Richard Guy, PhD
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| Title | Professor |
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| School | UCSF School of Pharmacy |
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| Department | Bioengineering and Therapeutic Sciences |
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| Address | 1700 4th Street, Byers Hall San Francisco CA 94158
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| Phone | 415-476-1936 |
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Overview Richard Guy received an M.A. in Chemistry from Oxford University, and his Ph.D. in Pharmaceutical Chemistry from the University of London. He has held academic posts at the University of California, San Francisco (where he remains an Adjunct Professor) and the University of Geneva. In 2004, he joined the University of Bath as Professor of Pharmaceutical Sciences, and he currently serves as the Chair of the Research Committee of the Department of Pharmacy & Pharmacology. Dr. Guy is an elected fellow of the Academy of Pharmaceutical Scientists, Great Britain, the Royal Society of Chemistry, the Controlled Release Society, the American Association of Pharmaceutical Scientists, and the American Association for the Advancement of Science.
Dr. Guy's research focuses on skin barrier function characterization, transdermal drug delivery, enhancement of percutaneous absorption, iontophoresis, noninvasive biosensing, and the prediction and assessment of skin penetration and topical bioavailability. Dr. Guy has published 300+ peer-reviewed articles and over 70 book chapters. He has co-authored one book and co-edited 7 others. He is also co-inventor of 12 patents. Specific ongoing projects include: measurement of the skin's biomechanical properties at the nanoscale using atomic force microscopy; the detection and quantification of skin barrier disruption by surfactants found in commonly used cosmetic, personal care and pharmaceutical products; the potential of polymeric film-forming systems as sustained release platforms for topical drugs; determination of the disposition of drug and formulation excipients (including nanoparticles) post-application to the skin using coherent Raman scattering and confocal microscopy; identification of skin-penetrating constituents of traditional, topical Thai medicines and their re-formulation; development of an integrated iontophoretic delivery system for buprenorphine and naltrexone to treat polydrug abuse; examination of a graphene-based biosensor for noninvasive, transdermal glucose monitoring; and derivation and evaluation of predictive models of percutaneous penetration for pharmaceutical and cosmetic 'actives', and for potentially toxic chemicals, which come into contact with skin.
Bibliographic
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Benzeval I, Bowen CR, Guy RH, Delgado-Charro MB. Effects of iontophoresis, hydration, and permeation enhancers on human nail plate: infrared and impedance spectroscopy assessment. Pharm Res. 2013 Jun; 30(6):1652-62.
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Gelfuso GM, Gratieri T, Delgado-Charro MB, Guy RH, Vianna Lopez RF. Iontophoresis-targeted, follicular delivery of minoxidil sulfate for the treatment of alopecia. J Pharm Sci. 2013 May; 102(5):1488-94.
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Russell LM, Guy RH. Novel Imaging Method to Quantify Stratum Corneum in Dermatopharmacokinetic Studies: Proof-of-Concept with Acyclovir Formulations. Pharm Res. 2012 Dec; 29(12):3362-72.
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Campbell CS, Contreras-Rojas LR, Delgado-Charro MB, Guy RH. Objective assessment of nanoparticle disposition in mammalian skin after topical exposure. J Control Release. 2012 Aug 20; 162(1):201-7.
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Mohammed D, Yang Q, Guy RH, Matts PJ, Hadgraft J, Lane ME. Comparison of gravimetric and spectroscopic approaches to quantify stratum corneum removed by tape-stripping. Eur J Pharm Biopharm. 2012 Sep; 82(1):171-4.
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Russell LM, Guy RH. Novel imaging method to quantify stratum corneum in dermatopharmacokinetic studies. Pharm Res. 2012 Sep; 29(9):2389-97.
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Djabri A, Guy RH, Delgado-Charro MB. Transdermal iontophoresis of ranitidine: an opportunity in paediatric drug therapy. Int J Pharm. 2012 Oct 1; 435(1):27-32.
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Djabri A, Guy RH, Delgado-Charro MB. Passive and iontophoretic transdermal delivery of phenobarbital: Implications in paediatric therapy. Int J Pharm. 2012 Oct 1; 435(1):76-82.
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Saar BG, Contreras-Rojas LR, Xie XS, Guy RH. Imaging drug delivery to skin with stimulated Raman scattering microscopy. Mol Pharm. 2011 Jun 6; 8(3):969-75.
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Belsey NA, Cordery SF, Bunge AL, Guy RH. Assessment of dermal exposure to pesticide residues during re-entry. Environ Sci Technol. 2011 May 15; 45(10):4609-15.
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Mitragotri S, Anissimov YG, Bunge AL, Frasch HF, Guy RH, Hadgraft J, Kasting GB, Lane ME, Roberts MS. Mathematical models of skin permeability: an overview. Int J Pharm. 2011 Oct 10; 418(1):115-29.
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Guy RH, Szoka FC. Perturbation of solute transport at a liquid-liquid interface by polyethylene glycol (PEG): implications for PEG-induced biomembrane fusion. Phys Chem Chem Phys. 2011 Mar 28; 13(12):5346-52.
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Tsang M, Guy RH. Effect of Aqueous Cream BP on human stratum corneum in vivo. Br J Dermatol. 2010 Nov; 163(5):954-8.
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Sylvestre JP, Bouissou CC, Guy RH, Delgado-Charro MB. Extraction and quantification of amino acids in human stratum corneum in vivo. Br J Dermatol. 2010 Sep; 163(3):458-65.
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Hathout RM, Mansour S, Mortada ND, Geneidi AS, Guy RH. Uptake of microemulsion components into the stratum corneum and their molecular effects on skin barrier function. Mol Pharm. 2010 Aug 2; 7(4):1266-73.
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Güngör S, Delgado-Charro MB, Ruiz-Perez B, Schubert W, Isom P, Moslemy P, Patane MA, Guy RH. Trans-scleral iontophoretic delivery of low molecular weight therapeutics. J Control Release. 2010 Oct 15; 147(2):225-31.
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Watkinson RM, Guy RH, Oliveira G, Hadgraft J, Lane ME. Optimisation of cosolvent concentration for topical drug delivery III--influence of lipophilic vehicles on ibuprofen permeation. Skin Pharmacol Physiol. 2011; 24(1):22-6.
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Guy RH. Predicting the rate and extent of fragrance chemical absorption into and through the skin. Chem Res Toxicol. 2010 May 17; 23(5):864-70.
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Hathout RM, Woodman TJ, Mansour S, Mortada ND, Geneidi AS, Guy RH. Microemulsion formulations for the transdermal delivery of testosterone. Eur J Pharm Sci. 2010 Jun 14; 40(3):188-96.
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Guy RH. Transdermal drug delivery. Handb Exp Pharmacol. 2010; (197):399-410.
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Wu X, Landfester K, Musyanovych A, Guy RH. Disposition of charged nanoparticles after their topical application to the skin. Skin Pharmacol Physiol. 2010; 23(3):117-23.
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Bouissou CC, Sylvestre JP, Guy RH, Delgado-Charro MB. Reverse iontophoresis of amino acids: identification and separation of stratum corneum and subdermal sources in vitro. Pharm Res. 2009 Dec; 26(12):2630-8.
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Wu X, Griffin P, Price GJ, Guy RH. Preparation and in vitro evaluation of topical formulations based on polystyrene-poly-2-hydroxyl methacrylate nanoparticles. Mol Pharm. 2009 Sep-Oct; 6(5):1449-56.
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Wu X, Price GJ, Guy RH. Disposition of nanoparticles and an associated lipophilic permeant following topical application to the skin. Mol Pharm. 2009 Sep-Oct; 6(5):1441-8.
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Watkinson RM, Guy RH, Hadgraft J, Lane ME. Optimisation of cosolvent concentration for topical drug delivery - II: influence of propylene glycol on ibuprofen permeation. Skin Pharmacol Physiol. 2009; 22(4):225-30.
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Wu X, Biatry B, Cazeneuve C, Guy RH. Drug delivery to the skin from sub-micron polymeric particle formulations: influence of particle size and polymer hydrophobicity. Pharm Res. 2009 Aug; 26(8):1995-2001.
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Cork MJ, Danby SG, Vasilopoulos Y, Hadgraft J, Lane ME, Moustafa M, Guy RH, Macgowan AL, Tazi-Ahnini R, Ward SJ. Epidermal barrier dysfunction in atopic dermatitis. J Invest Dermatol. 2009 Aug; 129(8):1892-908.
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Sieg A, Jeanneret F, Fathi M, Hochstrasser D, Rudaz S, Veuthey JL, Guy RH, Delgado-Charro MB. Extraction of amino acids by reverse iontophoresis in vivo. Eur J Pharm Biopharm. 2009 May; 72(1):226-31.
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Russell LM, Guy RH. Measurement and prediction of the rate and extent of drug delivery into and through the skin. Expert Opin Drug Deliv. 2009 Apr; 6(4):355-69.
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Mehier-Humbert S, Bettinger T, Yan F, Guy R. Influence of polymer adjuvants on the ultrasound-mediated transfection of cells in culture. Eur J Pharm Biopharm. 2009 Aug; 72(3):567-73.
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Wiedersberg S, Leopold CS, Guy RH. Effects of various vehicles on skin hydration in vivo. Skin Pharmacol Physiol. 2009; 22(3):128-30.
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Watkinson RM, Herkenne C, Guy RH, Hadgraft J, Oliveira G, Lane ME. Influence of ethanol on the solubility, ionization and permeation characteristics of ibuprofen in silicone and human skin. Skin Pharmacol Physiol. 2009; 22(1):15-21.
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Yow HN, Wu X, Routh AF, Guy RH. Dye diffusion from microcapsules with different shell thickness into mammalian skin. Eur J Pharm Biopharm. 2009 May; 72(1):62-8.
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Nicoli S, Bunge AL, Delgado-Charro MB, Guy RH. Dermatopharmacokinetics: factors influencing drug clearance from the stratum corneum. Pharm Res. 2009 Apr; 26(4):865-71.
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N'Dri-Stempfer B, Navidi WC, Guy RH, Bunge AL. Improved bioequivalence assessment of topical dermatological drug products using dermatopharmacokinetics. Pharm Res. 2009 Feb; 26(2):316-28.
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Wiedersberg S, Leopold CS, Guy RH. Dermatopharmacokinetics of betamethasone 17-valerate: influence of formulation viscosity and skin surface cleaning procedure. Eur J Pharm Biopharm. 2009 Feb; 71(2):362-6.
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Grégoire S, Ribaud C, Benech F, Meunier JR, Garrigues-Mazert A, Guy RH. Prediction of chemical absorption into and through the skin from cosmetic and dermatological formulations. Br J Dermatol. 2009 Jan; 160(1):80-91.
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Wiedersberg S, Naik A, Leopold CS, Guy RH. Pharmacodynamics and dermatopharmacokinetics of betamethasone 17-valerate: assessment of topical bioavailability. Br J Dermatol. 2009 Mar; 160(3):676-86.
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Sylvestre JP, Guy RH, Delgado-Charro MB. In vitro optimization of dexamethasone phosphate delivery by iontophoresis. Phys Ther. 2008 Oct; 88(10):1177-85.
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Sieg A, Jeanneret F, Fathi M, Hochstrasser D, Rudaz S, Veuthey JL, Guy RH, Delgado-Charro MB. Extraction of amino acids by reverse iontophoresis: simulation of therapeutic monitoring in vitro. Eur J Pharm Biopharm. 2008 Nov; 70(3):908-13.
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Sylvestre JP, Díaz-Marín C, Delgado-Charro MB, Guy RH. Iontophoresis of dexamethasone phosphate: competition with chloride ions. J Control Release. 2008 Oct 6; 131(1):41-6.
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N'Dri-Stempfer B, Navidi WC, Guy RH, Bunge AL. Optimizing metrics for the assessment of bioequivalence between topical drug products. Pharm Res. 2008 Jul; 25(7):1621-30.
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Wascotte V, Rozet E, Salvaterra A, Hubert P, Jadoul M, Guy RH, Préat V. Non-invasive diagnosis and monitoring of chronic kidney disease by reverse iontophoresis of urea in vivo. Eur J Pharm Biopharm. 2008 Aug; 69(3):1077-82.
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Dias M, Naik A, Guy RH, Hadgraft J, Lane ME. In vivo infrared spectroscopy studies of alkanol effects on human skin. Eur J Pharm Biopharm. 2008 Aug; 69(3):1171-5.
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Herkenne C, Naik A, Kalia YN, Hadgraft J, Guy RH. Effect of propylene glycol on ibuprofen absorption into human skin in vivo. J Pharm Sci. 2008 Jan; 97(1):185-97.
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Nixon S, Sieg A, Delgado-Charro MB, Guy RH. Reverse iontophoresis of L-lactate: in vitro and in vivo studies. J Pharm Sci. 2007 Dec; 96(12):3457-65.
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Herkenne C, Alberti I, Naik A, Kalia YN, Mathy FX, Préat V, Guy RH. In vivo methods for the assessment of topical drug bioavailability. Pharm Res. 2008 Jan; 25(1):87-103.
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Wiedersberg S, Leopold CS, Guy RH. Bioavailability and bioequivalence of topical glucocorticoids. Eur J Pharm Biopharm. 2008 Mar; 68(3):453-66.
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Trichard L, Delgado-Charro MB, Guy RH, Fattal E, Bochot A. Novel beads made of alpha-cyclodextrin and oil for topical delivery of a lipophilic drug. Pharm Res. 2008 Feb; 25(2):435-40.
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Mudry B, Carrupt PA, Guy RH, Delgado-Charro MB. Quantitative structure-permeation relationship for iontophoretic transport across the skin. J Control Release. 2007 Sep 26; 122(2):165-72.
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Kroes R, Renwick AG, Feron V, Galli CL, Gibney M, Greim H, Guy RH, Lhuguenot JC, van de Sandt JJ. Application of the threshold of toxicological concern (TTC) to the safety evaluation of cosmetic ingredients. Food Chem Toxicol. 2007 Dec; 45(12):2533-62.
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Diaz del Consuelo I, Falson F, Guy RH, Jacques Y. Ex vivo evaluation of bioadhesive films for buccal delivery of fentanyl. J Control Release. 2007 Sep 26; 122(2):135-40.
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Wascotte V, Caspers P, de Sterke J, Jadoul M, Guy RH, Préat V. Assessment of the "skin reservoir" of urea by confocal Raman microspectroscopy and reverse iontophoresis in vivo. Pharm Res. 2007 Oct; 24(10):1897-901.
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Mehier-Humbert S, Yan F, Frinking P, Schneider M, Guy RH, Bettinger T. Ultrasound-mediated gene delivery: influence of contrast agent on transfection. Bioconjug Chem. 2007 May-Jun; 18(3):652-62.
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Wascotte V, Delgado-Charro MB, Rozet E, Wallemacq P, Hubert P, Guy RH, Préat V. Monitoring of urea and potassium by reverse iontophoresis in vitro. Pharm Res. 2007 Jun; 24(6):1131-7.
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Leichtnam ML, Rolland H, Wüthrich P, Guy RH. Impact of antinucleants on transdermal delivery of testosterone from a spray. J Pharm Sci. 2007 Jan; 96(1):84-92.
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Herkenne C, Naik A, Kalia YN, Hadgraft J, Guy RH. Dermatopharmacokinetic prediction of topical drug bioavailability in vivo. J Invest Dermatol. 2007 Apr; 127(4):887-94.
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Leichtnam ML, Rolland H, Wüthrich P, Guy RH. Enhancement of transdermal testosterone delivery by supersaturation. J Pharm Sci. 2006 Nov; 95(11):2373-9.
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Leichtnam ML, Rolland H, Wüthrich P, Guy RH. Formulation and evaluation of a testosterone transdermal spray. J Pharm Sci. 2006 Aug; 95(8):1693-702.
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Herkenne C, Naik A, Kalia YN, Hadgraft J, Guy RH. Pig ear skin ex vivo as a model for in vivo dermatopharmacokinetic studies in man. Pharm Res. 2006 Aug; 23(8):1850-6.
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Abla N, Naik A, Guy RH, Kalia YN. Topical iontophoresis of valaciclovir hydrochloride improves cutaneous aciclovir delivery. Pharm Res. 2006 Aug; 23(8):1842-9.
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Herkenne C, Naik A, Kalia YN, Hadgraft J, Guy RH. Ibuprofen transport into and through skin from topical formulations: in vitro-in vivo comparison. J Invest Dermatol. 2007 Jan; 127(1):135-42.
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Leichtnam ML, Rolland H, Wüthrich P, Guy RH. Testosterone hormone replacement therapy: state-of-the-art and emerging technologies. Pharm Res. 2006 Jun; 23(6):1117-32.
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Schuetz YB, Carrupt PA, Naik A, Guy RH, Kalia YN. Structure-permeation relationships for the non-invasive transdermal delivery of cationic peptides by iontophoresis. Eur J Pharm Sci. 2006 Sep; 29(1):53-9.
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Leichtnam ML, Rolland H, Wüthrich P, Guy RH. Identification of penetration enhancers for testosterone transdermal delivery from spray formulations. J Control Release. 2006 Jun 12; 113(1):57-62.
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Mudry B, Guy RH, Delgado-Charro MB. Electromigration of ions across the skin: determination and prediction of transport numbers. J Pharm Sci. 2006 Mar; 95(3):561-9.
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Mudry B, Guy RH, Begoña Delgado-Charro M. Prediction of iontophoretic transport across the skin. J Control Release. 2006 Apr 10; 111(3):362-7.
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Mudry B, Guy RH, Delgado-Charro MB. Transport numbers in transdermal iontophoresis. Biophys J. 2006 Apr 15; 90(8):2822-30.
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Diaz Del Consuelo I, Pizzolato GP, Falson F, Guy RH, Jacques Y. Evaluation of pig esophageal mucosa as a permeability barrier model for buccal tissue. J Pharm Sci. 2005 Dec; 94(12):2777-88.
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Abla N, Geiser L, Mirgaldi M, Naik A, Veuthey JL, Guy RH, Kalia YN. Capillary zone electrophoresis for the estimation of transdermal iontophoretic mobility. J Pharm Sci. 2005 Dec; 94(12):2667-75.
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Schuetz YB, Naik A, Guy RH, Vuaridel E, Kalia YN. Transdermal iontophoretic delivery of triptorelin in vitro. J Pharm Sci. 2005 Oct; 94(10):2175-82.
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Abla N, Naik A, Guy RH, Kalia YN. Effect of charge and molecular weight on transdermal peptide delivery by iontophoresis. Pharm Res. 2005 Dec; 22(12):2069-78.
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Abla N, Naik A, Guy RH, Kalia YN. Contributions of electromigration and electroosmosis to peptide iontophoresis across intact and impaired skin. J Control Release. 2005 Nov 28; 108(2-3):319-30.
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Schuetz YB, Naik A, Guy RH, Kalia YN. Effect of amino acid sequence on transdermal iontophoretic peptide delivery. Eur J Pharm Sci. 2005 Dec; 26(5):429-37.
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Diaz Del Consuelo I, Falson F, Guy RH, Jacques Y. Transport of fentanyl through pig buccal and esophageal epithelia in vitro: influence of concentration and vehicle pH. Pharm Res. 2005 Sep; 22(9):1525-9.
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Schuetz YB, Naik A, Guy RH, Vuaridel E, Kalia YN. Transdermal iontophoretic delivery of vapreotide acetate across porcine skin in vitro. Pharm Res. 2005 Aug; 22(8):1305-12.
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Diaz-Del Consuelo I, Jacques Y, Pizzolato GP, Guy RH, Falson F. Comparison of the lipid composition of porcine buccal and esophageal permeability barriers. Arch Oral Biol. 2005 Dec; 50(12):981-7.
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Touraille GD, McCarley KD, Bunge AL, Marty JP, Guy RH. Percutaneous absorption of 4-cyanophenol from freshly contaminated soil in vitro: effects of soil loading and contamination concentration. Environ Sci Technol. 2005 May 15; 39(10):3723-31.
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Schuetz YB, Naik A, Guy RH, Kalia YN. Emerging strategies for the transdermal delivery of peptide and protein drugs. Expert Opin Drug Deliv. 2005 May; 2(3):533-48.
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Mehier-Humbert S, Guy RH. Physical methods for gene transfer: improving the kinetics of gene delivery into cells. Adv Drug Deliv Rev. 2005 Apr 5; 57(5):733-53.
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Mehier-Humbert S, Bettinger T, Yan F, Guy RH. Plasma membrane poration induced by ultrasound exposure: implication for drug delivery. J Control Release. 2005 May 5; 104(1):213-22.
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Mehier-Humbert S, Bettinger T, Yan F, Guy RH. Ultrasound-mediated gene delivery: kinetics of plasmid internalization and gene expression. J Control Release. 2005 May 5; 104(1):203-11.
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Sieg A, Guy RH, Delgado-Charro MB. Noninvasive and minimally invasive methods for transdermal glucose monitoring. Diabetes Technol Ther. 2005 Feb; 7(1):174-97.
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Wascotte V, Leboulanger B, Guy RH, Begoña Delgado-Charro M. Reverse iontophoresis of lithium: electrode formulation using a thermoreversible polymer. Eur J Pharm Biopharm. 2005 Jan; 59(1):237-40.
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Sekkat N, Kalia YN, Guy RH. Development of an in vitro model for premature neonatal skin: biophysical characterization using transepidermal water loss. J Pharm Sci. 2004 Dec; 93(12):2936-40.
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Merclin N, Bender J, Sparr E, Guy RH, Ehrsson H, Engström S. Transdermal delivery from a lipid sponge phase--iontophoretic and passive transport in vitro of 5-aminolevulinic acid and its methyl ester. J Control Release. 2004 Nov 24; 100(2):191-8.
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Sieg A, Guy RH, Delgado-Charro MB. Simultaneous extraction of urea and glucose by reverse iontophoresis in vivo. Pharm Res. 2004 Oct; 21(10):1805-10.
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Alvarez-Román R, Naik A, Kalia YN, Guy RH, Fessi H. Enhancement of topical delivery from biodegradable nanoparticles. Pharm Res. 2004 Oct; 21(10):1818-25.
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Alvarez-Román R, Naik A, Kalia YN, Guy RH, Fessi H. Skin penetration and distribution of polymeric nanoparticles. J Control Release. 2004 Sep 14; 99(1):53-62.
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Alvarez-Román R, Naik A, Kalia YN, Fessi H, Guy RH. Visualization of skin penetration using confocal laser scanning microscopy. Eur J Pharm Biopharm. 2004 Sep; 58(2):301-16.
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Sieg A, Guy RH, Delgado-Charro MB. Electroosmosis in transdermal iontophoresis: implications for noninvasive and calibration-free glucose monitoring. Biophys J. 2004 Nov; 87(5):3344-50.
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Leboulanger B, Guy RH, Delgado-Charro MB. Non-invasive monitoring of phenytoin by reverse iontophoresis. Eur J Pharm Sci. 2004 Aug; 22(5):427-33.
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Sekkat N, Kalia YN, Guy RH. Porcine ear skin as a model for the assessment of transdermal drug delivery to premature neonates. Pharm Res. 2004 Aug; 21(8):1390-7.
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Leboulanger B, Fathi M, Guy RH, Delgado-Charro MB. Reverse iontophoresis as a noninvasive tool for lithium monitoring and pharmacokinetic profiling. Pharm Res. 2004 Jul; 21(7):1214-22.
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Leboulanger B, Aubry JM, Bondolfi G, Guy RH, Delgado-Charro MB. Lithium monitoring by reverse iontophoresis in vivo. Clin Chem. 2004 Nov; 50(11):2091-100.
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Leboulanger B, Guy RH, Delgado-Charro MB. Reverse iontophoresis for non-invasive transdermal monitoring. Physiol Meas. 2004 Jun; 25(3):R35-50.
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Sieg A, Guy RH, Delgado-Charro MB. Noninvasive glucose monitoring by reverse iontophoresis in vivo: application of the internal standard concept. Clin Chem. 2004 Aug; 50(8):1383-90.
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Kalia YN, Naik A, Garrison J, Guy RH. Iontophoretic drug delivery. Adv Drug Deliv Rev. 2004 Mar 27; 56(5):619-58.
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Curdy C, Naik A, Kalia YN, Alberti I, Guy RH. Non-invasive assessment of the effect of formulation excipients on stratum corneum barrier function in vivo. Int J Pharm. 2004 Mar 1; 271(1-2):251-6.
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Lopez RF, Lange N, Guy R, Bentley MV. Photodynamic therapy of skin cancer: controlled drug delivery of 5-ALA and its esters. Adv Drug Deliv Rev. 2004 Jan 13; 56(1):77-94.
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Geinoz S, Guy RH, Testa B, Carrupt PA. Quantitative structure-permeation relationships (QSPeRs) to predict skin permeation: a critical evaluation. Pharm Res. 2004 Jan; 21(1):83-92.
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Hadgraft J, Guy R. Biotechnological aspects of transport across human skin. Biotechnol Genet Eng Rev. 2004; 21:183-93.
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Sieg A, Guy RH, Delgado-Charro MB. Reverse iontophoresis for noninvasive glucose monitoring: the internal standard concept. J Pharm Sci. 2003 Nov; 92(11):2295-302.
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Delgado-Charro MB, Guy RH. Transdermal reverse iontophoresis of valproate: a noninvasive method for therapeutic drug monitoring. Pharm Res. 2003 Sep; 20(9):1508-13.
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Merino G, Kalia YN, Guy RH. Ultrasound-enhanced transdermal transport. J Pharm Sci. 2003 Jun; 92(6):1125-37.
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Alvarez-Román R, Merino G, Kalia YN, Naik A, Guy RH. Skin permeability enhancement by low frequency sonophoresis: lipid extraction and transport pathways. J Pharm Sci. 2003 Jun; 92(6):1138-46.
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Lopez RF, Bentley MV, Delgado-Charro MB, Salomon D, van den Bergh H, Lange N, Guy RH. Enhanced delivery of 5-aminolevulinic acid esters by iontophoresis in vitro. Photochem Photobiol. 2003 Mar; 77(3):304-8.
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Lopez RF, Bentley MV, Begoña Delgado-Charro M, Guy RH. Optimization of aminolevulinic acid delivery by iontophoresis. J Control Release. 2003 Feb 14; 88(1):65-70.
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Merino G, Kalia YN, Delgado-Charro MB, Potts RO, Guy RH. Frequency and thermal effects on the enhancement of transdermal transport by sonophoresis. J Control Release. 2003 Feb 14; 88(1):85-94.
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Geinoz S, Rey S, Boss G, Bunge AL, Guy RH, Carrupt PA, Reist M, Testa B. Quantitative structure-permeation relationships for solute transport across silicone membranes. Pharm Res. 2002 Nov; 19(11):1622-9.
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Sekkat N, Kalia YN, Guy RH. Biophysical study of porcine ear skin in vitro and its comparison to human skin in vivo. J Pharm Sci. 2002 Nov; 91(11):2376-81.
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Sekkat N, Naik A, Kalia YN, Glikfeld P, Guy RH. Reverse iontophoretic monitoring in premature neonates: feasibility and potential. J Control Release. 2002 May 17; 81(1-2):83-9.
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Reddy MB, Stinchcomb AL, Guy RH, Bunge AL. Determining dermal absorption parameters in vivo from tape strip data. Pharm Res. 2002 Mar; 19(3):292-8.
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Dujardin N, Staes E, Kalia Y, Clarys P, Guy R, Préat V. In vivo assessment of skin electroporation using square wave pulses. J Control Release. 2002 Feb 19; 79(1-3):219-27.
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Veuillez F, Rieg FF, Guy RH, Deshusses J, Buri P. Permeation of a myristoylated dipeptide across the buccal mucosa: topological distribution and evaluation of tissue integrity. Int J Pharm. 2002 Jan 1; 231(1):1-9.
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Curdy C, Kalia YN, Guy RH. Post-iontophoresis recovery of human skin impedance in vivo. Eur J Pharm Biopharm. 2002 Jan; 53(1):15-21.
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Marro D, Kalia YN, Delgado-Charro MB, Guy RH. Optimizing iontophoretic drug delivery: identification and distribution of the charge-carrying species. Pharm Res. 2001 Dec; 18(12):1709-13.
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Marro D, Kalia YN, Delgado-Charro MB, Guy RH. Contributions of electromigration and electroosmosis to iontophoretic drug delivery. Pharm Res. 2001 Dec; 18(12):1701-8.
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Alberti I, Kalia YN, Naik A, Guy RH. Assessment and prediction of the cutaneous bioavailability of topical terbinafine, in vivo, in man. Pharm Res. 2001 Oct; 18(10):1472-5.
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Curdy C, Kalia YN, Naik A, Guy RH. Piroxicam delivery into human stratum corneum in vivo: iontophoresis versus passive diffusion. J Control Release. 2001 Sep 11; 76(1-2):73-9.
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Moser K, Kriwet K, Naik A, Kalia YN, Guy RH. Passive skin penetration enhancement and its quantification in vitro. Eur J Pharm Biopharm. 2001 Sep; 52(2):103-12.
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Alvarez-Román R, Barré G, Guy RH, Fessi H. Biodegradable polymer nanocapsules containing a sunscreen agent: preparation and photoprotection. Eur J Pharm Biopharm. 2001 Sep; 52(2):191-5.
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Moser K, Kriwet K, Kalia YN, Guy RH. Stabilization of supersaturated solutions of a lipophilic drug for dermal delivery. Int J Pharm. 2001 Aug 14; 224(1-2):169-76.
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Moser K, Kriwet K, Froehlich C, Kalia YN, Guy RH. Supersaturation: enhancement of skin penetration and permeation of a lipophilic drug. Pharm Res. 2001 Jul; 18(7):1006-11.
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Moser K, Kriwet K, Kalia YN, Guy RH. Enhanced skin permeation of a lipophilic drug using supersaturated formulations. J Control Release. 2001 Jun 15; 73(2-3):245-53.
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Kalia YN, Guy RH. Modeling transdermal drug release. Adv Drug Deliv Rev. 2001 Jun 11; 48(2-3):159-72.
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Curdy C, Kalia YN, Guy RH. Non-invasive assessment of the effects of iontophoresis on human skin in-vivo. J Pharm Pharmacol. 2001 Jun; 53(6):769-77.
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Alberti I, Kalia YN, Naik A, Bonny J, Guy RH. Effect of ethanol and isopropyl myristate on the availability of topical terbinafine in human stratum corneum, in vivo. Int J Pharm. 2001 May 21; 219(1-2):11-9.
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Moser K, Kriwet K, Froehlich C, Naik A, Kalia YN, Guy RH. Permeation enhancement of a highly lipophilic drug using supersaturated systems. J Pharm Sci. 2001 May; 90(5):607-16.
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Alberti I, Kalia YN, Naik A, Bonny JD, Guy RH. In vivo assessment of enhanced topical delivery of terbinafine to human stratum corneum. J Control Release. 2001 Apr 28; 71(3):319-27.
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Lopez RF, Bentley MV, Delgado-Charro MB, Guy RH. Iontophoretic delivery of 5-aminolevulinic acid (ALA): effect of pH. Pharm Res. 2001 Mar; 18(3):311-5.
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Marro D, Guy RH, Delgado-Charro MB. Characterization of the iontophoretic permselectivity properties of human and pig skin. J Control Release. 2001 Jan 29; 70(1-2):213-7.
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Guy RH, Delgado-Charro MB, Kalia YN. Iontophoretic transport across the skin. Skin Pharmacol Appl Skin Physiol. 2001; 14 Suppl 1:35-40.
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Kalia YN, Alberti I, Naik A, Guy RH. Assessment of topical bioavailability in vivo: the importance of stratum corneum thickness. Skin Pharmacol Appl Skin Physiol. 2001; 14 Suppl 1:82-6.
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Reddy MB, Guy RH, Bunge AL. Does epidermal turnover reduce percutaneous penetration? Pharm Res. 2000 Nov; 17(11):1414-9.
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Kalia YN, Alberti I, Sekkat N, Curdy C, Naik A, Guy RH. Normalization of stratum corneum barrier function and transepidermal water loss in vivo. Pharm Res. 2000 Sep; 17(9):1148-50.
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Nonato LB, Lund CH, Kalia YN, Guy RH. Transepidermal water loss in 24 and 25 weeks gestational age infants. Acta Paediatr. 2000 Jun; 89(6):747-8.
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Guy RH, Kalia YN, Delgado-Charro MB, Merino V, López A, Marro D. Iontophoresis: electrorepulsion and electroosmosis. J Control Release. 2000 Feb 14; 64(1-3):129-32.
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Curdy C, Kalia YN, Falson-Rieg F, Guy RH. Recovery of human skin impedance in vivo after iontophoresis: effect of metal ions. AAPS PharmSci. 2000; 2(3):E23.
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Bunge AL, Guy RH, Hadgraft J. The determination of a diffusional pathlength through the stratum corneum. Int J Pharm. 1999 Oct 15; 188(1):121-4.
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Merino V, López A, Hochstrasser D, Guy RH. Noninvasive sampling of phenylalanine by reverse iontophoresis. J Control Release. 1999 Aug 27; 61(1-2):65-9.
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Stinchcomb AL, Pirot F, Touraille GD, Bunge AL, Guy RH. Chemical uptake into human stratum corneum in vivo from volatile and non-volatile solvents. Pharm Res. 1999 Aug; 16(8):1288-93.
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Merino V, López A, Kalia YN, Guy RH. Electrorepulsion versus electroosmosis: effect of pH on the iontophoretic flux of 5-fluorouracil. Pharm Res. 1999 May; 16(5):758-61.
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Lim KC, Sun E, Bahgat M, Bucks D, Guy R, Hinz RS, Cullander C, McKerrow JH. Blockage of skin invasion by schistosome cercariae by serine protease inhibitors. Am J Trop Med Hyg. 1999 Mar; 60(3):487-92.
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Kalia YN, Pirot F, Potts RO, Guy RH. Ion mobility across human stratum corneum in vivo. J Pharm Sci. 1998 Dec; 87(12):1508-11.
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Turner NG, Guy RH. Visualization and quantitation of iontophoretic pathways using confocal microscopy. J Investig Dermatol Symp Proc. 1998 Aug; 3(2):136-42.
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Kalia YN, Nonato LB, Lund CH, Guy RH. Development of skin barrier function in premature infants. J Invest Dermatol. 1998 Aug; 111(2):320-6.
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Turner NG, Cullander C, Guy RH. Determination of the pH gradient across the stratum corneum. J Investig Dermatol Symp Proc. 1998 Aug; 3(2):110-3.
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Luzardo-Alvarez A, Rodríguez-Fernández M, Blanco-Méndez J, Guy RH, Delgado-Charro MB. Iontophoretic permselectivity of mammalian skin: characterization of hairless mouse and porcine membrane models. Pharm Res. 1998 Jul; 15(7):984-7.
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Guy R, Kealey T. The effects of inflammatory cytokines on the isolated human sebaceous infundibulum. J Invest Dermatol. 1998 Apr; 110(4):410-5.
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Kalia YN, Merino V, Guy RH. Transdermal drug delivery. Clinical aspects. Dermatol Clin. 1998 Apr; 16(2):289-99.
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Guy RH. Iontophoresis--recent developments. J Pharm Pharmacol. 1998 Apr; 50(4):371-4.
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Pirot F, Berardesca E, Kalia YN, Singh M, Maibach HI, Guy RH. Stratum corneum thickness and apparent water diffusivity: facile and noninvasive quantitation in vivo. Pharm Res. 1998 Mar; 15(3):492-4.
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Langkjaer L, Brange J, Grodsky GM, Guy RH. Iontophoresis of monomeric insulin analogues in vitro: effects of insulin charge and skin pretreatment. J Control Release. 1998 Jan 23; 51(1):47-56.
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Hirvonen J, Guy RH. Transdermal iontophoresis: modulation of electroosmosis by polypeptide. J Control Release. 1998 Jan 2; 50(1-3):283-9.
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Turner NG, Guy RH. Iontophoretic transport pathways: dependence on penetrant physicochemical properties. J Pharm Sci. 1997 Dec; 86(12):1385-9.
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Turner NG, Ferry L, Price M, Cullander C, Guy RH. Iontophoresis of poly-L-lysines: the role of molecular weight? Pharm Res. 1997 Oct; 14(10):1322-31.
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Hirvonen J, Guy RH. Iontophoretic delivery across the skin: electroosmosis and its modulation by drug substances. Pharm Res. 1997 Sep; 14(9):1258-63.
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Turner NG, Kalia YN, Guy RH. The effect of current on skin barrier function in vivo: recovery kinetics post-iontophoresis. Pharm Res. 1997 Sep; 14(9):1252-7.
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Merino V, Kalia YN, Guy RH. Transdermal therapy and diagnosis by iontophoresis. Trends Biotechnol. 1997 Aug; 15(8):288-90.
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Pirot F, Kalia YN, Stinchcomb AL, Keating G, Bunge A, Guy RH. Characterization of the permeability barrier of human skin in vivo. Proc Natl Acad Sci U S A. 1997 Feb 18; 94(4):1562-7.
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Prausnitz MR, Gimm JA, Guy RH, Langer R, Weaver JC, Cullander C. Imaging regions of transport across human stratum corneum during high-voltage and low-voltage exposures. J Pharm Sci. 1996 Dec; 85(12):1363-70.
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Hirvonen J, Kalia YN, Guy RH. Transdermal delivery of peptides by iontophoresis. Nat Biotechnol. 1996 Dec; 14(13):1710-3.
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Guy RH. Current status and future prospects of transdermal drug delivery. Pharm Res. 1996 Dec; 13(12):1765-9.
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Kalia YN, Pirot F, Guy RH. Homogeneous transport in a heterogeneous membrane: water diffusion across human stratum corneum in vivo. Biophys J. 1996 Nov; 71(5):2692-700.
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Kennedy AH, Golden GM, Gay CL, Guy RH, Francoeur ML, Mak VH. Stratum corneum lipids of human epidermal keratinocyte air-liquid cultures: implications for barrier function. Pharm Res. 1996 Aug; 13(8):1162-7.
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Tsai JC, Guy RH, Thornfeldt CR, Gao WN, Feingold KR, Elias PM. Metabolic approaches to enhance transdermal drug delivery. 1. Effect of lipid synthesis inhibitors. J Pharm Sci. 1996 Jun; 85(6):643-8.
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Kalia YN, Nonato LB, Guy RH. The effect of iontophoresis on skin barrier integrity: non-invasive evaluation by impedance spectroscopy and transepidermal water loss. Pharm Res. 1996 Jun; 13(6):957-60.
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Rodríguez Bayón AM, Guy RH. Iontophoresis of nafarelin across human skin in vitro. Pharm Res. 1996 May; 13(5):798-800.
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van der Geest R, Hueber F, Szoka FC, Guy RH. Iontophoresis of bases, nucleosides, and nucleotides. Pharm Res. 1996 Apr; 13(4):553-8.
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Rao G, Guy RH, Glikfeld P, LaCourse WR, Leung L, Tamada J, Potts RO, Azimi N. Reverse iontophoresis: noninvasive glucose monitoring in vivo in humans. Pharm Res. 1995 Dec; 12(12):1869-73.
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Kalia YN, Guy RH. The electrical characteristics of human skin in vivo. Pharm Res. 1995 Nov; 12(11):1605-13.
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Potts RO, Guy RH. A predictive algorithm for skin permeability: the effects of molecular size and hydrogen bond activity. Pharm Res. 1995 Nov; 12(11):1628-33.
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Guy RH. A sweeter life for diabetics? Nat Med. 1995 Nov; 1(11):1132-3.
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Aspe E, Guy RH, Lee WA, Kennedy JA, Visor GC, Ennis RD. Optimization of in vitro flux through hairless mouse skin of cidofovir, a potent nucleotide analog. J Pharm Sci. 1995 Jun; 84(6):750-4.
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Guy RH. Percutaneous absorption: physical chemistry meets the skin. Curr Probl Dermatol. 1995; 22:132-8.
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Gay CL, Guy RH, Golden GM, Mak VH, Francoeur ML. Characterization of low-temperature (i.e., < 65 degrees C) lipid transitions in human stratum corneum. J Invest Dermatol. 1994 Aug; 103(2):233-9.
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Delgado-Charro MB, Guy RH. Characterization of convective solvent flow during iontophoresis. Pharm Res. 1994 Jul; 11(7):929-35.
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Rao G, Glikfeld P, Guy RH. Reverse iontophoresis: development of a noninvasive approach for glucose monitoring. Pharm Res. 1993 Dec; 10(12):1751-5.
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Higo N, Naik A, Bommannan DB, Potts RO, Guy RH. Validation of reflectance infrared spectroscopy as a quantitative method to measure percutaneous absorption in vivo. Pharm Res. 1993 Oct; 10(10):1500-6.
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Kim A, Green PG, Rao G, Guy RH. Convective solvent flow across the skin during iontophoresis. Pharm Res. 1993 Sep; 10(9):1315-20.
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Bucks DA, Hostynek JJ, Hinz RS, Guy RH. Uptake of two zwitterionic surfactants into human skin in vivo. Toxicol Appl Pharmacol. 1993 Jun; 120(2):224-7.
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Guy RH, Potts RO. Penetration of industrial chemicals across the skin: a predictive model. Am J Ind Med. 1993 May; 23(5):711-9.
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Potts RO, Guy RH. The influence of molecular volume and hydrogen-bonding on peptide transport across epithelial membranes. Pharm Res. 1993 Apr; 10(4):635-7.
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Guy R, Ridden C, Barth J, Kealey T. Isolation and maintenance of the human pilosebaceous duct: 13-cis retinoic acid acts directly on the duct in vitro. Br J Dermatol. 1993 Mar; 128(3):242-8.
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Hostýnek JJ, Hinz RS, Lorence CR, Price M, Guy RH. Metals and the skin. Crit Rev Toxicol. 1993; 23(2):171-235.
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Tur E, Tamir A, Guy RH. Cutaneous blood flow in gestational hypertension and normal pregnancy. J Invest Dermatol. 1992 Sep; 99(3):310-4.
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Bommannan D, Menon GK, Okuyama H, Elias PM, Guy RH. Sonophoresis. II. Examination of the mechanism(s) of ultrasound-enhanced transdermal drug delivery. Pharm Res. 1992 Aug; 9(8):1043-7.
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Ridout G, Houk J, Guy RH, Santus GC, Hadgraft J, Hall LL. An evaluation of structure-penetration relationships in percutaneous absorption. Farmaco. 1992 Jun; 47(6):869-92.
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Hadgraft J, Walters KA, Guy RH. Epidermal lipids and topical drug delivery. Semin Dermatol. 1992 Jun; 11(2):139-44.
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Guy RH, Potts RO. Structure-permeability relationships in percutaneous penetration. J Pharm Sci. 1992 Jun; 81(6):603-4.
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Potts RO, Guy RH. Predicting skin permeability. Pharm Res. 1992 May; 9(5):663-9.
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Hori M, Maibach HI, Guy RH. Enhancement of propranolol hydrochloride and diazepam skin absorption in vitro. II: Drug, vehicle, and enhancer penetration kinetics. J Pharm Sci. 1992 Apr; 81(4):330-3.
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Bommannan D, Okuyama H, Stauffer P, Guy RH. Sonophoresis. I. The use of high-frequency ultrasound to enhance transdermal drug delivery. Pharm Res. 1992 Apr; 9(4):559-64.
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Higo N, Hinz RS, Lau DT, Benet LZ, Guy RH. Cutaneous metabolism of nitroglycerin in vitro. II. Effects of skin condition and penetration enhancement. Pharm Res. 1992 Mar; 9(3):303-6.
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Higo N, Hinz RS, Lau DT, Benet LZ, Guy RH. Cutaneous metabolism of nitroglycerin in vitro. I. Homogenized versus intact skin. Pharm Res. 1992 Feb; 9(2):187-90.
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Guy RH, Potts RO, Francoeur ML. Skin barrier function and the mechanism(s) of percutaneous penetration. Acta Pharm Nord. 1992; 4(2):115.
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Kikkoji T, Gumbleton M, Higo N, Guy RH, Benet LZ. Percutaneous penetration kinetics of nitroglycerin and its dinitrate metabolites across hairless mouse skin in vitro. Pharm Res. 1991 Oct; 8(10):1231-7.
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Hinz RS, Lorence CR, Hodson CD, Hansch C, Hall LL, Guy RH. Percutaneous penetration of para-substituted phenols in vitro. Fundam Appl Toxicol. 1991 Oct; 17(3):575-83.
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Green PG, Hinz RS, Cullander C, Yamane G, Guy RH. Iontophoretic delivery of amino acids and amino acid derivatives across the skin in vitro. Pharm Res. 1991 Sep; 8(9):1113-20.
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Green PG, Hinz RS, Kim A, Szoka FC, Guy RH. Iontophoretic delivery of a series of tripeptides across the skin in vitro. Pharm Res. 1991 Sep; 8(9):1121-7.
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Shah VP, Flynn GL, Guy RH, Maibach HI, Schaefer H, Skelly JP, Wester RC, Yacobi A. In vivo percutaneous penetration/absorption, Washington, D.C., May 1989. Pharm Res. 1991 Aug; 8(8):1071-5.
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Mak VH, Potts RO, Guy RH. Does hydration affect intercellular lipid organization in the stratum corneum? Pharm Res. 1991 Aug; 8(8):1064-5.
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Cullander C, Guy RH. Sites of iontophoretic current flow into the skin: identification and characterization with the vibrating probe electrode. J Invest Dermatol. 1991 Jul; 97(1):55-64.
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Mak VH, Cumpstone MB, Kennedy AH, Harmon CS, Guy RH, Potts RO. Barrier function of human keratinocyte cultures grown at the air-liquid interface. J Invest Dermatol. 1991 Mar; 96(3):323-7.
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Tur E, Maibach HI, Guy RH. Percutaneous penetration of methyl nicotinate at three anatomic sites: evidence for an appendageal contribution to transport? Skin Pharmacol. 1991; 4(4):230-4.
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Shah VP, Flynn GL, Guy RH, Maibach HI, Schaefer H, Skelly JP, Wester RC, Yacobi A. Workshop report on in vivo percutaneous penetration/absorption. Washington D.C., May 1-3, 1989. Skin Pharmacol. 1991; 4(3):220-8.
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Potts RO, Mak VH, Guy RH, Francoeur ML. Strategies to enhance permeability via stratum corneum lipid pathways. Adv Lipid Res. 1991; 24:173-210.
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Hori M, Satoh S, Maibach HI, Guy RH. Enhancement of propranolol hydrochloride and diazepam skin absorption in vitro: effect of enhancer lipophilicity. J Pharm Sci. 1991 Jan; 80(1):32-5.
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Ridout G, Hinz RS, Hostynek JJ, Reddy AK, Wiersema RJ, Hodson CD, Lorence CR, Guy RH. The effects of zwitterionic surfactants on skin barrier function. Fundam Appl Toxicol. 1991 Jan; 16(1):41-50.
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Hori M, Ohtsuka S, Sunami M, Guy RH, Maibach HI. Cutaneous pharmacodynamics of transdermally delivered isosorbide dinitrate. Pharm Res. 1990 Dec; 7(12):1298-301.
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Surber C, Wilhelm KP, Hori M, Maibach HI, Guy RH. Optimization of topical therapy: partitioning of drugs into stratum corneum. Pharm Res. 1990 Dec; 7(12):1320-4.
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Berner B, Wilson DR, Steffens RJ, Mazzenga GC, Hinz R, Guy RH, Maibach HI. The relationship between pKa and skin irritation for a series of basic penetrants in man. Fundam Appl Toxicol. 1990 Nov; 15(4):760-6.
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Bommannan D, Potts RO, Guy RH. Examination of stratum corneum barrier function in vivo by infrared spectroscopy. J Invest Dermatol. 1990 Oct; 95(4):403-8.
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Mak VH, Potts RO, Guy RH. Percutaneous penetration enhancement in vivo measured by attenuated total reflectance infrared spectroscopy. Pharm Res. 1990 Aug; 7(8):835-41.
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Surber C, Wilhelm KP, Maibach HI, Hall LL, Guy RH. Partitioning of chemicals into human stratum corneum: implications for risk assessment following dermal exposure. Fundam Appl Toxicol. 1990 Jul; 15(1):99-107.
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Bucks DA, Hinz RS, Sarason R, Maibach HI, Guy RH. In vivo percutaneous absorption of chemicals: a multiple dose study in rhesus monkeys. Food Chem Toxicol. 1990 Feb; 28(2):129-32.
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Roskos KV, Bircher AJ, Maibach HI, Guy RH. Pharmacodynamic measurements of methyl nicotinate percutaneous absorption: the effect of aging on microcirculation. Br J Dermatol. 1990 Feb; 122(2):165-71.
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Roskos KV, Maibach HI, Guy RH. The effect of aging on percutaneous absorption in man. J Pharmacokinet Biopharm. 1989 Dec; 17(6):617-30.
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Glikfeld P, Hinz RS, Guy RH. Noninvasive sampling of biological fluids by iontophoresis. Pharm Res. 1989 Nov; 6(11):988-90.
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Roskos KV, Guy RH. Assessment of skin barrier function using transepidermal water loss: effect of age. Pharm Res. 1989 Nov; 6(11):949-53.
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Hinz RS, Hodson CD, Lorence CR, Guy RH. In vitro percutaneous penetration: evaluation of the utility of hairless mouse skin. J Invest Dermatol. 1989 Jul; 93(1):87-91.
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Ashworth J, Coady AT, Guy R, Breathnach SM. Brawny cutaneous induration and granulomatous panniculitis in large cell non-Hodgkin's (T suppressor/cytotoxic cell) lymphoma. Br J Dermatol. 1989 Apr; 120(4):563-9.
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Gean CJ, Tur E, Maibach HI, Guy RH. Cutaneous responses to topical methyl nicotinate in black, oriental, and caucasian subjects. Arch Dermatol Res. 1989; 281(2):95-8.
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Guy RH, Hadgraft J. Physicochemical aspects of percutaneous penetration and its enhancement. Pharm Res. 1988 Dec; 5(12):753-8.
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Berner B, Wilson DR, Guy RH, Mazzenga GC, Clarke FH, Maibach HI. The relationship of pKa and acute skin irritation in man. Pharm Res. 1988 Oct; 5(10):660-3.
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Ryatt KS, Mobayen M, Stevenson JM, Maibach HI, Guy RH. Methodology to measure the transient effect of occlusion on skin penetration and stratum corneum hydration in vivo. Br J Dermatol. 1988 Sep; 119(3):307-12.
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Ridout G, Santus GC, Guy RH. Pharmacokinetic considerations in the use of newer transdermal formulations. Clin Pharmacokinet. 1988 Aug; 15(2):114-31.
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Bucks DA, McMaster JR, Maibach HI, Guy RH. Bioavailability of topically administered steroids: a "mass balance" technique. J Invest Dermatol. 1988 Jul; 91(1):29-33.
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Glikfeld P, Cullander C, Hinz RS, Guy RH. A new system for in vitro studies of iontophoresis. Pharm Res. 1988 Jul; 5(7):443-6.
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Bucks DA, Maibach HI, Guy RH. Mass balance and dose accountability in percutaneous absorption studies: development of a nonocclusive application system. Pharm Res. 1988 May; 5(5):313-5.
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Bucks DA, McMaster JR, Guy RH, Maibach HI. Percutaneous absorption of hydroquinone in humans: effect of 1-dodecylazacycloheptan-2-one (azone) and the 2-ethylhexyl ester of 4-(dimethylamino)benzoic acid (Escalol 507). J Toxicol Environ Health. 1988; 24(3):279-89.
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Khan A, Schall LM, Tur E, Maibach HI, Guy RH. Blood flow in psoriatic skin lesions: the effect of treatment. Br J Dermatol. 1987 Aug; 117(2):193-201.
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Guy RH, Hadgraft J, Bucks DA. Transdermal drug delivery and cutaneous metabolism. Xenobiotica. 1987 Mar; 17(3):325-43.
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Knepp VM, Hadgraft J, Guy RH. Transdermal drug delivery: problems and possibilities. Crit Rev Ther Drug Carrier Syst. 1987; 4(1):13-37.
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Guy RH, Carlström EM, Bucks DA, Hinz RS, Maibach HI. Percutaneous penetration of nicotinates: in vivo and in vitro measurements. J Pharm Sci. 1986 Oct; 75(10):968-72.
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Roskos KV, Guy RH, Maibach HI. Percutaneous absorption in the aged. Dermatol Clin. 1986 Jul; 4(3):455-65.
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Ryatt KS, Stevenson JM, Maibach HI, Guy RH. Pharmacodynamic measurement of percutaneous penetration enhancement in vivo. J Pharm Sci. 1986 Apr; 75(4):374-7.
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Guy RH, Tur E, Schall LM, Elamir S, Maibach HI. Determination of vehicle effects on percutaneous absorption by laser Doppler velocimetry. Arch Dermatol Res. 1986; 278(6):500-2.
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Bucks DA, Maibach HI, Guy RH. Percutaneous absorption of steroids: effect of repeated application. J Pharm Sci. 1985 Dec; 74(12):1337-9.
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Young AR, Guy RH, Maibach HI. Laser Doppler velocimetry to quantify UV-B induced increase in human skin blood flow. Photochem Photobiol. 1985 Oct; 42(4):385-90.
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Guy RH, Hadgraft J. Pharmacokinetic interpretation of the plasma levels of clonidine following transdermal delivery. J Pharm Sci. 1985 Sep; 74(9):1016-8.
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Tur E, Maibach HI, Guy RH. Spatial variability of vasodilatation in human forearm skin. Br J Dermatol. 1985 Aug; 113(2):197-203.
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Guy RH, Tur E, Bjerke S, Maibach HI. Are there age and racial differences to methyl nicotinate-induced vasodilatation in human skin? J Am Acad Dermatol. 1985 Jun; 12(6):1001-6.
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Guy RH, Hadgraft J, Maibach HI. Percutaneous absorption in man: a kinetic approach. Toxicol Appl Pharmacol. 1985 Mar 30; 78(1):123-9.
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Guy RH, Tur E, Maibach HI. Optical techniques for monitoring cutaneous microcirculation. Recent applications. Int J Dermatol. 1985 Mar; 24(2):88-94.
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Zackheim HS, Tur E, Guy RH. Regional blood flow and mycosis fungoides. J Am Acad Dermatol. 1985 Mar; 12(3):578-80.
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Drouard V, Wilson DR, Maibach HI, Guy RH. Quantitative assessment of UV-induced changes in microcirculatory flow by laser Doppler velocimetry. J Invest Dermatol. 1984 Sep; 83(3):188-92.
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Guy RH, Hadgraft J. Prediction of drug disposition kinetics in skin and plasma following topical administration. J Pharm Sci. 1984 Jul; 73(7):883-7.
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Wester RC, Maibach HI, Guy RH, Novak E. Minoxidil stimulates cutaneous blood flow in human balding scalps: pharmacodynamics measured by laser Doppler velocimetry and photopulse plethysmography. J Invest Dermatol. 1984 May; 82(5):515-7.
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Guy RH, Maibach HI. Correction factors for determining body exposure from forearm percutaneous absorption data. J Appl Toxicol. 1984 Feb; 4(1):26-8.
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Guy RH, Hinz RS, Amantea M. Solute transport and perturbation at liquid/liquid interfaces. Faraday Discuss Chem Soc. 1984; (77):127-37.
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Guy RH, Maibach HI. Drug delivery to local subcutaneous structures following topical administration. J Pharm Sci. 1983 Dec; 72(12):1375-80.
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Tur E, Tur M, Maibach HI, Guy RH. Basal perfusion of the cutaneous microcirculation: measurements as a function of anatomic position. J Invest Dermatol. 1983 Nov; 81(5):442-6.
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Guy RH, Wester RC, Tur E, Maibach HI. Noninvasive assessments of the percutaneous absorption of methyl nicotinate in humans. J Pharm Sci. 1983 Sep; 72(9):1077-9.
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Tur E, Guy RH, Tur M, Maibach HI. Noninvasive assessment of local nicotinate pharmacodynamics by photoplethysmography. J Invest Dermatol. 1983 Jun; 80(6):499-503.
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Guy RH, Hadgraft J. Physicochemical interpretation of the pharmacokinetics of percutaneous absorption. J Pharmacokinet Biopharm. 1983 Apr; 11(2):189-203.
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Wester RC, Maibach HI, Bucks DA, Guy RH. Malathion percutaneous absorption after repeated administration to man. Toxicol Appl Pharmacol. 1983 Mar 30; 68(1):116-9.
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Fleming R, Guy RH, Hadgraft J. Kinetics and thermodynamics of interfacial transfer. J Pharm Sci. 1983 Feb; 72(2):142-5.
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Guy RH, Hadgraft J, Taylor MJ, Kellaway IW. Release of non-electrolytes from liposomes. J Pharm Pharmacol. 1983 Jan; 35(1):12-4.
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Amantea M, Tur E, Maibach HI, Guy RH. Preliminary skin blood flow measurements appear unsuccessful for assessing topical corticosteroid effect. Arch Dermatol Res. 1983; 275(6):419-20.
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Cadman AD, Fleming R, Guy RH. Diffusion of lysozyme chloride in water and aqueous potassium chloride solutions. Biophys J. 1982 Mar; 37(3):569-74.
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Guy RH, Maibach HI. Rapid radial transport of methyl nicotinate in the dermis. Arch Dermatol Res. 1982; 273(1-2):91-5.
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Guy RH, Hadgraft J. Theoretical comparison of release rates of drugs into sink and nonsink conditions. J Pharm Sci. 1981 Nov; 70(11):1243-5.
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