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Richard Weiskopf, MD

TitleProfessor Emeritus
SchoolUCSF School of Medicine
DepartmentAnesthesia
Address521 Parnassus Ave, Clinic Sci
San Francisco CA 94143
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    Collapse Research 
    Collapse Research Activities and Funding
    Transfusion and Lung Injury
    NIH/NHLBI P50HL081027Sep 30, 2005 - Aug 31, 2011
    Role: Co-Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000079Dec 1, 1974 - Mar 31, 2009
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Feiner JR, Weiskopf RB. Evaluating Pulmonary Function: An Assessment of PaO2/FIO2. Crit Care Med. 2017 Jan; 45(1):e40-e48. PMID: 27618274.
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    2. Weiskopf RB, Beliaev AM, Shander A, Guinn NR, Cap AP, Ness PM, Silverman TA. Addressing the unmet need of life-threatening anemia with hemoglobin-based oxygen carriers. Transfusion. 2016 Nov 18. PMID: 27859328.
      View in: PubMed
    3. Weiskopf RB, Cook RJ. Understanding non-inferiority trials and tests for the non-statistician: when to use them and how to interpret them. Transfusion. 2016 Nov 10. PMID: 27861971.
      View in: PubMed
    4. Weiskopf RB. What is innovation? Transfusion. 2016 Mar; 56 Suppl 1:S3-5. PMID: 27001359.
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    5. Weiskopf RB. Lack of Nephrotoxicity of Hydroxyethyl Starch 130/0.4 When Used in Surgery. Anesthesiology. 2015 Aug; 123(2):482-3. PMID: 26196877.
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    6. Feiner JR, Gropper MA, Toy P, Lieberman J, Twiford J, Weiskopf RB. A Clinical Trial to Detect Subclinical Transfusion-induced Lung Injury during Surgery. Anesthesiology. 2015 Jul; 123(1):126-35. PMID: 25946480; PMCID: PMC4626309 [Available on 07/01/16].
    7. Weiskopf RB, James MF. Update of use of hydroxyethyl starches in surgery and trauma. J Trauma Acute Care Surg. 2015 Jun; 78(6 Suppl 1):S54-9. PMID: 26002264.
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    8. Weiskopf RB. Hemoglobin-based oxygen carriers: disclosed history and the way ahead: the relativity of safety. Anesth Analg. 2014 Oct; 119(4):758-60. PMID: 25232689.
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    9. Weiskopf RB. Hydroxyethyl starches: a tale of two contexts: the problem of knowledge. Anesth Analg. 2014 Sep; 119(3):509-13. PMID: 25136996.
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    10. Weiskopf RB. The efficacy and safety of liquid stored blood and storage duration: a confused subject; are patients confused? Anesth Analg. 2014 Aug; 119(2):224-9. PMID: 25046778.
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    11. Jenkins DH, Rappold JF, Badloe JF, Berséus O, Blackbourne L, Brohi KH, Butler FK, Cap AP, Cohen MJ, Davenport R, DePasquale M, Doughty H, Glassberg E, Hervig T, Hooper TJ, Kozar R, Maegele M, Moore EE, Murdock A, Ness PM, Pati S, Rasmussen T, Sailliol A, Schreiber MA, Sunde GA, van de Watering LM, Ward KR, Weiskopf RB, White NJ, Strandenes G, Spinella PC. Trauma hemostasis and oxygenation research position paper on remote damage control resuscitation: definitions, current practice, and knowledge gaps. Shock. 2014 May; 41 Suppl 1:3-12. PMID: 24430539; PMCID: PMC4309265.
    12. Butler FK, Holcomb JB, Schreiber MA, Kotwal RS, Jenkins DA, Champion HR, Bowling F, Cap AP, Dubose JJ, Dorlac WC, Dorlac GR, McSwain NE, Timby JW, Blackbourne LH, Stockinger ZT, Standenes G, Weiskopf RB, Gross KR, Bailey JA. Fluid Resuscitation for Hemorrhagic Shock in Tactical Combat Casualty Care: TCCC Guidelines Change 14-01 - 2 June 2014. J Spec Oper Med. 2014; 14(3):13-38. PMID: 25344706.
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    13. Weiskopf RB. Equivalent efficacy of hydroxyethyl starch 130/0.4 and human serum albumin: if nothing is the same, is everything different? The importance of context in clinical trials and statistics. Anesthesiology. 2013 Dec; 119(6):1249-54. PMID: 24126265.
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    14. Van Der Linden P, James M, Mythen M, Weiskopf RB. In response. Anesth Analg. 2013 Aug; 117(2):530-1. PMID: 24044131.
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    15. Weiskopf RB, Silverman TA. Balancing potential risks and benefits of hemoglobin-based oxygen carriers. Transfusion. 2013 Oct; 53(10):2327-33. PMID: 23869543.
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    16. Pusateri AE, Weiskopf RB, Bebarta V, Butler F, Cestero RF, Chaudry IH, Deal V, Dorlac WC, Gerhardt RT, Given MB, Hansen DR, Hoots WK, Klein HG, Macdonald VW, Mattox KL, Michael RA, Mogford J, Montcalm-Smith EA, Niemeyer DM, Prusaczyk WK, Rappold JF, Rassmussen T, Rentas F, Ross J, Thompson C, Tucker LD. Tranexamic acid and trauma: current status and knowledge gaps with recommended research priorities. Shock. 2013 Feb; 39(2):121-6. PMID: 23222525.
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    17. Weiskopf RB, Ness PM. Transfusion for remote damage control resuscitation. Transfusion. 2013 Jan; 53(1):8-12. PMID: 23294208.
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    18. Weiskopf RB, Ness PM. Transfusion for remote damage control resuscitation. Transfusion. 2013 Jan; 53 Suppl 1:1S-5S. PMID: 23301968.
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    19. Van Der Linden P, James M, Mythen M, Weiskopf RB. Safety of modern starches used during surgery. Anesth Analg. 2013 Jan; 116(1):35-48. PMID: 23115254.
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    20. Rollins MD, Molofsky AB, Nambiar A, Pandey S, Weiskopf RB, Toy P. Two septic transfusion reactions presenting as transfusion-related acute lung injury from a split plateletpheresis unit. Crit Care Med. 2012 Aug; 40(8):2488-91. PMID: 22809916; PMCID: PMC3733455.
    21. Weiskopf RB. Reconstructing deconstructed blood for trauma. Anesthesiology. 2012 Mar; 116(3):518-21. PMID: 22258018.
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    22. Weiskopf RB. From life-blood streaming to hemostasis. Anesth Analg. 2012 Feb; 114(2):247-9. PMID: 22266693.
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    23. Kor DJ, Kashyap R, Weiskopf RB, Wilson GA, van Buskirk CM, Winters JL, Malinchoc M, Hubmayr RD, Gajic O. Fresh red blood cell transfusion and short-term pulmonary, immunologic, and coagulation status: a randomized clinical trial. Am J Respir Crit Care Med. 2012 Apr 15; 185(8):842-50. PMID: 22281833; PMCID: PMC3360568.
    24. Weiskopf RB, Feiner J, Toy P, Twiford J, Shimabukuro D, Lieberman J, Looney MR, Lowell CA, Gropper MA. Fresh and stored red blood cell transfusion equivalently induce subclinical pulmonary gas exchange deficit in normal humans. Anesth Analg. 2012 Mar; 114(3):511-9. PMID: 22262647; PMCID: PMC3927839.
    25. Toy P, Gajic O, Bacchetti P, Looney MR, Gropper MA, Hubmayr R, Lowell CA, Norris PJ, Murphy EL, Weiskopf RB, Wilson G, Koenigsberg M, Lee D, Schuller R, Wu P, Grimes B, Gandhi MJ, Winters JL, Mair D, Hirschler N, Sanchez Rosen R, Matthay MA. Transfusion-related acute lung injury: incidence and risk factors. Blood. 2012 Feb 16; 119(7):1757-67. PMID: 22117051; PMCID: PMC3286351.
    26. Feiner JR, Finlay-Morreale HE, Toy P, Lieberman JA, Viele MK, Hopf HW, Weiskopf RB. High oxygen partial pressure decreases anemia-induced heart rate increase equivalent to transfusion. Anesthesiology. 2011 Sep; 115(3):492-8. PMID: 21768873; PMCID: PMC3166888.
    27. Weiskopf RB. Blood samples, repositories, and ethics. Transfusion. 2011 May; 51(5):1123-5; author reply 1125. PMID: 21545597.
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    28. Holcomb JB, Weiskopf R, Champion H, Gould SA, Sauer RM, Brasel K, Bochicchio G, Bulger E, Cotton BA, Davis D, Dutton R, Hauser CJ, Hess JR, Hides GA, Knudson P, MacKenzie E, McGinnis RL, Michalek J, Moore FA, Omert L, Pollock BH, Tortella B, Sugarman J, Schreiber MA, Wade CE. Challenges to effective research in acute trauma resuscitation: consent and endpoints. Shock. 2011 Feb; 35(2):107-13. PMID: 20926987.
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    29. Weiskopf RB. Emergency transfusion for acute severe anemia: a calculated risk. Anesth Analg. 2010 Nov; 111(5):1088-92. PMID: 20971958.
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    30. Weiskopf RB. Conflicts of interest in expert-authored practice parameters, standards, guidelines, recommendations. Anesthesiology. 2010 Sep; 113(3):751-2; author reply 752-3. PMID: 20733391.
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    31. Weiskopf RB. Hemoglobin-based oxygen carriers: compassionate use and compassionate clinical trials. Anesth Analg. 2010 Mar 1; 110(3):659-62. PMID: 20185643.
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    32. Weiskopf RB. Perioperative use of beta-adrenergic antagonists and anemia: known knowns, known unknowns, unknown unknowns; and Unknown Knowns. Anesthesiology. 2010 Jan; 112(1):12-5. PMID: 20032697.
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    33. Weiskopf RB. Hemostasis in trauma. Transfusion. 2009 Dec; 49 Suppl 5:237S-9S. PMID: 19954485.
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    34. Silverman TA, Weiskopf RB. Hemoglobin-based oxygen carriers: current status and future directions. Transfusion. 2009 Nov; 49(11):2495-515. PMID: 19903298.
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    35. Silverman TA, Weiskopf RB. Hemoglobin-based oxygen carriers: current status and future directions. Anesthesiology. 2009 Nov; 111(5):946-63. PMID: 19858869.
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    36. Weiskopf RB. Prospective randomized clinical transfusion trials and statistical analysis. Transfusion. 2009 Aug; 49(8):1770; author reply 1770-1. PMID: 19732405.
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    37. Weiskopf RB, Yau R, Sanchez R, Lowell C, Toy P. Microarray kit analysis of cytokines in blood product units and segments. Transfusion. 2009 Nov; 49(11):2269-75. PMID: 19548981; PMCID: PMC2783862.
    38. Weiskopf RB, Feiner J, Toy P. Red blood cell age and function. Transfusion. 2008 Sep; 48(9):2026. PMID: 18811899.
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    39. Weiskopf RB. The ethics of blood management. Vox Sang. 2007 Jul; 93(1):91. PMID: 17547572.
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    40. Gandhi SD, Weiskopf RB, Jungheinrich C, Koorn R, Miller D, Shangraw RE, Prough DS, Baus D, Bepperling F, Warltier DC. Volume replacement therapy during major orthopedic surgery using Voluven (hydroxyethyl starch 130/0.4) or hetastarch. Anesthesiology. 2007 Jun; 106(6):1120-7. PMID: 17525586.
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    41. Weiskopf RB, Feiner J, Lieberman J, Hu SS. Visual loss after spinal surgery. Anesthesiology. 2007 Jun; 106(6):1250-1; author reply 1251-2. PMID: 17525614.
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    42. Weiskopf RB. Recombinant-activated coagulation factor VIIa (NovoSeven): current development. Vox Sang. 2007 May; 92(4):281-8. PMID: 17456151.
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    43. Weiskopf RB. Food and Drug Administration public hearing on the draft guidance for exception from informed consent requirements for emergency research: testimony of Novo Nordisk. Acad Emerg Med. 2007 Apr; 14(4):e71-3. PMID: 17322571.
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    44. Champion HR, Fingerhut A, Escobar MA, Weiskopf RB. The role of data and safety monitoring in acute trauma resuscitation research. J Am Coll Surg. 2007 Jan; 204(1):73-83. PMID: 17189115.
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    45. Weiskopf RB. If you prick us, do we not bleed? Anesthesiology. 2006 Nov; 105(5):873-6. PMID: 17065878.
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    46. Weiskopf RB. Assessment of hemostasis through the retrospectroscope. J Thromb Haemost. 2006 Sep; 4(9):2074-8. PMID: 16869932.
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    47. Madjdpour C, Spahn DR, Weiskopf RB. Anemia and perioperative red blood cell transfusion: a matter of tolerance. Crit Care Med. 2006 May; 34(5 Suppl):S102-8. PMID: 16617252.
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    48. Weiskopf RB, Feiner J, Hopf H, Lieberman J, Finlay HE, Quah C, Kramer JH, Bostrom A, Toy P. Fresh blood and aged stored blood are equally efficacious in immediately reversing anemia-induced brain oxygenation deficits in humans. Anesthesiology. 2006 May; 104(5):911-20. PMID: 16645441.
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    49. Weiskopf RB, Schnapp S, Rouine-Rapp K, Bostrom A, Toy P. Extracellular potassium concentrations in red blood cell suspensions after irradiation and washing. Transfusion. 2005 Aug; 45(8):1295-301. PMID: 16078915.
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    50. Hardy JF, Weiskopf RB. Choosing the optimal endpoint(s) for a clinical trial on transfusion. Transfusion. 2005 Jul; 45(1 Suppl):1S. PMID: 15989683.
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    51. Weiskopf RB, Webb M, Stangle D, Klinbergs G, Toy P. A procedure for rapid issue of red cells for emergency use. Arch Pathol Lab Med. 2005 Apr; 129(4):492-6. PMID: 15794672.
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    52. Neumann MA, Eger EI, Weiskopf RB. Solubility of volatile anesthetics in bovine white matter, cortical gray matter, thalamus, hippocampus, and hypothalamic area. Anesth Analg. 2005 Apr; 100(4):1003-6. PMID: 15781514.
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    53. Weiskopf RB, Toy P, Hopf HW, Feiner J, Finlay HE, Takahashi M, Bostrom A, Songster C, Aminoff MJ. Acute isovolemic anemia impairs central processing as determined by P300 latency. Clin Neurophysiol. 2005 May; 116(5):1028-32. PMID: 15826842.
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    54. Szpalski M, Gunzburg R, Aebi M, Weiskopf R. Research and evidence about blood sparing in spine surgery. Eur Spine J. 2004 Oct; 13 Suppl 1:S1-2. PMID: 15480822; PMCID: PMC3592177.
    55. Weiskopf RB. The use of recombinant activated coagulation factor VII for spine surgery. Eur Spine J. 2004 Oct; 13 Suppl 1:S83-8. PMID: 15160317; PMCID: PMC3592181.
    56. Weiskopf RB, Aminoff MJ, Hopf HW, Feiner J, Viele MK, Watson JJ, Ho R, Songster C, Toy P. Acute isovolemic anemia does not impair peripheral or central nerve conduction. Anesthesiology. 2003 Sep; 99(3):546-51. PMID: 12960537.
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    57. Fléron MH, Weiskopf RB, Bertrand M, Mouren S, Eyraud D, Godet G, Riou B, Kieffer E, Coriat P. A comparison of intrathecal opioid and intravenous analgesia for the incidence of cardiovascular, respiratory, and renal complications after abdominal aortic surgery. Anesth Analg. 2003 Jul; 97(1):2-12, table of contents. PMID: 12818934.
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    58. Weiskopf RB, Feiner J, Hopf H, Viele MK, Watson JJ, Lieberman J, Kelley S, Toy P. Heart rate increases linearly in response to acute isovolemic anemia. Transfusion. 2003 Feb; 43(2):235-40. PMID: 12559019.
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    59. Weiskopf RB. Hemodilution and candles. Anesthesiology. 2002 Oct; 97(4):773-5. PMID: 12357138.
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    60. Weiskopf RB. Intraoperative use of recombinant activated coagulation factor vII. Anesthesiology. 2002 Jun; 96(6):1287-9. PMID: 12170037.
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    61. Weiskopf RB, Feiner J, Hopf HW, Viele MK, Watson JJ, Kramer JH, Ho R, Toy P. Oxygen reverses deficits of cognitive function and memory and increased heart rate induced by acute severe isovolemic anemia. Anesthesiology. 2002 Apr; 96(4):871-7. PMID: 11964594.
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    62. Weiskopf RB. Efficacy of acute normovolemic hemodilution assessed as a function of fraction of blood volume lost. Anesthesiology. 2001 Mar; 94(3):439-46. PMID: 11374603.
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    63. Hopf HW, Viele M, Watson JJ, Feiner J, Weiskopf R, Hunt TK, Noorani M, Yeap H, Ho R, Toy P. Subcutaneous perfusion and oxygen during acute severe isovolemic hemodilution in healthy volunteers. Arch Surg. 2000 Dec; 135(12):1443-9. PMID: 11115350.
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    64. Leung JM, Weiskopf RB, Feiner J, Hopf HW, Kelley S, Viele M, Lieberman J, Watson J, Noorani M, Pastor D, Yeap H, Ho R, Toy P. Electrocardiographic ST-segment changes during acute, severe isovolemic hemodilution in humans. Anesthesiology. 2000 Oct; 93(4):1004-10. PMID: 11020755.
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    65. Weiskopf RB. Erythrocyte salvage during cesarean section. Anesthesiology. 2000 Jun; 92(6):1519-22. PMID: 10839899.
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    66. Weiskopf RB, Kramer JH, Viele M, Neumann M, Feiner JR, Watson JJ, Hopf HW, Toy P. Acute severe isovolemic anemia impairs cognitive function and memory in humans. Anesthesiology. 2000 Jun; 92(6):1646-52. PMID: 10839915.
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    67. Toy P, Feiner J, Viele MK, Watson J, Yeap H, Weiskopf RB. Fatigue during acute isovolemic anemiain healthy, resting humans. Transfusion. 2000 Apr; 40(4):457-60. PMID: 10773059.
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    68. Lieberman JA, Weiskopf RB, Kelley SD, Feiner J, Noorani M, Leung J, Toy P, Viele M. Critical oxygen delivery in conscious humans is less than 7.3 ml O2 x kg(-1) x min(-1). Anesthesiology. 2000 Feb; 92(2):407-13. PMID: 10691227.
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    69. Neumann MA, Laster MJ, Weiskopf RB, Gong DH, Dudziak R, Förster H, Eger EI. The elimination of sodium and potassium hydroxides from desiccated soda lime diminishes degradation of desflurane to carbon monoxide and sevoflurane to compound A but does not compromise carbon dioxide absorption. Anesth Analg. 1999 Sep; 89(3):768-73. PMID: 10475323.
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    70. Weiskopf RB. Clinical concepts and commentary. Anesthesiology. 1999 Jul; 91(1):6-7. PMID: 10422922.
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    71. Weiskopf RB. Red cell transfusion outcome studies require a prospective, randomized design. Transfusion. 1999 Jun; 39(6):657-60. PMID: 10378848.
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    72. Weiskopf RB. Simple, easy, safe, and inexpensive. But is it efficacious? Anesthesiology. 1999 Feb; 90(2):358-9. PMID: 9952137.
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    73. Weiskopf RB. Do we know when to transfuse red cells to treat acute anemia? Transfusion. 1998 Jun; 38(6):517-21. PMID: 9661684.
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    74. Stowell CP, Giordano GF, Kiss JE, Renner SW, Thurer RL, Weiskopf RB. An annotated bibliography on autologous transfusion: second edition. Transfusion. 1998 Apr; 38(4):400-9. PMID: 9595024.
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    75. Neumann MA, Weiskopf RB, Gong DH, Eger EI, Ionescu P. Changing from isoflurane to desflurane toward the end of anesthesia does not accelerate recovery in humans. Anesthesiology. 1998 Apr; 88(4):914-21. PMID: 9579499.
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    76. Eger EI, Gong D, Koblin DD, Bowland T, Ionescu P, Laster MJ, Weiskopf RB. The effect of anesthetic duration on kinetic and recovery characteristics of desflurane versus sevoflurane, and on the kinetic characteristics of compound A, in volunteers. Anesth Analg. 1998 Feb; 86(2):414-21. PMID: 9459259.
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    77. Toy P, Viele M, Weiskopf R. Unnecessary autologous donation and hemodilution for low blood loss procedures. J Clin Anesth. 1998 Feb; 10(1):86. PMID: 9526945.
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    78. Weiskopf RB, Viele MK, Feiner J, Kelley S, Lieberman J, Noorani M, Leung JM, Fisher DM, Murray WR, Toy P, Moore MA. Human cardiovascular and metabolic response to acute, severe isovolemic anemia. JAMA. 1998 Jan 21; 279(3):217-21. PMID: 9438742.
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    79. Gong DH, Weiskopf RB, Neumann MA, Laster MJ, Eger EI. In rats breathing from a nonrebreathing system, substitution of desflurane for isoflurane toward the end of anesthesia incompletely restores the time of recovery toward that of desflurane. Anesth Analg. 1998 Jan; 86(1):198-201. PMID: 9428878.
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    80. Daniel M, Weiskopf RB, Noorani M, Eger EI. Fentanyl augments the blockade of the sympathetic response to incision (MAC-BAR) produced by desflurane and isoflurane: desflurane and isoflurane MAC-BAR without and with fentanyl. Anesthesiology. 1998 Jan; 88(1):43-9. PMID: 9447854.
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    81. Steffey EP, Laster MJ, Ionescu P, Eger EI, Gong D, Weiskopf RB. Dehydration of Baralyme increases compound A resulting from sevoflurane degradation in a standard anesthetic circuit used to anesthetize swine. Anesth Analg. 1997 Dec; 85(6):1382-6. PMID: 9390613.
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    82. Eger EI, Ionescu P, Laster MJ, Gong D, Weiskopf RB, Kerschmann RL. Quantitative differences in the production and toxicity of CF2=BrCl versus CH2F-O-C(=CF2)(CF3) (compound A): the safety of halothane does not indicate the safety of sevoflurane. Anesth Analg. 1997 Nov; 85(5):1164-70. PMID: 9356119.
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    83. Eger EI, Gong D, Koblin DD, Bowland T, Ionescu P, Laster MJ, Weiskopf RB. Dose-related biochemical markers of renal injury after sevoflurane versus desflurane anesthesia in volunteers. Anesth Analg. 1997 Nov; 85(5):1154-63. PMID: 9356118.
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    84. Eger EI, Ionescu P, Laster MJ, Weiskopf RB. Baralyme dehydration increases and soda lime dehydration decreases the concentration of compound A resulting from sevoflurane degradation in a standard anesthetic circuit. Anesth Analg. 1997 Oct; 85(4):892-8. PMID: 9322476.
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    85. Eger EI, Bowland T, Ionescu P, Laster MJ, Fang Z, Gong D, Sonner J, Weiskopf RB. Recovery and kinetic characteristics of desflurane and sevoflurane in volunteers after 8-h exposure, including kinetics of degradation products. Anesthesiology. 1997 Sep; 87(3):517-26. PMID: 9316955.
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    86. Viele MK, Weiskopf RB, Fisher D. Recombinant human hemoglobin does not affect renal function in humans: analysis of safety and pharmacokinetics. Anesthesiology. 1997 Apr; 86(4):848-58. PMID: 9105229.
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    87. Weiskopf RB. 'Practice guidelines for blood component therapy' summarized. West J Med. 1997 Mar; 166(3):204-5. PMID: 9143200; PMCID: PMC1304124.
    88. Eger EI, Koblin DD, Bowland T, Ionescu P, Laster MJ, Fang Z, Gong D, Sonner J, Weiskopf RB. Nephrotoxicity of sevoflurane versus desflurane anesthesia in volunteers. Anesth Analg. 1997 Jan; 84(1):160-8. PMID: 8989018.
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    89. Eger EI, Ionescu P, Koblin DD, Weiskopf RB. Compound A: solubility in saline and olive oil; destruction by blood. Anesth Analg. 1996 Oct; 83(4):849-53. PMID: 8831333.
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    90. Weiskopf RB. More on the changing indications for transfusion of blood and blood components during anesthesia. Anesthesiology. 1996 Mar; 84(3):498-501. PMID: 8659775.
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    91. Daniel M, Eger EI, Weiskopf RB, Noorani M. Propofol fails to attenuate the cardiovascular response to rapid increases in desflurane concentration. Anesthesiology. 1996 Jan; 84(1):75-80. PMID: 8572357.
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    92. Weiskopf RB, Eger EI, Daniel M, Noorani M. Cardiovascular stimulation induced by rapid increases in desflurane concentration in humans results from activation of tracheopulmonary and systemic receptors. Anesthesiology. 1995 Dec; 83(6):1173-8. PMID: 8533909.
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    93. Weiskopf RB. Implications of chemical and physical properties of desflurane for longer surgery. Anaesthesia. 1995 Oct; 50 Suppl:9-13. PMID: 7485920.
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    94. Weiskopf RB. Cardiovascular effects of desflurane in experimental animals and volunteers. Anaesthesia. 1995 Oct; 50 Suppl:14-7. PMID: 7485911.
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    95. Daniel M, Larson MD, Eger EI, Noorani M, Weiskopf RB. Fentanyl, clonidine, and repeated increases in desflurane concentration, but not nitrous oxide or esmolol, block the transient mydriasis caused by rapid increases in desflurane concentration. Anesth Analg. 1995 Aug; 81(2):372-8. PMID: 7618730.
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    96. Gonsowski CT, Chortkoff BS, Eger EI, Bennett HL, Weiskopf RB. Subanesthetic concentrations of desflurane and isoflurane suppress explicit and implicit learning. Anesth Analg. 1995 Mar; 80(3):568-72. PMID: 7864427.
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    97. Weiskopf RB. Mathematical analysis of isovolemic hemodilution indicates that it can decrease the need for allogeneic blood transfusion. Transfusion. 1995 Jan; 35(1):37-41. PMID: 7503829.
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    98. Weiskopf RB, Eger EI, Noorani M, Daniel M. Fentanyl, esmolol, and clonidine blunt the transient cardiovascular stimulation induced by desflurane in humans. Anesthesiology. 1994 Dec; 81(6):1350-5. PMID: 7992902.
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    99. Weiskopf RB, Eger EI, Noorani M, Daniel M. Repetitive rapid increases in desflurane concentration blunt transient cardiovascular stimulation in humans. Anesthesiology. 1994 Oct; 81(4):843-9. PMID: 7943835.
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    100. Moore MA, Weiskopf RB, Eger EI, Noorani M, McKay L, Damask M. Rapid 1% increases of end-tidal desflurane concentration to greater than 5% transiently increase heart rate and blood pressure in humans. Anesthesiology. 1994 Jul; 81(1):94-8. PMID: 8042815.
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    101. Weiskopf RB, Moore MA, Eger EI, Noorani M, McKay L, Chortkoff B, Hart PS, Damask M. Rapid increase in desflurane concentration is associated with greater transient cardiovascular stimulation than with rapid increase in isoflurane concentration in humans. Anesthesiology. 1994 May; 80(5):1035-45. PMID: 8017643.
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    102. Viele MK, Weiskopf RB. What can we learn about the need for transfusion from patients who refuse blood? The experience with Jehovah's Witnesses. Transfusion. 1994 May; 34(5):396-401. PMID: 8191563.
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    103. Weiskopf RB, Sampson D, Moore MA. The desflurane (Tec 6) vaporizer: design, design considerations and performance evaluation. Br J Anaesth. 1994 Apr; 72(4):474-9. PMID: 8155456.
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    104. Navarro R, Weiskopf RB, Moore MA, Lockhart S, Eger EI, Koblin D, Lu G, Wilson C. Humans anesthetized with sevoflurane or isoflurane have similar arrhythmic response to epinephrine. Anesthesiology. 1994 Mar; 80(3):545-9. PMID: 7511357.
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    105. Eger EI, Weiskopf RB. Sympathetic hyperactivity during desflurane anesthesia. Anesthesiology. 1994 Feb; 80(2):482-3. PMID: 8311337.
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    106. Weiskopf RB, Eger EI. Comparing the costs of inhaled anesthetics. Anesthesiology. 1993 Dec; 79(6):1413-8. PMID: 8068064.
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    107. Moore MA, Weiskopf RB, Eger EI, Wilson C, Lu G. Arrhythmogenic doses of epinephrine are similar during desflurane or isoflurane anesthesia in humans. Anesthesiology. 1993 Nov; 79(5):943-7. PMID: 7694528.
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    108. Weiskopf R, Eger EI, Ionescu P, Yasuda N, Cahalan MK, Freire B, Peterson N, Lockhart SH, Rampil IJ, Laster M. Desflurane does not produce hepatic or renal injury in human volunteers. Anesth Analg. 1992 Apr; 74(4):570-4. PMID: 1554124.
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    109. Yasuda N, Weiskopf R, Cahalan MK, Ionescu P, Caldwell JE, Eger EI, Rampil IJ, Lockhart SH. Does desflurane modify circulatory responses to stimulation in humans? Anesth Analg. 1991 Aug; 73(2):175-9. PMID: 1854032.
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    110. Cahalan MK, Weiskopf R, Eger EI, Yasuda N, Ionescu P, Rampil IJ, Lockhart SH, Freire B, Peterson NA. Hemodynamic effects of desflurane/nitrous oxide anesthesia in volunteers. Anesth Analg. 1991 Aug; 73(2):157-64. PMID: 1854030.
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    111. Sutton TS, Koblin DD, Gruenke LD, Weiskopf R, Rampil IJ, Waskell L, Eger EI. Fluoride metabolites after prolonged exposure of volunteers and patients to desflurane. Anesth Analg. 1991 Aug; 73(2):180-5. PMID: 1854033.
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    112. Weiskopf R, Cahalan MK, Ionescu P, Eger EI, Yasuda N, Lockhart SH, Rampil IJ, Laster M, Freire B, Peterson N. Cardiovascular actions of desflurane with and without nitrous oxide during spontaneous ventilation in humans. Anesth Analg. 1991 Aug; 73(2):165-74. PMID: 1854031.
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    113. Weiskopf R, Cahalan MK, Eger EI, Yasuda N, Rampil IJ, Ionescu P, Lockhart SH, Johnson BH, Freire B, Kelley S. Cardiovascular actions of desflurane in normocarbic volunteers. Anesth Analg. 1991 Aug; 73(2):143-56. PMID: 1854029.
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    114. Yasuda N, Eger EI, Weiskopf R, Tanifuji Y, Kobayashi K. [Solubility of desflurane (I-653), sevoflurane, isoflurane, and halothane in human blood]. Masui. 1991 Jul; 40(7):1059-62. PMID: 1920779.
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    115. Fassoulaki A, Lockhart SH, Freire BA, Yasuda N, Eger EI, Weiskopf R, Johnson BH. Percutaneous loss of desflurane, isoflurane, and halothane in humans. Anesthesiology. 1991 Mar; 74(3):479-83. PMID: 2001027.
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    116. Caldwell JE, Laster MJ, Magorian T, Heier T, Yasuda N, Lynam DP, Eger EI, Weiskopf R. The neuromuscular effects of desflurane, alone and combined with pancuronium or succinylcholine in humans. Anesthesiology. 1991 Mar; 74(3):412-8. PMID: 2001017.
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    117. Yasuda N, Lockhart SH, Eger EI, Weiskopf R, Liu J, Laster M, Taheri S, Peterson NA. Comparison of kinetics of sevoflurane and isoflurane in humans. Anesth Analg. 1991 Mar; 72(3):316-24. PMID: 1994760.
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    118. Lockhart SH, Rampil IJ, Yasuda N, Eger EI, Weiskopf R. Depression of ventilation by desflurane in humans. Anesthesiology. 1991 Mar; 74(3):484-8. PMID: 1900396.
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    119. Rampil IJ, Lockhart SH, Zwass MS, Peterson N, Yasuda N, Eger EI, Weiskopf R, Damask MC. Clinical characteristics of desflurane in surgical patients: minimum alveolar concentration. Anesthesiology. 1991 Mar; 74(3):429-33. PMID: 2001020.
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    120. Rampil IJ, Lockhart SH, Eger EI, Yasuda N, Weiskopf R, Cahalan MK. The electroencephalographic effects of desflurane in humans. Anesthesiology. 1991 Mar; 74(3):434-9. PMID: 2001021.
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    121. Yasuda N, Lockhart SH, Eger EI, Weiskopf R, Johnson BH, Freire BA, Fassoulaki A. Kinetics of desflurane, isoflurane, and halothane in humans. Anesthesiology. 1991 Mar; 74(3):489-98. PMID: 2001028.
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    122. Lockhart SH, Yasuda N, Peterson N, Laster M, Taheri S, Weiskopf R, Eger EI. Comparison of percutaneous losses of sevoflurane and isoflurane in humans. Anesth Analg. 1991 Feb; 72(2):212-5. PMID: 1985506.
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    123. Yasuda N, Targ AG, Eger EI, Johnson BH, Weiskopf R. Pharmacokinetics of desflurane, sevoflurane, isoflurane, and halothane in pigs. Anesth Analg. 1990 Oct; 71(4):340-8. PMID: 2400116.
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    124. Holmes MA, Weiskopf R, Eger EI, Johnson BH, Rampil IJ. Hepatocellular integrity in swine after prolonged desflurane (I-653) and isoflurane anesthesia: evaluation of plasma alanine aminotransferase activity. Anesth Analg. 1990 Sep; 71(3):249-53. PMID: 2393108.
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    125. Weiskopf R, Eger EI, Holmes MA, Yasuda N, Johnson BH, Targ AG, Rampil IJ. Cardiovascular actions of common anesthetic adjuvants during desflurane (I-653) and isoflurane anesthesia in swine. Anesth Analg. 1990 Aug; 71(2):144-8. PMID: 2375516.
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    126. Holmes MA, Weiskopf R. A minimally invasive surgical technique for implantation of a chronically indwelling thermodilution catheter in swine pulmonary artery. Lab Anim Sci. 1990 Jan; 40(1):93-4. PMID: 2153874.
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    127. Nussmeier NA, Lambert ML, Moskowitz GJ, Cohen NH, Weiskopf R, Fisher DM, Eger EI. Washin and washout of isoflurane administered via bubble oxygenators during hypothermic cardiopulmonary bypass. Anesthesiology. 1989 Oct; 71(4):519-25. PMID: 2802209.
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    128. Weiskopf R, Holmes MA, Rampil IJ, Johnson BH, Yasuda N, Targ AG, Eger EI. Cardiovascular safety and actions of high concentrations of I-653 and isoflurane in swine. Anesthesiology. 1989 May; 70(5):793-8. PMID: 2719313.
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    129. Weiskopf R, Eger EI, Holmes MA, Rampil IJ, Johnson B, Brown JG, Yasuda N, Targ AG. Epinephrine-induced premature ventricular contractions and changes in arterial blood pressure and heart rate during I-653, isoflurane, and halothane anesthesia in swine. Anesthesiology. 1989 Feb; 70(2):293-8. PMID: 2464293.
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    130. Koblin DD, Weiskopf R, Holmes MA, Konopka K, Rampil IJ, Eger EI, Waskell L. Metabolism of I-653 and isoflurane in swine. Anesth Analg. 1989 Feb; 68(2):147-9. PMID: 2913848.
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    131. Eger EI, Johnson BH, Weiskopf R, Holmes MA, Yasuda N, Targ A, Rampil IJ. Minimum alveolar concentration of I-653 and isoflurane in pigs: definition of a supramaximal stimulus. Anesth Analg. 1988 Dec; 67(12):1174-6. PMID: 3195734.
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    132. Nussmeier NA, Moskowitz GJ, Weiskopf R, Cohen NH, Fisher DM, Eger EI. In vitro anesthetic washin and washout via bubble oxygenators: influence of anesthetic solubility and rates of carrier gas inflow and pump blood flow. Anesth Analg. 1988 Oct; 67(10):982-7. PMID: 3048150.
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    133. Weiskopf RB, Holmes MA, Eger EI, Johnson BH, Rampil IJ, Brown JG. Cardiovascular effects of I653 in swine. Anesthesiology. 1988 Sep; 69(3):303-9. PMID: 3415011.
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    134. Rampil IJ, Weiskopf RB, Brown JG, Eger EI, Johnson BH, Holmes MA, Donegan JH. I653 and isoflurane produce similar dose-related changes in the electroencephalogram of pigs. Anesthesiology. 1988 Sep; 69(3):298-302. PMID: 3415010.
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    135. Weiskopf R, Reid IA, Fisher DM, Holmes MA, Rosen JI, Keil LC. Effects of fentanyl on vasopressin secretion in human subjects. J Pharmacol Exp Ther. 1987 Sep; 242(3):970-3. PMID: 3116201.
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    136. Holmes MA, Weiskopf RB. Determination of plasma volume in swine by the enzyme-dilution method. Am J Physiol. 1987 May; 252(5 Pt 2):R1003-8. PMID: 3555120.
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    137. Weiskopf RB, Bogetz MS. Cardiovascular actions of nitrous oxide or halothane in hypovolemic swine. Anesthesiology. 1985 Nov; 63(5):509-16. PMID: 3901822.
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    138. Weiskopf RB, Bogetz MS. Haemorrhage decreases the anaesthetic requirement for ketamine and thiopentone in the pig. Br J Anaesth. 1985 Oct; 57(10):1022-5. PMID: 4041308.
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    139. Weiskopf RB, Bogetz MS. Minimum alveolar concentrations (MAC) of halothane and nitrous oxide in swine. Anesth Analg. 1984 May; 63(5):529-32. PMID: 6711846.
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    140. Weiskopf RB, Bogetz MS, Roizen MF, Reid IA. Cardiovascular and metabolic sequelae of inducing anesthesia with ketamine or thiopental in hypovolemic swine. Anesthesiology. 1984 Mar; 60(3):214-9. PMID: 6696255.
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    141. Weiskopf RB, Townsley MI, Riordan KK, Harris D, Chadwick K. Acid-base curve and alignment nomograms for swine blood. J Appl Physiol Respir Environ Exerc Physiol. 1983 Apr; 54(4):978-83. PMID: 6853305.
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    142. Weiskopf RB, Fairley HB. Anesthesia for major trauma. Surg Clin North Am. 1982 Feb; 62(1):31-45. PMID: 7064062.
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    143. Weiskopf RB, Townsley MI, Riordan KK, Chadwick K, Baysinger M, Mahoney E. Comparison of cardiopulmonary responses to graded hemorrhage during enflurane, halothane, isoflurane, and ketamine anesthesia. Anesth Analg. 1981 Jul; 60(7):481-91. PMID: 7195663.
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    144. Riordan KK, Weiskopf RB, Townsley MI, Chadwick KR. Oxygen-linked hydrogen ion binding of canine blood. Pflugers Arch. 1981 Apr; 390(1):99-101. PMID: 6787565.
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    145. Moores WY, Weiskopf RB, Baysinger M, Utley JR. Effects of halothane and morphine sulfate on myocardial compliance following total cardiopulmonary bypass. J Thorac Cardiovasc Surg. 1981 Feb; 81(2):163-70. PMID: 7192784.
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    146. Moores WY, De Venuto F, Heydorn WH, Weiskopf RB, Baysinger M, Greenburg AG, Utley JR. Extending the limits of hemodilution on cardiopulmonary bypass using stroma-free hemoglobin solution. J Thorac Cardiovasc Surg. 1981 Feb; 81(2):155-62. PMID: 7453225.
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    147. Horstman D, Weiskopf R, Jackson RE. Work capacity during 3-wk sojourn at 4,300 m: effects of relative polycythemia. J Appl Physiol Respir Environ Exerc Physiol. 1980 Aug; 49(2):311-8. PMID: 7400014.
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    148. Weiskopf R. Health information series draws community audiences. Volunt Leader. 1980; 21(1):1-3. PMID: 10247786.
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    149. Moores WY, Weiskopf R, Dembitsky WP, Utley JR. Comparative effects of halothane and morphine anesthesia on myocardial function and metabolism during cyanosis in swine. Surg Forum. 1979; 30:221-3. PMID: 538601.
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    150. Horstman DH, Weiskopf R, Robinson S. The nature of the perception of effort at sea level and high altitude. Med Sci Sports. 1979; 11(2):150-4. PMID: 491872.
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    151. Weiskopf R, Fencl V, Gabel RA. CSF pH and PCO2 measurement. J Appl Physiol Respir Environ Exerc Physiol. 1977 Sep; 43(3):566-7. PMID: 21155.
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    152. Weiskopf RB, Gabel RA, Fencl V. Alkaline shift in lumbar and intracranial CSF in man after 5 days at high altitude. J Appl Physiol. 1976 Jul; 41(1):93-7. PMID: 9373.
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    153. Evans WO, Robinson SM, Horstman DH, Jackson RE, Weiskopf R. Amelioration of the symptoms of acute mountain sickness by staging and acetazolamide. Aviat Space Environ Med. 1976 May; 47(5):512-6. PMID: 1275841.
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    154. Speer DC, Barnes K, Bloch JP, Clark C, Eichel E, Franz S, Weiskopf R. Self-study within a social system: a system analysis of a community mental health center. J Ment Health Adm. 1976-1977 Winter; 5(2):46-59. PMID: 10308355.
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    155. Gabel RA, Weiskopf R. Ventilatory interaction between hypoxia and [H+] at chemoreceptors of man. J Appl Physiol. 1975 Aug; 39(2):292-6. PMID: 240797.
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    156. Weiskopf RB, Raymond LW, Severinghaus JW. Effects of halothane on canine respiratory responses to hypoxia with and without hypercarbia. Anesthesiology. 1974 Oct; 41(4):350-60. PMID: 4413139.
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    157. Weiskopf RB, Severinghaus JW. Lack of effect of high altitude on hemoglobin oxygen affinity. J Appl Physiol. 1972 Aug; 33(2):276-7. PMID: 5054436.
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    158. Raymond L, Weiskopf RB, Halsey MJ, Goldfien A, Eger EI, Severinghaus JW. Possible mechanism for the antiarrhythmic effect of helium in anesthetized dogs. Science. 1972 Jun 16; 176(4040):1250-2. PMID: 5033644.
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    159. Weiskopf RB, Severinghaus JW. Diffusing capacity of the lung for CO in man during acute acclimation to 14,246 ft. J Appl Physiol. 1972 Mar; 32(3):285-9. PMID: 5010037.
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    160. Weiskopf RB, Nishimura M, Severinghaus JW. The absence of an effect of halothane on blood hemoglobin O 2 equilibrium in vitro. Anesthesiology. 1971 Dec; 35(6):579-81. PMID: 5124738.
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    161. Severinghaus JW, Weiskopf RB, Nishimura M, Bradley AF. Oxygen electrode errors due to polarographic reduction of halothane. J Appl Physiol. 1971 Oct; 31(4):640-2. PMID: 5111019.
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    162. Weiskopf RB. Unexplained failure of a continuous spinal anesthetic. Anesthesiology. 1970 Jul; 33(1):114-6. PMID: 5430285.
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    163. Domingo M, Mais RF, Weiskopf R, Fink S. Detection of schistosome ova by dark field fluorescence microscopy. Gastroenterology. 1968 May; 54(5):884-6. PMID: 5652522.
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    164. Smith JC, Weiskopf RB. Effect of cysteine on acetylcholine synthesis. Nature. 1967 Sep 23; 215(5108):1379-80. PMID: 6055450.
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    165. Jagatic J, Weiskopf R. A fluorescent method for staining mast cells. Arch Pathol. 1966 Nov; 82(5):430-3. PMID: 4162523.
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