RH, Potts RO, Francoeur ML. Skin barrier function and the mechanism(s) of percutaneous penetration. Acta Pharm Nord. 1992; 4(2):115. PMID: 1388754.
        View in: PubMed
      233. Kikkoji T, Gumbleton M, Higo N, Guy RH, Benet LZ. Percutaneous penetration kinetics of nitroglycerin and its dinitrate metabolites across hairless mouse skin in vitro. Pharm Res. 1991 Oct; 8(10):1231-7. PMID: 1796039.
        View in: PubMed
      234. Hinz RS, Lorence CR, Hodson CD, Hansch C, Hall LL, Guy RH. Percutaneous penetration of para-substituted phenols in vitro. Fundam Appl Toxicol. 1991 Oct; 17(3):575-83. PMID: 1794659.
        View in: PubMed
      235. Green PG, Hinz RS, Cullander C, Yamane G, Guy RH. Iontophoretic delivery of amino acids and amino acid derivatives across the skin in vitro. Pharm Res. 1991 Sep; 8(9):1113-20. PMID: 1788156.
        View in: PubMed
      236. Green PG, Hinz RS, Kim A, Szoka FC, Guy RH. Iontophoretic delivery of a series of tripeptides across the skin in vitro. Pharm Res. 1991 Sep; 8(9):1121-7. PMID: 1788157.
        View in: PubMed
      237. Shah VP, Flynn GL, Guy RH, Maibach HI, Schaefer H, Skelly JP, Wester RC, Yacobi A. In vivo percutaneous penetration/absorption, Washington, D.C., May 1989. Pharm Res. 1991 Aug; 8(8):1071-5. PMID: 1924164.
        View in: PubMed
      238. Mak VH, Potts RO, Guy RH. Does hydration affect intercellular lipid organization in the stratum corneum? Pharm Res. 1991 Aug; 8(8):1064-5. PMID: 1924161.
        View in: PubMed
      239. Cullander C, Guy RH. Sites of iontophoretic current flow into the skin: identification and characterization with the vibrating probe electrode. J Invest Dermatol. 1991 Jul; 97(1):55-64. PMID: 2056194.
        View in: PubMed
      240. Mak VH, Cumpstone MB, Kennedy AH, Harmon CS, Guy RH, Potts RO. Barrier function of human keratinocyte cultures grown at the air-liquid interface. J Invest Dermatol. 1991 Mar; 96(3):323-7. PMID: 2002253.
        View in: PubMed
      241. Tur E, Maibach HI, Guy RH. Percutaneous penetration of methyl nicotinate at three anatomic sites: evidence for an appendageal contribution to transport? Skin Pharmacol. 1991; 4(4):230-4. PMID: 1789984.
        View in: PubMed
      242. Shah VP, Flynn GL, Guy RH, Maibach HI, Schaefer H, Skelly JP, Wester RC, Yacobi A. Workshop report on in vivo percutaneous penetration/absorption. Washington D.C., May 1-3, 1989. Skin Pharmacol. 1991; 4(3):220-8. PMID: 1685087.
        View in: PubMed
      243. Potts RO, Mak VH, Guy RH, Francoeur ML. Strategies to enhance permeability via stratum corneum lipid pathways. Adv Lipid Res. 1991; 24:173-210. PMID: 1763712.
        View in: PubMed
      244. Hori M, Satoh S, Maibach HI, Guy RH. Enhancement of propranolol hydrochloride and diazepam skin absorption in vitro: effect of enhancer lipophilicity. J Pharm Sci. 1991 Jan; 80(1):32-5. PMID: 2013847.
        View in: PubMed
      245. Ridout G, Hinz RS, Hostynek JJ, Reddy AK, Wiersema RJ, Hodson CD, Lorence CR, Guy RH. The effects of zwitterionic surfactants on skin barrier function. Fundam Appl Toxicol. 1991 Jan; 16(1):41-50. PMID: 1826892.
        View in: PubMed
      246. Hori M, Ohtsuka S, Sunami M, Guy RH, Maibach HI. Cutaneous pharmacodynamics of transdermally delivered isosorbide dinitrate. Pharm Res. 1990 Dec; 7(12):1298-301. PMID: 2095569.
        View in: PubMed
      247. Surber C, Wilhelm KP, Hori M, Maibach HI, Guy RH. Optimization of topical therapy: partitioning of drugs into stratum corneum. Pharm Res. 1990 Dec; 7(12):1320-4. PMID: 2095573.
        View in: PubMed
      248. Berner B, Wilson DR, Steffens RJ, Mazzenga GC, Hinz R, Guy RH, Maibach HI. The relationship between pKa and skin irritation for a series of basic penetrants in man. Fundam Appl Toxicol. 1990 Nov; 15(4):760-6. PMID: 2086317.
        View in: PubMed
      249. Bommannan D, Potts RO, Guy RH. Examination of stratum corneum barrier function in vivo by infrared spectroscopy. J Invest Dermatol. 1990 Oct; 95(4):403-8. PMID: 2212725.
        View in: PubMed
      250. Mak VH, Potts RO, Guy RH. Percutaneous penetration enhancement in vivo measured by attenuated total reflectance infrared spectroscopy. Pharm Res. 1990 Aug; 7(8):835-41. PMID: 2235880.
        View in: PubMed
      251. Surber C, Wilhelm KP, Maibach HI, Hall LL, Guy RH. Partitioning of chemicals into human stratum corneum: implications for risk assessment following dermal exposure. Fundam Appl Toxicol. 1990 Jul; 15(1):99-107. PMID: 2373304.
        View in: PubMed
      252. Bucks DA, Hinz RS, Sarason R, Maibach HI, Guy RH. In vivo percutaneous absorption of chemicals: a multiple dose study in rhesus monkeys. Food Chem Toxicol. 1990 Feb; 28(2):129-32. PMID: 2341090.
        View in: PubMed
      253. Roskos KV, Bircher AJ, Maibach HI, Guy RH. Pharmacodynamic measurements of methyl nicotinate percutaneous absorption: the effect of aging on microcirculation. Br J Dermatol. 1990 Feb; 122(2):165-71. PMID: 2317445.
        View in: PubMed
      254. Roskos KV, Maibach HI, Guy RH. The effect of aging on percutaneous absorption in man. J Pharmacokinet Biopharm. 1989 Dec; 17(6):617-30. PMID: 2635737.
        View in: PubMed
      255. Glikfeld P, Hinz RS, Guy RH. Noninvasive sampling of biological fluids by iontophoresis. Pharm Res. 1989 Nov; 6(11):988-90. PMID: 2594693.
        View in: PubMed
      256. Roskos KV, Guy RH. Assessment of skin barrier function using transepidermal water loss: effect of age. Pharm Res. 1989 Nov; 6(11):949-53. PMID: 2594686.
        View in: PubMed
      257. Hinz RS, Hodson CD, Lorence CR, Guy RH. In vitro percutaneous penetration: evaluation of the utility of hairless mouse skin. J Invest Dermatol. 1989 Jul; 93(1):87-91. PMID: 2746008.
        View in: PubMed
      258. Ashworth J, Coady AT, Guy R, Breathnach SM. Brawny cutaneous induration and granulomatous panniculitis in large cell non-Hodgkin's (T suppressor/cytotoxic cell) lymphoma. Br J Dermatol. 1989 Apr; 120(4):563-9. PMID: 2786426.
        View in: PubMed
      259. Gean CJ, Tur E, Maibach HI, Guy RH. Cutaneous responses to topical methyl nicotinate in black, oriental, and caucasian subjects. Arch Dermatol Res. 1989; 281(2):95-8. PMID: 2774642.
        View in: PubMed
      260. Guy RH, Hadgraft J. Physicochemical aspects of percutaneous penetration and its enhancement. Pharm Res. 1988 Dec; 5(12):753-8. PMID: 3247284.
        View in: PubMed
      261. Berner B, Wilson DR, Guy RH, Mazzenga GC, Clarke FH, Maibach HI. The relationship of pKa and acute skin irritation in man. Pharm Res. 1988 Oct; 5(10):660-3. PMID: 3244620.
        View in: PubMed
      262. Ryatt KS, Mobayen M, Stevenson JM, Maibach HI, Guy RH. Methodology to measure the transient effect of occlusion on skin penetration and stratum corneum hydration in vivo. Br J Dermatol. 1988 Sep; 119(3):307-12. PMID: 3179203.
        View in: PubMed
      263. Ridout G, Santus GC, Guy RH. Pharmacokinetic considerations in the use of newer transdermal formulations. Clin Pharmacokinet. 1988 Aug; 15(2):114-31. PMID: 3064951.
        View in: PubMed
      264. Bucks DA, McMaster JR, Maibach HI, Guy RH. Bioavailability of topically administered steroids: a "mass balance" technique. J Invest Dermatol. 1988 Jul; 91(1):29-33. PMID: 3385214.
        View in: PubMed
      265. Glikfeld P, Cullander C, Hinz RS, Guy RH. A new system for in vitro studies of iontophoresis. Pharm Res. 1988 Jul; 5(7):443-6. PMID: 3247315.
        View in: PubMed
      266. Bucks DA, Maibach HI, Guy RH. Mass balance and dose accountability in percutaneous absorption studies: development of a nonocclusive application system. Pharm Res. 1988 May; 5(5):313-5. PMID: 3244642.
        View in: PubMed
      267. Bucks DA, McMaster JR, Guy RH, Maibach HI. Percutaneous absorption of hydroquinone in humans: effect of 1-dodecylazacycloheptan-2-one (azone) and the 2-ethylhexyl ester of 4-(dimethylamino)benzoic acid (Escalol 507). J Toxicol Environ Health. 1988; 24(3):279-89. PMID: 3260963.
        View in: PubMed
      268. Khan A, Schall LM, Tur E, Maibach HI, Guy RH. Blood flow in psoriatic skin lesions: the effect of treatment. Br J Dermatol. 1987 Aug; 117(2):193-201. PMID: 2958077.
        View in: PubMed
      269. Guy RH, Hadgraft J, Bucks DA. Transdermal drug delivery and cutaneous metabolism. Xenobiotica. 1987 Mar; 17(3):325-43. PMID: 3107225.
        View in: PubMed
      270. Knepp VM, Hadgraft J, Guy RH. Transdermal drug delivery: problems and possibilities. Crit Rev Ther Drug Carrier Syst. 1987; 4(1):13-37. PMID: 3315235.
        View in: PubMed
      271. Guy RH, Carlström EM, Bucks DA, Hinz RS, Maibach HI. Percutaneous penetration of nicotinates: in vivo and in vitro measurements. J Pharm Sci. 1986 Oct; 75(10):968-72. PMID: 3795027.
        View in: PubMed
      272. Beastall J, Guy RH, Hadgraft J, Wilding I. The influence of urea on percutaneous absorption. Pharm Res. 1986 Oct; 3(5):294-7. PMID: 24271713.
        View in: PubMed
      273. Guy RH, Guy AH, Maibach HI, Shah VP. The bioavailability of dermatological and other topically administered drugs. Pharm Res. 1986 Oct; 3(5):253-62. PMID: 24271707.
        View in: PubMed
      274. Roskos KV, Guy RH, Maibach HI. Percutaneous absorption in the aged. Dermatol Clin. 1986 Jul; 4(3):455-65. PMID: 3521990.
        View in: PubMed
      275. Ryatt KS, Stevenson JM, Maibach HI, Guy RH. Pharmacodynamic measurement of percutaneous penetration enhancement in vivo. J Pharm Sci. 1986 Apr; 75(4):374-7. PMID: 2941564.
        View in: PubMed
      276. Guy RH, Tur E, Schall LM, Elamir S, Maibach HI. Determination of vehicle effects on percutaneous absorption by laser Doppler velocimetry. Arch Dermatol Res. 1986; 278(6):500-2. PMID: 2947545.
        View in: PubMed
      277. Bucks DA, Maibach HI, Guy RH. Percutaneous absorption of steroids: effect of repeated application. J Pharm Sci. 1985 Dec; 74(12):1337-9. PMID: 4087204.
        View in: PubMed
      278. Young AR, Guy RH, Maibach HI. Laser Doppler velocimetry to quantify UV-B induced increase in human skin blood flow. Photochem Photobiol. 1985 Oct; 42(4):385-90. PMID: 4089026.
        View in: PubMed
      279. Guy RH, Hadgraft J. Pharmacokinetic interpretation of the plasma levels of clonidine following transdermal delivery. J Pharm Sci. 1985 Sep; 74(9):1016-8. PMID: 4067843.
        View in: PubMed
      280. Guy RH, Hadgraft J. Kinetic analysis of transdermal nitroglycerin delivery. Pharm Res. 1985 Sep; 2(5):206-11. PMID: 24272837.
        View in: PubMed
      281. Tur E, Maibach HI, Guy RH. Spatial variability of vasodilatation in human forearm skin. Br J Dermatol. 1985 Aug; 113(2):197-203. PMID: 4027187.
        View in: PubMed
      282. Guy RH, Tur E, Bjerke S, Maibach HI. Are there age and racial differences to methyl nicotinate-induced vasodilatation in human skin? J Am Acad Dermatol. 1985 Jun; 12(6):1001-6. PMID: 3159763.
        View in: PubMed
      283. Guy RH, Hadgraft J, Maibach HI. Percutaneous absorption in man: a kinetic approach. Toxicol Appl Pharmacol. 1985 Mar 30; 78(1):123-9. PMID: 4035664.
        View in: PubMed
      284. Guy RH, Tur E, Maibach HI. Optical techniques for monitoring cutaneous microcirculation. Recent applications. Int J Dermatol. 1985 Mar; 24(2):88-94. PMID: 3157651.
        View in: PubMed
      285. Zackheim HS, Tur E, Guy RH. Regional blood flow and mycosis fungoides. J Am Acad Dermatol. 1985 Mar; 12(3):578-80. PMID: 3989018.
        View in: PubMed
      286. Drouard V, Wilson DR, Maibach HI, Guy RH. Quantitative assessment of UV-induced changes in microcirculatory flow by laser Doppler velocimetry. J Invest Dermatol. 1984 Sep; 83(3):188-92. PMID: 6470523.
        View in: PubMed
      287. Guy RH, Hadgraft J. Prediction of drug disposition kinetics in skin and plasma following topical administration. J Pharm Sci. 1984 Jul; 73(7):883-7. PMID: 6470948.
        View in: PubMed
      288. Wester RC, Maibach HI, Guy RH, Novak E. Minoxidil stimulates cutaneous blood flow in human balding scalps: pharmacodynamics measured by laser Doppler velocimetry and photopulse plethysmography. J Invest Dermatol. 1984 May; 82(5):515-7. PMID: 6239893.
        View in: PubMed
      289. Guy RH, Tur E, Bugatto B, Gaebel C, Sheiner LB, Maibach HI. Pharmacodynamic measurements of methyl nicotinate percutaneous absorption. Pharm Res. 1984 Mar; 1(2):76-81. PMID: 24277216.
        View in: PubMed
      290. Guy RH, Maibach HI. Correction factors for determining body exposure from forearm percutaneous absorption data. J Appl Toxicol. 1984 Feb; 4(1):26-8. PMID: 6715780.
        View in: PubMed
      291. Guy RH, Hinz RS, Amantea M. Solute transport and perturbation at liquid/liquid interfaces. Faraday Discuss Chem Soc. 1984; (77):127-37. PMID: 6526077.
        View in: PubMed
      292. Guy RH, Maibach HI. Drug delivery to local subcutaneous structures following topical administration. J Pharm Sci. 1983 Dec; 72(12):1375-80. PMID: 6363673.
        View in: PubMed
      293. Tur E, Tur M, Maibach HI, Guy RH. Basal perfusion of the cutaneous microcirculation: measurements as a function of anatomic position. J Invest Dermatol. 1983 Nov; 81(5):442-6. PMID: 6631055.
        View in: PubMed
      294. Guy RH, Wester RC, Tur E, Maibach HI. Noninvasive assessments of the percutaneous absorption of methyl nicotinate in humans. J Pharm Sci. 1983 Sep; 72(9):1077-9. PMID: 6631699.
        View in: PubMed
      295. Tur E, Guy RH, Tur M, Maibach HI. Noninvasive assessment of local nicotinate pharmacodynamics by photoplethysmography. J Invest Dermatol. 1983 Jun; 80(6):499-503. PMID: 6854050.
        View in: PubMed
      296. Guy RH, Hadgraft J. Physicochemical interpretation of the pharmacokinetics of percutaneous absorption. J Pharmacokinet Biopharm. 1983 Apr; 11(2):189-203. PMID: 6886974.
        View in: PubMed
      297. Wester RC, Maibach HI, Bucks DA, Guy RH. Malathion percutaneous absorption after repeated administration to man. Toxicol Appl Pharmacol. 1983 Mar 30; 68(1):116-9. PMID: 6845371.
        View in: PubMed
      298. Fleming R, Guy RH, Hadgraft J. Kinetics and thermodynamics of interfacial transfer. J Pharm Sci. 1983 Feb; 72(2):142-5. PMID: 6834250.
        View in: PubMed
      299. Guy RH, Hadgraft J, Taylor MJ, Kellaway IW. Release of non-electrolytes from liposomes. J Pharm Pharmacol. 1983 Jan; 35(1):12-4. PMID: 6131957.
        View in: PubMed
      300. Amantea M, Tur E, Maibach HI, Guy RH. Preliminary skin blood flow measurements appear unsuccessful for assessing topical corticosteroid effect. Arch Dermatol Res. 1983; 275(6):419-20. PMID: 6660915.
        View in: PubMed
      301. Cadman AD, Fleming R, Guy RH. Diffusion of lysozyme chloride in water and aqueous potassium chloride solutions. Biophys J. 1982 Mar; 37(3):569-74. PMID: 7074186; PMCID: PMC1328842.
      302. Guy RH, Maibach HI. Rapid radial transport of methyl nicotinate in the dermis. Arch Dermatol Res. 1982; 273(1-2):91-5. PMID: 7184475.
        View in: PubMed
      303. Guy RH, Hadgraft J. Theoretical comparison of release rates of drugs into sink and nonsink conditions. J Pharm Sci. 1981 Nov; 70(11):1243-5. PMID: 7299670.
        View in: PubMed
      Richard's Networks
      Related Concepts
      Derived automatically from this person's publications.
      _
      Co-Authors
      People in Profiles who have published with this person.
      _
      Related Authors
      People who share related concepts with this person.
      _
      Back to TOP