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    Ronald Clyman, MD

    TitleProfessor in Residence
    SchoolUCSF School of Medicine
    DepartmentPediatrics
    AddressHSW-1408
    Phone415-476-4462

       Overview 
       Overview
      Dr. Ronald Clyman is a neonatologist and an expert in the treatment of extremely premature infants. He is internationally renowned for his basic and clinical studies of the ductus arteriousus, a blood vessel that transports blood from the right side of the heart to the aorta, which is the large blood vessel that distributes blood to a baby's body while still in the womb. He has helped define the role of oxygen and prostaglandins in ductus patency and is currently studying the mechanisms leading to irreversible ductal closure. Clyman is a professor of pediatrics at the University of California, San Francisco and a member of the Cardiovascular Research Institute. He earned his medical degree at Columbia University and is board certified in pediatrics and neonatal and perinatal medicine.

      Education
      Columbia University School of Medicine 1971


       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Clyman RI. The role of patent ductus arteriosus and its treatments in the development of bronchopulmonary dysplasia. Semin Perinatol. 2013 Apr; 37(2):102-7.
        View in: PubMed
      2. Wickremasinghe AC, Rogers EE, Piecuch RE, Johnson BC, Golden S, Moon-Grady AJ, Clyman RI. Neurodevelopmental outcomes following two different treatment approaches (early ligation and selective ligation) for patent ductus arteriosus. J Pediatr. 2012 Dec; 161(6):1065-72.
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      3. Clyman RI. Surgical ligation of the patent ductus arteriosus: treatment or morbidity? J Pediatr. 2012 Oct; 161(4):583-4.
        View in: PubMed
      4. Clyman RI, Couto J, Murphy GM. Patent ductus arteriosus: are current neonatal treatment options better or worse than no treatment at all? Semin Perinatol. 2012 Apr; 36(2):123-9.
        View in: PubMed
      5. Sutherland MR, Yoder BA, McCurnin D, Seidner S, Gubhaju L, Clyman RI, Black MJ. Effects of ibuprofen treatment on the developing preterm baboon kidney. Am J Physiol Renal Physiol. 2012 May 15; 302(10):F1286-92.
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      6. Waleh N, Seidner S, McCurnin D, Giavedoni L, Hodara V, Goelz S, Liu BM, Roman C, Clyman RI. Anatomic closure of the premature patent ductus arteriosus: The role of CD14+/CD163+ mononuclear cells and VEGF in neointimal mound formation. Pediatr Res. 2011 Oct; 70(4):332-8.
        View in: PubMed
      7. Waleh N, McCurnin DC, Yoder BA, Shaul PW, Clyman RI. Patent ductus arteriosus ligation alters pulmonary gene expression in preterm baboons. Pediatr Res. 2011 Mar; 69(3):212-6.
        View in: PubMed
      8. Shah NA, Hills NK, Waleh N, McCurnin D, Seidner S, Chemtob S, Clyman R. Relationship between circulating platelet counts and ductus arteriosus patency after indomethacin treatment. J Pediatr. 2011 Jun; 158(6):919-923.e1-2.
        View in: PubMed
      9. Loeliger M, Shields A, McCurnin D, Clyman RI, Yoder B, Inder TE, Rees SM. Ibuprofen treatment for closure of patent ductus arteriosus is not associated with increased risk of neuropathology. Pediatr Res. 2010 Oct; 68(4):298-302.
        View in: PubMed
      10. Waleh N, Hodnick R, Jhaveri N, McConaghy S, Dagle J, Seidner S, McCurnin D, Murray JC, Ohls R, Clyman RI. Patterns of gene expression in the ductus arteriosus are related to environmental and genetic risk factors for persistent ductus patency. Pediatr Res. 2010 Oct; 68(4):292-7.
        View in: PubMed
      11. Jhaveri N, Moon-Grady A, Clyman RI. Early surgical ligation versus a conservative approach for management of patent ductus arteriosus that fails to close after indomethacin treatment. J Pediatr. 2010 Sep; 157(3):381-7, 387.e1.
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      12. Chen S, Tacy T, Clyman R. How useful are B-type natriuretic peptide measurements for monitoring changes in patent ductus arteriosus shunt magnitude? J Perinatol. 2010 Dec; 30(12):780-5.
        View in: PubMed
      13. Jhaveri N, Soll RF, Clyman RI. Feeding practices and patent ductus arteriosus ligation preferences-are they related? Am J Perinatol. 2010 Sep; 27(8):667-74.
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      14. Clyman R, Chemtob S. Vessel remodeling in the newborn: platelets fill the gap. Nat Med. 2010 Jan; 16(1):33-5.
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      15. Reese J, Waleh N, Poole SD, Brown N, Roman C, Clyman RI. Chronic in utero cyclooxygenase inhibition alters PGE2-regulated ductus arteriosus contractile pathways and prevents postnatal closure. Pediatr Res. 2009 Aug; 66(2):155-61.
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      16. Clyman R, Cassady G, Kirklin JK, Collins M, Philips JB. The role of patent ductus arteriosus ligation in bronchopulmonary dysplasia: reexamining a randomized controlled trial. J Pediatr. 2009 Jun; 154(6):873-6.
        View in: PubMed
      17. Waleh N, Reese J, Kajino H, Roman C, Seidner S, McCurnin D, Clyman RI. Oxygen-induced tension in the sheep ductus arteriosus: effects of gestation on potassium and calcium channel regulation. Pediatr Res. 2009 Mar; 65(3):285-90.
        View in: PubMed
      18. Loeliger M, Inder TE, Dalitz PA, Cain S, Camm EJ, Yoder B, McCurnin D, Shaul PW, Clyman R, Rees SM. Developmental and neuropathological consequences of ductal ligation in the preterm baboon. Pediatr Res. 2009 Feb; 65(2):209-14.
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      19. McCurnin DC, Pierce RA, Willis BC, Chang LY, Yoder BA, Yuhanna IS, Ballard PL, Clyman RI, Waleh N, Maniscalco W, Crapo JD, Grubb PH, Shaul PW. Postnatal estradiol up-regulates lung nitric oxide synthases and improves lung function in bronchopulmonary dysplasia. Am J Respir Crit Care Med. 2009 Mar 15; 179(6):492-500.
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      20. Aranda JV, Clyman R, Cox B, Van Overmeire B, Wozniak P, Sosenko I, Carlo WA, Ward RM, Shalwitz R, Baggs G, Seth A, Darko L. A randomized, double-blind, placebo-controlled trial on intravenous ibuprofen L-lysine for the early closure of nonsymptomatic patent ductus arteriosus within 72 hours of birth in extremely low-birth-weight infants. Am J Perinatol. 2009 Mar; 26(3):235-45.
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      21. McCurnin D, Clyman RI. Effects of a patent ductus arteriosus on postprandial mesenteric perfusion in premature baboons. Pediatrics. 2008 Dec; 122(6):e1262-7.
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      22. Liu H, Manganiello V, Waleh N, Clyman RI. Expression, activity, and function of phosphodiesterases in the mature and immature ductus arteriosus. Pediatr Res. 2008 Nov; 64(5):477-81.
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      23. Ivey KN, Sutcliffe D, Richardson J, Clyman RI, Garcia JA, Srivastava D. Transcriptional regulation during development of the ductus arteriosus. Circ Res. 2008 Aug 15; 103(4):388-95.
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      24. McCurnin D, Seidner S, Chang LY, Waleh N, Ikegami M, Petershack J, Yoder B, Giavedoni L, Albertine KH, Dahl MJ, Wang ZM, Clyman RI. Ibuprofen-induced patent ductus arteriosus closure: physiologic, histologic, and biochemical effects on the premature lung. Pediatrics. 2008 May; 121(5):945-56.
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      25. Jegatheesan P, Ianus V, Buchh B, Yoon G, Chorne N, Ewig A, Lin E, Fields S, Moon-Grady A, Tacy T, Milstein J, Schreiber M, Padbury J, Clyman R. Increased indomethacin dosing for persistent patent ductus arteriosus in preterm infants: a multicenter, randomized, controlled trial. J Pediatr. 2008 Aug; 153(2):183-9.
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      26. Chang LY, McCurnin D, Yoder B, Shaul PW, Clyman RI. Ductus arteriosus ligation and alveolar growth in preterm baboons with a patent ductus arteriosus. Pediatr Res. 2008 Mar; 63(3):299-302.
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      27. Chorne N, Jegatheesan P, Lin E, Shi R, Clyman RI. Risk factors for persistent ductus arteriosus patency during indomethacin treatment. J Pediatr. 2007 Dec; 151(6):629-34.
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      28. Clyman RI, Roman C. The effects of caffeine on the preterm sheep ductus arteriosus. Pediatr Res. 2007 Aug; 62(2):167-9.
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      29. Clyman RI, Waleh N, Kajino H, Roman C, Mauray F. Calcium-dependent and calcium-sensitizing pathways in the mature and immature ductus arteriosus. Am J Physiol Regul Integr Comp Physiol. 2007 Oct; 293(4):R1650-6.
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      30. Chorne N, Leonard C, Piecuch R, Clyman RI. Patent ductus arteriosus and its treatment as risk factors for neonatal and neurodevelopmental morbidity. Pediatrics. 2007 Jun; 119(6):1165-74.
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      31. Clyman RI, Chorne N. Patent ductus arteriosus: evidence for and against treatment. J Pediatr. 2007 Mar; 150(3):216-9.
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      32. Clyman RI, Saha S, Jobe A, Oh W. Indomethacin prophylaxis for preterm infants: the impact of 2 multicentered randomized controlled trials on clinical practice. J Pediatr. 2007 Jan; 150(1):46-50.e2.
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      33. Reese J, Anderson JD, Brown N, Roman C, Clyman RI. Inhibition of cyclooxygenase isoforms in late- but not midgestation decreases contractility of the ductus arteriosus and prevents postnatal closure in mice. Am J Physiol Regul Integr Comp Physiol. 2006 Dec; 291(6):R1717-1723.
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      34. Asikainen TM, Chang LY, Coalson JJ, Schneider BK, Waleh NS, Ikegami M, Shannon JM, Winter VT, Grubb P, Clyman RI, Yoder BA, Crapo JD, White CW. Improved lung growth and function through hypoxia-inducible factor in primate chronic lung disease of prematurity. FASEB J. 2006 Aug; 20(10):1698-700.
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      35. Clyman RI. Mechanisms regulating the ductus arteriosus. Biol Neonate. 2006; 89(4):330-5.
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      36. Asikainen TM, Waleh NS, Schneider BK, Clyman RI, White CW. Enhancement of angiogenic effectors through hypoxia-inducible factor in preterm primate lung in vivo. Am J Physiol Lung Cell Mol Physiol. 2006 Oct; 291(4):L588-95.
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      37. Miller SP, Mayer EE, Clyman RI, Glidden DV, Hamrick SE, Barkovich AJ. Prolonged indomethacin exposure is associated with decreased white matter injury detected with magnetic resonance imaging in premature newborns at 24 to 28 weeks' gestation at birth. Pediatrics. 2006 May; 117(5):1626-31.
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      38. Hermes-DeSantis ER, Clyman RI. Patent ductus arteriosus: pathophysiology and management. J Perinatol. 2006 May; 26 Suppl 1:S14-8; discussion S22-3.
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      39. Keller RL, Tacy TA, Fields S, Ofenstein JP, Aranda JV, Clyman RI. Combined treatment with a nonselective nitric oxide synthase inhibitor (l-NMMA) and indomethacin increases ductus constriction in extremely premature newborns. Pediatr Res. 2005 Dec; 58(6):1216-21.
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      40. Levin M, McCurnin D, Seidner SR, Yoder B, Waleh N, Goldbarg S, Roman C, Liu BM, Borén J, Clyman RI. Postnatal constriction, ATP depletion, and cell death in the mature and immature ductus arteriosus. Am J Physiol Regul Integr Comp Physiol. 2006 Feb; 290(2):R359-64.
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      41. McCurnin DC, Yoder BA, Coalson J, Grubb P, Kerecman J, Kupferschmid J, Breuer C, Siler-Khodr T, Shaul PW, Clyman R. Effect of ductus ligation on cardiopulmonary function in premature baboons. Am J Respir Crit Care Med. 2005 Dec 15; 172(12):1569-74.
        View in: PubMed
      42. Asikainen TM, Schneider BK, Waleh NS, Clyman RI, Ho WB, Flippin LA, Günzler V, White CW. Activation of hypoxia-inducible factors in hyperoxia through prolyl 4-hydroxylase blockade in cells and explants of primate lung. Proc Natl Acad Sci U S A. 2005 Jul 19; 102(29):10212-7.
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      43. Levin M, Goldbarg S, Lindqvist A, Swärd K, Roman C, Liu BM, Hultén LM, Borén J, Clyman RI. ATP depletion and cell death in the neonatal lamb ductus arteriosus. Pediatr Res. 2005 Jun; 57(6):801-5.
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      44. Waleh N, Seidner S, McCurnin D, Yoder B, Liu BM, Roman C, Mauray F, Clyman RI. The role of monocyte-derived cells and inflammation in baboon ductus arteriosus remodeling. Pediatr Res. 2005 Feb; 57(2):254-62.
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      45. Waleh N, Kajino H, Marrache AM, Ginzinger D, Roman C, Seidner SR, Moss TJ, Fouron JC, Vazquez-Tello A, Chemtob S, Clyman RI. Prostaglandin E2--mediated relaxation of the ductus arteriosus: effects of gestational age on g protein-coupled receptor expression, signaling, and vasomotor control. Circulation. 2004 Oct 19; 110(16):2326-32.
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      46. Vazquez-Tello A, Fan L, Hou X, Joyal JS, Mancini JA, Quiniou C, Clyman RI, Gobeil F, Varma DR, Chemtob S. Intracellular-specific colocalization of prostaglandin E2 synthases and cyclooxygenases in the brain. Am J Physiol Regul Integr Comp Physiol. 2004 Nov; 287(5):R1155-63.
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      47. Clyman R. Oxygen-saturation targets and outcomes in extremely preterm infants. J Pediatr. 2004 Mar; 144(3):408.
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      48. Bouayad A, Fouron JC, Hou X, Beauchamp M, Quiniou C, Abran D, Peri K, Clyman RI, Varma DR, Chemtob S. Developmental regulation of prostaglandin E2 synthase in porcine ductus arteriosus. Am J Physiol Regul Integr Comp Physiol. 2004 May; 286(5):R903-9.
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      49. Keller RL, Clyman RI. Persistent Doppler flow predicts lack of response to multiple courses of indomethacin in premature infants with recurrent patent ductus arteriosus. Pediatrics. 2003 Sep; 112(3 Pt 1):583-7.
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      50. Goldbarg S, Quinn T, Waleh N, Roman C, Liu BM, Mauray F, Clyman RI. Effects of hypoxia, hypoglycemia, and muscle shortening on cell death in the sheep ductus arteriosus. Pediatr Res. 2003 Aug; 54(2):204-11.
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      51. Quinn D, Cooper B, Clyman RI. Factors associated with permanent closure of the ductus arteriosus: a role for prolonged indomethacin therapy. Pediatrics. 2002 Jul; 110(1 Pt 1):e10.
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      52. Kajino H, Goldbarg S, Roman C, Liu BM, Mauray F, Chen YQ, Takahashi Y, Koch CJ, Clyman RI. Vasa vasorum hypoperfusion is responsible for medial hypoxia and anatomic remodeling in the newborn lamb ductus arteriosus. Pediatr Res. 2002 Feb; 51(2):228-35.
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      53. Kajino H, Roman C, Clyman RI. Renal effects of cyclooxygenase-2 inhibition in fetal lambs. Biol Neonate. 2002; 82(4):257-62.
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      54. Goldbarg SH, Takahashi Y, Cruz C, Kajino H, Roman C, Liu BM, Chen YQ, Mauray F, Clyman RI. In utero indomethacin alters O2 delivery to the fetal ductus arteriosus: implications for postnatal patency. Am J Physiol Regul Integr Comp Physiol. 2002 Jan; 282(1):R184-90.
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      55. Clyman RI, Seidner SR, Kajino H, Roman C, Koch CJ, Ferrara N, Waleh N, Mauray F, Chen YQ, Perkett EA, Quinn T. VEGF regulates remodeling during permanent anatomic closure of the ductus arteriosus. Am J Physiol Regul Integr Comp Physiol. 2002 Jan; 282(1):R199-206.
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      56. Wright DH, Abran D, Bhattacharya M, Hou X, Bernier SG, Bouayad A, Fouron JC, Vazquez-Tello A, Beauchamp MH, Clyman RI, Peri K, Varma DR, Chemtob S. Prostanoid receptors: ontogeny and implications in vascular physiology. Am J Physiol Regul Integr Comp Physiol. 2001 Nov; 281(5):R1343-60.
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      57. Seidner SR, Chen YQ, Oprysko PR, Mauray F, Tse MM, Lin E, Koch C, Clyman RI. Combined prostaglandin and nitric oxide inhibition produces anatomic remodeling and closure of the ductus arteriosus in the premature newborn baboon. Pediatr Res. 2001 Sep; 50(3):365-73.
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      58. Kajino H, Chen YQ, Seidner SR, Waleh N, Mauray F, Roman C, Chemtob S, Koch CJ, Clyman RI. Factors that increase the contractile tone of the ductus arteriosus also regulate its anatomic remodeling. Am J Physiol Regul Integr Comp Physiol. 2001 Jul; 281(1):R291-301.
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      59. Bouayad A, Kajino H, Waleh N, Fouron JC, Andelfinger G, Varma DR, Skoll A, Vazquez A, Gobeil F, Clyman RI, Chemtob S. Characterization of PGE2 receptors in fetal and newborn lamb ductus arteriosus. Am J Physiol Heart Circ Physiol. 2001 May; 280(5):H2342-9.
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      60. Clyman RI, Chen YQ, Chemtob S, Mauray F, Kohl T, Varma DR, Roman C. In utero remodeling of the fetal lamb ductus arteriosus: the role of antenatal indomethacin and avascular zone thickness on vasa vasorum proliferation, neointima formation, and cell death. Circulation. 2001 Apr 3; 103(13):1806-12.
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      61. Bouayad A, Bernier SG, Asselin P, Hardy P, Bhattacharya M, Quiniou C, Fouron JC, Guerguerian AM, Varma DR, Clyman RI, Chemtob S. Characterization of PGE2 receptors in fetal and newborn ductus arteriosus in the pig. Semin Perinatol. 2001 Apr; 25(2):70-5.
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      62. Clyman RI. Ibuprofen and patent ductus arteriosus. N Engl J Med. 2000 Sep 7; 343(10):728-30.
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      63. Kajino H, Chen YQ, Chemtob S, Waleh N, Koch CJ, Clyman RI. Tissue hypoxia inhibits prostaglandin and nitric oxide production and prevents ductus arteriosus reopening. Am J Physiol Regul Integr Comp Physiol. 2000 Jul; 279(1):R278-86.
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      64. Takahashi Y, Roman C, Chemtob S, Tse MM, Lin E, Heymann MA, Clyman RI. Cyclooxygenase-2 inhibitors constrict the fetal lamb ductus arteriosus both in vitro and in vivo. Am J Physiol Regul Integr Comp Physiol. 2000 Jun; 278(6):R1496-505.
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      65. Scheidt PC, Brenner RA, Rossi MW, Clyman R, Boyle KE. Parental attitudes regarding interviews about injuries to their children. Inj Prev. 2000 Mar; 6(1):51-5.
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      66. Narayanan M, Cooper B, Weiss H, Clyman RI. Prophylactic indomethacin: factors determining permanent ductus arteriosus closure. J Pediatr. 2000 Mar; 136(3):330-7.
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      67. Bhattacharya M, Asselin P, Hardy P, Guerguerian AM, Shichi H, Hou X, Varma DR, Bouayad A, Fouron JC, Clyman RI, Chemtob S. Developmental changes in prostaglandin E(2) receptor subtypes in porcine ductus arteriosus. Possible contribution in altered responsiveness to prostaglandin E(2). Circulation. 1999 Oct 19; 100(16):1751-6.
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      68. Narayanan M, Schlueter M, Clyman RI. Incidence and outcome of a 10-fold indomethacin overdose in premature infants. J Pediatr. 1999 Jul; 135(1):105-7.
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      69. Clyman RI, Hardy P, Waleh N, Chen YQ, Mauray F, Fouron JC, Chemtob S. Cyclooxygenase-2 plays a significant role in regulating the tone of the fetal lamb ductus arteriosus. Am J Physiol. 1999 Mar; 276(3 Pt 2):R913-21.
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      70. Clyman RI, Chan CY, Mauray F, Chen YQ, Cox W, Seidner SR, Lord EM, Weiss H, Waleh N, Evans SM, Koch CJ. Permanent anatomic closure of the ductus arteriosus in newborn baboons: the roles of postnatal constriction, hypoxia, and gestation. Pediatr Res. 1999 Jan; 45(1):19-29.
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      71. Guerguerian AM, Hardy P, Bhattacharya M, Olley P, Clyman RI, Fouron JC, Chemtob S. Expression of cyclooxygenases in ductus arteriosus of fetal and newborn pigs. Am J Obstet Gynecol. 1998 Dec; 179(6 Pt 1):1618-26.
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      72. Fineman JR, Takahashi Y, Roman C, Clyman RI. Endothelin-receptor blockade does not alter closure of the ductus arteriosus. Am J Physiol. 1998 Nov; 275(5 Pt 2):H1620-6.
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      73. Clyman RI, Waleh N, Black SM, Riemer RK, Mauray F, Chen YQ. Regulation of ductus arteriosus patency by nitric oxide in fetal lambs: the role of gestation, oxygen tension, and vasa vasorum. Pediatr Res. 1998 May; 43(5):633-44.
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      74. Piecuch RE, Leonard CH, Clyman RI, Cooper BA. Risk factors associated with infant death among very low birth weight infants after discharge from an intensive care nursery. J Dev Behav Pediatr. 1998 Apr; 19(2):84-8.
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      75. Koch CJ, Lord EM, Shapiro IM, Clyman RI, Evans SM. Imaging hypoxia and blood flow in normal tissues. Adv Exp Med Biol. 1997; 428:585-93.
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      76. Clyman RI, Goetzman BW, Chen YQ, Mauray F, Kramer RH, Pytela R, Schnapp LM. Changes in endothelial cell and smooth muscle cell integrin expression during closure of the ductus arteriosus: an immunohistochemical comparison of the fetal, preterm newborn, and full-term newborn rhesus monkey ductus. Pediatr Res. 1996 Aug; 40(2):198-208.
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      77. Clyman RI. Recommendations for the postnatal use of indomethacin: an analysis of four separate treatment strategies. J Pediatr. 1996 May; 128(5 Pt 1):601-7.
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      78. Tannenbaum JE, Waleh NS, Mauray F, Gold L, Perkett EA, Clyman RI. Transforming growth factor-beta protein and messenger RNA expression is increased in the closing ductus arteriosus. Pediatr Res. 1996 Mar; 39(3):427-34.
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      79. Weiss H, Cooper B, Brook M, Schlueter M, Clyman R. Factors determining reopening of the ductus arteriosus after successful clinical closure with indomethacin. J Pediatr. 1995 Sep; 127(3):466-71.
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      80. Tannenbaum JE, Waleh NS, Mauray F, Breuss J, Pytela R, Kramer RH, Clyman RI. Transforming growth factor beta 1 inhibits fetal lamb ductus arteriosus smooth muscle cell migration. Pediatr Res. 1995 May; 37(5):561-70.
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      81. Merrill JD, Clyman RI, Norton ME. Indomethacin as a tocolytic agent: the controversy continues. J Pediatr. 1994 May; 124(5 Pt 1):734-6.
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      82. Clyman RI, Tannenbaum J, Chen YQ, Cooper D, Yurchenco PD, Kramer RH, Waleh NS. Ductus arteriosus smooth muscle cell migration on collagen: dependence on laminin and its receptors. J Cell Sci. 1994 Apr; 107 ( Pt 4):1007-18.
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      83. Clyman RI, Peters KG, Chen YQ, Escobedo J, Williams LT, Ives HE, Wilson E. Phospholipase C gamma activation, phosphotidylinositol hydrolysis, and calcium mobilization are not required for FGF receptor-mediated chemotaxis. Cell Adhes Commun. 1994 Jan; 1(4):333-42.
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      84. Norton ME, Merrill J, Cooper BA, Kuller JA, Clyman RI. Neonatal complications after the administration of indomethacin for preterm labor. N Engl J Med. 1993 Nov 25; 329(22):1602-7.
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      85. Clyman RI, Mauray F, Kramer RH. Beta 1 and beta 3 integrins have different roles in the adhesion and migration of vascular smooth muscle cells on extracellular matrix. Exp Cell Res. 1992 Jun; 200(2):272-84.
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      86. Alpan G, Scheerer R, Bland R, Clyman R. Patent ductus arteriosus increases lung fluid filtration in preterm lambs. Pediatr Res. 1991 Dec; 30(6):616-21.
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      87. Meyers RL, Alpan G, Lin E, Clyman RI. Patent ductus arteriosus, indomethacin, and intestinal distension: effects on intestinal blood flow and oxygen consumption. Pediatr Res. 1991 Jun; 29(6):569-74.
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      88. Cheng YF, Clyman RI, Enenstein J, Waleh N, Pytela R, Kramer RH. The integrin complex alpha v beta 3 participates in the adhesion of microvascular endothelial cells to fibronectin. Exp Cell Res. 1991 May; 194(1):69-77.
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      89. Clyman RI. Persistent patent ductus arteriosus. Int J Technol Assess Health Care. 1991; 7 Suppl 1:70-8.
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      90. Alpan G, Mauray F, Clyman RI. The effects of the patent ductus arteriosus on diaphragmatic blood flow and function. Pediatr Res. 1990 Nov; 28(5):437-45.
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      91. Kramer RH, Cheng YF, Clyman R. Human microvascular endothelial cells use beta 1 and beta 3 integrin receptor complexes to attach to laminin. J Cell Biol. 1990 Sep; 111(3):1233-43.
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      92. Clyman RI, McDonald KA, Kramer RH. Integrin receptors on aortic smooth muscle cells mediate adhesion to fibronectin, laminin, and collagen. Circ Res. 1990 Jul; 67(1):175-86.
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      93. Clyman RI, Turner DC, Kramer RH. An alpha 1/beta 1-like integrin receptor on rat aortic smooth muscle cells mediates adhesion to laminin and collagen types I and IV. Arteriosclerosis. 1990 May-Jun; 10(3):402-9.
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      94. Leonard CH, Clyman RI, Piecuch RE, Juster RP, Ballard RA, Behle MB. Effect of medical and social risk factors on outcome of prematurity and very low birth weight. J Pediatr. 1990 Apr; 116(4):620-6.
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      95. Alpan G, Clyman RI. The effect of methylprednisolone on hypoxic pulmonary vasoconstriction in the newborn late-gestation lamb. Pediatr Res. 1990 Feb; 27(2):133-6.
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      96. Alpan G, Mauray F, Clyman RI. Effect of patent ductus arteriosus on water accumulation and protein permeability in the lungs of mechanically ventilated premature lambs. Pediatr Res. 1989 Dec; 26(6):570-5.
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      97. Frantz E, Soifer SJ, Clyman RI, Heymann MA. Bradykinin produces pulmonary vasodilation in fetal lambs: role of prostaglandin production. J Appl Physiol. 1989 Oct; 67(4):1512-7.
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      98. Wallen LD, Murai DT, Clyman RI, Lee CH, Mauray FE, Ballard PL, Kitterman JA. Meclofenamate does not affect lung development in fetal sheep. J Dev Physiol. 1989 Aug; 12(2):109-15.
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      99. Clyman RI, Mauray F, Heymann MA, Roman C. Influence of increased pulmonary vascular pressures on the closure of the ductus arteriosus in newborn lambs. Pediatr Res. 1989 Feb; 25(2):136-42.
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      100. Guerra FA, Savich RD, Clyman RI, Kitterman JA. Meclofenamate increases ventilation in lambs. J Dev Physiol. 1989 Jan; 11(1):1-6.
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      101. Clyman RI, Saugstad OD, Mauray F. Reactive oxygen metabolites relax the lamb ductus arteriosus by stimulating prostaglandin production. Circ Res. 1989 Jan; 64(1):1-8.
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      102. Soifer SJ, Clyman RI, Heymann MA. Effects of prostaglandin D2 on pulmonary arterial pressure and oxygenation in newborn infants with persistent pulmonary hypertension. J Pediatr. 1988 May; 112(5):774-7.
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      103. Guerra FA, Savich RD, Wallen LD, Lee CH, Clyman RI, Mauray FE, Kitterman JA. Prostaglandin E2 causes hypoventilation and apnea in newborn lambs. J Appl Physiol. 1988 May; 64(5):2160-6.
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      104. Clyman RI, Teitel D, Padbury J, Roman C, Mauray F. The role of beta-adrenoreceptor stimulation and contractile state in the preterm lamb's response to altered ductus arteriosus patency. Pediatr Res. 1988 Mar; 23(3):316-22.
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      105. Heymann MA, LeBidois J, Soifer SJ, Clyman RI. Leukotriene synthesis inhibition increases pulmonary blood flow in fetal lambs. Chest. 1988 Mar; 93(3 Suppl):117S.
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      106. Wallen LD, Murai DT, Clyman RI, Lee CH, Mauray FE, Kitterman JA. Effects of meclofenamate on breathing movements in fetal sheep before delivery. J Appl Physiol. 1988 Feb; 64(2):759-66.
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      107. Gleason CA, Clyman RI, Heymann MA, Mauray F, Leake R, Roman C. Indomethacin and patent ductus arteriosus: effects on renal function in preterm lambs. Am J Physiol. 1988 Jan; 254(1 Pt 2):F38-44.
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      108. Pérez Fontán JJ, Clyman RI, Mauray F, Heymann MA, Roman C. Respiratory effects of a patent ductus arteriosus in premature newborn lambs. J Appl Physiol. 1987 Dec; 63(6):2315-24.
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      109. Teague WG, Raj JU, Braun D, Berner ME, Clyman RI, Bland RD. Lung vascular effects of lipid infusion in awake lambs. Pediatr Res. 1987 Dec; 22(6):714-9.
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      110. Clyman RI, Roman C, Heymann MA, Mauray F. How a patent ductus arteriosus effects the premature lamb's ability to handle additional volume loads. Pediatr Res. 1987 Nov; 22(5):531-5.
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      111. Clyman RI, Campbell D. Indomethacin therapy for patent ductus arteriosus: when is prophylaxis not prophylactic? J Pediatr. 1987 Nov; 111(5):718-22.
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      112. Durand DJ, Goodman A, Ray P, Ballard RA, Clyman RI. Theophylline treatment in the extubation of infants weighing less than 1,250 grams: a controlled trial. Pediatrics. 1987 Nov; 80(5):684-8.
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      113. Clyman RI, Mauray F, Heymann MA, Roman C. Cardiovascular effects of patent ductus arteriosus in preterm lambs with respiratory distress. J Pediatr. 1987 Oct; 111(4):579-87.
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      114. Lebidois J, Soifer SJ, Clyman RI, Heymann MA. Piriprost: a putative leukotriene synthesis inhibitor increases pulmonary blood flow in fetal lambs. Pediatr Res. 1987 Sep; 22(3):350-4.
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      115. Norcia AM, Tyler CW, Piecuch R, Clyman R, Grobstein J. Visual acuity development in normal and abnormal preterm human infants. J Pediatr Ophthalmol Strabismus. 1987 Mar-Apr; 24(2):70-4.
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      116. Murai DT, Wallen LD, Lee CC, Clyman RI, Mauray F, Kitterman JA. Effects of prostaglandins on fetal breathing do not involve peripheral chemoreceptors. J Appl Physiol. 1987 Jan; 62(1):271-7.
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      117. Clyman RI. Ductus arteriosus: current theories of prenatal and postnatal regulation. Semin Perinatol. 1987 Jan; 11(1):64-71.
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      118. Wallen LD, Murai DT, Clyman RI, Lee CH, Mauray FE, Kitterman JA. Regulation of breathing movements in fetal sheep by prostaglandin E2. J Appl Physiol. 1986 Feb; 60(2):526-31.
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      119. Clozel M, Clyman RI, Soifer SJ, Heymann MA. Thromboxane is not responsible for the high pulmonary vascular resistance in fetal lambs. Pediatr Res. 1985 Dec; 19(12):1254-7.
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      120. Durand DJ, Clyman RI, Heymann MA, Clements JA, Mauray F, Kitterman J, Ballard P. Effects of a protein-free, synthetic surfactant on survival and pulmonary function in preterm lambs. J Pediatr. 1985 Nov; 107(5):775-80.
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      121. Maher P, Lane B, Ballard R, Piecuch R, Clyman RI. Does indomethacin cause extension of intracranial hemorrhages: a preliminary study. Pediatrics. 1985 Mar; 75(3):497-500.
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      122. Clyman RI, Campbell D, Heymann MA, Mauray F. Persistent responsiveness of the neonatal ductus arteriosus in immature lambs: a possible cause for reopening of patent ductus arteriosus after indomethacin-induced closure. Circulation. 1985 Jan; 71(1):141-5.
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      123. Murai DT, Clyman RI, Mauray FE, Lee CC, Kitterman JA. Meclofenamate and prostaglandin E2 affect breathing movements independently of glucose concentrations in fetal sheep. Am J Obstet Gynecol. 1984 Nov 15; 150(6):758-64.
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      124. Clyman R. The role of the patent ductus arteriosus in respiratory distress syndrome. Semin Perinatol. 1984 Oct; 8(4):293-9.
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      125. Mahony L, Clyman RI, Heymann MA. Decreased contractility of the ductus arteriosus in experimental pulmonic stenosis. Circulation. 1984 Oct; 70(4):695-9.
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      126. Piecuch RE, Roth RS, Clyman RI, Sniderman SH, Riedel PA, Ballard RA. Videophone use improves maternal interest in transported infants. Crit Care Med. 1983 Aug; 11(8):655-6.
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      127. Clyman RI, Mauray F, Roman C, Heymann MA, Payne B. Factors determining the loss of ductus arteriosus responsiveness to prostaglandin E. Circulation. 1983 Aug; 68(2):433-6.
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      128. Karsdon J, Clyman RI. A comparison of continuous wave Doppler ultrasonography with microsphere measured left-to-right shunt through the patent ductus arteriosus. Crit Care Med. 1983 Jul; 11(7):556-8.
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      129. Clyman RI, Mauray F, Roman C, Heymann MA, Payne B. Effect of gestational age on ductus arteriosus response to circulating prostaglandin E2. J Pediatr. 1983 Jun; 102(6):907-11.
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      130. Clyman RI, Heymann MA, Mauray F. Role of circulating prostaglandin E2 in regulation of the ductus arteriosus. Adv Prostaglandin Thromboxane Leukot Res. 1983; 12:495-8.
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      131. Mahony L, Heymann MA, Carnero V, Brett C, Clyman RI. When to treat the patent ductus arteriosus with indomethacin in very-low-birth-weight infants. Adv Prostaglandin Thromboxane Leukot Res. 1983; 12:491-4.
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      132. Heymann MA, Clyman RI. Evaluation of alprostadil (prostaglandin E1) in the management of congenital heart disease in infancy. Pharmacotherapy. 1982 May-Jun; 2(3):148-55.
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      133. Mahony L, Carnero V, Brett C, Heymann MA, Clyman RI. Prophylactic indomethacin therapy for patent ductus arteriosus in very-low-birth-weight infants. N Engl J Med. 1982 Mar 4; 306(9):506-10.
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      134. Ballard PL, Kitterman JA, Bland RD, Clyman RI, Gluckman PD, Platzker AC, Kaplan SL, Grumbach MM. Ontogeny and regulation of corticosteroid binding globulin capacity in plasma of fetal and newborn lambs. Endocrinology. 1982 Feb; 110(2):359-66.
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      135. Clyman RI, Jobe A, Heymann M, Ikegami M, Roman C, Payne B, Mauray F. Increased shunt through the patent ductus arteriosus after surfactant replacement therapy. J Pediatr. 1982 Jan; 100(1):101-7.
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      136. Brett C, Dekle M, Leonard CH, Clark C, Sniderman S, Roth R, Ballard R, Clyman R. Developmental follow-up of hyperventilated neonates: preliminary observations. Pediatrics. 1981 Oct; 68(4):588-91.
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      137. Clark CE, Clyman RI, Roth RS, Sniderman SH, Lane B, Ballard RA. Risk factor analysis of intraventricular hemorrhage in low-birth-weight infants. J Pediatr. 1981 Oct; 99(4):625-8.
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      138. Clyman RI, Mauray F, Roman C, Heymann MA, Ballard PL, Rudolph AM, Payne B. Effects of antenatal glucocorticoid administration on ductus arteriosus of preterm lambs. Am J Physiol. 1981 Sep; 241(3):H415-20.
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      139. Clyman RI, Mauray F, Heymann MA, Roman C. Effect of gestational age on pulmonary metabolism of prostaglandin E1 & E2. Prostaglandins. 1981 Mar; 21(3):505-13.
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      140. Clyman RI, Heymann MA. Pharmacology of the ductus arteriosus. Pediatr Clin North Am. 1981 Feb; 28(1):77-93.
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      141. Clyman RI, Mauray F, Roman C, Rudolph AM, Heymann MA. Glucocorticoids alter the sensitivity of the lamb ductus arteriosus to prostaglandin E2. J Pediatr. 1981 Jan; 98(1):126-8.
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      142. Clyman RI, Ballard PL, Sniderman S, Ballard RA, Roth R, Heymann MA, Granberg JP. Prenatal administration of betamethasone for prevention of patient ductus arteriosus. J Pediatr. 1981 Jan; 98(1):123-6.
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      143. Clyman RI, Brett C, Mauray F. Circulating prostaglandin E2 concentrations and incidence of patent ductus arteriosus in preterm infants with respiratory distress syndrome. Pediatrics. 1980 Nov; 66(5):725-9.
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      144. Clyman RI, Mauray F, Roman C, Rudolph AM, Heymann MA. Circulating prostaglandin E2 concentrations and patent ductus arteriosus in fetal and neonatal lambs. J Pediatr. 1980 Sep; 97(3):455-61.
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      145. Miller C, Clyman RI, Roth RS, Sniderman SH, Ballard RA, Henning D, Riedel P, Rosen A, Burden L. Control of oxygenation during the transport of sick neonates. Pediatrics. 1980 Jul; 66(1):117-9.
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      146. Clyman RI, Roth RS, Sniderman SH, Charrier J. Does a belief in a 'just world' affect health care providers' reactions to perinatal illness? J Med Educ. 1980 Jun; 55(6):538-9.
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      147. Clyman RI. Ontogeny of the ductus arteriosus response to prostaglandins and inhibitors of their synthesis. Semin Perinatol. 1980 Apr; 4(2):115-24.
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      148. Clyman RI, Green C, Rowe J, Mikkelsen C, Ataide L. Issues concerning parents after the death of their newborn. Crit Care Med. 1980 Apr; 8(4):215-8.
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      149. Clyman RI, Mauray F, Demers LM, Rudolph AM, Roman C. Does oxygen regulate prostaglandin-induced relaxation in the lamb ductus arteriosus? Prostaglandins. 1980 Mar; 19(3):489-98.
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      150. Clyman RI. Ductus arteriosus: developmental response to endogenous prostaglandins, oxygen, and indomethacin. Adv Prostaglandin Thromboxane Res. 1980; 7:887-90.
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      151. Clyman RI, Mauray F, Rudolph AM, Heymann MA. Age-dependent sensitivity of the lamb ductus arteriosus to indomethacin and prostaglandins. J Pediatr. 1980 Jan; 96(1):94-8.
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      152. Leonard CH, Irwin N, Ballard RA, Ferris C, Clyman R. Preliminary observations on the behavior of children present at the birth of a sibling. Pediatrics. 1979 Dec; 64(6):949-51.
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      153. Clyman RI, Mauray F, Demers LM, Rudolph AM, Roman C. Developmental response to indomethacin: a comparison of isometric tension with PGE2 formation in the lamb ductus arteriosus. Prostaglandins. 1979 Nov; 18(5):721-30.
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      154. Clyman RI, Green C, Mikkelsen C, Rowe J, Ataide L. Do parents utilize physician follow-up after death of their newborn? Pediatrics. 1979 Nov; 64(5):665-7.
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      155. Clyman RI, Sniderman SH, Ballard RA, Roth RS. What pediatricians say to mothers of sick newborns: an indirect evaluation of the counseling process. Pediatrics. 1979 May; 63(5):719-23.
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      156. Clyman RI, Mauray F, Koerper MA, Wiemer F, Heymann MA, Rudolph AM. Formation of prostacyclin (PGI2) by the ductus arteriosus of fetal lambs at different stages of gestation. Prostaglandins. 1978 Oct; 16(4):633-42.
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      157. Rowe J, Clyman R, Green C, Mikkelsen C, Haight J, Ataide L. Follow-up families who experience a perinatal death. Pediatrics. 1978 Aug; 62(2):166-70.
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      158. Clyman RI. Developmental responses to oxygen, arachidonic acid, and indomethacin in the fetal lamb ductus arteriosus in vitro. Prostaglandins Med. 1978 Aug; 1(2):167-74.
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      159. Clyman RI, Mauray F, Roman C, Rudolph AM. PGE2 is a more potent vasodilator of the lamb ductus arteriosus than is either PGI2 or 6 keto PGF1alpha. Prostaglandins. 1978 Aug; 16(2):259-64.
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      160. Clyman RI, Mauray F, Heymann MA, Rudolph AM. Ductus arteriosus: developmental response to oxygen and indomethacin. Prostaglandins. 1978 Jun; 15(6):993-8.
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      161. Gallin JI, Sandler JA, Clyman RI, Manganiello VC, Vaughan M. Agents that increase cyclic AMP inhibit accumulation of cGMP and depress human monocyte locomotion. J Immunol. 1978 Feb; 120(2):492-6.
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      162. Clyman RI, Wong L, Heymann MA, Rudolph AM. Responsiveness of the lamb ductus arteriosus to prostaglandins and their metabolites. Prostaglandins. 1978 Feb; 15(2):325-31.
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      163. Clyman RI, Rudolph AM. Patent ductus arteriosus: a new light on an old problem. Pediatr Res. 1978 Feb; 12(2):92-4.
        View in: PubMed
      164. Clyman RI. Regulation of Cyclic nucleotide metabolism in the human umbilical artery. Adv Prostaglandin Thromboxane Res. 1978; 4:175-83.
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      165. Clyman RI, Mauray F, Wong L, Heymann MA, Rudolph AM. The developmental response of the ductus arteriosus to oxygen. Biol Neonate. 1978; 34(3-4):177-81.
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      166. Clyman RI, Heymann MA, Rudolph AM. Oxygen tension and the response of the ductus arteriosus to PGE: searching high and low for a solution. Prostaglandins. 1977 Sep; 14(3):599-600.
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      167. Clyman RI, Manganiello VC, Vaughan M. Oxygen: influence on cyclic nucleotides and calcium sequestration in the human umbilical artery. Chest. 1977 Feb; 71(2 suppl):247-9.
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      168. Clyman RI, Heymann MA, Rudolph AM. Ductus arteriosus responses to prostaglandin E1 at high and low oxygen concentrations. Prostaglandins. 1977 Feb; 13(2):219-23.
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      169. Clyman RI, Manganiello VC, Lovell-Smith CJ, Vaughan M. Calcium uptake by subcellular fractions of human umbilical artery. Am J Physiol. 1976 Oct; 231(4):1074-81.
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      170. Clyman RI, Blacksin AS, Manganiello VC, Vaughan M. Oxygen and cyclic nucleotides in human umbilical artery. Proc Natl Acad Sci U S A. 1975 Oct; 72(10):3883-7.
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      171. Clyman RI, Blacksin AS, Sandler JA, Manganiello VC, Vaughan M. The role of calcium in regulation of cyclic nucleotide content in human umbilical artery. J Biol Chem. 1975 Jun 25; 250(12):4718-21.
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      172. Clyman RI, Sandler JA, Manganiello VC, Vaughan M. Guanosine 3',5'-monophosphate and adenosine 3',5'-monophosphate content of human umbilical artery. J Clin Invest. 1975 May; 55(5):1020-5.
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      173. Sandler JA, Clyman RI, Manganiello VC, Vaughan M. The effect of serotonin (5-hydroxytryptamine) and derivatives on guanosine 3',5'-monophosphate in human monocytes. J Clin Invest. 1975 Feb; 55(2):431-5.
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      174. Wallace H, Clyman RI, Pierro LP. Nucleic acid deficiency in the prothanic homozygous mutant of creeper fowl. J Exp Zool. 1969 Oct; 172(2):245-52.
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