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    Roly Gosling, PhD, MS

    TitleAssociate Professor
    SchoolUCSF School of Medicine
    DepartmentEpidemiology & Biostatistics
    Address550 16th Street
    San Francisco CA 94158
    Phone415-476-5620

       Overview 
       Overview
      The malaria elimination initiative is focussed on supporting countries to succeed in elimination of both falciparum and vivax malaria. We have a broad range of activities from desk based research producing advocacy and summary materials to highlight the substantial progress of malaria control and elimination world wide, to field based research exploring active surveillance strategies, efficacy of drug based transmission interventions, costing studies of elimination programs and more qualitative research such as case studies. The program also supports countries by supporting regional networks of countries to eliminate malaria (the Asia Pacific Malaria Elimination Network, APMEN and the Eliminating 8, E8 in southern Africa).

      We do have opportunities to send students to support field research studies.


       ORNG Applications 
       Websites
       Global Health

       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. White NJ, Ashley EA, Recht J, Delves MJ, Ruecker A, Smithuis FM, Eziefula AC, Bousema T, Drakeley C, Chotivanich K, Imwong M, Pukrittayakamee S, Prachumsri J, Chu C, Andolina C, Bancone G, Hien TT, Mayxay M, Taylor WR, von Seidlein L, Price RN, Barnes KI, Djimdé A, Ter Kuile F, Gosling R, Chen I, Dhorda MJ, Stepniewska K, Guérin P, Woodrow CJ, Dondorp AM, Day NP, Nosten FH. Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria. Malar J. 2014; 13(1):483.
        View in: PubMed
      2. Chen IT, Gosling RD. Targeting Plasmodium falciparum transmission with primaquine: same efficacy, improved safety with a lower dose? Expert Rev Clin Pharmacol. 2014 Nov; 7(6):681-6.
        View in: PubMed
      3. Smith Gueye C, Newby G, Hwang J, Phillips AA, Whittaker M, MacArthur JR, Gosling RD, Feachem RG. The challenge of artemisinin resistance can only be met by eliminating Plasmodium falciparum malaria across the Greater Mekong subregion. Malar J. 2014; 13(1):286.
        View in: PubMed
      4. Cao J, Sturrock HJ, Cotter C, Zhou S, Zhou H, Liu Y, Tang L, Gosling RD, Feachem RG, Gao Q. Communicating and Monitoring Surveillance and Response Activities for Malaria Elimination: China's "1-3-7" Strategy. PLoS Med. 2014 May; 11(5):e1001642.
        View in: PubMed
      5. Liu JX, Bousema T, Zelman B, Gesase S, Hashim R, Maxwell C, Chandramohan D, Gosling R. Is Housing Quality Associated with Malaria Incidence among Young Children and Mosquito Vector Numbers? Evidence from Korogwe, Tanzania. PLoS One. 2014; 9(2):e87358.
        View in: PubMed
      6. Dial NJ, Ceesay SJ, Gosling RD, D'Alessandro U, Baltzell KA. A qualitative study to assess community barriers to malaria mass drug administration trials in the Gambia. Malar J. 2014; 13(1):47.
        View in: PubMed
      7. Liu Y, Hsiang MS, Zhou H, Wang W, Cao Y, Gosling RD, Cao J, Gao Q. Malaria in overseas labourers returning to China: an analysis of imported malaria in Jiangsu Province, 2001-2011. Malar J. 2014; 13(1):29.
        View in: PubMed
      8. Sanders KC, Rundi C, Jelip J, Rashman Y, Smith Gueye C, Gosling RD. Eliminating malaria in Malaysia: the role of partnerships between the public and commercial sectors in Sabah. Malar J. 2014; 13(1):24.
        View in: PubMed
      9. Gosling RD, Hsiang MS. Malaria and Severe Anemia: Thinking beyond Plasmodium falciparum. PLoS Med. 2013 Dec; 10(12):e1001576.
        View in: PubMed
      10. Hsiang MS, Hwang J, Tao AR, Liu Y, Bennett A, Shanks GD, Cao J, Kachur SP, Feachem RG, Gosling RD, Gao Q. Mass drug administration for the control and elimination of Plasmodium vivax malaria: an ecological study from Jiangsu province, China. Malar J. 2013; 12(1):383.
        View in: PubMed
      11. Smith Gueye C, Sanders KC, Galappaththy GN, Rundi C, Tobgay T, Sovannaroth S, Gao Q, Surya A, Thakur GD, Baquilod M, Lee WJ, Bobogare A, Deniyage SL, Satimai W, Taleo G, Hung NM, Cotter C, Hsiang MS, Vestergaard LS, Gosling RD. Active case detection for malaria elimination: a survey among Asia Pacific countries. Malar J. 2013; 12(1):358.
        View in: PubMed
      12. Mosha JF, Sturrock HJ, Greenhouse B, Greenwood B, Sutherland CJ, Gadalla N, Atwal S, Drakeley C, Kibiki G, Bousema T, Chandramohan D, Gosling R. Epidemiology of subpatent Plasmodium falciparum infection: implications for detection of hotspots with imperfect diagnostics. Malar J. 2013; 12:221.
        View in: PubMed
      13. Liu J, Modrek S, Gosling RD, Feachem RG. Malaria eradication: is it possible? Is it worth it? Should we do it? Lancet Glob Health. 2013 Jul; 1(1):e2-3.
        View in: PubMed
      14. Smith DL, Cohen JM, Chiyaka C, Johnston G, Gething PW, Gosling R, Buckee CO, Laxminarayan R, Hay SI, Tatem AJ. A sticky situation: the unexpected stability of malaria elimination. Philos Trans R Soc Lond B Biol Sci. 2013 Aug 5; 368(1623):20120145.
        View in: PubMed
      15. Sturrock HJ, Hsiang MS, Cohen JM, Smith DL, Greenhouse B, Bousema T, Gosling RD. Targeting asymptomatic malaria infections: active surveillance in control and elimination. PLoS Med. 2013; 10(6):e1001467.
        View in: PubMed
      16. Sturrock HJ, Novotny JM, Kunene S, Dlamini S, Zulu Z, Cohen JM, Hsiang MS, Greenhouse B, Gosling RD. Reactive case detection for malaria elimination: real-life experience from an ongoing program in Swaziland. PLoS One. 2013; 8(5):e63830.
        View in: PubMed
      17. Cotter C, Sturrock HJ, Hsiang MS, Liu J, Phillips AA, Hwang J, Gueye CS, Fullman N, Gosling RD, Feachem RG. The changing epidemiology of malaria elimination: new strategies for new challenges. Lancet. 2013 Sep 7; 382(9895):900-11.
        View in: PubMed
      18. Bauch JA, Gu JJ, Msellem M, Mårtensson A, Ali AS, Gosling R, Baltzell KA. Perception of malaria risk in a setting of reduced malaria transmission: a qualitative study in Zanzibar. Malar J. 2013; 12:75.
        View in: PubMed
      19. Chiyaka C, Tatem AJ, Cohen JM, Gething PW, Johnston G, Gosling R, Laxminarayan R, Hay SI, Smith DL. Infectious disease. The stability of malaria elimination. Science. 2013 Feb 22; 339(6122):909-10.
        View in: PubMed
      20. Eziefula AC, Gosling R, Hwang J, Hsiang MS, Bousema T, von Seidlein L, Drakeley C. Rationale for short course primaquine in Africa to interrupt malaria transmission. Malar J. 2012; 11:360.
        View in: PubMed
      21. Gosling RD, Whittaker M, Gueye CS, Fullman N, Baquilod M, Kusriastuti R, Feachem RG. Malaria elimination gaining ground in the Asia Pacific. Malar J. 2012; 11:346.
        View in: PubMed
      22. Gueye CS, Teng A, Kinyua K, Wafula F, Gosling R, McCoy D. Parasites and vectors carry no passport: how to fund cross-border and regional efforts to achieve malaria elimination. Malar J. 2012; 11:344.
        View in: PubMed
      23. Stone W, Bousema T, Jones S, Gesase S, Hashim R, Gosling R, Carneiro I, Chandramohan D, Theander T, Ronca R, Modiano D, Arcà B, Drakeley C. IgG responses to Anopheles gambiae salivary antigen gSG6 detect variation in exposure to malaria vectors and disease risk. PLoS One. 2012; 7(6):e40170.
        View in: PubMed
      24. Bousema T, Griffin JT, Sauerwein RW, Smith DL, Churcher TS, Takken W, Ghani A, Drakeley C, Gosling R. Hitting hotspots: spatial targeting of malaria for control and elimination. PLoS Med. 2012 Jan; 9(1):e1001165.
        View in: PubMed
      25. Yangzom T, Gueye CS, Namgay R, Galappaththy GN, Thimasarn K, Gosling R, Murugasampillay S, Dev V. Malaria control in Bhutan: case study of a country embarking on elimination. Malar J. 2012; 11:9.
        View in: PubMed
      26. Kunene S, Phillips AA, Gosling RD, Kandula D, Novotny JM. A national policy for malaria elimination in Swaziland: a first for sub-Saharan Africa. Malar J. 2011; 10:313.
        View in: PubMed
      27. Gosling RD, Okell L, Mosha J, Chandramohan D. The role of antimalarial treatment in the elimination of malaria. Clin Microbiol Infect. 2011 Nov; 17(11):1617-23.
        View in: PubMed
      28. Shekalaghe SA, Drakeley C, van den Bosch S, ter Braak R, van den Bijllaardt W, Mwanziva C, Semvua S, Masokoto A, Mosha F, Teelen K, Hermsen R, Okell L, Gosling R, Sauerwein R, Bousema T. A cluster-randomized trial of mass drug administration with a gametocytocidal drug combination to interrupt malaria transmission in a low endemic area in Tanzania. Malar J. 2011; 10:247.
        View in: PubMed
      29. Bousema T, Kreuels B, Gosling R. Adjusting for heterogeneity of malaria transmission in longitudinal studies. J Infect Dis. 2011 Jul 1; 204(1):1-3.
        View in: PubMed
      30. Cairns M, Ghani A, Okell L, Gosling R, Carneiro I, Anto F, Asoala V, Owusu-Agyei S, Greenwood B, Chandramohan D, Milligan P. Modelling the protective efficacy of alternative delivery schedules for intermittent preventive treatment of malaria in infants and children. PLoS One. 2011; 6(4):e18947.
        View in: PubMed
      31. Griffin JT, Cairns M, Ghani AC, Roper C, Schellenberg D, Carneiro I, Newman RD, Grobusch MP, Greenwood B, Chandramohan D, Gosling RD. Protective efficacy of intermittent preventive treatment of malaria in infants (IPTi) using sulfadoxine-pyrimethamine and parasite resistance. PLoS One. 2010; 5(9):e12618.
        View in: PubMed
      32. Conteh L, Sicuri E, Manzi F, Hutton G, Obonyo B, Tediosi F, Biao P, Masika P, Matovu F, Otieno P, Gosling RD, Hamel M, Odhiambo FO, Grobusch MP, Kremsner PG, Chandramohan D, Aponte JJ, Egan A, Schellenberg D, Macete E, Slutsker L, Newman RD, Alonso P, Menéndez C, Tanner M. The cost-effectiveness of intermittent preventive treatment for malaria in infants in Sub-Saharan Africa. PLoS One. 2010; 5(6):e10313.
        View in: PubMed
      33. Bousema T, Drakeley C, Gesase S, Hashim R, Magesa S, Mosha F, Otieno S, Carneiro I, Cox J, Msuya E, Kleinschmidt I, Maxwell C, Greenwood B, Riley E, Sauerwein R, Chandramohan D, Gosling R. Identification of hot spots of malaria transmission for targeted malaria control. J Infect Dis. 2010 Jun 1; 201(11):1764-74.
        View in: PubMed
      34. Gosling RD, Cairns ME, Chico RM, Chandramohan D. Intermittent preventive treatment against malaria: an update. Expert Rev Anti Infect Ther. 2010 May; 8(5):589-606.
        View in: PubMed
      35. Cairns M, Gosling R, Carneiro I, Gesase S, Mosha JF, Hashim R, Kaur H, Lemnge M, Mosha FW, Greenwood B, Chandramohan D. Duration of protection against clinical malaria provided by three regimens of intermittent preventive treatment in Tanzanian infants. PLoS One. 2010; 5(3):e9467.
        View in: PubMed
      36. Mosha JF, Conteh L, Tediosi F, Gesase S, Bruce J, Chandramohan D, Gosling R. Cost implications of improving malaria diagnosis: findings from north-eastern Tanzania. PLoS One. 2010; 5(1):e8707.
        View in: PubMed
      37. Yip K, Gosling RD, Jones V, Hosein IK. An unusual case of meningococcal meningitis complicated with subdural empyema in a 3 month old infant: a case report. Cases J. 2009; 2:6335.
        View in: PubMed
      38. Gosling RD, Gesase S, Mosha JF, Carneiro I, Hashim R, Lemnge M, Mosha FW, Greenwood B, Chandramohan D. Protective efficacy and safety of three antimalarial regimens for intermittent preventive treatment for malaria in infants: a randomised, double-blind, placebo-controlled trial. Lancet. 2009 Oct 31; 374(9700):1521-32.
        View in: PubMed
      39. Cairns M, Gosling R, Gesase S, Mosha J, Greenwood B, Chandramohan D. Mode of action and choice of antimalarial drugs for intermittent preventive treatment in infants. Trans R Soc Trop Med Hyg. 2009 Dec; 103(12):1199-201.
        View in: PubMed
      40. Gysels M, Pell C, Mathanga DP, Adongo P, Odhiambo F, Gosling R, Akweongo P, Mwangi R, Okello G, Mangesho P, Slutsker L, Kremsner PG, Grobusch MP, Hamel MJ, Newman RD, Pool R. Community response to intermittent preventive treatment of malaria in infants (IPTi) delivered through the expanded programme of immunization in five African settings. Malar J. 2009; 8:191.
        View in: PubMed
      41. Stewart L, Gosling R, Griffin J, Gesase S, Campo J, Hashim R, Masika P, Mosha J, Bousema T, Shekalaghe S, Cook J, Corran P, Ghani A, Riley EM, Drakeley C. Rapid assessment of malaria transmission using age-specific sero-conversion rates. PLoS One. 2009; 4(6):e6083.
        View in: PubMed
      42. Gosling RD, Carneiro I, Chandramohan D. Intermittent preventive treatment of malaria in infants: how does it work and where will it work? Trop Med Int Health. 2009 Sep; 14(9):1003-10.
        View in: PubMed
      43. Gosling RD, Chandramohan D. RTS,S/AS01E vaccine against malaria. N Engl J Med. 2009 Mar 19; 360(12):1253; author reply 1253-4.
        View in: PubMed
      44. Gesase S, Gosling RD, Hashim R, Ord R, Naidoo I, Madebe R, Mosha JF, Joho A, Mandia V, Mrema H, Mapunda E, Savael Z, Lemnge M, Mosha FW, Greenwood B, Roper C, Chandramohan D. High resistance of Plasmodium falciparum to sulphadoxine/pyrimethamine in northern Tanzania and the emergence of dhps resistance mutation at Codon 581. PLoS One. 2009; 4(2):e4569.
        View in: PubMed
      45. Cairns M, Gosling R, Chandramohan D. Placental malaria increases malaria risk in the first 30 months of life: not causal. Clin Infect Dis. 2009 Feb 15; 48(4):497-8; author reply 498-9.
        View in: PubMed
      46. Ghani AC, Sutherland CJ, Riley EM, Drakeley CJ, Griffin JT, Gosling RD, Filipe JA. Loss of population levels of immunity to malaria as a result of exposure-reducing interventions: consequences for interpretation of disease trends. PLoS One. 2009; 4(2):e4383.
        View in: PubMed
      47. Mwanziva C, Shekalaghe S, Ndaro A, Mengerink B, Megiroo S, Mosha F, Sauerwein R, Drakeley C, Gosling R, Bousema T. Overuse of artemisinin-combination therapy in Mto wa Mbu (river of mosquitoes), an area misinterpreted as high endemic for malaria. Malar J. 2008; 7:232.
        View in: PubMed
      48. Gosling RD, Chandramohan D. Tackling malaria today: Beware resurgence of malaria where incidence has fallen. BMJ. 2008; 337:a1592.
        View in: PubMed
      49. Gosling RD, Drakeley CJ, Mwita A, Chandramohan D. Presumptive treatment of fever cases as malaria: help or hindrance for malaria control? Malar J. 2008; 7:132.
        View in: PubMed
      50. Gosling RD. Asymptomatic malaria associated with protection: not causal. Clin Infect Dis. 2008 Jul 1; 47(1):147; author reply 147-8.
        View in: PubMed
      51. Cairns M, Carneiro I, Milligan P, Owusu-Agyei S, Awine T, Gosling R, Greenwood B, Chandramohan D. Duration of protection against malaria and anaemia provided by intermittent preventive treatment in infants in Navrongo, Ghana. PLoS One. 2008; 3(5):e2227.
        View in: PubMed
      52. Gosling RD, Ghani AC, Deen JL, von Seidlein L, Greenwood BM, Chandramohan D. Can changes in malaria transmission intensity explain prolonged protection and contribute to high protective efficacy of intermittent preventive treatment for malaria in infants? Malar J. 2008; 7:54.
        View in: PubMed
      53. Gosling RD, Drakeley CJ, Chandramohan D. Effective malaria control: better burden estimates needed. Lancet. 2008 Mar 1; 371(9614):724.
        View in: PubMed
      54. Whitty C, Gosling R. Implications of attempts to eliminate malaria for front-line clinicians. Trop Doct. 2008 Jan; 38(1):1-2.
        View in: PubMed
      55. Grobusch MP, Egan A, Gosling RD, Newman RD. Intermittent preventive therapy for malaria: progress and future directions. Curr Opin Infect Dis. 2007 Dec; 20(6):613-20.
        View in: PubMed
      56. Shekalaghe S, Drakeley C, Gosling R, Ndaro A, van Meegeren M, Enevold A, Alifrangis M, Mosha F, Sauerwein R, Bousema T. Primaquine clears submicroscopic Plasmodium falciparum gametocytes that persist after treatment with sulphadoxine-pyrimethamine and artesunate. PLoS One. 2007; 2(10):e1023.
        View in: PubMed
      57. Masika PM, Semarundu WJ, Urassa R, Mosha J, Chandramohan D, Gosling RD. Over-diagnosis of malaria is not a lost cause. Malar J. 2006; 5:120.
        View in: PubMed
      58. Gosling RD, Schellenberg DM, Chandramohan D. Single-dose sulfadoxine-pyrimethamine in intermittent preventive treatment of malaria. J Infect Dis. 2006 Jun 1; 193(11):1609-10; author reply 1610-1.
        View in: PubMed
      59. Uriyo J, Gosling RD, Maddox V, Sam NE, Schimana W, Gillespie SH, McHugh TD. Prevalences of Pneumocystis jiroveci, Mycobacterium tuberculosis and Streptococcus pneumoniae infection in children with severe pneumonia, in a tertiary referral hospital in northern Tanzania. Ann Trop Med Parasitol. 2006 Apr; 100(3):245-9.
        View in: PubMed
      60. Gillespie SH, Gosling RD, Uiso L, Sam NE, Kanduma EG, McHugh TD. Early bactericidal activity of a moxifloxacin and isoniazid combination in smear-positive pulmonary tuberculosis. J Antimicrob Chemother. 2005 Dec; 56(6):1169-71.
        View in: PubMed
      61. Urassa P, Gosling R, Pool R, Reyburn H. Attitudes to voluntary counselling and testing prior to the offer of Nevirapine to prevent vertical transmission of HIV in northern Tanzania. AIDS Care. 2005 Oct; 17(7):842-52.
        View in: PubMed
      62. Drakeley C, Gosling R, Reyburn H. Malaria diagnosis and treatment: one size does not fit all. PLoS Med. 2005 Jun; 2(6):e156; author reply e165.
        View in: PubMed
      63. McHugh TD, Batt SL, Shorten RJ, Gosling RD, Uiso L, Gillespie SH. Mycobacterium tuberculosis lineage: a naming of the parts. Tuberculosis (Edinb). 2005 May; 85(3):127-36.
        View in: PubMed
      64. McHugh TD, Pope CF, Ling CL, Patel S, Billington OJ, Gosling RD, Lipman MC, Gillespie SH. Prospective evaluation of BDProbeTec strand displacement amplification (SDA) system for diagnosis of tuberculosis in non-respiratory and respiratory samples. J Med Microbiol. 2004 Dec; 53(Pt 12):1215-9.
        View in: PubMed
      65. Bigley VH, Duarte RF, Gosling RD, Kibbler CC, Seaton S, Potter M. Fusarium dimerum infection in a stem cell transplant recipient treated successfully with voriconazole. Bone Marrow Transplant. 2004 Nov; 34(9):815-7.
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      66. Gosling RD, Uiso LO, Sam NE, Bongard E, Kanduma EG, Nyindo M, Morris RW, Gillespie SH. The bactericidal activity of moxifloxacin in patients with pulmonary tuberculosis. Am J Respir Crit Care Med. 2003 Dec 1; 168(11):1342-5.
        View in: PubMed
      67. Gosling RD, Heifets L, Gillespie SH. A multicentre comparison of a novel surrogate marker for determining the specific potency of anti-tuberculosis drugs. J Antimicrob Chemother. 2003 Sep; 52(3):473-6.
        View in: PubMed
      68. Gosling R, Mbatia R, Savage A, Mulligan JA, Reyburn H. Prevalence of hospital-acquired infections in a tertiary referral hospital in northern Tanzania. Ann Trop Med Parasitol. 2003 Jan; 97(1):69-73.
        View in: PubMed
      69. Gosling R, Walraven G, Manneh F, Bailey R, Lewis SM. Training health workers to assess anaemia with the WHO haemoglobin colour scale. Trop Med Int Health. 2000 Mar; 5(3):214-21.
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      70. von Seidlein L, Milligan P, Pinder M, Bojang K, Anyalebechi C, Gosling R, Coleman R, Ude JI, Sadiq A, Duraisingh M, Warhurst D, Alloueche A, Targett G, McAdam K, Greenwood B, Walraven G, Olliaro P, Doherty T. Efficacy of artesunate plus pyrimethamine-sulphadoxine for uncomplicated malaria in Gambian children: a double-blind, randomised, controlled trial. Lancet. 2000 Jan 29; 355(9201):352-7.
        View in: PubMed
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