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    Robin Shaw, MD, PhD

    TitleAssociate Professor in Residence
    SchoolUCSF School of Medicine
    DepartmentMedicine
    Address555 Mission Bay Blvd South
    San Francisco CA 94158
    Phone415-514-0992

       Overview 
       Overview
      CLINICAL INTERESTS: Dr. Shaw is a Cardiologist with an interest in heart failure and ventricular arrythmias. His main clinical activities include heart failure, dilated cardiomyopathy, left ventricular assist devices, inherited cardiomyopathy, heart transplant, and sudden cardiac death.


      RESEARCH INTERESTS: Cardiomyocyte biology, heart failure, arrhythmogenic right ventricular cardiomyopathy, mechanisms of arrhythmias, mechanisms of heart failure progression, clinical biomarkers of heart disease, cell biology, cardiomyocyte signaling, membrane protein trafficking, gap junctions, L-type calcium channels, T-tubules, and cytoskeleton.


       Bibliographic 
       Publications
      Publications by year:
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      1. Gao D, Zhang L, Dhillon R, Hong TT, Shaw RM, Zhu J. Dynasore protects mitochondria and improves cardiac lusitropy in langendorff perfused mouse heart. PLoS One. 2013; 8(4):e60967.
        View in: PubMed
      2. Shaw RM, Colecraft HM. L-type calcium channel targeting and local signalling in cardiac myocytes. Cardiovasc Res. 2013 May 1; 98(2):177-86.
        View in: PubMed
      3. Shaw RM. Reduced sodium channels in human ARVC. Heart Rhythm. 2013 Mar; 10(3):420-1.
        View in: PubMed
      4. Zhang SS, Shaw RM. Multilayered regulation of cardiac ion channels. Biochim Biophys Acta. 2013 Apr; 1833(4):876-85.
        View in: PubMed
      5. Smyth JW, Vogan JM, Buch PJ, Zhang SS, Fong TS, Hong TT, Shaw RM. Actin cytoskeleton rest stops regulate anterograde traffic of connexin 43 vesicles to the plasma membrane. Circ Res. 2012 Mar 30; 110(7):978-89.
        View in: PubMed
      6. Hong TT, Cogswell R, James CA, Kang G, Pullinger CR, Malloy MJ, Kane JP, Wojciak J, Calkins H, Scheinman MM, Tseng ZH, Ganz P, De Marco T, Judge DP, Shaw RM. Plasma BIN1 correlates with heart failure and predicts arrhythmia in patients with arrhythmogenic right ventricular cardiomyopathy. Heart Rhythm. 2012 Jun; 9(6):961-7.
        View in: PubMed
      7. Smyth JW, Shaw RM. Visualizing cardiac ion channel trafficking pathways. Methods Enzymol. 2012; 505:187-202.
        View in: PubMed
      8. Hong TT, Smyth JW, Chu KY, Vogan JM, Fong TS, Jensen BC, Fang K, Halushka MK, Russell SD, Colecraft H, Hoopes CW, Ocorr K, Chi NC, Shaw RM. BIN1 is reduced and Cav1.2 trafficking is impaired in human failing cardiomyocytes. Heart Rhythm. 2012 May; 9(5):812-20.
        View in: PubMed
      9. Zhang SS, Kim KH, Rosen A, Smyth JW, Sakuma R, Delgado-Olguín P, Davis M, Chi NC, Puviindran V, Gaborit N, Sukonnik T, Wylie JN, Brand-Arzamendi K, Farman GP, Kim J, Rose RA, Marsden PA, Zhu Y, Zhou YQ, Miquerol L, Henkelman RM, Stainier DY, Shaw RM, Hui CC, Bruneau BG, Backx PH. Iroquois homeobox gene 3 establishes fast conduction in the cardiac His-Purkinje network. Proc Natl Acad Sci U S A. 2011 Aug 16; 108(33):13576-81.
        View in: PubMed
      10. Smyth JW, Shaw RM. The gap junction life cycle. Heart Rhythm. 2012 Jan; 9(1):151-3.
        View in: PubMed
      11. Chi NC, Bussen M, Brand-Arzamendi K, Ding C, Olgin JE, Shaw RM, Martin GR, Stainier DY. Cardiac conduction is required to preserve cardiac chamber morphology. Proc Natl Acad Sci U S A. 2010 Aug 17; 107(33):14662-7.
        View in: PubMed
      12. Smyth JW, Shaw RM. Forward trafficking of ion channels: what the clinician needs to know. Heart Rhythm. 2010 Aug; 7(8):1135-40.
        View in: PubMed
      13. Hong TT, Smyth JW, Gao D, Chu KY, Vogan JM, Fong TS, Jensen BC, Colecraft HM, Shaw RM. BIN1 localizes the L-type calcium channel to cardiac T-tubules. PLoS Biol. 2010 Feb; 8(2):e1000312.
        View in: PubMed
      14. Smyth JW, Hong TT, Gao D, Vogan JM, Jensen BC, Fong TS, Simpson PC, Stainier DY, Chi NC, Shaw RM. Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardium. J Clin Invest. 2010 Jan; 120(1):266-79.
        View in: PubMed
      15. Ieda M, Tsuchihashi T, Ivey KN, Ross RS, Hong TT, Shaw RM, Srivastava D. Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signaling. Dev Cell. 2009 Feb; 16(2):233-44.
        View in: PubMed
      16. Chi NC, Shaw RM, Jungblut B, Huisken J, Ferrer T, Arnaout R, Scott I, Beis D, Xiao T, Baier H, Jan LY, Tristani-Firouzi M, Stainier DY. Genetic and physiologic dissection of the vertebrate cardiac conduction system. PLoS Biol. 2008 May 13; 6(5):e109.
        View in: PubMed
      17. Saxena A, Fish JE, White MD, Yu S, Smyth JW, Shaw RM, DiMaio JM, Srivastava D. Stromal cell-derived factor-1alpha is cardioprotective after myocardial infarction. Circulation. 2008 Apr 29; 117(17):2224-31.
        View in: PubMed
      18. Chi NC, Shaw RM, De Val S, Kang G, Jan LY, Black BL, Stainier DY. Foxn4 directly regulates tbx2b expression and atrioventricular canal formation. Genes Dev. 2008 Mar 15; 22(6):734-9.
        View in: PubMed
      19. Smyth JW, Shaw RM. Visualizing ion channel dynamics at the plasma membrane. Heart Rhythm. 2008 Jun; 5(6 Suppl):S7-11.
        View in: PubMed
      20. Shaw RM, Fay AJ, Puthenveedu MA, von Zastrow M, Jan YN, Jan LY. Microtubule plus-end-tracking proteins target gap junctions directly from the cell interior to adherens junctions. Cell. 2007 Feb 9; 128(3):547-60.
        View in: PubMed
      21. Ionescu-Zanetti C, Shaw RM, Seo J, Jan YN, Jan LY, Lee LP. Mammalian electrophysiology on a microfluidic platform. Proc Natl Acad Sci U S A. 2005 Jun 28; 102(26):9112-7.
        View in: PubMed
      22. Viswanathan PC, Shaw RM, Rudy Y. Effects of IKr and IKs heterogeneity on action potential duration and its rate dependence: a simulation study. Circulation. 1999 May 11; 99(18):2466-74.
        View in: PubMed
      23. Shaw RM, Rudy Y. Ionic mechanisms of propagation in cardiac tissue. Roles of the sodium and L-type calcium currents during reduced excitability and decreased gap junction coupling. Circ Res. 1997 Nov; 81(5):727-41.
        View in: PubMed
      24. Shaw RM, Rudy Y. Electrophysiologic effects of acute myocardial ischemia: a theoretical study of altered cell excitability and action potential duration. Cardiovasc Res. 1997 Aug; 35(2):256-72.
        View in: PubMed
      25. Shaw RM, Rudy Y. Electrophysiologic effects of acute myocardial ischemia. A mechanistic investigation of action potential conduction and conduction failure. Circ Res. 1997 Jan; 80(1):124-38.
        View in: PubMed
      26. Rudy Y, Shaw RM. Cardiac excitation: an interactive process of ion channels and gap junctions. Adv Exp Med Biol. 1997; 430:269-79.
        View in: PubMed
      27. Shaw RM, Rudy Y. The vulnerable window for unidirectional block in cardiac tissue: characterization and dependence on membrane excitability and intercellular coupling. J Cardiovasc Electrophysiol. 1995 Feb; 6(2):115-31.
        View in: PubMed
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