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    Robert Blelloch, MD, PhD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentUrology
    Address35 Medical Center way
    San Fancisco CA 94143
    Phone415-476-2838

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       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Wang SY, Shiboski S, Belair CD, Cooperberg MR, Simko JP, Stoppler H, Cowan J, Carroll PR, Blelloch R. miR-19, miR-345, miR-519c-5p Serum Levels Predict Adverse Pathology in Prostate Cancer Patients Eligible for Active Surveillance. PLoS One. 2014; 9(6):e98597.
        View in: PubMed
      2. Parchem RJ, Ye J, Judson RL, Larussa MF, Krishnakumar R, Blelloch A, Oldham MC, Blelloch R. Two miRNA Clusters Reveal Alternative Paths in Late-Stage Reprogramming. Cell Stem Cell. 2014 May 1; 14(5):617-31.
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      3. Judson RL, Greve TS, Parchem RJ, Blelloch R. MicroRNA-based discovery of barriers to dedifferentiation of fibroblasts to pluripotent stem cells. Nat Struct Mol Biol. 2013 Oct; 20(10):1227-35.
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      4. Krishnakumar R, Blelloch RH. Epigenetics of cellular reprogramming. Curr Opin Genet Dev. 2013 Oct; 23(5):548-55.
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      5. Greve TS, Judson RL, Blelloch R. microRNA control of mouse and human pluripotent stem cell behavior. Annu Rev Cell Dev Biol. 2013; 29:213-39.
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      6. Wang Y, Melton C, Li YP, Shenoy A, Zhang XX, Subramanyam D, Blelloch R. miR-294/miR-302 promotes proliferation, suppresses G1-S restriction point, and inhibits ESC differentiation through separable mechanisms. Cell Rep. 2013 Jul 11; 4(1):99-109.
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      7. Jeker LT, Zhou X, Blelloch R, Bluestone JA. DGCR8-mediated production of canonical microRNAs is critical for regulatory T cell function and stability. PLoS One. 2013; 8(5):e66282.
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      8. Blelloch R, Gutkind JS. Epigenetics, noncoding RNAs, and cell signaling--crossroads in the regulation of cell fate decisions. Curr Opin Cell Biol. 2013 Apr; 25(2):149-51.
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      9. Lamouille S, Subramanyam D, Blelloch R, Derynck R. Regulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by microRNAs. Curr Opin Cell Biol. 2013 Apr; 25(2):200-7.
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      10. Cook MS, Blelloch R. Small RNAs in germline development. Curr Top Dev Biol. 2013; 102:159-205.
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      11. Venere M, Han YG, Bell R, Song JS, Alvarez-Buylla A, Blelloch R. Sox1 marks an activated neural stem/progenitor cell in the hippocampus. Development. 2012 Nov; 139(21):3938-49.
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      12. Hsu R, Schofield CM, Dela Cruz CG, Jones-Davis DM, Blelloch R, Ullian EM. Loss of microRNAs in pyramidal neurons leads to specific changes in inhibitory synaptic transmission in the prefrontal cortex. Mol Cell Neurosci. 2012 Jul; 50(3-4):283-92.
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      13. Manoli DS, Subramanyam D, Carey C, Sudin E, Van Westerhuyzen JA, Bales KL, Blelloch R, Shah NM. Generation of induced pluripotent stem cells from the prairie vole. PLoS One. 2012; 7(5):e38119.
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      14. Barad O, Mann M, Chapnik E, Shenoy A, Blelloch R, Barkai N, Hornstein E. Efficiency and specificity in microRNA biogenesis. Nat Struct Mol Biol. 2012 Jun; 19(6):650-2.
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      15. Shenoy A, Blelloch R. microRNA induced transdifferentiation. F1000 Biol Rep. 2012; 4:3.
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      16. Chapnik E, Sasson V, Blelloch R, Hornstein E. Dgcr8 controls neural crest cells survival in cardiovascular development. Dev Biol. 2012 Feb 1; 362(1):50-6.
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      17. Steiner DF, Thomas MF, Hu JK, Yang Z, Babiarz JE, Allen CD, Matloubian M, Blelloch R, Ansel KM. MicroRNA-29 regulates T-box transcription factors and interferon-? production in helper T cells. Immunity. 2011 Aug 26; 35(2):169-81.
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      18. Moltzahn F, Hunkapiller N, Mir AA, Imbar T, Blelloch R. High throughput microRNA profiling: optimized multiplex qRT-PCR at nanoliter scale on the fluidigm dynamic arrayTM IFCs. J Vis Exp. 2011; (54).
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      19. Babiarz JE, Hsu R, Melton C, Thomas M, Ullian EM, Blelloch R. A role for noncanonical microRNAs in the mammalian brain revealed by phenotypic differences in Dgcr8 versus Dicer1 knockouts and small RNA sequencing. RNA. 2011 Aug; 17(8):1489-501.
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      20. Subramanyam D, Blelloch R. From microRNAs to targets: pathway discovery in cell fate transitions. Curr Opin Genet Dev. 2011 Aug; 21(4):498-503.
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      21. Suh N, Blelloch R. Small RNAs in early mammalian development: from gametes to gastrulation. Development. 2011 May; 138(9):1653-61.
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      22. Subramanyam D, Lamouille S, Judson RL, Liu JY, Bucay N, Derynck R, Blelloch R. Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells. Nat Biotechnol. 2011 May; 29(5):443-8.
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      23. Schofield CM, Hsu R, Barker AJ, Gertz CC, Blelloch R, Ullian EM. Monoallelic deletion of the microRNA biogenesis gene Dgcr8 produces deficits in the development of excitatory synaptic transmission in the prefrontal cortex. Neural Dev. 2011; 6:11.
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      24. Chen J, Melton C, Suh N, Oh JS, Horner K, Xie F, Sette C, Blelloch R, Conti M. Genome-wide analysis of translation reveals a critical role for deleted in azoospermia-like (Dazl) at the oocyte-to-zygote transition. Genes Dev. 2011 Apr 1; 25(7):755-66.
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      25. Wang Y, Blelloch R. Cell cycle regulation by microRNAs in stem cells. Results Probl Cell Differ. 2011; 53:459-72.
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      26. Moltzahn F, Olshen AB, Baehner L, Peek A, Fong L, Stöppler H, Simko J, Hilton JF, Carroll P, Blelloch R. Microfluidic-based multiplex qRT-PCR identifies diagnostic and prognostic microRNA signatures in the sera of prostate cancer patients. Cancer Res. 2011 Jan 15; 71(2):550-60.
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      27. Elefanty AG, Blelloch R, Passegué E, Wernig M, Mummery CL. On the streets of San Francisco: highlights from the ISSCR Annual Meeting 2010. Cell Stem Cell. 2010 Oct 8; 7(4):443-50.
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      28. Swarbrick A, Woods SL, Shaw A, Balakrishnan A, Phua Y, Nguyen A, Chanthery Y, Lim L, Ashton LJ, Judson RL, Huskey N, Blelloch R, Haber M, Norris MD, Lengyel P, Hackett CS, Preiss T, Chetcuti A, Sullivan CS, Marcusson EG, Weiss W, L'Etoile N, Goga A. miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma. Nat Med. 2010 Oct; 16(10):1134-40.
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      29. Subramanyam D, Belair CD, Barry-Holson KQ, Lin H, Kogan SC, Passegué E, Blelloch R. PML-RAR{alpha} and Dnmt3a1 cooperate in vivo to promote acute promyelocytic leukemia. Cancer Res. 2010 Nov 1; 70(21):8792-801.
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      30. Bezman NA, Cedars E, Steiner DF, Blelloch R, Hesslein DG, Lanier LL. Distinct requirements of microRNAs in NK cell activation, survival, and function. J Immunol. 2010 Oct 1; 185(7):3835-46.
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      31. Song G, Sharma AD, Roll GR, Ng R, Lee AY, Blelloch RH, Frandsen NM, Willenbring H. MicroRNAs control hepatocyte proliferation during liver regeneration. Hepatology. 2010 May; 51(5):1735-43.
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      32. Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP. Mammalian microRNAs: experimental evaluation of novel and previously annotated genes. Genes Dev. 2010 May 15; 24(10):992-1009.
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      33. Suh N, Baehner L, Moltzahn F, Melton C, Shenoy A, Chen J, Blelloch R. MicroRNA function is globally suppressed in mouse oocytes and early embryos. Curr Biol. 2010 Feb 9; 20(3):271-7.
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      34. Melton C, Judson RL, Blelloch R. Opposing microRNA families regulate self-renewal in mouse embryonic stem cells. Nature. 2010 Feb 4; 463(7281):621-6.
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      35. Melton C, Blelloch R. MicroRNA Regulation of Embryonic Stem Cell Self-Renewal and Differentiation. Adv Exp Med Biol. 2010; 695:105-17.
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      36. Blelloch R. Journal club. A computational biologist looks at how mRNA length changes during development. Nature. 2009 Nov 12; 462(7270):141.
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      37. Subramanyam D, Blelloch R. Watching reprogramming in real time. Nat Biotechnol. 2009 Nov; 27(11):997-8.
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      38. Shenoy A, Blelloch R. Genomic analysis suggests that mRNA destabilization by the microprocessor is specialized for the auto-regulation of Dgcr8. PLoS One. 2009; 4(9):e6971.
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      39. Rao PK, Toyama Y, Chiang HR, Gupta S, Bauer M, Medvid R, Reinhardt F, Liao R, Krieger M, Jaenisch R, Lodish HF, Blelloch R. Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure. Circ Res. 2009 Sep 11; 105(6):585-94.
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      40. Wang Y, Blelloch R. Cell cycle regulation by MicroRNAs in embryonic stem cells. Cancer Res. 2009 May 15; 69(10):4093-6.
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      41. Judson RL, Babiarz JE, Venere M, Blelloch R. Embryonic stem cell-specific microRNAs promote induced pluripotency. Nat Biotechnol. 2009 May; 27(5):459-61.
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      42. Han J, Pedersen JS, Kwon SC, Belair CD, Kim YK, Yeom KH, Yang WY, Haussler D, Blelloch R, Kim VN. Posttranscriptional crossregulation between Drosha and DGCR8. Cell. 2009 Jan 9; 136(1):75-84.
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      43. Wang Y, Baskerville S, Shenoy A, Babiarz JE, Baehner L, Blelloch R. Embryonic stem cell-specific microRNAs regulate the G1-S transition and promote rapid proliferation. Nat Genet. 2008 Dec; 40(12):1478-83.
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      44. Chaivorapol C, Melton C, Wei G, Yeh RF, Ramalho-Santos M, Blelloch R, Li H. CompMoby: comparative MobyDick for detection of cis-regulatory motifs. BMC Bioinformatics. 2008; 9:455.
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      45. Babiarz JE, Ruby JG, Wang Y, Bartel DP, Blelloch R. Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs. Genes Dev. 2008 Oct 15; 22(20):2773-85.
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      46. Blelloch R. Regenerative medicine: short cut to cell replacement. Nature. 2008 Oct 2; 455(7213):604-5.
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      47. Blelloch R, Venere M, Yen J, Ramalho-Santos M. Generation of induced pluripotent stem cells in the absence of drug selection. Cell Stem Cell. 2007 Sep 13; 1(3):245-7.
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      48. Wang Y, Medvid R, Melton C, Jaenisch R, Blelloch R. DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. Nat Genet. 2007 Mar; 39(3):380-5.
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      49. Blelloch R, Wang Z, Meissner A, Pollard S, Smith A, Jaenisch R. Reprogramming efficiency following somatic cell nuclear transfer is influenced by the differentiation and methylation state of the donor nucleus. Stem Cells. 2006 Sep; 24(9):2007-13.
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      50. Blelloch RH, Hochedlinger K, Yamada Y, Brennan C, Kim M, Mintz B, Chin L, Jaenisch R. Nuclear cloning of embryonal carcinoma cells. Proc Natl Acad Sci U S A. 2004 Sep 28; 101(39):13985-90.
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      51. Mathies LD, Schvarzstein M, Morphy KM, Blelloch R, Spence AM, Kimble J. TRA-1/GLI controls development of somatic gonadal precursors in C. elegans. Development. 2004 Sep; 131(17):4333-43.
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      52. Hochedlinger K, Blelloch R, Brennan C, Yamada Y, Kim M, Chin L, Jaenisch R. Reprogramming of a melanoma genome by nuclear transplantation. Genes Dev. 2004 Aug 1; 18(15):1875-85.
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      53. Hochedlinger K, Rideout WM, Kyba M, Daley GQ, Blelloch R, Jaenisch R. Nuclear transplantation, embryonic stem cells and the potential for cell therapy. Hematol J. 2004; 5 Suppl 3:S114-7.
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      54. Jaenisch R, Hochedlinger K, Blelloch R, Yamada Y, Baldwin K, Eggan K. Nuclear cloning, epigenetic reprogramming, and cellular differentiation. Cold Spring Harb Symp Quant Biol. 2004; 69:19-27.
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      55. Blelloch R, Anna-Arriola SS, Gao D, Li Y, Hodgkin J, Kimble J. The gon-1 gene is required for gonadal morphogenesis in Caenorhabditis elegans. Dev Biol. 1999 Dec 1; 216(1):382-93.
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      56. Blelloch R, Newman C, Kimble J. Control of cell migration during Caenorhabditis elegans development. Curr Opin Cell Biol. 1999 Oct; 11(5):608-13.
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      57. Blelloch R, Kimble J. Control of organ shape by a secreted metalloprotease in the nematode Caenorhabditis elegans. Nature. 1999 Jun 10; 399(6736):586-90.
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      58. Roehl H, Bosenberg M, Blelloch R, Kimble J. Roles of the RAM and ANK domains in signaling by the C. elegans GLP-1 receptor. EMBO J. 1996 Dec 16; 15(24):7002-12.
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      59. Reznikoff CA, Belair CD, Yeager TR, Savelieva E, Blelloch RH, Puthenveettil JA, Cuthill S. A molecular genetic model of human bladder cancer pathogenesis. Semin Oncol. 1996 Oct; 23(5):571-84.
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